BRPI1012959A2 - dispersoes solidas contendo um agente promotor de apoptose - Google Patents

dispersoes solidas contendo um agente promotor de apoptose

Info

Publication number
BRPI1012959A2
BRPI1012959A2 BRPI1012959A BRPI1012959A BRPI1012959A2 BR PI1012959 A2 BRPI1012959 A2 BR PI1012959A2 BR PI1012959 A BRPI1012959 A BR PI1012959A BR PI1012959 A BRPI1012959 A BR PI1012959A BR PI1012959 A2 BRPI1012959 A2 BR PI1012959A2
Authority
BR
Brazil
Prior art keywords
promoting agent
solid dispersions
dispersions containing
apoptosis promoting
apoptosis
Prior art date
Application number
BRPI1012959A
Other languages
English (en)
Inventor
Cristina M Fischer
Eric A Schmitt
Huailiang Wu
Jonathan Mark Miller
Justin S Lafountaine
Katherine Heemstra
Ping Tong
Yanxia Li
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BRPI1012959A2 publication Critical patent/BRPI1012959A2/pt
Publication of BRPI1012959A8 publication Critical patent/BRPI1012959A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI1012959A 2009-06-08 2010-06-08 Dispersoes solidas contendo um agente promotor de apoptose BRPI1012959A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18510509P 2009-06-08 2009-06-08
PCT/US2010/037795 WO2010144464A2 (en) 2009-06-08 2010-06-08 Solid dispersions containing an apoptosis-promoting agent

Publications (2)

Publication Number Publication Date
BRPI1012959A2 true BRPI1012959A2 (pt) 2016-03-29
BRPI1012959A8 BRPI1012959A8 (pt) 2016-09-13

Family

ID=43242850

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012959A BRPI1012959A8 (pt) 2009-06-08 2010-06-08 Dispersoes solidas contendo um agente promotor de apoptose

Country Status (16)

Country Link
US (1) US20100311751A1 (pt)
EP (1) EP2440208A2 (pt)
JP (1) JP5705840B2 (pt)
KR (1) KR20120032520A (pt)
CN (1) CN102802607A (pt)
AU (1) AU2010258943B2 (pt)
BR (1) BRPI1012959A8 (pt)
CA (1) CA2764103A1 (pt)
IL (1) IL216493A (pt)
MX (1) MX2011013167A (pt)
NZ (1) NZ597248A (pt)
RU (1) RU2550134C2 (pt)
SG (1) SG176728A1 (pt)
TW (1) TWI532484B (pt)
WO (1) WO2010144464A2 (pt)
ZA (1) ZA201108856B (pt)

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TWI471321B (zh) 2009-06-08 2015-02-01 亞培公司 Ｂｃｌ－２族群抑制劑之口服醫藥劑型
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
BR112012031516A2 (pt) 2010-06-09 2016-11-08 Abbott Lab dispersões sólidas contendo inibidores de quinase
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
RU2014111981A (ru) * 2011-10-05 2015-11-10 Дуглас Фармасьютикалс Лтд. Фармацевтические способы и композиции для местного применения, содержащие ацитретин
CN108542906A (zh) 2011-11-11 2018-09-18 诺华股份有限公司 治疗增生性疾病的方法
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JP6878398B2 (ja) 2015-04-03 2021-05-26 インパクト セラピューティクス インコーポレイティドＩｍｐａｃｔ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ Ｐａｒｐ阻害剤固形医薬剤型及びその使用
WO2018013693A1 (en) * 2016-07-13 2018-01-18 Celgene Corporation Solid dispersions and cocrystals comprising 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione compositions and methods of use thereof
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US20230025865A1 (en) * 2019-12-11 2023-01-26 The Regents Of The University Of Michigan COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS

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US20100311751A1 (en) 2010-12-09
NZ597248A (en) 2014-03-28
SG176728A1 (en) 2012-01-30
AU2010258943B2 (en) 2014-03-13
RU2011152628A (ru) 2013-07-20
CA2764103A1 (en) 2010-12-16
JP5705840B2 (ja) 2015-04-22
JP2012529521A (ja) 2012-11-22
MX2011013167A (es) 2012-01-30
TWI532484B (zh) 2016-05-11
CN102802607A (zh) 2012-11-28
IL216493A (en) 2015-05-31
ZA201108856B (en) 2012-08-29
IL216493A0 (en) 2012-01-31
WO2010144464A3 (en) 2011-02-24
EP2440208A2 (en) 2012-04-18
AU2010258943A1 (en) 2012-01-19
TW201102067A (en) 2011-01-16
BRPI1012959A8 (pt) 2016-09-13
RU2550134C2 (ru) 2015-05-10
KR20120032520A (ko) 2012-04-05

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