BRPI1013152A2 - composto que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais. - Google Patents

composto que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais.

Info

Publication number
BRPI1013152A2
BRPI1013152A2 BRPI1013152A BRPI1013152A BRPI1013152A2 BR PI1013152 A2 BRPI1013152 A2 BR PI1013152A2 BR PI1013152 A BRPI1013152 A BR PI1013152A BR PI1013152 A BRPI1013152 A BR PI1013152A BR PI1013152 A2 BRPI1013152 A2 BR PI1013152A2
Authority
BR
Brazil
Prior art keywords
activity
muscle
urethal
sphincters
destructive
Prior art date
Application number
BRPI1013152A
Other languages
English (en)
Inventor
Akihiro Kinoshita
Hidekazu Matsuya
Hiroki Okada
Kazuyuki Ohmoto
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BRPI1013152A2 publication Critical patent/BRPI1013152A2/pt
Publication of BRPI1013152B1 publication Critical patent/BRPI1013152B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26Radicals substituted by sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
BRPI1013152-3A 2009-06-10 2010-06-09 Composto, composição farmacêutica e medicamento que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais BRPI1013152B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009-139657 2009-06-10
JP2009139657 2009-06-10
JP2009-256008 2009-11-09
JP2009256008 2009-11-09
PCT/JP2010/059771 WO2010143661A1 (ja) 2009-06-10 2010-06-09 膀胱排尿筋収縮および尿道括約筋弛緩作用を有する化合物

Publications (2)

Publication Number Publication Date
BRPI1013152A2 true BRPI1013152A2 (pt) 2016-04-05
BRPI1013152B1 BRPI1013152B1 (pt) 2019-06-18

Family

ID=43308916

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013152-3A BRPI1013152B1 (pt) 2009-06-10 2010-06-09 Composto, composição farmacêutica e medicamento que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais

Country Status (19)

Country Link
US (3) US8410281B2 (pt)
EP (1) EP2441760B1 (pt)
JP (1) JP4807478B2 (pt)
KR (1) KR101633149B1 (pt)
CN (1) CN102803239B (pt)
AU (1) AU2010259585B2 (pt)
BR (1) BRPI1013152B1 (pt)
CA (1) CA2764782C (pt)
DK (1) DK2441760T3 (pt)
ES (1) ES2444500T3 (pt)
IL (1) IL216856A0 (pt)
MX (1) MX2011013283A (pt)
NZ (1) NZ596960A (pt)
PL (1) PL2441760T3 (pt)
PT (1) PT2441760E (pt)
RU (1) RU2531350C2 (pt)
TW (1) TWI437987B (pt)
WO (1) WO2010143661A1 (pt)
ZA (1) ZA201109103B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2531350C2 (ru) * 2009-06-10 2014-10-20 Оно Фармасьютикал Ко., Лтд. Соединение, обладающее сокращающей детрузор активностью и релаксирующей уретральный сфинктер активностью
ES2623788T3 (es) * 2012-08-31 2017-07-12 Ono Pharmaceutical Co., Ltd. Sal de amina y cristales de la misma
EP3027199B1 (en) 2013-08-01 2019-06-26 Dignify Therapeutics, LLC Compositions and methods for inducing urinary voiding and defecation
JP2017533227A (ja) * 2014-11-03 2017-11-09 ウィリアム・ボーモント・ホスピタルWilliam Beaumont Hospital 低活動膀胱症候群を治療するための方法
AU2019419750B2 (en) 2018-12-31 2025-07-10 Adama Makhteshim Ltd. Synthesis of 1,1,2-trifluoro-4-(substituted sufonyl)-but-1-ene
WO2021024253A1 (en) * 2019-08-04 2021-02-11 Yeda Research And Development Co. Ltd. Process for the preparation of fluensulfone
CN119039235B (zh) * 2024-08-20 2025-12-16 湖北省医药工业研究院有限公司 合成阿伐那非、中间体的方法及用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (pt) 1970-06-10 1975-02-04
JPS5231404B1 (pt) 1971-04-28 1977-08-15
JPS57156460A (en) 1981-03-20 1982-09-27 Ono Pharmaceut Co Ltd Stabilized composition of prostaglandin and prostaglandin mimic compound, and its preparation
JPS60197667A (ja) 1984-03-19 1985-10-07 Ono Pharmaceut Co Ltd 6―ケト―プロスタグランジン類似化合物及びその製造方法
JP4044967B2 (ja) 1997-02-10 2008-02-06 小野薬品工業株式会社 11,15−o−ジアルキルプロスタグランジンe誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
JPH11130678A (ja) 1997-08-27 1999-05-18 Kaken Pharmaceut Co Ltd 神経圧迫による神経障害改善剤
CN101921220B (zh) 2001-07-23 2013-05-22 小野药品工业株式会社 治疗与骨质损失有关的疾病的含有ep4激动剂作为活性成分的药物组合物
JP2005053707A (ja) 2001-07-30 2005-03-03 Kankyo Device Kenkyusho:Kk 可視光応答性材料の製造方法
EP1481976B1 (en) 2002-03-05 2012-11-07 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
AU2002345285A1 (en) 2002-07-11 2004-02-02 Nokia Corporation Method and device for automatically changing a digital content on a mobile device according to sensor data
WO2004065365A1 (ja) 2003-01-21 2004-08-05 Ono Pharmaceutical Co., Ltd. 8−アザプロスタグランジン誘導体およびその医薬用途
JPWO2004089411A1 (ja) 2003-04-03 2006-07-06 小野薬品工業株式会社 脊柱管狭窄症治療剤
US7833995B2 (en) 2003-12-05 2010-11-16 Ono Pharmaceutical Co., Ltd. Blood flow promoters for cauda equina tissues
WO2005061492A1 (ja) 2003-12-22 2005-07-07 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびそれらを有効成分とする薬剤
EP1782830A4 (en) * 2004-08-10 2009-07-29 Ono Pharmaceutical Co PREVENTION AND / OR REMEDY FOR LOWER URINARY TRACT DISEASES CONTAINING AN EP4 AGONIST
WO2006043655A1 (ja) 2004-10-22 2006-04-27 Ono Pharmaceutical Co., Ltd. 吸入用医薬組成物
JP2006129788A (ja) 2004-11-05 2006-05-25 Nippon Starch Chemical Co Ltd 揚げ物用ミックス
AU2006253356B2 (en) 2005-06-03 2011-12-01 Ono Pharmaceutical Co., Ltd. Agent for regeneration and/or protection of nerves
WO2009148163A1 (ja) * 2008-06-06 2009-12-10 小野薬品工業株式会社 膀胱排尿筋収縮および尿道括約筋弛緩剤
RU2531350C2 (ru) * 2009-06-10 2014-10-20 Оно Фармасьютикал Ко., Лтд. Соединение, обладающее сокращающей детрузор активностью и релаксирующей уретральный сфинктер активностью

Also Published As

Publication number Publication date
ZA201109103B (en) 2012-08-29
WO2010143661A1 (ja) 2010-12-16
CN102803239B (zh) 2015-04-15
PL2441760T3 (pl) 2014-05-30
RU2531350C2 (ru) 2014-10-20
US8410281B2 (en) 2013-04-02
ES2444500T3 (es) 2014-02-25
CA2764782A1 (en) 2010-12-16
JP4807478B2 (ja) 2011-11-02
US20130184236A1 (en) 2013-07-18
EP2441760B1 (en) 2013-11-20
US20140171387A1 (en) 2014-06-19
BRPI1013152B1 (pt) 2019-06-18
AU2010259585A1 (en) 2012-01-19
AU2010259585B2 (en) 2015-11-19
US20120088805A1 (en) 2012-04-12
US9150528B2 (en) 2015-10-06
IL216856A0 (en) 2012-03-01
CA2764782C (en) 2017-07-25
TW201103539A (en) 2011-02-01
CN102803239A (zh) 2012-11-28
HK1169117A1 (en) 2013-01-18
KR20120026088A (ko) 2012-03-16
MX2011013283A (es) 2012-01-12
TWI437987B (zh) 2014-05-21
JPWO2010143661A1 (ja) 2012-11-29
EP2441760A4 (en) 2012-12-05
EP2441760A1 (en) 2012-04-18
DK2441760T3 (en) 2014-02-17
US8716490B2 (en) 2014-05-06
NZ596960A (en) 2013-04-26
PT2441760E (pt) 2014-01-07
KR101633149B1 (ko) 2016-06-23

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Fields The psychology of pain

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/06/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/06/2010, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2778 DE 02-04-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.