BRPI1013399A2 - sistema de entrega de fármaco intervencional e métodos associados - Google Patents

sistema de entrega de fármaco intervencional e métodos associados

Info

Publication number
BRPI1013399A2
BRPI1013399A2 BRPI1013399A BRPI1013399A BRPI1013399A2 BR PI1013399 A2 BRPI1013399 A2 BR PI1013399A2 BR PI1013399 A BRPI1013399 A BR PI1013399A BR PI1013399 A BRPI1013399 A BR PI1013399A BR PI1013399 A2 BRPI1013399 A2 BR PI1013399A2
Authority
BR
Brazil
Prior art keywords
delivery system
drug delivery
associated methods
interventional drug
interventional
Prior art date
Application number
BRPI1013399A
Other languages
English (en)
Inventor
James Byrne
Jen Jen Yeh
Jonathan Pillai
Joseph M Desimone
Lukas Miller Roush
Mary Elizabeth Napier
Matt Parrott
Original Assignee
Liquidia Technologies Inc
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liquidia Technologies Inc, Univ North Carolina filed Critical Liquidia Technologies Inc
Publication of BRPI1013399A2 publication Critical patent/BRPI1013399A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0536—Preventing neurodegenerative response or inflammatory reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0548—Oral electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00898—Alarms or notifications created in response to an abnormal condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0509—Stomach and intestinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0512—Anal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0514—Electrodes for the urinary tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0517—Esophageal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0519—Endotracheal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0521—Genital electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
BRPI1013399A 2009-02-26 2010-02-25 sistema de entrega de fármaco intervencional e métodos associados BRPI1013399A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15588009P 2009-02-26 2009-02-26
PCT/US2010/025416 WO2010099321A1 (en) 2009-02-26 2010-02-25 Interventional drug delivery system and associated methods

Publications (1)

Publication Number Publication Date
BRPI1013399A2 true BRPI1013399A2 (pt) 2016-04-05

Family

ID=42144891

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013399A BRPI1013399A2 (pt) 2009-02-26 2010-02-25 sistema de entrega de fármaco intervencional e métodos associados

Country Status (11)

Country Link
US (4) US20110306878A1 (pt)
EP (1) EP2401027B1 (pt)
JP (1) JP5653942B2 (pt)
KR (1) KR101674904B1 (pt)
CN (1) CN102421479A (pt)
AU (1) AU2010217957B2 (pt)
BR (1) BRPI1013399A2 (pt)
CA (2) CA3152896C (pt)
ES (1) ES2655714T3 (pt)
PL (1) PL2401027T3 (pt)
WO (1) WO2010099321A1 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9750568B2 (en) * 2012-03-08 2017-09-05 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
AU2013230776B2 (en) * 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
CN102698354B (zh) * 2012-04-12 2014-03-12 上海微创医疗器械（集团）有限公司 一种用于溶栓的双球囊导管
WO2014113679A1 (en) * 2013-01-18 2014-07-24 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
GB201412842D0 (en) * 2014-07-18 2014-09-03 Combat Medical Sl Catheter for the delivery of therapeutic fluid
PL3236838T3 (pl) * 2014-12-24 2022-12-19 The University Of North Carolina At Chapel Hill Miejscowe dostarczanie skojarzonych środków terapeutycznych za pomocą urządzeń interwencyjnych i promieniowania
EP3322354B1 (en) 2015-07-14 2025-06-25 Mor Research Applications Ltd. System for monitoring a surgical site
US10525256B2 (en) * 2015-07-29 2020-01-07 Medtronic, Inc. Interventional medical systems, catheters, and methods
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
US12446956B2 (en) * 2015-10-22 2025-10-21 Shanghai Golden Leaf Med Tec Co., Ltd. Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor
US20170319851A1 (en) * 2016-05-06 2017-11-09 Pulse Biosciences, Inc. Low-voltage impedance check pulse generator
CN121974842A (zh) 2016-05-10 2026-05-05 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
MX2018016046A (es) 2016-06-27 2019-05-02 Achillion Pharmaceuticals Inc Quinazolina y compuestos indol para tratar trastornos medicos.
KR101886217B1 (ko) * 2016-11-14 2018-08-07 전남대학교산학협력단 패치형 능동 약물전달 시스템
CA3053818A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
EP4717317A3 (en) 2017-06-20 2026-06-03 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
US12649056B2 (en) * 2017-10-23 2026-06-09 Cardiac Pacemakers, Inc. Medical devices for treatment of cancer with electric fields
US12403306B2 (en) 2017-10-23 2025-09-02 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US11723583B2 (en) * 2017-10-25 2023-08-15 Skindicator Ab Device and a method for detection of changes in tissue
CN111902141A (zh) 2018-03-26 2020-11-06 C4医药公司 用于ikaros降解的羟脑苷脂结合剂
EP3841086B1 (en) 2018-08-20 2025-04-23 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
JP7443375B2 (ja) 2018-09-06 2024-03-05 アキリオン ファーマシューティカルズ， インコーポレーテッド 医学的障害の治療のための大環状化合物
CN113365617B (zh) 2018-10-16 2025-12-23 乔治亚州立大学研究基金会股份有限公司 用于医学疾病治疗的一氧化碳前药
PL3886975T3 (pl) 2018-11-26 2024-06-24 Focal Medical, Inc. Wszczepialny zbiornik do stosowania z wyrobem medycznym i układem interwencyjnego podawania leku
EP3682941B1 (en) * 2019-01-18 2021-11-10 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Biomedical device comprising a mechanically adaptive member
MX2021011507A (es) 2019-03-22 2021-12-15 Achillion Pharmaceuticals Inc Compuestos farmaceuticos para el tratamiento de trastornos mediados por complemento.
JP7593942B2 (ja) 2019-04-22 2024-12-03 ボストン サイエンティフィック サイムド，インコーポレイテッド 癌治療のための電気刺激機器
US12109412B2 (en) 2019-04-22 2024-10-08 Boston Scientific Scimed, Inc. Combination electrical and chemotherapeutic treatment of cancer
WO2020219521A1 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation with thermal treatment or thermal monitoring
US11607542B2 (en) 2019-04-23 2023-03-21 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
US12599429B2 (en) 2019-11-27 2026-04-14 North Carolina State University Methods for controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses in pulsed electric field treatments
US12458709B2 (en) 2019-12-11 2025-11-04 Novocure Gmbh Compositions and methods for imaging a cell
JP2023515073A (ja) 2020-02-20 2023-04-12 アキリオン ファーマシューティカルズ， インコーポレーテッド 補体因子ｄ媒介障害の処置用のヘテロアリール化合物
CN119823124A (zh) 2020-03-05 2025-04-15 C4医药公司 用于brd9的靶向降解的化合物
EP4647112A3 (en) * 2020-03-30 2026-01-07 Berlin Heals GmbH An electric field or electric voltage delivering electrode system for the treatment of internal organ oedema
KR102770797B1 (ko) * 2020-04-14 2025-02-24 삼성전자주식회사 무선 전력 수신 장치 및 오브젝트 자극 장치
CA3193488A1 (en) 2020-09-23 2022-03-31 Jason Allan Wiles Pharmaceutical compounds for the treatment of complement mediated disorders
KR102861749B1 (ko) * 2022-10-28 2025-09-18 서울대학교산학협력단 대상체에 약물의 주입을 제어하는 장치, 방법, 및 컴퓨터 프로그램을 저장하는 기록 매체
EP4368236A1 (en) 2022-11-11 2024-05-15 Cambridge Enterprise Limited Iontophoretic drug delivery device
WO2025160435A1 (en) * 2024-01-26 2025-07-31 Medtronic, Inc. Electric field therapy for pancreatic cancer
WO2025179247A1 (en) * 2024-02-23 2025-08-28 Focal Medical, Inc. Delivery of chemotherapy drug via an implantable iontophoresis drug delivery device
US20250360295A1 (en) * 2024-05-21 2025-11-27 Wisconsin Alumni Research Foundation Adaptive, Multi-Injection Port, Double Balloon Catheter for Organ-Based Local Delivery of Gene Therapy
US20260083966A1 (en) 2024-09-25 2026-03-26 Continuity Biosciences, Llc Reservoir for use with a medical device and system for interventional drug delivery
WO2026161809A1 (en) 2025-01-24 2026-07-30 Continuity Biosciences, Llc System and method for delivery of nucleic acid molecules by iontophoresis

Family Cites Families (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4419092A (en) 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
JPS59502026A (ja) 1982-11-17 1984-12-06 シエブロン　リサ−チ　コンパニ− 電気活性ポリマ−
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4744787A (en) 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4747819A (en) 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4915685A (en) 1986-03-19 1990-04-10 Petelenz Tomasz J Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5496266A (en) 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5057072A (en) 1988-10-28 1991-10-15 Medtronic, Inc. Iontophoresis electrode
CA2001444C (en) 1988-10-28 2000-07-25 Darrel F. Untereker Iontophoresis electrode
US5248295A (en) 1989-05-08 1993-09-28 Iomed, Inc. Bioelectrode seal
US4968297A (en) 1989-05-09 1990-11-06 Iomec, Inc. Iontophoretic electrode with solution containment system
US4979938A (en) 1989-05-11 1990-12-25 Iomed, Inc. Method of iontophoretically treating acne, furuncles and like skin disorders
US5328455A (en) 1989-07-21 1994-07-12 Iomed, Inc. Rehydratable product and method of preparation thereof
US5236412A (en) 1989-07-21 1993-08-17 Iomed, Inc. Rehydratable product and method of preparation thereof
US5087242A (en) 1989-07-21 1992-02-11 Iomed, Inc. Hydratable bioelectrode
US5374241A (en) 1989-07-21 1994-12-20 Iomed, Inc. Electrodes for iontophoresis
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US5320597A (en) 1991-02-08 1994-06-14 Becton, Dickinson And Company Device and method for renewing electrodes during iontophoresis
US5084008A (en) 1989-12-22 1992-01-28 Medtronic, Inc. Iontophoresis electrode
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5084006A (en) 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
DE69110467T2 (de) 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
WO1992007618A1 (en) 1990-10-29 1992-05-14 Alza Corporation Iontophoretic drug delivery electrode and method of hydrating the same
US5158537A (en) 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5443727A (en) 1990-10-30 1995-08-22 Minnesota Mining And Manufacturing Company Articles having a polymeric shell and method for preparing same
US5492547B1 (en) 1993-09-14 1998-06-30 Dekalb Genetics Corp Process for predicting the phenotypic trait of yield in maize
ZA921736B (en) 1991-03-11 1992-11-25 Alza Corp Iontophoretic delivery device and method of making same
US5405317A (en) 1991-05-03 1995-04-11 Alza Corporation Iontophoretic delivery device
EP0612258B1 (en) 1991-11-13 1997-07-09 Elan Corporation Plc Drug delivery device
MX9206990A (es) 1991-12-03 1993-06-01 Alza Corp Dispositivo iontoforetico de surtido y suministro de energia para el mismo.
GB2265088B (en) 1992-03-10 1996-02-07 Kyosti Eero Antero Kontturi Electrochemical device for drug delivery
US5310404A (en) 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
DE69314634T2 (de) 1992-06-02 1998-05-20 Alza Corp., Palo Alto, Calif. Vorrichtung zur iontophoretischen verabreichung von medikamenten
US6287484B1 (en) 1992-11-12 2001-09-11 Robert Hausslein Iontophoretic material
US5667487A (en) 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
US5458569A (en) 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
US5415629A (en) 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
US20050159700A1 (en) 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
WO1995009032A1 (en) 1993-09-30 1995-04-06 Becton, Dickinson And Company Iontophoretic drug delivery system and method
US6377847B1 (en) 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5540669A (en) 1993-09-30 1996-07-30 Becton, Dickinson And Company Iontophoretic drug delivery system and method for using same
US5387189A (en) * 1993-12-02 1995-02-07 Alza Corporation Electrotransport delivery device and method of making same
US5503632A (en) 1994-04-08 1996-04-02 Alza Corporation Electrotransport device having improved cathodic electrode assembly
US5871460A (en) 1994-04-08 1999-02-16 Alza Corporation Electrotransport system with ion exchange material providing enhanced drug delivery
WO1995027530A1 (en) 1994-04-08 1995-10-19 Alza Corporation Electrotransport system with ion exchange competitive ion capture
US5925066A (en) 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5505700A (en) * 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US6048545A (en) 1994-06-24 2000-04-11 Biozone Laboratories, Inc. Liposomal delivery by iontophoresis
WO1996002232A1 (en) 1994-07-13 1996-02-01 Alza Corporation Composition and method for enhancing transdermal electrotransport agent delivery
JPH09511671A (ja) 1994-08-22 1997-11-25 イオメド インコーポレイテッド 水和水段を組み込んだイオントフォレティック（ｉｏｎｔｏｐｈｏｒｅｔｉｃ）デリバリー装置
US5795321A (en) 1994-09-30 1998-08-18 Becton Dickinson And Company Iontophoretic drug delivery system, including removable controller
US5876368A (en) 1994-09-30 1999-03-02 Becton Dickinson And Company Iontophoretic drug delivery device having improved controller
US5645526A (en) 1994-09-30 1997-07-08 Becton Dickinson And Company Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch
US5895369A (en) 1994-09-30 1999-04-20 Becton Dickinson And Company Iontophoresis patch/controller interconnection using a conductive elastomer to provide noise-free electrical contact between patch and controller
IL113459A (en) * 1995-04-23 2000-07-16 Electromagnetic Bracing System Electrophoretic cuff apparatus
US5840056A (en) 1995-06-15 1998-11-24 Empi, Inc. Iontophoresis electrode
US5788666A (en) 1995-06-15 1998-08-04 Empi, Inc. Iontophoresis electrode
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CA2233068A1 (en) 1995-09-28 1997-04-03 Vyteris, Inc. Iontophoretic drug delivery system, including disposable patch
US5645527A (en) 1996-02-09 1997-07-08 Iomed, Inc. Hydration assembly for hydrating a bioelectrode element
FR2747313B1 (fr) 1996-04-16 1998-06-05 Lhd Lab Hygiene Dietetique Dispositif d'administration transdermique de medicaments par ionophorese
US6185453B1 (en) 1996-06-19 2001-02-06 Dupont Pharmaceuticals Company Iontophoretic delivery of integrin inhibitors
US5871461A (en) 1996-07-12 1999-02-16 Empi, Inc. Method of making an iontophoresis electrode
US5857993A (en) 1996-07-12 1999-01-12 Empi, Inc. Process of making an iontophoresis electrode
US5941843A (en) 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5693024A (en) 1996-09-27 1997-12-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for determining hydration of patch
US5919156A (en) 1996-09-27 1999-07-06 Becton, Dickinson And Company Iontophoretic drug delivery system, including unit for dispensing patches
US5713846A (en) 1996-09-27 1998-02-03 Becton Dickinson And Company Iontophoretic drug delivery system, including method for activating same for attachment to patient
US6350259B1 (en) 1996-09-30 2002-02-26 Vyteris, Inc. Selected drug delivery profiles using competing ions
US5857994A (en) 1996-10-01 1999-01-12 Becton, Dickinson And Company Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US6258276B1 (en) 1996-10-18 2001-07-10 Mcmaster University Microporous membranes and uses thereof
FR2755372B1 (fr) 1996-11-07 1998-12-24 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet
FR2755842B1 (fr) 1996-11-19 1999-04-23 Lhd Lab Hygiene Dietetique Procede de mesure de la resistance electrique cutanee d'un patient soumis a une administration transdermique de medicament
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US5991655A (en) 1997-03-03 1999-11-23 Drug Delivery Systems, Inc. Iontophoretic drug delivery device and method of manufacturing the same
US6219964B1 (en) 1997-03-20 2001-04-24 E. I. Du Pont De Nemours And Company Method for identifying genetic marker loci associated with trait loci
US6029083A (en) 1997-04-04 2000-02-22 Becton, Dickinson And Company Circuit and method for automatically turning off an iontophoresis system
US5961796A (en) 1997-06-03 1999-10-05 Lynntech, Inc. Bipolar membranes with fluid distribution passages
WO1999004850A1 (en) 1997-07-22 1999-02-04 Emed Corporation Needle for iontophoretic delivery of agent
US6009344A (en) 1997-07-25 1999-12-28 Becton, Dickinson And Company Iontophoretic drug delivery system
US5846217A (en) 1997-07-29 1998-12-08 Iomed, Inc. Iontophoretic bioelectrode and method of using same
US5983133A (en) 1997-09-29 1999-11-09 Becton, Dickinson And Company Iontophoresis system with voltage step-up circuit
US6139538A (en) * 1997-10-06 2000-10-31 Iotek, Inc. Iontophoretic agent delivery to the female reproductive tract
US6775569B2 (en) 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
US6399855B1 (en) 1997-12-22 2002-06-04 Pioneer Hi-Bred International, Inc. QTL mapping in plant breeding populations
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
AU742057B2 (en) 1998-04-14 2001-12-13 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
EP1079890A4 (en) 1998-05-08 2008-12-03 Genetronics Inc VASODILATION OF AN ELECTRICALLY INDUCED VESSEL
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1115454B1 (en) 1998-08-31 2006-10-25 Travanti Pharma Inc Controlled dosage drug delivery system
US6858018B1 (en) 1998-09-28 2005-02-22 Vyteris, Inc. Iontophoretic devices
FR2785544B1 (fr) 1998-11-09 2001-01-05 Lhd Lab Hygiene Dietetique Electrode de transfert d'un courant electrique traversant la peau d'un patient
US6062915A (en) 1999-02-05 2000-05-16 Iomed, Inc. Nondeforming electrode connector
US6424862B1 (en) 1999-02-10 2002-07-23 Gmp Drug Delivery, Inc. Iontophoresis electroporation and combination patches for local drug delivery to body tissues
HK1041228A1 (zh) 1999-02-18 2002-07-05 Biovalve Technologies, Inc. 电活动孔
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
US7252655B2 (en) 1999-05-25 2007-08-07 Iomed, Inc. Ocular iontophoretic apparatus handle
US6319240B1 (en) 1999-05-25 2001-11-20 Iomed, Inc. Methods and apparatus for ocular iontophoresis
US6539251B2 (en) 1999-05-25 2003-03-25 Iomed, Inc. Ocular iontophoretic apparatus
US6728573B1 (en) 2000-02-23 2004-04-27 Iomed, Inc. Ocular iontophoretic apparatus handle
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6377848B1 (en) 1999-08-25 2002-04-23 Vyteris, Inc. Devices activating an iontophoretic delivery device
US6394994B1 (en) 1999-08-27 2002-05-28 Vyteris, Inc. Method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
EP1230385A4 (en) 1999-10-08 2004-12-08 Pioneer Hi Bred Int MARKER-BASED IDENTIFICATION OF A GENE RESPONSIBLE FOR A PHENOTYPICAL PROPERTY
US6687536B1 (en) 1999-12-09 2004-02-03 Iomed, Inc. Connection system for an iontophoretic drug delivery device
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
WO2001049104A2 (en) 1999-12-30 2001-07-12 Pioneer Hi-Bred International, Inc. Mqm mapping using haplotyped putative qtl-alleles: a simple approach for mapping qtl's in plant breeding populations
US6477411B1 (en) 2000-06-05 2002-11-05 Iomed, Inc. Bioelectrode having a crushable hydrating assembly and associated method
US6629968B1 (en) 2000-06-30 2003-10-07 Vyteris, Inc. Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
CA2415076C (en) 2000-07-07 2010-04-13 Mikhail M. Feldstein Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6546283B1 (en) 2000-10-18 2003-04-08 Iomed, Inc. High current density iontophoretic device and method of use thereof
US6553255B1 (en) 2000-10-27 2003-04-22 Aciont Inc. Use of background electrolytes to minimize flux variability during iontophoresis
US6579276B2 (en) 2001-01-22 2003-06-17 Iomed, Inc. Ocular iontophoretic device and method for inhibiting vascular endothelial growth factor (VEGF) using the same
US6731977B2 (en) 2001-01-22 2004-05-04 Iomed, Inc. Iontophoretic electrode with improved current distribution
US6697668B2 (en) 2001-01-25 2004-02-24 Iomed, Inc. Ocular iontophoretic device and method for using the same
US6546284B2 (en) 2001-01-25 2003-04-08 Iomed, Inc. Fluid retention assembly for an iontophoretic delivery device and associated method for preparing the same
US6488428B1 (en) 2001-02-08 2002-12-03 Iomed, Inc. Fluid assembly containing a breaking component for release of fluid and method therefore
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6625486B2 (en) * 2001-04-11 2003-09-23 Advanced Cardiovascular Systems, Inc. Method and apparatus for intracellular delivery of an agent
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6953446B2 (en) 2001-09-21 2005-10-11 Iomed, Inc. Method and device for the iontophoretic delivery of a drug
IL161529A0 (en) 2001-10-31 2004-09-27 R & R Ventures Inc Iontophoresis device
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
US9084879B2 (en) 2002-01-22 2015-07-21 Encore Medical Asset Corporation Method and device for the iontophoretic delivery of a drug
IL147921A0 (en) 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
US6823202B2 (en) 2002-04-01 2004-11-23 Iomed, Inc. Iontophoretic power supply
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
WO2004030743A2 (en) 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
US7018345B2 (en) 2002-12-06 2006-03-28 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
US20060047261A1 (en) 2004-06-28 2006-03-02 Shailendra Joshi Intra-arterial catheter for drug delivery
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040167459A1 (en) 2003-02-21 2004-08-26 Higuchi William I. Methods and systems for controlling and/or increasing iontophoretic flux
US6745071B1 (en) 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system
US7482381B2 (en) * 2003-03-19 2009-01-27 Sylvia Daunert Artificial muscle hydrogel blends reversibly electroactuated near neutral pH, implantable actuating devices, and methods using the same
RU2326893C2 (ru) 2003-04-16 2008-06-20 Кориум Интернэшнл Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
WO2007030698A2 (en) 2005-09-07 2007-03-15 The University Of North Carolina At Chapel Hill Materials and methods for fabricating isolated micro-and nano-structures having chemical functionality
WO2005101466A2 (en) 2003-12-19 2005-10-27 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- and nano- structures using soft or imprint lithography
US20050153994A1 (en) 2004-01-13 2005-07-14 Iomed, Inc. The use of 5-fluorourcil, delivered by iontophoresis as an inhibitor of cell proliferation in the eye, bulbar and palpebral conjunctiva, eyelid, peri-orbital soft tissues and skin
US20050153969A1 (en) 2004-01-13 2005-07-14 Iomed, Inc. Methods for treating neoplastic, angiogenic, fibroblastic, and/or immunosuppressive ocular irregularities via administration of methotrexate based medicaments, and ocular iontophoretic devices for delivering methotrexate based medicament
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
EP1812480A4 (en) 2004-10-14 2010-11-03 Tufts College ELECTROCHEMICAL DEGRADABLE POLYMERS
US20060095001A1 (en) 2004-10-29 2006-05-04 Transcutaneous Technologies Inc. Electrode and iontophoresis device
US20060135906A1 (en) 2004-11-16 2006-06-22 Akihiko Matsumura Iontophoretic device and method for administering immune response-enhancing agents and compositions
JP4728631B2 (ja) 2004-11-30 2011-07-20 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
US7590444B2 (en) 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (ja) 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
JP4793806B2 (ja) 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP2006334164A (ja) 2005-06-02 2006-12-14 Transcutaneous Technologies Inc イオントフォレーシス装置及びその制御方法
CA2611985C (en) 2005-06-17 2016-08-16 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials
JP2006346368A (ja) 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
US20070027426A1 (en) 2005-06-24 2007-02-01 Transcutaneous Technologies Inc. Iontophoresis device to deliver active agents to biological interfaces
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
US20070088332A1 (en) 2005-08-22 2007-04-19 Transcutaneous Technologies Inc. Iontophoresis device
US20070112294A1 (en) 2005-09-14 2007-05-17 Transcutaneous Technologies Inc. Iontophoresis device
KR20080047600A (ko) * 2005-09-15 2008-05-29 티티아이 엘뷰 가부시키가이샤 로드형 이온토포레시스 장치
US20070073212A1 (en) 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
WO2007041526A2 (en) 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
WO2007038555A1 (en) 2005-09-30 2007-04-05 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US20070135754A1 (en) 2005-09-30 2007-06-14 Hidero Akiyama Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same
KR20080066712A (ko) 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
KR20080080087A (ko) 2005-09-30 2008-09-02 티티아이 엘뷰 가부시키가이샤 신규 약학 담체를 이용한 경피 약물 전달시스템, 장치 및방법
US20070093787A1 (en) 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis device to deliver multiple active agents to biological interfaces
WO2007041322A2 (en) 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic delivery of active agents conjugated to nanoparticles
JP2007111365A (ja) * 2005-10-21 2007-05-10 Samii Kk 遊技機
WO2007094829A2 (en) 2005-11-07 2007-08-23 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
US20070106143A1 (en) 2005-11-08 2007-05-10 Flaherty J C Electrode arrays and related methods
US8036738B2 (en) 2006-03-14 2011-10-11 New Jersey Institute Of Technology Iontophoretic transdermal drug delivery system based on conductive polyaniline membrane
JPWO2007111365A1 (ja) * 2006-03-29 2009-08-13 Ｔｔｉ・エルビュー株式会社 カテーテル型イオントフォレーシス装置
WO2008013952A2 (en) 2006-07-27 2008-01-31 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
WO2008030497A2 (en) * 2006-09-05 2008-03-13 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods using inductive power supplies
US20080065002A1 (en) 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
EP2101864A2 (en) 2006-12-20 2009-09-23 ALZA Corporation Anode for electrotransport of cationic drug
US20080214987A1 (en) 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
WO2008087803A1 (ja) 2007-01-16 2008-07-24 Hokkaido University 抗酸化成分を封入したイオントフォレーシス用リポソーム製剤
EP2111252A4 (en) 2007-01-31 2010-12-01 Adam Heller MANAGEMENT OF PAIN BY ELECTROCHEMICAL PATHWAY
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
AU2008247544A1 (en) 2007-05-03 2008-11-13 Emory University Fulvene and fulvalene analogs and their use in treating cancers
US20090043276A1 (en) * 2007-08-09 2009-02-12 Boston Scientific Scimed, Inc. Drug delivery device, compositions and methods relating thereto
WO2009097508A2 (en) * 2008-01-30 2009-08-06 Mcanulty, Jonathan Methods and compositions for wound healing
US8221411B2 (en) * 2008-07-28 2012-07-17 Medtronic, Inc. Systems and methods for cardiac tissue electroporation ablation
US20100331760A1 (en) * 2009-06-30 2010-12-30 Boston Scientific Scimed, Inc. Biodegradable implant for treating or preventing reperfusion injury
EP2768528A1 (en) 2011-10-20 2014-08-27 Novartis AG Adjuvanted influenza b virus vaccines for pediatric priming
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device

Also Published As

Publication number Publication date
AU2010217957A1 (en) 2011-10-13
CA3152896A1 (en) 2010-09-02
CA3152896C (en) 2024-04-23
US20250303150A1 (en) 2025-10-02
JP2012519032A (ja) 2012-08-23
EP2401027A1 (en) 2012-01-04
EP2401027B1 (en) 2017-11-01
CA2790324A1 (en) 2010-09-02
CN102421479A (zh) 2012-04-18
WO2010099321A1 (en) 2010-09-02
AU2010217957B2 (en) 2015-08-13
US20200398049A1 (en) 2020-12-24
US20160022985A1 (en) 2016-01-28
US20110306878A1 (en) 2011-12-15
KR20110138357A (ko) 2011-12-27
US10695562B2 (en) 2020-06-30
ES2655714T3 (es) 2018-02-21
KR101674904B1 (ko) 2016-11-10
CA2790324C (en) 2022-06-14
JP5653942B2 (ja) 2015-01-14
PL2401027T3 (pl) 2018-04-30

Similar Documents

Publication Publication Date Title
BR112013012818A2 (pt) módulo medicamentoso e sistema de administração de fármaco
BRPI0917030A2 (pt) sistema de liberação de fármaco contendo progestina
IL262376A (en) Method and system for drug delivery
BRPI1014975A2 (pt) sistema de entrega de implante
PL2401027T3 (pl) Układ do interwencyjnego dostarczania leku
BRPI1015947A2 (pt) dispositivos para distribuição de fármacos e sistemas e métodos relacionados
BRPI0823301A2 (pt) Sistema e dispositivo de implante analgésico
BRPI1014285A2 (pt) sistema de suporte de fio-guia e fio-guia.
BR112012007472A2 (pt) "aparelho e sistema"
DK2398500T3 (da) Glutathion-baseret lægemiddelafgivelsessystem
BR112012012231A2 (pt) método e sistema
BR112013011702A2 (pt) sistema de distribuição de sirna in vivo à base de peptídeo
BRPI1010279A2 (pt) dispositivo de distribuição de fármaco
BRPI0913214A2 (pt) sistema de fornecimento de drogas transdérmico estabilizado
BRPI1014139A2 (pt) sistema de liberação de fármacos compreendendo polioxazolina e um agente biotivo.
BRPI1006398A2 (pt) método e sistema
BR112012002301A2 (pt) método e sistema
BR112012000516A2 (pt) sistema de histórico médico
BRPI1012730A2 (pt) dispositivo de distribuição de fármaco
BRPI1010203A2 (pt) sistema e método
DK2493532T3 (da) Lægemiddelfremføringsanordning
BR112012003867A2 (pt) sistema de visão e exibição integrado
BRPI1007070A2 (pt) sistema de dispositivo implantável.
DK3756657T3 (da) Synkbar anordning til lægemiddelfremføring
BR112013020363A2 (pt) sistema de transferência e injeção de tecido

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US)

Owner name: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (U

B25G Requested change of headquarter approved

Owner name: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (U

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements