BRPI1013561A8 - processo para a preparação de alogliptina - Google Patents
processo para a preparação de alogliptinaInfo
- Publication number
- BRPI1013561A8 BRPI1013561A8 BRPI1013561A BRPI1013561A BRPI1013561A8 BR PI1013561 A8 BRPI1013561 A8 BR PI1013561A8 BR PI1013561 A BRPI1013561 A BR PI1013561A BR PI1013561 A BRPI1013561 A BR PI1013561A BR PI1013561 A8 BRPI1013561 A8 BR PI1013561A8
- Authority
- BR
- Brazil
- Prior art keywords
- alogliptin
- preparation
- Prior art date
Links
- ZSBOMTDTBDDKMP-OAHLLOKOSA-N alogliptin Chemical compound C=1C=CC=C(C#N)C=1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1 ZSBOMTDTBDDKMP-OAHLLOKOSA-N 0.000 title 1
- 229960001667 alogliptin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/50—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16348109P | 2009-03-26 | 2009-03-26 | |
| PCT/IL2010/000260 WO2010109468A1 (en) | 2009-03-26 | 2010-03-25 | Process for the preparation of alogliptin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1013561A2 BRPI1013561A2 (pt) | 2015-08-25 |
| BRPI1013561A8 true BRPI1013561A8 (pt) | 2015-09-22 |
Family
ID=42780220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1013561A BRPI1013561A8 (pt) | 2009-03-26 | 2010-03-25 | processo para a preparação de alogliptina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8841447B2 (pt) |
| EP (1) | EP2410855B1 (pt) |
| JP (1) | JP2012521411A (pt) |
| CN (1) | CN102361557A (pt) |
| AU (1) | AU2010228902A1 (pt) |
| BR (1) | BRPI1013561A8 (pt) |
| CA (1) | CA2755561A1 (pt) |
| MX (1) | MX2011010079A (pt) |
| WO (1) | WO2010109468A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2673256B1 (en) | 2011-02-10 | 2015-04-08 | Solvay SA | Process for the manufacture of fluoromethoxymalonic acid derivatives |
| WO2013046229A1 (en) * | 2011-09-26 | 2013-04-04 | Hetero Research Foundation | Novel salts of alogliptin |
| CN102942556A (zh) * | 2012-12-04 | 2013-02-27 | 成都天翼医药科技有限公司 | 一种苯甲酸阿格列汀的制备工艺 |
| CN103910710B (zh) * | 2012-12-29 | 2017-06-16 | 乳源东阳光药业有限公司 | 阿格列汀新晶型及其制备方法 |
| CN103193762B (zh) * | 2013-03-29 | 2015-07-29 | 山东罗欣药业集团股份有限公司 | 苯甲酸阿格列汀的制备方法 |
| US9776985B2 (en) | 2013-05-24 | 2017-10-03 | Glenmark Pharmaceuticals Limited | Process for preparation of alogliptin |
| CN104447685A (zh) * | 2013-09-23 | 2015-03-25 | 上海天慈生物谷生物工程有限公司 | 一种阿洛利汀的制备方法 |
| WO2015092739A1 (en) * | 2013-12-19 | 2015-06-25 | Mylan Laboratories Ltd. | Process for preparation of alogliptin |
| CN105085475B (zh) * | 2014-05-09 | 2019-05-21 | 上海科胜药物研发有限公司 | 一种合成阿格列汀中间体的方法 |
| CN104086527B (zh) * | 2014-07-03 | 2016-09-21 | 湖南欧亚生物有限公司 | 一种苯甲酸阿格列汀的合成方法 |
| CN105315256B (zh) * | 2014-07-07 | 2018-02-06 | 广州朗圣药业有限公司 | 一种适合工业化的高纯度琥珀酸曲格列汀的制备方法 |
| CN105777709A (zh) * | 2014-12-22 | 2016-07-20 | 上海医药工业研究院 | 阿格列汀的制备工艺 |
| WO2016178246A1 (en) | 2015-05-04 | 2016-11-10 | Indoco Remedies Limited | Process for the preparation of alogliptin |
| CN104961726A (zh) * | 2015-06-19 | 2015-10-07 | 浙江永宁药业股份有限公司 | 一种曲格列汀的制备方法 |
| CN105801490B (zh) * | 2016-05-05 | 2019-08-23 | 傅晓倩 | 一种制备阿格列汀中间体的方法 |
| CN105837557A (zh) * | 2016-05-05 | 2016-08-10 | 青岛辰达生物科技有限公司 | 一种用于治疗ii型糖尿病的阿格列汀的制备方法 |
| CN105968091A (zh) * | 2016-05-05 | 2016-09-28 | 青岛辰达生物科技有限公司 | 一种制备治疗ii型糖尿病药物阿格列汀的方法 |
| CN107311940B (zh) * | 2017-07-26 | 2019-08-30 | 中国人民解放军第三军医大学 | 一种嘧啶二酮类化合物的制备方法 |
| CN110128401B (zh) * | 2018-02-02 | 2020-04-28 | 新发药业有限公司 | 一种苯甲酸阿格列汀的简便制备方法 |
| CN109232443B (zh) * | 2018-10-29 | 2022-03-08 | 中国药科大学 | 嘧啶酮衍生物、其制备方法及医药用途 |
| CN114057685A (zh) * | 2020-07-31 | 2022-02-18 | 西安新通药物研究有限公司 | 一种高收率苯甲酸阿格列汀的制备方法 |
| CN114105889B (zh) * | 2021-12-16 | 2023-06-13 | 山东创新药物研发有限公司 | 一种dpp-iv抑制剂关键中间体的制备方法及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8031A (en) * | 1851-04-08 | Gkraih separator and ban | ||
| US2598936A (en) * | 1950-04-13 | 1952-06-03 | Searle & Co | Disubstituted cyanoalkanoylureas and thioureas and methods for their production |
| US4089959A (en) * | 1976-03-31 | 1978-05-16 | Cooper Laboratories, Inc. | Long-acting xanthine bronchodilators and antiallergy agents |
| DE4114238A1 (de) * | 1991-04-26 | 1992-10-29 | Zentralinstitut Fuer Organisch | Neue substituierte 2,2 -pentamethylen-(delta)(pfeil hoch)3(pfeil hoch)-imidazolin-5-one bzw. 2,2 -pentamethylen-imidazolidin-5-one und verfahren zu deren herstellung |
| TW252044B (pt) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| JPH08319288A (ja) * | 1994-06-20 | 1996-12-03 | Takeda Chem Ind Ltd | 縮合イミダゾール誘導体、その製造法及び剤 |
| JPH10508032A (ja) * | 1994-12-13 | 1998-08-04 | ユーロ−セルティーク，エス．エイ． | アリールチオキサンチン類 |
| US6248746B1 (en) * | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
| JP2002516315A (ja) * | 1998-05-26 | 2002-06-04 | ナチュラル ドラッグ サイエンシズ，リミティド ライアビリティ カンパニー | ５−オキシミノバルビツール酸のｎ−置換誘導体 |
| WO2001029010A1 (en) * | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
| GB0008694D0 (en) * | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
| US20080194593A1 (en) | 2001-11-09 | 2008-08-14 | Rao Kalla | A2b adenosine receptor antagonists |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| ZA200607252B (en) * | 2004-03-15 | 2008-05-28 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors |
| CN102079743B (zh) * | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| US7378423B2 (en) * | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| KR100883289B1 (ko) * | 2004-06-11 | 2009-02-11 | 니뽄 다바코 산교 가부시키가이샤 | 암 치료용5-아미노-2,4,7-트리옥소-3,4,7,8-테트라히드로-2ｈ-피리도[2,3-ｄ]피리미딘 유도체 및 관련 화합물 |
| AU2006229791A1 (en) * | 2005-03-24 | 2006-10-05 | Janssen Pharmaceutica, N.V. | Pyrimidindione derivatives as prokineticin 2 receptor antagonists |
| TW200745079A (en) | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| WO2007035629A2 (en) | 2005-09-16 | 2007-03-29 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| TW200745080A (en) | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| GB0605785D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| TWI394747B (zh) * | 2006-06-23 | 2013-05-01 | Smithkline Beecham Corp | 脯胺醯基羥化酶抑制劑 |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| AR067557A1 (es) | 2007-07-19 | 2009-10-14 | Takeda Pharmaceutical | Preparacion solida y metodo de preparacion |
| CA2749893A1 (en) | 2009-02-04 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
-
2010
- 2010-03-25 AU AU2010228902A patent/AU2010228902A1/en not_active Abandoned
- 2010-03-25 US US13/258,816 patent/US8841447B2/en not_active Expired - Fee Related
- 2010-03-25 CA CA2755561A patent/CA2755561A1/en not_active Abandoned
- 2010-03-25 CN CN2010800136497A patent/CN102361557A/zh active Pending
- 2010-03-25 JP JP2012501503A patent/JP2012521411A/ja active Pending
- 2010-03-25 EP EP10755533.6A patent/EP2410855B1/en not_active Not-in-force
- 2010-03-25 MX MX2011010079A patent/MX2011010079A/es not_active Application Discontinuation
- 2010-03-25 WO PCT/IL2010/000260 patent/WO2010109468A1/en not_active Ceased
- 2010-03-25 BR BRPI1013561A patent/BRPI1013561A8/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2755561A1 (en) | 2010-09-30 |
| MX2011010079A (es) | 2011-10-10 |
| AU2010228902A1 (en) | 2011-10-06 |
| US20120029000A1 (en) | 2012-02-02 |
| EP2410855A1 (en) | 2012-02-01 |
| BRPI1013561A2 (pt) | 2015-08-25 |
| JP2012521411A (ja) | 2012-09-13 |
| EP2410855A4 (en) | 2012-10-17 |
| CN102361557A (zh) | 2012-02-22 |
| EP2410855B1 (en) | 2016-06-01 |
| US8841447B2 (en) | 2014-09-23 |
| WO2010109468A1 (en) | 2010-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2331 DE 08/09/2015 |