BRPI1013932A2 - "derivados de 7-aza-espiro [3.5]nonano-7- carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica" - Google Patents

"derivados de 7-aza-espiro [3.5]nonano-7- carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica"

Info

Publication number: BRPI1013932A2
Authority: BR; Brazil
Prior art keywords: group; therapeutics; espiro; nonano; aza
Prior art date: 2009-05-12

Application number

BRPI1013932-0A

Other languages

English (en)

Inventor

Abouabdellah Ahmed

Chereze Nathalie

Fayol Aude

Lochead Alistair

Saady Mourad

Vache Julien

Yaiche Philippe

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-12

Filing date

2010-05-11

Publication date

2018-02-27

2010-05-11 Application filed by Sanofi filed Critical Sanofi

2018-02-27 Publication of BRPI1013932A2 publication Critical patent/BRPI1013932A2/pt

Links

239000003814 drug Substances 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052731 fluorine Chemical group 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
150000000565 5-membered heterocyclic compounds Chemical class 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
-1 bicyclic compound Chemical class 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI1013932-0A 2009-05-12 2010-05-11 "derivados de 7-aza-espiro [3.5]nonano-7- carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica" BRPI1013932A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR09/02269		2009-05-12
FR0902269A FR2945531A1 (fr)	2009-05-12	2009-05-12	Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
PCT/FR2010/050914 WO2010130945A1 (fr)	2009-05-12	2010-05-11	Dérivés de 7-aza-spiro[3.5]nonane-7-carboxylates, leur prépraration et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
BRPI1013932A2 true BRPI1013932A2 (pt)	2018-02-27

Family

ID=41258889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1013932-0A BRPI1013932A2 (pt)	2009-05-12	2010-05-11	"derivados de 7-aza-espiro [3.5]nonano-7- carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica"

Country Status (21)

Country	Link
US (2)	US8394787B2 (pt)
EP (1)	EP2430012B1 (pt)
JP (1)	JP5680624B2 (pt)
KR (1)	KR20120015454A (pt)
CN (1)	CN102459232B (pt)
AR (1)	AR076563A1 (pt)
AU (1)	AU2010247214B2 (pt)
BR (1)	BRPI1013932A2 (pt)
CA (1)	CA2761663C (pt)
CL (1)	CL2011002835A1 (pt)
CO (1)	CO6460743A2 (pt)
EA (1)	EA201171387A1 (pt)
FR (1)	FR2945531A1 (pt)
IL (1)	IL216238A0 (pt)
MA (1)	MA33354B1 (pt)
MX (1)	MX2011012061A (pt)
SG (1)	SG176042A1 (pt)
TN (1)	TN2011000570A1 (pt)
TW (1)	TW201043619A (pt)
UY (1)	UY32630A (pt)
WO (1)	WO2010130945A1 (pt)

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WO2011085216A2 (en)	2010-01-08	2011-07-14	Ironwood Pharmaceuticals, Inc.	Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
CA2787476C (en) *	2010-01-20	2017-07-11	Sanofi	Alkyl-heterocycle carbamate derivatives, their preparation and their therapeutic application
US20130224151A1 (en)	2010-03-31	2013-08-29	United States Of America	Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
EP2780015B1 (en)	2011-11-18	2017-01-04	Heptares Therapeutics Limited	Muscarinic m1 receptor agonists
US9822129B2 (en)	2012-03-02	2017-11-21	Genentech, Inc.	Amido spirocyclic amide and sulfonamide derivatives
SG11201606269WA (en)	2014-02-06	2016-09-29	Heptares Therapeutics Ltd	Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists
GB201404922D0 (en)	2014-03-19	2014-04-30	Heptares Therapeutics Ltd	Pharmaceutical compounds
CN107108562B (zh) *	2015-05-14	2020-07-10	四川海思科制药有限公司	具有β2受体激动及M受体拮抗活性的含氮杂螺环衍生物及其在医药上的用途
UA121775C2 (uk)	2015-07-31	2020-07-27	Пфайзер Інк.	1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl
GB201513740D0 (en)	2015-08-03	2015-09-16	Heptares Therapeutics Ltd	Muscarinic agonist
GB201513743D0 (en)	2015-08-03	2015-09-16	Heptares Therapeutics Ltd	Muscarinic agonists
GB201519352D0 (en)	2015-11-02	2015-12-16	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201617454D0 (en)	2016-10-14	2016-11-30	Heptares Therapeutics Limited	Pharmaceutical compounds
EP3571191A1 (en) *	2017-01-20	2019-11-27	Pfizer Inc	1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors
EP3571202B1 (en)	2017-01-23	2021-06-30	Pfizer Inc.	Heterocyclic spiro compounds as magl inhibitors
EP4335848A3 (en) *	2017-03-13	2024-06-19	Lundbeck La Jolla Research Center, Inc.	Dual magl and faah inhibitors
AU2018300980A1 (en)	2017-07-12	2020-01-02	Vanderbilt University	Antagonists of the muscarinic acetylcholine receptor M4
AU2018352828A1 (en) *	2017-10-17	2020-04-23	Vanderbilt University	Antagonists of the muscarinic acetylcholine receptor M4
IL273924B2 (en)	2017-10-20	2024-07-01	Univ Vanderbilt	Antagonists of the muscarinic acetylcholine receptor m4
WO2019126559A1 (en) *	2017-12-20	2019-06-27	Vanderbilt University	Antagonists of the muscarinic acetylcholine receptor m4
GB201810239D0 (en)	2018-06-22	2018-08-08	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201819960D0 (en)	2018-12-07	2019-01-23	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201819961D0 (en)	2018-12-07	2019-01-23	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB202020191D0 (en)	2020-12-18	2021-02-03	Heptares Therapeutics Ltd	Pharmaceutical compounds

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JPH0678335B2 (ja)	1991-06-19	1994-10-05	ファイザー・インコーポレーテッド	アザスピロキノロン化合物、その製法および抗菌組成物
US6518423B1 (en) *	1996-08-09	2003-02-11	Eisai Co., Ltd.	Benzopiperidine derivatives
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US6995144B2 (en)	2002-03-14	2006-02-07	Eisai Co., Ltd.	Nitrogen containing heterocyclic compounds and medicines containing the same
FR2854633B1 (fr) *	2003-05-07	2005-06-24	Sanofi Synthelabo	Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2866888B1 (fr) *	2004-02-26	2006-05-05	Sanofi Synthelabo	Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) *	2004-02-26	2007-08-31	Sanofi Synthelabo	Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) *	2004-02-26	2007-08-31	Sanofi Synthelabo	Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
MX2007000015A (es) *	2004-06-22	2007-03-07	Schering Corp	Ligandos de receptor de canabinoide.
WO2006006490A1 (ja) *	2004-07-08	2006-01-19	Ono Pharmaceutical Co., Ltd.	スピロ化合物
US8049012B2 (en) *	2005-06-28	2011-11-01	Neurosearch A/S	3-aza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2008013834A1 (en)	2006-07-24	2008-01-31	Gilead Sciences, Inc.,	Bisfuranyl protease inhibitors
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AU2008317057B8 (en) *	2007-10-22	2014-02-13	Merck Sharp & Dohme Corp.	Bicyclic Heterocycle Derivatives and their use as modulators of the activity of GPR119

2009
- 2009-05-12 FR FR0902269A patent/FR2945531A1/fr active Pending
2010
- 2010-05-11 EP EP10728742.7A patent/EP2430012B1/fr active Active
- 2010-05-11 SG SG2011083524A patent/SG176042A1/en unknown
- 2010-05-11 JP JP2012510342A patent/JP5680624B2/ja not_active Expired - Fee Related
- 2010-05-11 US US13/320,199 patent/US8394787B2/en active Active
- 2010-05-11 WO PCT/FR2010/050914 patent/WO2010130945A1/fr not_active Ceased
- 2010-05-11 CN CN201080031190.3A patent/CN102459232B/zh not_active Expired - Fee Related
- 2010-05-11 AU AU2010247214A patent/AU2010247214B2/en not_active Ceased
- 2010-05-11 EA EA201171387A patent/EA201171387A1/ru unknown
- 2010-05-11 MX MX2011012061A patent/MX2011012061A/es active IP Right Grant
- 2010-05-11 CA CA2761663A patent/CA2761663C/fr not_active Expired - Fee Related
- 2010-05-11 KR KR1020117029469A patent/KR20120015454A/ko not_active Withdrawn
- 2010-05-11 TW TW099115021A patent/TW201043619A/zh unknown
- 2010-05-11 MA MA34439A patent/MA33354B1/fr unknown
- 2010-05-11 AR ARP100101601A patent/AR076563A1/es not_active Application Discontinuation
- 2010-05-11 BR BRPI1013932-0A patent/BRPI1013932A2/pt not_active Application Discontinuation
- 2010-05-12 UY UY0001032630A patent/UY32630A/es not_active Application Discontinuation
2011
- 2011-11-09 IL IL216238A patent/IL216238A0/en unknown
- 2011-11-10 TN TNP2011000570A patent/TN2011000570A1/fr unknown
- 2011-11-11 CO CO11153621A patent/CO6460743A2/es not_active Application Discontinuation
- 2011-11-11 CL CL2011002835A patent/CL2011002835A1/es unknown
2013
- 2013-01-28 US US13/751,661 patent/US20130211087A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5680624B2 (ja)	2015-03-04
IL216238A0 (en)	2012-01-31
MA33354B1 (fr)	2012-06-01
CA2761663A1 (fr)	2010-11-18
CN102459232B (zh)	2014-05-07
US8394787B2 (en)	2013-03-12
CO6460743A2 (es)	2012-06-15
CN102459232A (zh)	2012-05-16
AR076563A1 (es)	2011-06-22
AU2010247214A1 (en)	2011-12-08
US20130211087A1 (en)	2013-08-15
FR2945531A1 (fr)	2010-11-19
UY32630A (es)	2010-12-31
CL2011002835A1 (es)	2012-06-22
KR20120015454A (ko)	2012-02-21
TW201043619A (en)	2010-12-16
TN2011000570A1 (fr)	2013-05-24
US20120129830A1 (en)	2012-05-24
EA201171387A1 (ru)	2012-05-30
CA2761663C (fr)	2017-04-18
EP2430012B1 (fr)	2014-11-05
EP2430012A1 (fr)	2012-03-21
JP2012526784A (ja)	2012-11-01
AU2010247214B2 (en)	2015-07-02
MX2011012061A (es)	2012-02-28
WO2010130945A1 (fr)	2010-11-18
SG176042A1 (en)	2011-12-29

Legal Events

Date	Code	Title
2018-04-10	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-10-23	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-01-29	B11E	Dismissal acc. art. 34 of ipl - requirements for examination incomplete
2020-09-24	B11T	Dismissal of application maintained [chapter 11.20 patent gazette]

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