BRPI1014718A2 - polipeptídeo do papiloma vírus humano, capsômero, partícula tipo vírus, composição imunogência, molécula de ácido nucléico, e, métodos para produzir o polipeptídeo, e, para preparar uma composição imunogênica - Google Patents

polipeptídeo do papiloma vírus humano, capsômero, partícula tipo vírus, composição imunogência, molécula de ácido nucléico, e, métodos para produzir o polipeptídeo, e, para preparar uma composição imunogênica

Info

Publication number: BRPI1014718A2
Authority: BR; Brazil
Prior art keywords: polypeptide; virus; composition; capsomer; particle
Prior art date: 2009-06-25

Application number

BRPI1014718A

Other languages

English (en)

Inventor

Brigitte Desiree Albert Colau

Guy Jean Marie Fernand Pierre Baudoux

Najoua Dendouga

Nicolas Pierre Fernand Lecrenier

Sandra Giannini

Original Assignee

Glaxonsmithkline Biolog S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-25

Filing date

2010-06-24

Publication date

2016-04-12

2010-06-24 Application filed by Glaxonsmithkline Biolog S A filed Critical Glaxonsmithkline Biolog S A

2016-04-12 Publication of BRPI1014718A2 publication Critical patent/BRPI1014718A2/pt

Links

230000002163 immunogen Effects 0.000 title 2
229920001184 polypeptide Polymers 0.000 title 2
102000004196 processed proteins & peptides Human genes 0.000 title 2
108090000765 processed proteins & peptides Proteins 0.000 title 2
241000701806 Human papillomavirus Species 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
239000002245 particle Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Mycology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI1014718A 2009-06-25 2010-06-24 polipeptídeo do papiloma vírus humano, capsômero, partícula tipo vírus, composição imunogência, molécula de ácido nucléico, e, métodos para produzir o polipeptídeo, e, para preparar uma composição imunogênica BRPI1014718A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US22035809P	2009-06-25	2009-06-25
US23988009P	2009-09-04	2009-09-04
US32210210P	2010-04-08	2010-04-08
PCT/EP2010/059024 WO2010149752A2 (en)	2009-06-25	2010-06-24	Novel compositions

Publications (1)

Publication Number	Publication Date
BRPI1014718A2 true BRPI1014718A2 (pt)	2016-04-12

Family

ID=43014491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1014718A BRPI1014718A2 (pt)	2009-06-25	2010-06-24	polipeptídeo do papiloma vírus humano, capsômero, partícula tipo vírus, composição imunogência, molécula de ácido nucléico, e, métodos para produzir o polipeptídeo, e, para preparar uma composição imunogênica

Country Status (20)

Country	Link
US (1)	US20120087937A1 (pt)
EP (1)	EP2445525A2 (pt)
JP (1)	JP2012530505A (pt)
KR (1)	KR20120098580A (pt)
CN (1)	CN102497880A (pt)
AU (1)	AU2010264695A1 (pt)
BR (1)	BRPI1014718A2 (pt)
CA (1)	CA2768172A1 (pt)
CL (1)	CL2011003271A1 (pt)
CO (1)	CO6480995A2 (pt)
CR (1)	CR20120026A (pt)
DO (1)	DOP2011000396A (pt)
EA (1)	EA022213B1 (pt)
IL (1)	IL217094A0 (pt)
MA (1)	MA33440B1 (pt)
MX (1)	MX2011013744A (pt)
PE (1)	PE20120563A1 (pt)
SG (1)	SG177269A1 (pt)
WO (1)	WO2010149752A2 (pt)
ZA (1)	ZA201109453B (pt)

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EP2416798B1 (en) *	2009-04-10	2017-09-20	The Johns Hopkins University	Papillomavirus-like particles (vlp) as broad spectrum human papillomavirus (hpv) vaccines
CN103890177B (zh) *	2011-12-01	2016-03-09	开普敦大学	Hpv嵌合颗粒
CN104203270A (zh)	2012-03-18	2014-12-10	葛兰素史密丝克莱恩生物有限公司	针对人乳头状瘤病毒的接种方法
CN103864936B (zh) *	2012-12-11	2018-01-23	中国疾病预防控制中心病毒病预防控制所	Hpv18型l2ne7e6融合蛋白基因、表达载体、方法、菌株和用途
WO2014103608A1 (ja) *	2012-12-25	2014-07-03	一般財団法人化学及血清療法研究所	HPV/HBsキメラタンパク質を有効成分とするHPV感染症及び／又はＢ型肝炎用ワクチン
CN104845985B (zh) *	2014-02-18	2020-02-07	上海泽润生物科技有限公司	重组人乳头瘤病毒蛋白表达
CN104531741B (zh) *	2014-08-22	2016-08-24	天津康希诺生物技术有限公司	增强hpv抗原表位肽免疫原性的方法及类病毒颗粒、颗粒制备方法与应用
CA2965498A1 (en) *	2014-10-24	2016-04-28	Hpvvax, Llc.	Compositions and uses of a papilloma virus (hpv) vaccine for the treatment of hpv related cancer and skin lesions
US10799574B2 (en)	2014-10-24	2020-10-13	Hpvvax. Llc	Method and composition for treating cancer or skin lesion using a vaccine
WO2017071713A1 (en)	2015-10-30	2017-05-04	University Of Copenhagen	Virus like particle with efficient epitope display
EP3385273A4 (en) *	2015-12-04	2019-08-07	Xiamen University	MUTANT OF HUMAN PAPILLOMAIRUS TYPE 58 L1 PROTEIN
CN122399006A (zh) *	2016-02-27	2026-07-17	哈普威克斯有限责任公司	使用疫苗治疗癌症或皮肤病变的方法和组合物
CN107188966B (zh) *	2016-03-15	2020-03-31	中国医学科学院基础医学研究所	一种乳头瘤病毒嵌合蛋白及其用途
CN107188967B (zh) *	2016-03-15	2020-03-31	中国医学科学院基础医学研究所	一种乳头瘤病毒嵌合蛋白及其用途
KR102567627B1 (ko) *	2017-07-14	2023-08-17	시아먼 유니버시티	인간 유두종 바이러스 타입 16의 l1 단백질의 변이체
BR112020024699A2 (pt) *	2018-06-04	2021-03-09	Xiamen University	Mutante da proteína l1 do papilomavírus humano tipo 18
WO2020063724A1 (zh) *	2018-09-26	2020-04-02	厦门大学	一种人乳头瘤病毒51型l1蛋白的突变体
WO2021013079A1 (zh) *	2019-07-19	2021-01-28	神州细胞工程有限公司	嵌合的人乳头瘤病毒56型l1蛋白
CN114127094B (zh) *	2019-07-19	2024-04-26	神州细胞工程有限公司	嵌合的人乳头瘤病毒58型l1蛋白
WO2021013067A1 (zh) *	2019-07-19	2021-01-28	神州细胞工程有限公司	嵌合的人乳头瘤病毒6型l1蛋白
CN111944834A (zh) *	2020-09-04	2020-11-17	吉林医药学院	人乳头瘤病毒16型表位嵌合l1的重组载体、重组蛋白、病毒样颗粒及其制备和应用
CN112300290B (zh) *	2020-09-30	2022-04-01	北京康乐卫士生物技术股份有限公司	一种使用乳头瘤病毒类病毒颗粒递呈抗原的新型冠状病毒多肽疫苗
CN114716561B (zh) *	2021-01-04	2024-03-12	中国医学科学院基础医学研究所	一种人乳头瘤病毒31型嵌合蛋白及其用途
CN114716562B (zh) *	2021-01-04	2023-11-10	中国医学科学院基础医学研究所	一种人乳头瘤病毒58型嵌合蛋白及其用途
CN114716560B (zh) *	2021-01-04	2024-02-02	中国医学科学院基础医学研究所	一种人乳头瘤病毒18型嵌合蛋白及其用途
CN117285618A (zh) *	2023-08-25	2023-12-26	黑龙江省安碧捷生物科技有限责任公司	一种抗人乳头瘤病毒IgY抗体的制备方法及应用

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US7351533B2 (en)	1997-09-05	2008-04-01	Medimmune, Inc.	In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents
DE69806024T2 (de)	1997-09-16	2003-02-13	Delft Diagnostic Laboratory B.V., Delft	Erkennung und identifizierung von menschlichem papillomavirus durch pcr und typ-spezifischer reverser hybridisierung
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GB9921146D0 (en) *	1999-09-07	1999-11-10	Smithkline Beecham Biolog	Novel composition
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GB0206360D0 (en) *	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
US7407807B2 (en)	2002-05-17	2008-08-05	University Of Cape Town	Chimaeric human papillomavirus 16 I1 virus like particles and a method for preparing the particles
GB0228715D0 (en)	2002-12-09	2003-01-15	Glaxosmithkline Biolog Sa	Vaccine
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ES2519490T3 (es)	2008-07-31	2014-11-07	Glaxosmithkline Biologicals S.A.	Vacuna contra HPV

2010
- 2010-06-24 CA CA2768172A patent/CA2768172A1/en not_active Abandoned
- 2010-06-24 KR KR1020127001919A patent/KR20120098580A/ko not_active Withdrawn
- 2010-06-24 BR BRPI1014718A patent/BRPI1014718A2/pt not_active IP Right Cessation
- 2010-06-24 PE PE2011002154A patent/PE20120563A1/es not_active Application Discontinuation
- 2010-06-24 SG SG2011093572A patent/SG177269A1/en unknown
- 2010-06-24 AU AU2010264695A patent/AU2010264695A1/en not_active Abandoned
- 2010-06-24 CN CN2010800386242A patent/CN102497880A/zh active Pending
- 2010-06-24 EA EA201190327A patent/EA022213B1/ru not_active IP Right Cessation
- 2010-06-24 WO PCT/EP2010/059024 patent/WO2010149752A2/en not_active Ceased
- 2010-06-24 EP EP10727731A patent/EP2445525A2/en not_active Withdrawn
- 2010-06-24 MX MX2011013744A patent/MX2011013744A/es not_active Application Discontinuation
- 2010-06-24 US US13/378,446 patent/US20120087937A1/en not_active Abandoned
- 2010-06-24 JP JP2012516750A patent/JP2012530505A/ja active Pending
- 2010-06-24 MA MA34546A patent/MA33440B1/fr unknown
2011
- 2011-12-19 DO DO2011000396A patent/DOP2011000396A/es unknown
- 2011-12-20 IL IL217094A patent/IL217094A0/en unknown
- 2011-12-21 ZA ZA2011/09453A patent/ZA201109453B/en unknown
- 2011-12-22 CL CL2011003271A patent/CL2011003271A1/es unknown
2012
- 2012-01-04 CO CO12001297A patent/CO6480995A2/es unknown
- 2012-01-16 CR CR20120026A patent/CR20120026A/es unknown

Also Published As

Publication number	Publication date
CA2768172A1 (en)	2010-12-29
CN102497880A (zh)	2012-06-13
CL2011003271A1 (es)	2012-08-31
MA33440B1 (fr)	2012-07-03
KR20120098580A (ko)	2012-09-05
MX2011013744A (es)	2012-09-28
SG177269A1 (en)	2012-02-28
IL217094A0 (en)	2012-02-29
EP2445525A2 (en)	2012-05-02
EA201190327A1 (ru)	2012-07-30
JP2012530505A (ja)	2012-12-06
ZA201109453B (en)	2012-08-29
DOP2011000396A (es)	2012-02-15
CO6480995A2 (es)	2012-07-16
US20120087937A1 (en)	2012-04-12
WO2010149752A2 (en)	2010-12-29
AU2010264695A1 (en)	2012-01-19
CR20120026A (es)	2012-04-13
EA022213B1 (ru)	2015-11-30
WO2010149752A3 (en)	2011-03-31
PE20120563A1 (es)	2012-05-17

Legal Events

Date	Code	Title	Description
2016-06-21	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-10-11	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2372 DE 21-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
CL2011003271A1 (es)	2012-08-31	Polipeptido l1 del virus de papiloma humano (hpv) tipo 18 que comprende cuando menos un peptido que comprende un epitopo de un polipeptido l2; capsomero; particula parecida a virus (vlp); composicion inmunogenica; molecula de acido nucleico; polipeptido; metodo para producir polipeptido; metodo para producir composicion inmunogenica.
BRPI1014800A8 (pt)	2016-10-11	"composição compreendendo alfa-(1,6) oligodextranas alfa-(1,2) ramificadas, método para preparar as referidas oligodextranas e uso das mesmas"
BRPI0915896A2 (pt)	2019-09-24	ácido nucleico, método para produzir partículas similares ao vírus influenza (vlps) em uma planta, as ditas partículas similares ao vírus (vlp), uso das mesmas e composição
CY1118080T1 (el)	2017-06-28	Σωματιδια απελευθερωσης που ομοιαζουν με ιικα σωματιδια για αυτοαντιγραφικα rna μορια
BRPI0821805A2 (pt)	2015-06-16	Sistema para limitar a dose de radiação para um paciente durante uma varredura por tomografia computadorizada, métodos para reduzir a dose de radiação para um indivíduo e para varrer um volume de interesse, e, sistema para controlar a radiação durante uma varredura por tomografia computadorizada.
MX2012000036A (es)	2012-02-28	Vacuna.
ZA201200832B (en)	2014-07-30	Immunogenic composition comprising antigenic s. aureus proteins
EP2536428A4 (en)	2014-04-09	UNIVERSAL INFLUENZA VACCINES WITH VIRUSIC PARTICLES
BR112015029788A2 (pt)	2017-09-26	hetero-multímero, construto de anticorpo isolado, ácido nucleico, célula hospedeira, método para preparar o hetero-multímero, composição farmacêutica, método para tratar uma doença, uso do hetero-multímero, uso de uma quantia terapêutica do hetero-multímero e método para reduzir a função efetora de um construto de anticorpo
BRPI0916884A2 (pt)	2016-06-14	composição imunogênica, processo para preparar uma composição imunogênica, uso de uma composição imunogênica, e, kit
EP2467157A4 (en)	2014-01-22	MODIFICATION OF RECOMBINANT ADENOVIRES WITH IMMUNOGENOUS PLASMODIUM CIRCUMSPOROZOITE PROTEIN EPITOPES
BRPI0915084A2 (pt)	2015-10-27	composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, métodos para a profilaxia ou tratamento de um estado de doença ou uma condição e de câncer
BR112013030321A2 (pt)	2017-07-11	composição de vacina, método para preparar a composição de vacina, uso da composição de vacina, método para imunizar um porco, cepa de vacina contra csfv e uso de uma célula no cultivo de uma cepa de vacina contra csfv.
PL3321355T3 (pl)	2021-12-27	Sposoby i kompozycje do klinicznego pozyskiwania komórek alogenicznych oraz zastosowania terapeutyczne
EP3156070A3 (en)	2017-06-14	Newcastle disease virus vectored herpesvirus vaccines
BR112013015816A2 (pt)	2018-05-29	construção de dna para imunomodulação, composição farmacêutica, vacina e uso de uma construção de dna
IT1400545B1 (it)	2013-06-11	Procedimento per la preparazione di tessuto biologico per protesi biologiche.
NZ741875A (en)	2019-08-30	Canine parvovirus (cpv) virus-like particle (vlp) vaccines and uses thereof
WO2011094357A8 (en)	2012-04-19	Respiratory virus epitopes templated into double stranded coiled -coils and use thereof in immunization
HK1207152A1 (en)	2016-01-22	Multivalent breast cancer vaccine
BRPI0810951A2 (pt)	2015-07-21	Proteína l1 hpv6, polinucleotídeo, vetor, célula, composição, partícula semelhante ao vírus (vlp) hpv6, método para produzir uma proteína l1 do hpv, vacina para prevenção de condiloma acuminado ou de infecções porhpv, uso da proteína, método para prevenção de condiloma acuminado ou infecções por hpv, método pra obter uma vlp de uma proteína l1 do hpv6 e método para produzir uma vacina para a prevenção de condiloma acuminado ou de infecções por hpv
ZA201004337B (en)	2012-12-27	Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing the same
EP2313108A4 (en)	2013-06-12	MALARIA VACCINE FROM SELF-ORGANIZING POLYPEPTIDE NANOTEHICLES
FR2932681B1 (fr)	2012-08-31	Peptides immunogenes issus de la proteine midkine comme vaccin anticancereux
CL2013001219A1 (es)	2014-04-04	Metodo para producir virus monoglucosilado de influenza; virus monoglucosilado del antígeno de influenza ha (virus completo o recombinante); uso del virus para preparar vacuna.