BRPI1016102A2 - Inibidores de proteínas anti-apoptótica baseados em naftaleno - Google Patents
Inibidores de proteínas anti-apoptótica baseados em naftalenoInfo
- Publication number
- BRPI1016102A2 BRPI1016102A2 BRPI1016102-3A BRPI1016102A BRPI1016102A2 BR PI1016102 A2 BRPI1016102 A2 BR PI1016102A2 BR PI1016102 A BRPI1016102 A BR PI1016102A BR PI1016102 A2 BRPI1016102 A2 BR PI1016102A2
- Authority
- BR
- Brazil
- Prior art keywords
- naphthalene
- based anti
- protein inhibitors
- apoptotic protein
- apoptotic
- Prior art date
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16968609P | 2009-04-15 | 2009-04-15 | |
| US25417209P | 2009-10-22 | 2009-10-22 | |
| PCT/US2010/031113 WO2010120943A1 (en) | 2009-04-15 | 2010-04-14 | Naphthalene-based inhibitors of anti-apoptotic proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1016102A2 true BRPI1016102A2 (pt) | 2015-09-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1016102-3A BRPI1016102A2 (pt) | 2009-04-15 | 2010-04-14 | Inibidores de proteínas anti-apoptótica baseados em naftaleno |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8039668B2 (pt) |
| EP (1) | EP2418942B1 (pt) |
| JP (1) | JP2012524101A (pt) |
| KR (1) | KR20120011042A (pt) |
| CN (1) | CN102395268A (pt) |
| AU (1) | AU2010236416A1 (pt) |
| BR (1) | BRPI1016102A2 (pt) |
| CA (1) | CA2758491A1 (pt) |
| EA (1) | EA201101326A1 (pt) |
| IL (1) | IL215702A0 (pt) |
| MX (1) | MX2011010872A (pt) |
| SG (1) | SG175196A1 (pt) |
| WO (1) | WO2010120943A1 (pt) |
| ZA (1) | ZA201107274B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008311827A1 (en) * | 2007-10-19 | 2009-04-23 | Burnham Institute For Medical Research | Naphthalene-based inhibitors of anti-apoptotic proteins |
| US7956613B2 (en) * | 2008-05-02 | 2011-06-07 | The General Hospital Corporation | Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system |
| US8487131B2 (en) * | 2009-04-15 | 2013-07-16 | Sanford-Burnham Medical Research Institute | Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2) |
| BRPI1016102A2 (pt) * | 2009-04-15 | 2015-09-01 | Sanford Burhnham Medical Res Inst | Inibidores de proteínas anti-apoptótica baseados em naftaleno |
| WO2012151544A1 (en) | 2011-05-05 | 2012-11-08 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
| US9211082B2 (en) | 2011-06-30 | 2015-12-15 | The General Hospital Corporation | Method for magnetic resonance imaging using saturation harmonic induced rotary saturation |
| EP2748329B1 (en) * | 2011-11-07 | 2019-04-03 | The Regents of The University of California | Niche targeting of quiescent cancer stem cells |
| EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| US10071087B2 (en) | 2014-07-22 | 2018-09-11 | Bioventures, Llc | Compositions and methods for selectively depleting senescent cells |
| KR20170061704A (ko) * | 2014-10-02 | 2017-06-05 | 조라 바이오사이언시즈 오와이 | 난소암을 검출하는 방법 |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| US10518429B2 (en) | 2015-06-30 | 2019-12-31 | The Gillette Company Llc | Polymeric cutting edge structures and method of manufacturing polymeric cutting edge structures |
| JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
| CN106632409B (zh) * | 2016-12-19 | 2018-08-28 | 江苏度未生物工程科技有限公司 | 一种阿扑棉酚衍生物及其制备方法和抗肿瘤和免疫调节的应用 |
| EP3743069B1 (en) | 2018-01-22 | 2025-08-06 | BioVentures, LLC | Bcl-2 proteins degraders for cancer treatment |
| US12084423B2 (en) | 2018-05-18 | 2024-09-10 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| KR20210099911A (ko) * | 2020-02-05 | 2021-08-13 | 주식회사 하임바이오 | 고시폴, 또는 이의 유도체를 유효성분으로 포함하는 신경질환 예방 또는 치료용 약학조성물 |
| WO2023107606A1 (en) | 2021-12-09 | 2023-06-15 | University Of Florida Research Foundation, Incorporated | Bcl-xl/bcl-2 dual degraders for treatment of cancers |
| KR102898110B1 (ko) * | 2022-06-13 | 2025-12-12 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| ATE511856T1 (de) | 2000-03-13 | 2011-06-15 | Cornell Res Foundation Inc | Blockieren der leukozytenemigration und entzündung durch störung mit cd99/hec2 |
| WO2002040996A2 (en) | 2000-11-08 | 2002-05-23 | Mitokor | Differential gene expression in specific regions of the brain in neurodegenerative diseases |
| US7432304B2 (en) | 2001-05-30 | 2008-10-07 | The Regents Of The University Of Michigan | Small molecule antagonists of Bcl-2 family proteins |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| DE602004012279T3 (de) | 2003-06-25 | 2010-07-15 | The Burnham Institute, La Jolla | Katecholderivate zur behandlung von krebs |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| US20060144723A1 (en) * | 2004-11-02 | 2006-07-06 | Mary Fuller | Device for securing valuables |
| AU2006223257A1 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
| US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| EP1910385B1 (en) * | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| AU2008311827A1 (en) * | 2007-10-19 | 2009-04-23 | Burnham Institute For Medical Research | Naphthalene-based inhibitors of anti-apoptotic proteins |
| BRPI1016102A2 (pt) * | 2009-04-15 | 2015-09-01 | Sanford Burhnham Medical Res Inst | Inibidores de proteínas anti-apoptótica baseados em naftaleno |
-
2010
- 2010-04-14 BR BRPI1016102-3A patent/BRPI1016102A2/pt not_active IP Right Cessation
- 2010-04-14 AU AU2010236416A patent/AU2010236416A1/en not_active Abandoned
- 2010-04-14 CN CN2010800168407A patent/CN102395268A/zh active Pending
- 2010-04-14 CA CA2758491A patent/CA2758491A1/en not_active Abandoned
- 2010-04-14 MX MX2011010872A patent/MX2011010872A/es not_active Application Discontinuation
- 2010-04-14 EA EA201101326A patent/EA201101326A1/ru unknown
- 2010-04-14 WO PCT/US2010/031113 patent/WO2010120943A1/en not_active Ceased
- 2010-04-14 KR KR1020117027167A patent/KR20120011042A/ko not_active Ceased
- 2010-04-14 SG SG2011074457A patent/SG175196A1/en unknown
- 2010-04-14 US US12/760,380 patent/US8039668B2/en not_active Expired - Fee Related
- 2010-04-14 EP EP10765133.3A patent/EP2418942B1/en active Active
- 2010-04-14 JP JP2012506187A patent/JP2012524101A/ja active Pending
-
2011
- 2011-09-21 US US13/238,910 patent/US8436207B2/en not_active Expired - Fee Related
- 2011-10-05 ZA ZA2011/07274A patent/ZA201107274B/en unknown
- 2011-10-11 IL IL215702A patent/IL215702A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010236416A1 (en) | 2011-11-03 |
| EA201101326A1 (ru) | 2012-05-30 |
| EP2418942A1 (en) | 2012-02-22 |
| JP2012524101A (ja) | 2012-10-11 |
| WO2010120943A1 (en) | 2010-10-21 |
| US8436207B2 (en) | 2013-05-07 |
| KR20120011042A (ko) | 2012-02-06 |
| IL215702A0 (en) | 2012-01-31 |
| EP2418942A4 (en) | 2012-03-28 |
| US8039668B2 (en) | 2011-10-18 |
| SG175196A1 (en) | 2011-11-28 |
| CA2758491A1 (en) | 2010-10-21 |
| CN102395268A (zh) | 2012-03-28 |
| ZA201107274B (en) | 2012-06-26 |
| US20120015992A1 (en) | 2012-01-19 |
| MX2011010872A (es) | 2012-01-19 |
| US20100267781A1 (en) | 2010-10-21 |
| EP2418942B1 (en) | 2017-08-23 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |