BRPI9703099A - derivado de carboidrato, e, composição farmacêutica - Google Patents

derivado de carboidrato, e, composição farmacêutica

Info

Publication number
BRPI9703099A
BRPI9703099A BRPI9703099A BRPI9703099A BRPI9703099A BR PI9703099 A BRPI9703099 A BR PI9703099A BR PI9703099 A BRPI9703099 A BR PI9703099A BR PI9703099 A BRPI9703099 A BR PI9703099A BR PI9703099 A BRPI9703099 A BR PI9703099A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
carbohydrate derivative
derivative
carbohydrate
oso
Prior art date
Application number
BRPI9703099A
Other languages
English (en)
Inventor
Constant Adriaan A Van Boeckel
Pieter Westerduin
Original Assignee
Akzo Nobel Nv
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Sanofi Sa filed Critical Akzo Nobel Nv
Publication of BRPI9703099A publication Critical patent/BRPI9703099A/pt
Publication of BRPI9703099B1 publication Critical patent/BRPI9703099B1/pt
Publication of BRPI9703099B8 publication Critical patent/BRPI9703099B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

patente de invenção "derivado de carboidrato, composição farmacêutica, e, uso do derivado". a invenção refere-se a derivados de carboidratos a fórmula i (i) em que r^ 1^ é h ou ch~ 2~oso~ 3~^ -^ são independentemente h, alquila (1-6c) ou so~ 3~^ -^; r^ 4^ é oso~ 3~^ -^ ou nhso~ 3~^ -^; n é 0 ou 1; p é 1 ou 2; ou um sal farmaceuticamente aceitável dos mesmos. os compostos da invenção tem atividade antitrombótica e podem ser usados para inibir a proliferação de céulas músculo liso.
BRPI9703099 1996-05-08 1997-05-08 derivado de carboidrato, e, composição farmacêutica BRPI9703099B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201267 1996-05-08

Publications (3)

Publication Number Publication Date
BRPI9703099A true BRPI9703099A (pt) 1998-09-08
BRPI9703099B1 BRPI9703099B1 (pt) 2016-07-19
BRPI9703099B8 BRPI9703099B8 (pt) 2021-07-06

Family

ID=8223964

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9703099 BRPI9703099B8 (pt) 1996-05-08 1997-05-08 derivado de carboidrato, e, composição farmacêutica

Country Status (26)

Country Link
US (1) US5872110A (pt)
EP (1) EP0818459B1 (pt)
JP (1) JP4201360B2 (pt)
KR (1) KR100443802B1 (pt)
CN (1) CN1115345C (pt)
AR (1) AR007052A1 (pt)
AT (1) ATE215547T1 (pt)
AU (1) AU711630B2 (pt)
BR (1) BRPI9703099B8 (pt)
CA (1) CA2204204C (pt)
CZ (1) CZ292439B6 (pt)
DE (1) DE69711505T2 (pt)
DK (1) DK0818459T3 (pt)
ES (1) ES2176609T3 (pt)
HU (1) HU226370B1 (pt)
ID (1) ID17932A (pt)
IL (1) IL120722A (pt)
NO (1) NO308251B1 (pt)
NZ (1) NZ314745A (pt)
PL (1) PL183469B1 (pt)
PT (1) PT818459E (pt)
RU (1) RU2183638C2 (pt)
SG (2) SG55310A1 (pt)
TR (1) TR199700354A3 (pt)
TW (1) TW498078B (pt)
ZA (1) ZA973892B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289522A1 (en) * 1997-05-27 1998-12-03 Akzo Nobel Nv Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
NZ508623A (en) 1998-06-17 2002-11-26 Akzo Nobel Nv Antithrombotic peptide compounds with saccharide radicals
HK1045532A1 (zh) * 1999-06-30 2002-11-29 Hamilton Civic Hospitals Research Development, Inc. 抑制与凝结有关凝结因子的肝素成份
AU1594801A (en) * 1999-11-12 2001-06-06 Emisphere Technologies, Inc. Liquid heparin formulation
US8600783B2 (en) * 2000-08-18 2013-12-03 The Crawford Group, Inc. Business to business computer system for communicating and processing rental car reservations using web services
EP1315539A2 (en) * 2000-09-08 2003-06-04 Leo Pharma A/S Antithrombotic compositions
KR101156273B1 (ko) * 2004-03-04 2012-06-13 프로젠 파마슈티칼즈 리미티드 황산화 올리고사카라이드 유도체
DE602005007244D1 (de) * 2004-08-05 2008-07-10 Ivax Drug Res Inst Ltd Polysulfatierte glykoside und salze davon
RU2430729C2 (ru) * 2009-05-13 2011-10-10 Учреждение Российской академии наук Институт химии Коми научного центра Уральского отделения РАН Получение полифункциональных сульфатированных производных на основе порошковой целлюлозы, обладающих антикоагулянтной активностью
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN111057115B (zh) * 2019-12-17 2022-03-22 广东海洋大学 一种从贵妃蚌中提取的抗血栓类肝素及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
EP0347964A1 (en) * 1988-06-21 1989-12-27 Akzo N.V. New oligosaccharides with internal spacer
DK0454220T3 (da) * 1990-04-23 1993-11-22 Sanofi Elf Carbohydratderivater omfattende en trisaccharidenhed
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
CN1115345C (zh) 2003-07-23
IL120722A0 (en) 1997-08-14
BRPI9703099B8 (pt) 2021-07-06
TR199700354A2 (xx) 1997-11-21
PT818459E (pt) 2002-08-30
DE69711505D1 (de) 2002-05-08
CZ138697A3 (cs) 1998-02-18
CZ292439B6 (cs) 2003-09-17
RU2183638C2 (ru) 2002-06-20
DE69711505T2 (de) 2002-09-26
HK1004399A1 (en) 1998-11-27
IL120722A (en) 1999-07-14
KR100443802B1 (ko) 2004-10-08
HU9700852D0 (en) 1997-06-30
JP4201360B2 (ja) 2008-12-24
NO972120D0 (no) 1997-05-07
HU226370B1 (en) 2008-09-29
ATE215547T1 (de) 2002-04-15
AU2008697A (en) 1997-11-13
PL319843A1 (en) 1997-11-10
TW498078B (en) 2002-08-11
CN1169433A (zh) 1998-01-07
ZA973892B (en) 1998-08-19
SG55310A1 (en) 1998-12-21
US5872110A (en) 1999-02-16
SG46779A1 (en) 1998-01-20
MX9703365A (es) 1998-06-30
BRPI9703099B1 (pt) 2016-07-19
ID17932A (id) 1998-02-12
EP0818459A3 (en) 1998-04-29
HUP9700852A2 (en) 1997-12-29
JPH1045805A (ja) 1998-02-17
NO972120L (no) 1997-11-10
HUP9700852A3 (en) 1998-08-28
EP0818459B1 (en) 2002-04-03
AU711630B2 (en) 1999-10-21
ES2176609T3 (es) 2002-12-01
DK0818459T3 (da) 2002-07-01
KR19980018097A (ko) 1998-06-05
PL183469B1 (pl) 2002-06-28
NZ314745A (en) 1998-09-24
NO308251B1 (no) 2000-08-21
CA2204204C (en) 2006-02-28
TR199700354A3 (tr) 1997-11-21
CA2204204A1 (en) 1997-11-08
EP0818459A2 (en) 1998-01-14
AR007052A1 (es) 1999-10-13

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Legal Events

Date Code Title Description
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/05/1997, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 22A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2513 DE 06/03/2019 EM VIRTUDE DO DISPOSTO NO ART. 229, DA LPI.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/05/97, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 08/05/2017