BRPI9710363A - partícula de vírus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vírus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vírus sincicial respiratório recombinante (rsv) infeccioso. - Google Patents

partícula de vírus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vírus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vírus sincicial respiratório recombinante (rsv) infeccioso.

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Publication number
BRPI9710363A
BRPI9710363A BRPI9710363A BRPI9710363A BRPI9710363A BR PI9710363 A BRPI9710363 A BR PI9710363A BR PI9710363 A BRPI9710363 A BR PI9710363A BR PI9710363 A BRPI9710363 A BR PI9710363A BR PI9710363 A BRPI9710363 A BR PI9710363A
Authority
BR
Brazil
Prior art keywords
rsv
respiratory syncytial
syncytial virus
recombinant
recombinant respiratory
Prior art date
Application number
BRPI9710363A
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English (en)
Inventor
Brian R Murphy
Peter L Collins
Stephen S Whitehead
Alexander A Bukreyev
Katalin Juhasz
Michael N Teng
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Us Gov Health & Human Serv
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Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of BRPI9710363A publication Critical patent/BRPI9710363A/pt
Publication of BRPI9710363B1 publication Critical patent/BRPI9710363B1/pt
Publication of BRPI9710363B8 publication Critical patent/BRPI9710363B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

''vírus sincicial respiratório recombinante infeccioso isolado, partícula do mesmo, processos para estimular o sistema imunológico de um indivíduo para induzir proteção contra o vírus sincicial respiratório e para produzir uma partícula de vírus sincicial respiratório recombinante, vacina para induzir proteção contra o vírus sincicial respiratório recombinante, composição e cepa de vírus sincicial respiratório recombinante''. vírus sincicial respiratório (rsv) atenuado e suas composições de vacina são produzidos introduzindo-se mutações específicas associadas com fenótipos atenuantes em tipo selvagem ou rsv que é atenuado incompletamente por meio de passagem por frio ou introdução de mutações que produzem vírus com um fenótipo sensível à temperatura (<mv>ts<mu>) ou adaptado ao frio (<mu>ca<mv>). alternativamente, o rsv recombinante e suas composições de vacina incorporam mutações atenuantes e outras mutações que especificam caraceristicas estrurais ou fenotípicas desejdas em um rsv infeccioso. o rsv recombinante incorpora mutações desejadas especificadas por meio de inserção, deleção, substituição ou rearranjo de uma sequência de nucleotideo de nucleotídeo selecionada, gene ou segmento de gene em um clone de rsv infeccioso. o sistema imunológico de um indivíduo é estimulado a induzir proteção contra infeccção por rsv natural ou, de forma polivalente, contra infeccção por rsv e outro patógeno, como a piv, por meio de administração de rsv atenuado, biologicamente derivado ou recombinante.
BRPI9710363 1996-07-15 1997-07-15 partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso. BRPI9710363B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2177396P 1996-07-15 1996-07-15
US4614197P 1997-05-09 1997-05-09
US4763497P 1997-05-23 1997-05-23
PCT/US1997/012269 WO1998002530A1 (en) 1996-07-15 1997-07-15 Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences

Publications (3)

Publication Number Publication Date
BRPI9710363A true BRPI9710363A (pt) 2000-01-11
BRPI9710363B1 BRPI9710363B1 (pt) 2011-11-16
BRPI9710363B8 BRPI9710363B8 (pt) 2021-07-06

Family

ID=27361727

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9710363-2A BR9710363A (pt) 1996-07-15 1997-07-15 "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante"
BRPI9710363 BRPI9710363B8 (pt) 1996-07-15 1997-07-15 partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9710363-2A BR9710363A (pt) 1996-07-15 1997-07-15 "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante"

Country Status (12)

Country Link
US (2) US5993824A (pt)
EP (2) EP2112220A3 (pt)
JP (2) JP4413999B2 (pt)
KR (2) KR100894670B1 (pt)
CN (1) CN101012454B (pt)
AT (1) ATE451451T1 (pt)
AU (1) AU3799797A (pt)
BR (2) BR9710363A (pt)
CA (1) CA2257823A1 (pt)
DE (1) DE69739689D1 (pt)
ES (1) ES2345643T3 (pt)
WO (1) WO1998002530A1 (pt)

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