BRPI9908914A - composto de ferro-dextrana para uso como um componente em uma composição terapêutica, para profilaxia ou tratamento de deficiência de ferro; processo para a produção do referido composto de ferro-dextrana e uso do referido composto para preparação de uma composição terapêutica parenteralmente administrável. - Google Patents
composto de ferro-dextrana para uso como um componente em uma composição terapêutica, para profilaxia ou tratamento de deficiência de ferro; processo para a produção do referido composto de ferro-dextrana e uso do referido composto para preparação de uma composição terapêutica parenteralmente administrável.Info
- Publication number
- BRPI9908914A BRPI9908914A BRPI9908914A BRPI9908914A BRPI9908914A BR PI9908914 A BRPI9908914 A BR PI9908914A BR PI9908914 A BRPI9908914 A BR PI9908914A BR PI9908914 A BRPI9908914 A BR PI9908914A BR PI9908914 A BRPI9908914 A BR PI9908914A
- Authority
- BR
- Brazil
- Prior art keywords
- dextran
- iron
- compound
- daltons
- therapeutic composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
"composto de ferro-dextrana para uso como um componente em uma composição terapêutica, para profilaxia ou tratamento de deficiência de ferro; processo para a produção do referido composto de ferro-dextrana e uso do referido composto para preparação de uma composição terapêutica parenteralmente administrável" trata-se de um composto de ferro-dextrana, para tratamento parenteral de anemia por deficiência de ferro, compreende dextrana hidrogenada, tendo um peso molecular de média ponderal (mw) entre 700 e 1.400 daltons, de preferência aproximadamente, 1.000 daltons, um peso molecular médio númérico (mn) de 400 a 1.400 daltons, e em que 90 % do peso da dextrana tenha pesos moleculares menores do que 2.700 daltons e que o mw de 10 % em peso da fração de dextrana com peso molecular mais alto esteja abaixo de 3.200 daltons, tendo a referida dextrana hidrogenada sido submetida à purificação por um processo de membrana, com um valor de corte entre 340 e 800 daltons, em associação estável com oxi-hidróxido férrico. o composto é produzido através de um processo com membrana para eliminar dextranas de pesos moleculares mais altos do que, aproximadamente, 2.700 daltons, e um processo com membrana para remover sacarídeos de pesos moleculares menores do que, aproximadamente, 340 daltons de dextrana hidrogenada, antes da precipitação do hidróxido férrico na presença da referida dextrana, seguido por aquecimento e purificação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199800420A DK172860B1 (da) | 1998-03-25 | 1998-03-25 | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| PCT/DK1999/000160 WO1999048533A1 (en) | 1998-03-25 | 1999-03-24 | An iron-dextran compound for use as a component in a therapeutical composition for prophylaxis or treatment of iron-deficiency, a process for producing said iron-dextran compound and use of said compound for the preparation of a parenterally administrable therapeutical composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI9908914A true BRPI9908914A (pt) | 2000-11-21 |
| BRPI9908914B1 BRPI9908914B1 (pt) | 2012-06-12 |
| BRPI9908914B8 BRPI9908914B8 (pt) | 2021-07-06 |
Family
ID=8093321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9908914-9 BRPI9908914B8 (pt) | 1998-03-25 | 1999-03-24 | composto de ferro-dextrana para uso como um componente em uma composiÇço terapÊutica, para profilaxia ou tratamento de deficiÊncia de ferro; processo para a produÇço do referido composto de ferro-dextrana e uso do referido composto para preparaÇço de uma composiÇço terapÊutica parenteralmente administrÁvel. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6291440B1 (pt) |
| EP (1) | EP1066056B2 (pt) |
| JP (1) | JP4558198B2 (pt) |
| KR (1) | KR100612071B1 (pt) |
| CN (1) | CN1147322C (pt) |
| AR (1) | AR015738A1 (pt) |
| AT (1) | ATE220560T1 (pt) |
| AU (1) | AU740432B2 (pt) |
| BR (1) | BRPI9908914B8 (pt) |
| CA (1) | CA2322633C (pt) |
| CZ (1) | CZ300823B6 (pt) |
| DE (1) | DE69902154T3 (pt) |
| DK (2) | DK172860B1 (pt) |
| EA (1) | EA003427B1 (pt) |
| ES (1) | ES2180279T5 (pt) |
| HU (1) | HU228483B1 (pt) |
| ID (1) | ID26778A (pt) |
| NO (1) | NO329591B1 (pt) |
| NZ (1) | NZ505983A (pt) |
| PL (1) | PL195582B1 (pt) |
| PT (1) | PT1066056E (pt) |
| SI (1) | SI1066056T2 (pt) |
| SK (1) | SK284499B6 (pt) |
| TR (1) | TR200002733T2 (pt) |
| UA (1) | UA70939C2 (pt) |
| WO (1) | WO1999048533A1 (pt) |
| ZA (1) | ZA200004016B (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173138B1 (da) | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| WO2000061191A2 (en) * | 1999-04-09 | 2000-10-19 | Advanced Magnetics, Inc. | Heat stable coated colloidal iron oxides |
| KR20020003344A (ko) * | 2001-12-17 | 2002-01-12 | 유형선 | 철분 보급제 경구 투여 제제 조성물 |
| AU2003226923B2 (en) * | 2002-04-09 | 2006-08-17 | Pharmacosmos Holding A/S | iron dextrin compounds for the treatment of iron deficiency anaemia |
| DE10249552A1 (de) * | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US20060116349A1 (en) * | 2003-03-14 | 2006-06-01 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron for the treatment of restless leg syndrome |
| DE102004031181A1 (de) * | 2004-06-28 | 2006-01-19 | Vifor (International) Ag | Phosphatadsorbens |
| ITMO20050056A1 (it) * | 2005-03-15 | 2006-09-16 | Biofer Spa | Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi. |
| EP1757299A1 (de) | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| PT1973549T (pt) | 2006-01-06 | 2016-10-25 | Luitpold Pharm Inc | Métodos e composições para administração de ferro |
| EP1947120A1 (de) * | 2007-01-19 | 2008-07-23 | Vifor (International) Ag | Eisen-Kohlenhydrat-Komplex-Verbindungen |
| EP1997833A1 (de) * | 2007-05-29 | 2008-12-03 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| CN101585887B (zh) * | 2008-05-22 | 2011-12-14 | 中国科学院过程工程研究所 | 应用纳滤技术对右旋糖酐铁络合物水溶液进行脱盐和浓缩的方法 |
| LT3156075T (lt) | 2009-03-25 | 2021-01-11 | Pharmacosmos Holding A/S | Oligosacharidas ir jo paruošimo būdas |
| CN101967205B (zh) * | 2010-10-12 | 2013-04-17 | 滨州学院 | 一种β-葡聚糖铁复合物及其制备方法 |
| EP2537866A1 (en) * | 2011-06-21 | 2012-12-26 | Serumwerk Bernburg AG | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
| PL398814A1 (pl) | 2012-04-16 | 2013-10-28 | Uniwersytet Jagiellonski | Zastosowanie pochodnych dekstranu do przeciwdzialania lub leczenia niedokrwistosci |
| EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
| EP3212182B1 (en) * | 2014-10-27 | 2019-06-26 | Pharmacosmos Holding A/S | Treatment or prevention of anaemia in pregnant non-human mammals and offspring |
| AU2018328052C1 (en) * | 2017-09-11 | 2025-12-18 | Pharmacosmos Holding A/S | Iron complex compounds for therapeutic use |
| CN112203639A (zh) * | 2018-05-16 | 2021-01-08 | 法国诗华大药厂 | 兽医学组合物和其用于控制非人类哺乳动物的铁缺乏的用途 |
| CN109646454A (zh) * | 2018-12-29 | 2019-04-19 | 博瑞生物医药（苏州）股份有限公司 | 异麦芽糖酐铁1000的制备方法 |
| CN110183548B (zh) * | 2019-06-28 | 2021-05-18 | 瑞普（天津）生物药业有限公司 | 一种低分子葡聚糖铁的制备方法及其应用 |
| US20260108551A1 (en) | 2021-08-03 | 2026-04-23 | Pharmacosmos Holding A/S | Iron complex compounds for subcutaneous use in therapy of iron deficiency in companion animals |
| WO2026017897A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE24642E (en) | 1959-04-28 | Therapeutic preparations of iron | ||
| DK117730A (pt) | ||||
| US2885393A (en) | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| US3093545A (en) | 1960-08-29 | 1963-06-11 | Armour Pharma | Therapeutic iron-dextran preparations |
| US3234209A (en) * | 1963-09-13 | 1966-02-08 | Chemicals Inc | Process for making iron hydrogenated dextran |
| DE1293144B (de) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| GB1183940A (en) | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| GB1200902A (en) | 1967-05-13 | 1970-08-05 | Fisons Pharmaceuticals Ltd | Iron-dextran complexes |
| CH507993A (de) | 1967-07-13 | 1971-05-31 | Kutnowskie Zakl Farma | Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran |
| DK129353B (da) | 1968-04-29 | 1974-09-30 | Fisons Pharmaceuticals Ltd | Analogifremgangsmåde til fremstilling af et ferrihydroxid-dextranderivatkompleks eller en opløsning deraf. |
| US3697502A (en) | 1969-11-03 | 1972-10-10 | Christensen Henry M | Method of making iron dextran-preparations |
| GB1562913A (en) * | 1976-06-16 | 1980-03-19 | Fisons Ltd | Fractionating fluid mixtures of dextrans |
| DE3422249A1 (de) * | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| US5102652A (en) | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| US4827945A (en) | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| IT1263831B (it) * | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| RU2093577C1 (ru) * | 1993-11-04 | 1997-10-20 | Государственный институт кровезаменителей и медицинских препаратов | Способ получения декстрана |
| GB9402029D0 (en) * | 1994-02-03 | 1994-03-30 | Smithkline Beecham Plc | Novel formulation |
| US5624668A (en) * | 1995-09-29 | 1997-04-29 | Luitpold Pharmaceuticals, Inc. | Iron dextran formulations |
-
1998
- 1998-03-25 DK DK199800420A patent/DK172860B1/da not_active IP Right Cessation
-
1999
- 1999-03-24 NZ NZ505983A patent/NZ505983A/xx not_active IP Right Cessation
- 1999-03-24 US US09/509,454 patent/US6291440B1/en not_active Expired - Lifetime
- 1999-03-24 AU AU28273/99A patent/AU740432B2/en not_active Ceased
- 1999-03-24 HU HU0101189A patent/HU228483B1/hu unknown
- 1999-03-24 ES ES99908785T patent/ES2180279T5/es not_active Expired - Lifetime
- 1999-03-24 DK DK99908785T patent/DK1066056T4/da active
- 1999-03-24 EP EP99908785A patent/EP1066056B2/en not_active Expired - Lifetime
- 1999-03-24 AT AT99908785T patent/ATE220560T1/de active
- 1999-03-24 CN CNB998042498A patent/CN1147322C/zh not_active Expired - Lifetime
- 1999-03-24 EA EA200000981A patent/EA003427B1/ru not_active IP Right Cessation
- 1999-03-24 CZ CZ20003535A patent/CZ300823B6/cs not_active IP Right Cessation
- 1999-03-24 UA UA2000095459A patent/UA70939C2/uk unknown
- 1999-03-24 WO PCT/DK1999/000160 patent/WO1999048533A1/en not_active Ceased
- 1999-03-24 KR KR1020007010563A patent/KR100612071B1/ko not_active Expired - Lifetime
- 1999-03-24 PL PL99343164A patent/PL195582B1/pl unknown
- 1999-03-24 PT PT99908785T patent/PT1066056E/pt unknown
- 1999-03-24 AR ARP990101309A patent/AR015738A1/es active IP Right Grant
- 1999-03-24 SI SI9930103T patent/SI1066056T2/sl unknown
- 1999-03-24 CA CA002322633A patent/CA2322633C/en not_active Expired - Fee Related
- 1999-03-24 SK SK1409-2000A patent/SK284499B6/sk not_active IP Right Cessation
- 1999-03-24 JP JP2000537579A patent/JP4558198B2/ja not_active Expired - Lifetime
- 1999-03-24 ID IDW20001881A patent/ID26778A/id unknown
- 1999-03-24 BR BRPI9908914-9 patent/BRPI9908914B8/pt not_active IP Right Cessation
- 1999-03-24 DE DE69902154T patent/DE69902154T3/de not_active Expired - Lifetime
- 1999-03-24 TR TR2000/02733T patent/TR200002733T2/xx unknown
-
2000
- 2000-08-07 ZA ZA200004016A patent/ZA200004016B/xx unknown
- 2000-08-18 NO NO20004151A patent/NO329591B1/no not_active IP Right Cessation
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Legal Events
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/06/2012, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/03/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 24.03.2019 |