CA1006872A - Enzymatic salt, the process for its preparation and therapeutical compositions which contain it - Google Patents

Enzymatic salt, the process for its preparation and therapeutical compositions which contain it

Info

Publication number
CA1006872A
CA1006872A CA177,689A CA177689A CA1006872A CA 1006872 A CA1006872 A CA 1006872A CA 177689 A CA177689 A CA 177689A CA 1006872 A CA1006872 A CA 1006872A
Authority
CA
Canada
Prior art keywords
enzymatic
salt
contain
preparation
therapeutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA177,689A
Other languages
English (en)
Other versions
CA177689S (en
Inventor
Alberto Fiecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORESEARCH-LIMITED PARTNERSHIP
Original Assignee
BIORESEARCH-LIMITED PARTNERSHIP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH-LIMITED PARTNERSHIP filed Critical BIORESEARCH-LIMITED PARTNERSHIP
Application granted granted Critical
Publication of CA1006872A publication Critical patent/CA1006872A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA177,689A 1972-08-02 1973-07-27 Enzymatic salt, the process for its preparation and therapeutical compositions which contain it Expired CA1006872A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2779372 1972-08-02

Publications (1)

Publication Number Publication Date
CA1006872A true CA1006872A (en) 1977-03-15

Family

ID=11222342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA177,689A Expired CA1006872A (en) 1972-08-02 1973-07-27 Enzymatic salt, the process for its preparation and therapeutical compositions which contain it

Country Status (29)

Country Link
US (1) US3893999A (fr)
JP (1) JPS5235726B2 (fr)
AR (1) AR195350A1 (fr)
AT (1) AT341684B (fr)
AU (1) AU474015B2 (fr)
BE (1) BE802981A (fr)
CA (1) CA1006872A (fr)
CH (1) CH592112A5 (fr)
CS (1) CS195254B2 (fr)
DD (1) DD107461A5 (fr)
DE (1) DE2336401C3 (fr)
DK (1) DK131868C (fr)
ES (1) ES417377A1 (fr)
FI (1) FI52466C (fr)
FR (1) FR2194425B1 (fr)
GB (1) GB1425384A (fr)
HK (1) HK31580A (fr)
HU (1) HU167266B (fr)
IE (1) IE37913B1 (fr)
IL (1) IL42764A (fr)
MX (1) MX4544E (fr)
NL (1) NL152864B (fr)
NO (1) NO137941C (fr)
PL (1) PL87381B1 (fr)
RO (1) RO63451A (fr)
SE (1) SE400085B (fr)
SU (1) SU646915A3 (fr)
YU (1) YU36037B (fr)
ZA (1) ZA734876B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
US4109079A (en) * 1975-10-16 1978-08-22 Yamasa Shoyu Kabushiki Kaisha Stabilized s-adenosyl-l-methionine preparations
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137640B (it) 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
ATE80165T1 (de) * 1987-10-09 1992-09-15 Vincenzo Zappia Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
DE19515275A1 (de) * 1995-04-26 1996-10-31 Knoll Ag Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe)
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
WO2006079212A1 (fr) * 2005-01-26 2006-08-03 Diamedica Inc. Utilisation du compose s-adenosylmethionine, de la vitamine e, et de la vitamine c pour traiter les lesions hepatiques et la resistance a l'insuline causees par le stress oxydatif
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060026A1 (it) * 2006-01-10 2007-07-11 Truffini & Regge Farmaceutici Srl Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
CA2677053C (fr) * 2007-01-31 2016-03-15 Methylation Sciences International Srl Formulations pharmaceutiques a liberation prolongee de s-adenosylmethionine
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
US8329208B2 (en) * 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en) * 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
CN103906521A (zh) 2011-04-15 2014-07-02 塞玛尔有限公司 S-腺苷甲硫氨酸、维生素e和维生素c在预防和治疗心血管功能障碍中的应用
AU2013332209B2 (en) 2012-10-17 2016-02-04 Methylation Sciences International Srl Compositions comprising S-adenosylmethionine and a gallic acid ester
CN105073767B (zh) 2013-01-16 2018-01-02 赫伯特·山姆-E有限责任公司 稳定的s‑腺苷‑l‑蛋氨酸的吲哚‑3‑丙酸盐
AU2024274445A1 (en) 2023-05-15 2025-11-27 Bonafide Health, Llc Sleep-improving compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946781A (en) * 1957-02-06 1960-07-26 Merck & Co Inc Process for the preparation of adenosyl homocysteine
US3642772A (en) * 1968-09-04 1972-02-15 Boehringer Mannheim Gmbh Process for preparing s-adenosyl homocysteine

Also Published As

Publication number Publication date
AT341684B (de) 1978-02-27
GB1425384A (en) 1976-02-18
NL152864B (nl) 1977-04-15
ATA664173A (de) 1977-06-15
NO137941C (no) 1978-05-31
US3893999A (en) 1975-07-08
DE2336401C3 (de) 1980-03-13
IE37913L (en) 1974-02-02
MX4544E (es) 1982-06-08
SU646915A3 (ru) 1979-02-05
YU203073A (en) 1981-04-30
AR195350A1 (es) 1973-09-28
FI52466B (fr) 1977-05-31
DK131868B (da) 1975-09-15
JPS4992215A (fr) 1974-09-03
DE2336401B2 (de) 1979-07-12
YU36037B (en) 1981-11-13
IL42764A (en) 1976-04-30
NL7310706A (fr) 1974-02-05
DK131868C (da) 1976-03-08
SE400085B (sv) 1978-03-13
CS195254B2 (en) 1980-01-31
CH592112A5 (fr) 1977-10-14
HU167266B (fr) 1975-09-27
IE37913B1 (en) 1977-11-09
RO63451A (fr) 1978-07-15
BE802981A (fr) 1973-11-16
FI52466C (fi) 1977-09-12
FR2194425B1 (fr) 1976-04-09
DE2336401A1 (de) 1974-02-14
HK31580A (en) 1980-06-20
DD107461A5 (fr) 1974-08-05
NO137941B (no) 1978-02-13
PL87381B1 (fr) 1976-06-30
FR2194425A1 (fr) 1974-03-01
ES417377A1 (es) 1976-02-16
IL42764A0 (en) 1974-01-14
AU474015B2 (en) 1976-07-08
ZA734876B (en) 1974-06-26
AU5868073A (en) 1975-01-30
JPS5235726B2 (fr) 1977-09-10

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