CA1013341A - Compound of the pregnane series having anaesthetic activity - Google Patents

Compound of the pregnane series having anaesthetic activity

Info

Publication number
CA1013341A
CA1013341A CA170,482A CA170482A CA1013341A CA 1013341 A CA1013341 A CA 1013341A CA 170482 A CA170482 A CA 170482A CA 1013341 A CA1013341 A CA 1013341A
Authority
CA
Canada
Prior art keywords
compound
pregnane series
anaesthetic activity
anaesthetic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA170,482A
Other languages
English (en)
Other versions
CA170482S (en
Inventor
Gordon H. Phillipps
Christopher E. Newall
Robin Lawrence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1013341A publication Critical patent/CA1013341A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
CA170,482A 1972-05-05 1973-05-04 Compound of the pregnane series having anaesthetic activity Expired CA1013341A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2114272A GB1430942A (en) 1972-05-05 1972-05-05 21-substituted 3alpha-hydroxy pregnanes

Publications (1)

Publication Number Publication Date
CA1013341A true CA1013341A (en) 1977-07-05

Family

ID=10157915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA170,482A Expired CA1013341A (en) 1972-05-05 1973-05-04 Compound of the pregnane series having anaesthetic activity

Country Status (16)

Country Link
JP (1) JPS4961150A (fr)
AT (1) AT355232B (fr)
AU (1) AU475168B2 (fr)
BE (1) BE799102A (fr)
CA (1) CA1013341A (fr)
CH (1) CH617710A5 (fr)
DE (1) DE2322532A1 (fr)
ES (1) ES414411A1 (fr)
FR (1) FR2183792B1 (fr)
GB (1) GB1430942A (fr)
IE (1) IE37596B1 (fr)
IL (1) IL42196A (fr)
LU (1) LU67546A1 (fr)
NL (1) NL7306234A (fr)
SE (1) SE400771B (fr)
ZA (1) ZA733035B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5939545A (en) * 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
ES2296594T3 (es) * 1994-02-14 2008-05-01 Euro-Celtique S.A. Androstanos y pregnanos para la modulacion alosterica del receptor de gaba.
GR1003861B (el) * 2000-12-29 2002-04-11 Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
JP4915427B2 (ja) * 2009-03-30 2012-04-11 ブラザー工業株式会社 液体供給ジョイント、これを使用した液体吐出ヘッド及び記録装置
EP3572417B1 (fr) 2011-10-14 2025-12-17 Sage Therapeutics, LLC Composés de 19-nor prégnane disubstitués 3,3, compositions et leurs utilisations
EP2806877B2 (fr) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Formulations de stéroïdes neuroactifs comprenant un complexe d'allopregnanolone et de sulfobutyl ether beta-cyclodextrine
CA2882708A1 (fr) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Procedes de traitement de l'epilepsie ou d'un etat de mal epileptique
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
EP2986624B1 (fr) 2013-04-17 2020-03-25 Sage Therapeutics, Inc. Stéroïdes neuroactifs 19-nor et pour l'utilisation thérapeutique
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
SI3021852T1 (sl) 2013-07-19 2021-07-30 Sage Therapeutics, Inc. Nevroaktivni steroidi, sestavki in uporabe le-teh
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
ME03809B (fr) 2014-10-16 2021-04-20 Sage Therapeutics Inc Compositions et méthodes pour traiter des troubles du snc
CN117024501A (zh) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
WO2016082789A1 (fr) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions et procédés pour traiter des troubles du snc
RS61530B1 (sr) 2015-01-26 2021-04-29 Sage Therapeutics Inc Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (fr) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Stéroïdes neuroactifs, compositions et leurs utilisations
KR20240157128A (ko) 2016-03-08 2024-10-31 세이지 테라퓨틱스, 인크. 신경활성 스테로이드, 조성물, 및 그의 용도
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
WO2018013615A1 (fr) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1346292A (fr) * 1962-09-14 1963-12-20 Roussel Uclaf Nouveau procédé de préparation des 21-amino stéroïdes
US3144446A (en) * 1963-12-20 1964-08-11 Upjohn Co Mono and bis nu-(3alpha, 17alpha-dihydroxy-11, 20-dioxo-5beta-pregnan-21-yl) quaternary ammonium salts of triethylenediamine

Also Published As

Publication number Publication date
FR2183792B1 (fr) 1977-07-15
JPS4961150A (fr) 1974-06-13
AU5528473A (en) 1974-11-07
ES414411A1 (es) 1976-02-01
IE37596L (en) 1973-11-05
CH617710A5 (en) 1980-06-13
AT355232B (de) 1980-02-25
FR2183792A1 (fr) 1973-12-21
DE2322532A1 (de) 1973-11-22
IL42196A (en) 1978-10-31
NL7306234A (fr) 1973-11-07
ZA733035B (en) 1974-04-24
LU67546A1 (fr) 1973-07-13
ATA395173A (de) 1979-07-15
SE400771B (sv) 1978-04-10
GB1430942A (en) 1976-04-07
IE37596B1 (en) 1977-08-31
IL42196A0 (en) 1973-07-30
BE799102A (fr) 1973-11-05
AU475168B2 (en) 1976-08-12

Similar Documents

Publication Publication Date Title
CA1013341A (en) Compound of the pregnane series having anaesthetic activity
CA1014947A (en) Steroids of the pregnane series having anaesthetic activity
CA1003325A (en) Medical humidifier
CA1009533A (en) Catheter assembly
ZA734037B (en) Compounds of the androstane series having anaesthetic activity
CA1010847A (en) Compounds of the pregnane series having useful anaesthetic activity and processes for their preparation
CA995662A (en) Compounds of the pregnane series having useful anaesthetic activity and processes for their preparation
CA979885A (en) Compounds of the pregnane series having useful anaesthetic activity and process for their preparation
CA992068A (en) Steroid having anaesthetic activity
AU474774B2 (en) Catheter construction
CA996100A (en) Compounds of the pregnane series having anaesthetic activity
ZA733036B (en) Compounds of the pregnane series having anaesthetic activity
AU474093B2 (en) Chemosterilization of ixodides
CA996928A (en) Compounds of the androstane series having anaesthetic activity
AU475165B2 (en) Treatment of respiration conditions using hydroxycyclohexylamino compounds
CA981251A (en) Compounds of the pregnane series having useful anaesthetic activity
CA839556A (en) Medical dressings
AU486913B2 (en) Novel drug composition having antidlabetic activity
CA903401A (en) Diaper
CA907982A (en) Catheter
CA914536A (en) Catheter
CA898453A (en) Bedstead
AU455096B2 (en) Manufacture of chlorofluoropyridines
AU458647B2 (en) Manufacture of 6-60methylenetetracyclines
AU471181B2 (en) Manufacture of bipridyls