CA1022548A - Methode de preparation de derives d'iminomethyle-3 de rifamycine sv - Google Patents

Methode de preparation de derives d'iminomethyle-3 de rifamycine sv

Info

Publication number: CA1022548A
Authority: CA; Canada
Prior art keywords: rifamycin; preparation; iminomethyl; derivatives; iminomethyl derivatives
Prior art date: 1973-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA201,355A

Other languages

English (en)

Other versions

CA201355S (en

Inventor

Carmine Pasqualucci

Leonardo Marsili

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA

Original Assignee

ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-07-25

Filing date

1974-05-31

Publication date

1977-12-13

1973-07-25 Priority claimed from IT2706673A external-priority patent/IT1043857B/it

1974-01-24 Priority claimed from IT1977474A external-priority patent/IT1054154B/it

1974-05-31 Application filed by ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA filed Critical ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA

1977-12-13 Application granted granted Critical

1977-12-13 Publication of CA1022548A publication Critical patent/CA1022548A/fr

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA201,355A 1973-07-25 1974-05-31 Methode de preparation de derives d'iminomethyle-3 de rifamycine sv Expired CA1022548A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2706673A IT1043857B (it)	1973-07-25	1973-07-25	Derivati delle rifapicime procedimento della loro sintesi e loro impiego quali intermeni per la produzione di sofamicine
IT1977474A IT1054154B (it)	1974-01-24	1974-01-24	Procedimento per la preparazione di ossazino rifamione

Publications (1)

Publication Number	Publication Date
CA1022548A true CA1022548A (fr)	1977-12-13

Family

ID=26327298

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CA200,755A Expired CA1024139A (fr)	1973-07-25	1974-05-24	Procede de synthese des 1,3-oxazino(5,6-c)-rifamycines
CA201,355A Expired CA1022548A (fr)	1973-07-25	1974-05-31	Methode de preparation de derives d'iminomethyle-3 de rifamycine sv

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CA200,755A Expired CA1024139A (fr)	1973-07-25	1974-05-24	Procede de synthese des 1,3-oxazino(5,6-c)-rifamycines

Country Status (25)

Country	Link
US (3)	US3963705A (fr)
JP (2)	JPS5314080B2 (fr)
AR (2)	AR207762A1 (fr)
AT (2)	AT334530B (fr)
BE (2)	BE815122A (fr)
CA (2)	CA1024139A (fr)
CH (2)	CH615683A5 (fr)
DD (2)	DD112133A5 (fr)
DE (2)	DE2428387A1 (fr)
DK (2)	DK135286B (fr)
ES (2)	ES429059A1 (fr)
FI (2)	FI153574A7 (fr)
FR (2)	FR2257297B1 (fr)
GB (2)	GB1454801A (fr)
HU (2)	HU167983B (fr)
IE (2)	IE39389B1 (fr)
IN (2)	IN139074B (fr)
NL (2)	NL7409892A (fr)
NO (2)	NO741764L (fr)
PH (1)	PH13691A (fr)
PL (1)	PL91647B1 (fr)
RO (1)	RO63865A (fr)
SE (2)	SE407803B (fr)
SU (2)	SU613725A3 (fr)
YU (2)	YU36719B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR207762A1 (es) *	1973-07-25	1976-10-29	Archifar Ind Chim Trentino	Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina
GB1576886A (en) *	1977-04-20	1980-10-15	Lepetit Spa	Rifamycin derivatives
US4179439A (en) *	1977-07-01	1979-12-18	Intreprinderea De Antibiotice Iasi	Rifamycins and method for their preparation
JPS5473798A (en) *	1977-11-15	1979-06-13	Kanebo Ltd	Novel 1,3-oxazino (5,6-c) rifamycin derivative
JPS5473799A (en) *	1977-11-16	1979-06-13	Kanebo Ltd	Preparation of 1,3-oxazino (5,6-c) rifamycin derivative
GB1594134A (en) *	1977-11-25	1981-07-30	Holco Investment Inc	Rifamycins
JPS5484600A (en) *	1977-12-15	1979-07-05	Kanebo Ltd	Preparation of 1,3-oxazino 5,6-c rifamycin derivative
JPS5776597A (en) *	1980-10-30	1982-05-13	Kiyouritsu Kurieiteibu Asoshie	Electric musical instrument
JPS58115705U (ja) *	1982-02-01	1983-08-08	株式会社ニコン	カメラのフアインダ光学系
GB8308166D0 (en) *	1983-03-24	1983-05-05	Erba Farmitalia	Preparation of azinomethyl-rifamycins
GB8318072D0 (en) *	1983-07-04	1983-08-03	Lepetit Spa	Water-soluble rifampicin derivatives
DE69735383T2 (de) *	1996-11-19	2007-02-15	Georgetown University	Methode zur Inhibierung von HEREGULIN und seines Rezeptors sowie Verwendung zur Inhibierung von Krebszellen
RU2256663C2 (ru) *	2003-07-22	2005-07-20	Гитлин Исаак Григорьевич	Способ получения 3-аминорифампицина-s (варианты)
US20090275594A1 (en) *	2008-05-05	2009-11-05	Macielag Mark J	3-hydrazone piperazinyl rifamycin derivatives useful as antimicrobial agents
CN103755723B (zh) *	2014-02-07	2016-04-20	天津大学	一种利福平i晶型的制备方法
CN103951677B (zh) *	2014-03-17	2016-04-06	四川省长征药业股份有限公司	利福喷丁的制备方法
CN106632394A (zh) *	2016-11-15	2017-05-10	南京工业大学	一种利用釜式反应装置与微通道反应装置串联反应制备利福平的方法
CN106749326A (zh) *	2016-11-28	2017-05-31	南京工业大学	一种由利福霉素s钠盐连续生产制备利福平的方法
CN111848639A (zh) *	2020-07-09	2020-10-30	华东理工大学	一种合成利福平的工艺方法
KR102688151B1 (ko)	2021-12-28	2024-07-24	주식회사 종근당바이오	Mnp가 저감된 리팜피신의 신규 제조방법
CN119243181B (zh) *	2024-10-14	2025-10-10	河北欣港药业有限公司	一种微尺度下由利福霉素sv连续流电化学合成利福霉素s的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1090115A (en) *	1964-04-02	1967-11-08	Lepetit Spa	Mannich bases of rifamycin sv
FR208F (fr) *	1964-07-31
DE1795568C3 (de) *	1964-07-31	1974-07-18	Gruppo Lepetit S.P.A., Mailand (Italien)	3-Hydroxymethyl-rifamycin SV und Verfahren zu seiner Herstellung. Ausscheidung aus: 1595883
US3542762A (en) *	1967-06-07	1970-11-24	Lepetit Spa	Process for rifamycins
AR207762A1 (es) *	1973-07-25	1976-10-29	Archifar Ind Chim Trentino	Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina

1974
- 1974-01-01 AR AR254828A patent/AR207762A1/es active
- 1974-01-01 AR AR254829A patent/AR207763A1/es active
- 1974-05-07 SE SE7406073A patent/SE407803B/xx not_active IP Right Cessation
- 1974-05-07 SE SE7406074A patent/SE393112B/xx not_active IP Right Cessation
- 1974-05-08 GB GB2025674A patent/GB1454801A/en not_active Expired
- 1974-05-08 GB GB2025774A patent/GB1454802A/en not_active Expired
- 1974-05-08 FR FR7415837A patent/FR2257297B1/fr not_active Expired
- 1974-05-09 IN IN1039/CAL/74A patent/IN139074B/en unknown
- 1974-05-09 IN IN1038/CAL/74A patent/IN138735B/en unknown
- 1974-05-14 YU YU1324/74A patent/YU36719B/xx unknown
- 1974-05-14 IE IE1035/74A patent/IE39389B1/xx unknown
- 1974-05-14 YU YU1325/74A patent/YU36720B/xx unknown
- 1974-05-14 IE IE1034/74A patent/IE39388B1/xx unknown
- 1974-05-15 NO NO741764A patent/NO741764L/no unknown
- 1974-05-15 NO NO741763A patent/NO142305C/no unknown
- 1974-05-16 BE BE144391A patent/BE815122A/fr unknown
- 1974-05-17 FI FI1535/74A patent/FI153574A7/fi unknown
- 1974-05-21 RO RO7400078880A patent/RO63865A/fr unknown
- 1974-05-23 FI FI1575/74A patent/FI60397C/fi active
- 1974-05-23 PL PL1974171342A patent/PL91647B1/pl unknown
- 1974-05-23 US US05/472,887 patent/US3963705A/en not_active Expired - Lifetime
- 1974-05-23 US US472886A patent/US3925366A/en not_active Expired - Lifetime
- 1974-05-24 DK DK284774AA patent/DK135286B/da unknown
- 1974-05-24 CA CA200,755A patent/CA1024139A/fr not_active Expired
- 1974-05-24 DK DK284874A patent/DK284874A/da unknown
- 1974-05-31 CA CA201,355A patent/CA1022548A/fr not_active Expired
- 1974-06-10 DD DD179054A patent/DD112133A5/xx unknown
- 1974-06-12 DE DE19742428387 patent/DE2428387A1/de active Pending
- 1974-06-17 AT AT496174A patent/AT334530B/de not_active IP Right Cessation
- 1974-06-17 PH PH15952A patent/PH13691A/en unknown
- 1974-07-04 JP JP7592874A patent/JPS5314080B2/ja not_active Expired
- 1974-07-04 JP JP7592774A patent/JPS5339440B2/ja not_active Expired
- 1974-07-05 SU SU2041832A patent/SU613725A3/ru active
- 1974-07-09 SU SU742040820A patent/SU576943A3/ru active
- 1974-07-10 DE DE2433105A patent/DE2433105A1/de active Granted
- 1974-07-11 DD DD179869A patent/DD112267A5/xx unknown
- 1974-07-17 FR FR7424949A patent/FR2245631B1/fr not_active Expired
- 1974-07-18 BE BE146706A patent/BE817823A/fr not_active IP Right Cessation
- 1974-07-19 AT AT596774A patent/AT334531B/de not_active IP Right Cessation
- 1974-07-22 NL NL7409892A patent/NL7409892A/xx unknown
- 1974-07-23 NL NLAANVRAGE7409955,A patent/NL181992C/xx not_active IP Right Cessation
- 1974-07-24 CH CH1020074A patent/CH615683A5/de not_active IP Right Cessation
- 1974-07-24 ES ES429059A patent/ES429059A1/es not_active Expired
- 1974-07-24 CH CH1019974A patent/CH611296A5/xx not_active IP Right Cessation
- 1974-07-24 ES ES429060A patent/ES429060A1/es not_active Expired
- 1974-07-24 HU HUAI240A patent/HU167983B/hu unknown
- 1974-07-24 HU HUAI239A patent/HU168723B/hu unknown
1983
- 1983-04-11 US US06/483,683 patent/USRE31587E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE39389B1 (en)	1978-09-27
YU132474A (en)	1981-11-13
NL7409892A (nl)	1975-01-28
ES429059A1 (es)	1976-08-16
SU576943A3 (ru)	1977-10-15
DE2433105C2 (fr)	1988-03-31
FR2245631A1 (fr)	1975-04-25
USRE31587E (en)	1984-05-22
US3963705A (en)	1976-06-15
DD112133A5 (fr)	1975-03-20
FI60397C (fi)	1982-01-11
SE7406073L (fr)	1975-01-27
CA1024139A (fr)	1978-01-10
JPS5042021A (fr)	1975-04-16
SE393112B (sv)	1977-05-02
AU6990574A (en)	1975-12-11
AR207763A1 (es)	1976-10-29
FI153574A7 (fr)	1975-01-26
FR2257297A1 (fr)	1975-08-08
YU36720B (en)	1984-08-31
DE2433105A1 (de)	1975-02-06
FI157574A7 (fr)	1975-01-26
IE39388L (en)	1975-01-25
HU167983B (fr)	1976-02-28
AT334531B (de)	1976-01-25
YU36719B (en)	1984-08-31
JPS5314080B2 (fr)	1978-05-15
ATA596774A (de)	1976-05-15
IN138735B (fr)	1976-03-27
NL181992B (nl)	1987-07-16
GB1454802A (en)	1976-11-03
NL181992C (nl)	1987-12-16
YU132574A (en)	1981-11-13
SE407803B (sv)	1979-04-23
GB1454801A (en)	1976-11-03
AU6991074A (en)	1975-12-11
SU613725A3 (ru)	1978-06-30
NO741763L (fr)	1975-02-24
DK135286C (fr)	1977-09-05
AR207762A1 (es)	1976-10-29
FR2245631B1 (fr)	1978-09-15
NO142305C (no)	1980-07-30
SE7406074L (fr)	1975-01-27
CH611296A5 (fr)	1979-05-31
BE817823A (fr)	1974-11-18
DK135286B (da)	1977-03-28
FR2257297B1 (fr)	1978-07-21
RO63865A (fr)	1979-01-15
JPS5041897A (fr)	1975-04-16
CH615683A5 (fr)	1980-02-15
AT334530B (de)	1976-01-25
HU168723B (fr)	1976-07-28
SU613725A1 (fr)	1978-06-30
NO741764L (fr)	1975-02-24
DD112267A5 (fr)	1975-04-05
BE815122A (fr)	1974-09-16
FI60397B (fi)	1981-09-30
ES429060A1 (es)	1976-08-16
DK284774A (fr)	1975-01-26
NL7409955A (nl)	1975-01-28
IN139074B (fr)	1976-05-01
IE39389L (en)	1975-01-25
IE39388B1 (en)	1978-09-27
PL91647B1 (fr)	1977-03-31
US3925366A (en)	1975-12-09
JPS5339440B2 (fr)	1978-10-21
ATA496174A (de)	1976-05-15
DE2428387A1 (de)	1975-02-13
PH13691A (en)	1980-09-01
DK284874A (da)	1975-01-26
NO142305B (no)	1980-04-21

Publication	Publication Date	Title
PH13691A (en)	1980-09-01	Process for the preparation of 3-1 iminomethyl derivatives of rifamycin sv
CA1027946A (fr)	1978-03-14	Procede de preparation des derives 5-fluorouracile
AU476881B2 (en)	1976-10-07	Process for the preparation of 7-acylamino-desacetoxycephalosporanic acid derivatives
CH608809A5 (en)	1979-01-31	Process for the preparation of novel cephem derivatives
HK64479A (en)	1979-09-14	Process for the preparation of 7-amino-(delta)3-cephem derivatives
CA1014974A (en)	1977-08-02	Process for the preparation of 5-chloro-2-toluidine
CA1036169A (fr)	1978-08-08	Mode de fabrication de poly-n-alkyliminoalanes
CA1034114A (fr)	1978-07-04	Modes de preparation de derives steroides
EG11821A (en)	1977-12-31	Process for the preparation of cephem derivatives
CA1033742A (fr)	1978-06-27	Methode de preparation de derives de la quinoleine
CA1022946A (fr)	1977-12-20	Procede de preparation de nouveaux derives du thiazol 5-methanol
CA1029018A (fr)	1978-04-04	Mode de preparation de benzothiadiazines
AU481933B2 (en)	1975-12-11	Process forthe preparation of 3-iminomethyl derivatives of rifamycin sv
ZA743764B (en)	1975-06-25	Process for the preparation of antibiotic derivatives
CH609345A5 (en)	1979-02-28	Process for the preparation of pyrimidinoaminomethylergoline derivatives
AU487964B2 (en)	1976-05-06	Process for the preparation of 7-amino- 3 - cephem derivatives
CH610326A5 (en)	1979-04-12	Process for the preparation of novel 4-oxo-1-pyridinylpenicillin and -cephalosporin derivatives
CA1021770A (en)	1977-11-29	Process for the preparation of desmosterol derivatives
AU479962B2 (en)	1975-05-29	Process for the preparation of new diazepine derivatives
CA1034497A (fr)	1978-07-11	Procede de preparation du choleragene
ZA742924B (en)	1975-05-28	Process for the preparation of 3-iminomethyl derivatives of rifamycin sv
CH613458A5 (en)	1979-09-28	Process for the preparation of cephalosporin derivatives
CH612956A5 (en)	1979-08-31	Process for the preparation of 1H-tetrazole-5-thiol derivatives
CA1026344A (fr)	1978-02-14	Methode de preparation des derives d'oxadiazoline
CA1024161A (fr)	1978-01-10	Procede de fabrication des composes alkyles sulfones