CA1031767A - Procede de synthese de corticoides-16 substitues et etapes intermediaires - Google Patents

Procede de synthese de corticoides-16 substitues et etapes intermediaires

Info

Publication number: CA1031767A
Authority: CA; Canada
Prior art keywords: intermediates; substituted; corticoid; synthesis; corticoid synthesis
Prior art date: 1973-02-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA193,178A

Other languages

English (en)

Other versions

CA193178S (en

Inventor

Bjarte Loken

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Omni Research Inc

Original Assignee

Omni Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-02-21

Filing date

1974-02-21

Publication date

1978-05-23

1974-02-21 Application filed by Omni Research Inc filed Critical Omni Research Inc

1978-05-23 Application granted granted Critical

1978-05-23 Publication of CA1031767A publication Critical patent/CA1031767A/fr

Status Expired legal-status Critical Current

Links

239000003470 adrenal cortex hormone Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical class C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

CA193,178A 1973-02-21 1974-02-21 Procede de synthese de corticoides-16 substitues et etapes intermediaires Expired CA1031767A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US334358A US3876633A (en)	1973-02-21	1973-02-21	Processes and intermediates for 16-substituted corticoid synthesis

Publications (1)

Publication Number	Publication Date
CA1031767A true CA1031767A (fr)	1978-05-23

Family

ID=23306856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA193,178A Expired CA1031767A (fr)	1973-02-21	1974-02-21	Procede de synthese de corticoides-16 substitues et etapes intermediaires

Country Status (13)

Country	Link
US (1)	US3876633A (fr)
JP (1)	JPS5111754A (fr)
BE (1)	BE811325A (fr)
BR (1)	BR7401222D0 (fr)
CA (1)	CA1031767A (fr)
DE (1)	DE2407967A1 (fr)
ES (1)	ES423481A1 (fr)
FR (4)	FR2279761A1 (fr)
GB (2)	GB1462685A (fr)
IL (1)	IL44234A (fr)
IN (1)	IN139463B (fr)
NL (1)	NL7402331A (fr)
ZA (1)	ZA741133B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1505701A (en) *	1975-06-14	1978-03-30	Pierrel Spa	2-chloro-6beta-fluoropregnanes
NL7607283A (nl) *	1975-07-23	1977-01-25	Merck & Co Inc	Werkwijze voor het bereiden van nieuwe pregnaansteroiden.
US4189430A (en) *	1978-07-31	1980-02-19	The Upjohn Company	Epoxide process
JPS611699A (ja) *	1984-06-11	1986-01-07	ジ　アツプジヨン　カンパニー	１６α‐メチル化法
US4704455A (en) *	1984-06-11	1987-11-03	The Upjohn Company	16α-methylatedΔ17(20)-corticoids
US4990612A (en) *	1984-06-11	1991-02-05	The Upjohn Company	16α-methylation process
PT78973A (en) *	1984-07-25	1984-08-01	Joao Emerico Villax	New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
FR2692266B1 (fr) *	1992-06-11	1994-08-05	Roussel Uclaf	Nouveau procede de preparation de sterouides 16 alpha-methyles.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3053865A (en) *	1958-03-19	1962-09-11	Merck & Co Inc	Novel 16-alkyl and 16-alkylene steroids and processes
US3072686A (en) *	1958-10-10	1963-01-08	Ciba Geigy Corp	16alpha-alkyl-pregnane compounds and process for their manufacture
US3030389A (en) *	1961-01-23	1962-04-17	Julian Lab Inc	Processes for the preparation of 16-alkylpregnenes
US3120517A (en) *	1961-06-06	1964-02-04	American Cyanamid Co	Method of preparing allopregnenes and products resulting therefrom
CH529119A (de) *	1968-10-02	1972-10-15	Schering Ag	Verfahren zur Herstellung von 17a-Acyloxy-20-keto-steroiden

1973
- 1973-02-21 US US334358A patent/US3876633A/en not_active Expired - Lifetime
1974
- 1974-02-13 GB GB650274A patent/GB1462685A/en not_active Expired
- 1974-02-13 GB GB5327875A patent/GB1462686A/en not_active Expired
- 1974-02-19 DE DE19742407967 patent/DE2407967A1/de active Pending
- 1974-02-19 IL IL44234A patent/IL44234A/xx unknown
- 1974-02-20 NL NL7402331A patent/NL7402331A/xx unknown
- 1974-02-20 BE BE141174A patent/BE811325A/fr unknown
- 1974-02-20 BR BR741222A patent/BR7401222D0/pt unknown
- 1974-02-20 FR FR7405728A patent/FR2279761A1/fr not_active Withdrawn
- 1974-02-21 ES ES423481A patent/ES423481A1/es not_active Expired
- 1974-02-21 CA CA193,178A patent/CA1031767A/fr not_active Expired
- 1974-02-21 ZA ZA00741133A patent/ZA741133B/xx unknown
- 1974-02-21 JP JP49020976A patent/JPS5111754A/ja active Pending
- 1974-02-22 IN IN380/CAL/74A patent/IN139463B/en unknown
1975
- 1975-02-17 FR FR7504889A patent/FR2279758A1/fr active Granted
- 1975-02-17 FR FR7504890A patent/FR2279759A1/fr active Granted
- 1975-10-29 FR FR7533075A patent/FR2289521A1/fr active Granted

Also Published As

Publication number	Publication date
IN139463B (fr)	1976-06-19
IL44234A0 (en)	1974-05-16
FR2279759B1 (fr)	1978-02-03
FR2279761A1 (fr)	1976-02-20
GB1462686A (en)	1977-01-26
US3876633A (en)	1975-04-08
ES423481A1 (es)	1976-06-01
IL44234A (en)	1978-07-31
ZA741133B (en)	1975-04-30
AU6584774A (en)	1975-08-21
FR2289521A1 (fr)	1976-05-28
GB1462685A (en)	1977-01-26
BE811325A (fr)	1974-06-17
JPS5111754A (en)	1976-01-30
BR7401222D0 (pt)	1974-11-05
FR2289521B1 (fr)	1978-04-07
DE2407967A1 (de)	1974-08-29
FR2279758A1 (fr)	1976-02-20
FR2279759A1 (fr)	1976-02-20
FR2279758B1 (fr)	1978-02-03
NL7402331A (fr)	1974-08-23

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