CA1038292A - L'albumine du sang - Google Patents

L'albumine du sang

Info

Publication number: CA1038292A
Authority: CA; Canada
Prior art keywords: albumin; process according; plasma; alcohol; blood
Prior art date: 1974-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA223,373A

Other languages

English (en)

Other versions

CA223373S (en

Inventor

Waldemar Schneider

Christian Frohlich

Harald Fiedler

Hans Lefevre

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Plasmesco AG

Original Assignee

Plasmesco AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-28

Filing date

1975-03-26

Publication date

1978-09-12

1974-03-28 Priority claimed from DE2415079A external-priority patent/DE2415079C3/de

1975-03-26 Application filed by Plasmesco AG filed Critical Plasmesco AG

1976-12-28 Priority claimed from US05/755,126 external-priority patent/US4156681A/en

1978-09-12 Application granted granted Critical

1978-09-12 Publication of CA1038292A publication Critical patent/CA1038292A/fr

Status Expired legal-status Critical Current

Links

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210000004369 blood Anatomy 0.000 title claims abstract description 17
239000008280 blood Substances 0.000 title claims abstract description 17
102000009027 Albumins Human genes 0.000 title claims description 81
108010088751 Albumins Proteins 0.000 title claims description 81
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 86
210000002381 plasma Anatomy 0.000 claims abstract description 45
102000004169 proteins and genes Human genes 0.000 claims abstract description 38
108090000623 proteins and genes Proteins 0.000 claims abstract description 38
102000007562 Serum Albumin Human genes 0.000 claims abstract description 21
108010071390 Serum Albumin Proteins 0.000 claims abstract description 21
239000000470 constituent Substances 0.000 claims abstract description 17
239000003381 stabilizer Substances 0.000 claims abstract description 16
238000001556 precipitation Methods 0.000 claims abstract description 15
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DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims abstract description 6
239000010836 blood and blood product Substances 0.000 claims abstract description 6
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239000007788 liquid Substances 0.000 claims description 17
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108010074605 gamma-Globulins Proteins 0.000 description 4
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WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
108010049003 Fibrinogen Proteins 0.000 description 3
102000008946 Fibrinogen Human genes 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
239000000306 component Substances 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
238000001704 evaporation Methods 0.000 description 3
230000008020 evaporation Effects 0.000 description 3
229940012952 fibrinogen Drugs 0.000 description 3
238000001914 filtration Methods 0.000 description 3
238000000760 immunoelectrophoresis Methods 0.000 description 3
239000000843 powder Substances 0.000 description 3
239000013049 sediment Substances 0.000 description 3
239000007858 starting material Substances 0.000 description 3
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239000000725 suspension Substances 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
102000002572 Alpha-Globulins Human genes 0.000 description 2
108010068307 Alpha-Globulins Proteins 0.000 description 2
102000006734 Beta-Globulins Human genes 0.000 description 2
108010087504 Beta-Globulins Proteins 0.000 description 2
102000004506 Blood Proteins Human genes 0.000 description 2
108010017384 Blood Proteins Proteins 0.000 description 2
239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 2
239000002253 acid Substances 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
210000001772 blood platelet Anatomy 0.000 description 2
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229960002446 octanoic acid Drugs 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
UDWXLZLRRVQONG-UHFFFAOYSA-M sodium hexanoate Chemical compound [Na+].CCCCCC([O-])=O UDWXLZLRRVQONG-UHFFFAOYSA-M 0.000 description 2
238000012360 testing method Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 description 1
108010039209 Blood Coagulation Factors Proteins 0.000 description 1
102000015081 Blood Coagulation Factors Human genes 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
108010054218 Factor VIII Proteins 0.000 description 1
102000001690 Factor VIII Human genes 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
241000282887 Suidae Species 0.000 description 1
102000003929 Transaminases Human genes 0.000 description 1
108090000340 Transaminases Proteins 0.000 description 1
208000003441 Transfusion reaction Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
230000004075 alteration Effects 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000013060 biological fluid Substances 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
239000003114 blood coagulation factor Substances 0.000 description 1
239000012503 blood component Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
230000001112 coagulating effect Effects 0.000 description 1
229940105778 coagulation factor viii Drugs 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000012045 crude solution Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-M hexanoate Chemical compound CCCCCC([O-])=O FUZZWVXGSFPDMH-UHFFFAOYSA-M 0.000 description 1
GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000003053 immunization Effects 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
KFRPXSYXYLZSPQ-UHFFFAOYSA-N octanoic acid;2-phenylacetic acid Chemical compound CCCCCCCC(O)=O.OC(=O)CC1=CC=CC=C1 KFRPXSYXYLZSPQ-UHFFFAOYSA-N 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
229950009215 phenylbutanoic acid Drugs 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
230000003019 stabilising effect Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000010414 supernatant solution Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Landscapes

Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA223,373A 1974-03-28 1975-03-26 L'albumine du sang Expired CA1038292A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2415079A DE2415079C3 (de)	1974-03-28	1974-03-28	Verfahren zum Isolieren von Albumin aus Blutplasma
US05/755,126 US4156681A (en)	1974-03-28	1976-12-28	Process for isolating albumin from blood

Publications (1)

Publication Number	Publication Date
CA1038292A true CA1038292A (fr)	1978-09-12

Family

ID=25766899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA223,373A Expired CA1038292A (fr)	1974-03-28	1975-03-26	L'albumine du sang

Country Status (1)

Country	Link
CA (1)	CA1038292A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1983002057A1 (fr) *	1981-12-17	1983-06-23	Quinn, Patrick, James	Procede et composition contraceptifs
US5849874A (en) *	1991-07-12	1998-12-15	Gist-Brocades, N.V.	Process for the purification of serum albumin
US6504011B1 (en) *	1991-07-12	2003-01-07	Dsm N.V.	Process for the purification of serum albumin

1975
- 1975-03-26 CA CA223,373A patent/CA1038292A/fr not_active Expired

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1983002057A1 (fr) *	1981-12-17	1983-06-23	Quinn, Patrick, James	Procede et composition contraceptifs
US5849874A (en) *	1991-07-12	1998-12-15	Gist-Brocades, N.V.	Process for the purification of serum albumin
US6150504A (en) *	1991-07-12	2000-11-21	Dsm Patents & Trademarks	Process for the purification of serum albumin
US6504011B1 (en) *	1991-07-12	2003-01-07	Dsm N.V.	Process for the purification of serum albumin
US6831157B2 (en)	1991-07-12	2004-12-14	Dsm Ip Assets B.V.	Process for the purification of serum albumin

Publication	Publication Date	Title
US4156681A (en)	1979-05-29	Process for isolating albumin from blood
US4188318A (en)	1980-02-12	Simplified method for preparation of high yield, high purity Factor VIII concentrate
CA1111023A (fr)	1981-10-20	Procede pour recuperer l'albumine purifiee dans le plasma sanguin
US3992367A (en)	1976-11-16	Process for the preparation of purified albumin by thermocoagulation and albumin obtained by said process
US4216205A (en)	1980-08-05	Process of preparing a serum protein composition for intravenous application
CA1323139C (fr)	1993-10-12	Methode servant a la production d'albumine en grande partie pure
GB1473548A (en)	1977-05-11	Bovine immunoglobulin isolation process
JPH0676337B2 (ja)	1994-09-28	高純度抗血友病性因子濃縮物の製造法
US4104266A (en)	1978-08-01	Method for preparation of antihemophilic factor
FI72653C (fi)	1987-07-10	Foerfarande foer framstaellning av ett faktor viii(ahf)-koncentrat.
CA1054052A (fr)	1979-05-08	Methode simplifiee pour la preparation d'un concentre de facteur viii hautement purifie
CA1293941C (fr)	1992-01-07	Methode pour preparer un facteur antihenophile (fah) par precipitation a froid et pour ameliorer la solubilite du fah recupere
US4075197A (en)	1978-02-21	Serum albumin production
CA1112565A (fr)	1981-11-17	Procede de concentration du facteur de coagulation xiii derive du placenta humain
US2958628A (en)	1960-11-01	Heat treatable plasma protein product and method of preparation
CA1038292A (fr)	1978-09-12	L'albumine du sang
US4294826A (en)	1981-10-13	Process for the preparation of highly purified antihemophilic factor
US4478825A (en)	1984-10-23	Warm ethanol method for preparation of low fibrinogen antihemophilic factor
US2460550A (en)	1949-02-01	Modified globin and method for its preparation
US2797184A (en)	1957-06-25	Process for the recovery of heparin
JPS6242887B2 (fr)	1987-09-10
SU743564A3 (ru)	1980-06-25	Способ получени альбумина
US4169829A (en)	1979-10-02	Process for the preparation of purified albumin and albumin obtained by said process
IE42460B1 (en)	1980-08-13	Process for isolating albumin from blood
JP2931319B2 (ja)	1999-08-09	血液凝固第▲ｖｉｉｉ▼因子の製造法