CA1055498A - 2,4-diamino-5-benzylpyrimidines, process for their preparation and pharmaceutical compositions containing these compounds - Google Patents

2,4-diamino-5-benzylpyrimidines, process for their preparation and pharmaceutical compositions containing these compounds

Info

Publication number
CA1055498A
CA1055498A CA262,152A CA262152A CA1055498A CA 1055498 A CA1055498 A CA 1055498A CA 262152 A CA262152 A CA 262152A CA 1055498 A CA1055498 A CA 1055498A
Authority
CA
Canada
Prior art keywords
acid
diamino
benzylpyrimidine
chemical equivalent
obvious chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA262,152A
Other languages
English (en)
French (fr)
Inventor
Walter Liebenow
Jaroslav Prikryl
Edgar Fritschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Ludwig and Co GmbH
Original Assignee
Heumann Ludwig and Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Ludwig and Co GmbH filed Critical Heumann Ludwig and Co GmbH
Application granted granted Critical
Publication of CA1055498A publication Critical patent/CA1055498A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA262,152A 1975-10-17 1976-09-27 2,4-diamino-5-benzylpyrimidines, process for their preparation and pharmaceutical compositions containing these compounds Expired CA1055498A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2546667A DE2546667C3 (de) 1975-10-17 1975-10-17 2,4-DiamüH»-5-(3-methoxy-4-hydroxy-5-halogenbenzyl)-pyrimidine, und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CA1055498A true CA1055498A (en) 1979-05-29

Family

ID=5959437

Family Applications (1)

Application Number Title Priority Date Filing Date
CA262,152A Expired CA1055498A (en) 1975-10-17 1976-09-27 2,4-diamino-5-benzylpyrimidines, process for their preparation and pharmaceutical compositions containing these compounds

Country Status (17)

Country Link
JP (1) JPS5251376A (de)
AR (1) AR210905A1 (de)
AT (1) AT352735B (de)
AU (1) AU1724576A (de)
BE (1) BE846397A (de)
CA (1) CA1055498A (de)
CH (1) CH623313A5 (de)
DE (1) DE2546667C3 (de)
ES (1) ES451375A1 (de)
FR (1) FR2327786A1 (de)
GB (1) GB1522537A (de)
GR (1) GR60352B (de)
HU (1) HU174155B (de)
IL (1) IL50430A0 (de)
MX (1) MX4485E (de)
NL (1) NL7609652A (de)
PT (1) PT65482B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720771C3 (de) 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
NO791699L (no) * 1978-05-24 1979-11-27 Wellcome Found Benzylpyrimidinforbindelser og fremgangsmaate til deres fremstilling
HU188588B (en) * 1982-08-13 1986-04-28 Egyt Gyogyszervegyeszeti Gyar Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives

Also Published As

Publication number Publication date
HU174155B (hu) 1979-11-28
FR2327786A1 (fr) 1977-05-13
ES451375A1 (es) 1981-10-16
IL50430A0 (en) 1976-11-30
FR2327786B1 (de) 1980-04-18
GR60352B (en) 1978-05-18
DE2546667B2 (de) 1978-02-09
NL7609652A (nl) 1977-04-19
ATA649276A (de) 1979-03-15
PT65482A (de) 1976-09-01
CH623313A5 (en) 1981-05-29
AT352735B (de) 1979-10-10
AU1724576A (en) 1978-03-02
JPS5251376A (en) 1977-04-25
AR210905A1 (es) 1977-09-30
DE2546667A1 (de) 1977-04-28
BE846397A (fr) 1977-01-17
GB1522537A (en) 1978-08-23
DE2546667C3 (de) 1978-10-12
MX4485E (es) 1982-05-21
PT65482B (de) 1978-02-13

Similar Documents

Publication Publication Date Title
US5591743A (en) 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives as 5HT1A ligands
KR930009793B1 (ko) 벤조피란 유도체 및 이의 제조방법
CA1070691A (en) Guanidine derivatives
US4405635A (en) 4-Aroylimidazol-2-ones and their use as pharmaceuticals
US4704387A (en) N-benzyl, phenethyl, methoxyethyl or allyl substituted benzylphthalazinones having antiallergic and antihistamine action
US4883797A (en) Derivatives of piperazine, method for making the same
JP2860689B2 (ja) ピリミジン誘導体
CA1055498A (en) 2,4-diamino-5-benzylpyrimidines, process for their preparation and pharmaceutical compositions containing these compounds
US4436913A (en) 1H- and 2H- indazole derivatives
GB2161807A (en) Substituted alkyl piperazines
US3316266A (en) 3-aminopyrazinoic acid derivatives and process for their preparation
US3979408A (en) 2-(Pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole derivatives
EP0285089A2 (de) 4-Thiochinazolin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammenstellungen
EP0686631B1 (de) Pyrimidinderivate und pharmazeutische Zusammensetzungen
KR900001420B1 (ko) 4-아미노-6,7-디메톡시2-[4-(푸로-2-일)-피페라진-1-일]-퀴나졸린 및 생리적으로 적합한 그염의 제조방법
GB2142625A (en) Piperazino-quinazolines
IE52345B1 (en) Alkanolamine derivatives
US4180578A (en) 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use
EP0315115B1 (de) 1-Acyl-2,3-dihydro-4(1H)-chinolon-4-oxim-Derivate, Verfahren zu ihrer Herstellung und Verwendung davon
HU219231B (en) N-5-protected 2,5-diamino-4,6-dichloro-pyrimidine derivatives , process for producing them and intermediates
NO147838B (no) Mellomprodukt til bruk ved fremstilling av det hypotensive middel 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimetoksykinazolin
CA1084498A (en) Benzylpyrimidines and process for the preparation thereof
US4956463A (en) Pyrimidone compound and pharmaceutically acceptable salts thereof
US6348605B1 (en) Process for preparing 3-hydroxymethyl chromen-4-ones
US3426023A (en) 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl) 3-methyl-5-methoxypyrazole