CA1062614A - Oleophilic clay pharmaceutical formulations - Google Patents

Oleophilic clay pharmaceutical formulations

Info

Publication number: CA1062614A
Authority: CA; Canada
Prior art keywords: formulation; formulation according; clay; oil; natural
Prior art date: 1974-09-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA235,109A

Other languages

English (en)

French (fr)

Inventor

Christopher D. Clarke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee

Beecham Group PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-09-21

Filing date

1975-09-09

Publication date

1979-09-18

1975-09-09 Application filed by Beecham Group PLC filed Critical Beecham Group PLC

1979-09-18 Application granted granted Critical

1979-09-18 Publication of CA1062614A publication Critical patent/CA1062614A/en

Status Expired legal-status Critical Current

Links

239000004927 clay Substances 0.000 title claims abstract description 31
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
239000008157 edible vegetable oil Substances 0.000 claims abstract description 15
239000003814 drug Substances 0.000 claims abstract description 13
241001465754 Metazoa Species 0.000 claims abstract description 9
239000012530 fluid Substances 0.000 claims abstract description 8
150000001767 cationic compounds Chemical class 0.000 claims abstract description 6
229910001411 inorganic cation Inorganic materials 0.000 claims abstract description 6
150000002892 organic cations Chemical class 0.000 claims abstract description 5
239000000203 mixture Substances 0.000 claims description 46
238000009472 formulation Methods 0.000 claims description 45
239000003921 oil Substances 0.000 claims description 13
235000019198 oils Nutrition 0.000 claims description 13
239000002798 polar solvent Substances 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 11
230000003115 biocidal effect Effects 0.000 claims description 11
238000000034 method Methods 0.000 claims description 11
-1 ammonium ions Chemical class 0.000 claims description 10
229910052739 hydrogen Inorganic materials 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
239000003242 anti bacterial agent Substances 0.000 claims description 7
239000006185 dispersion Substances 0.000 claims description 7
230000008569 process Effects 0.000 claims description 7
230000002745 absorbent Effects 0.000 claims description 6
239000002250 absorbent Substances 0.000 claims description 6
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 6
229940088710 antibiotic agent Drugs 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
235000010469 Glycine max Nutrition 0.000 claims description 4
244000068988 Glycine max Species 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
239000000084 colloidal system Substances 0.000 claims description 4
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
150000002431 hydrogen Chemical class 0.000 claims description 4
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical group CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 4
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
235000019486 Sunflower oil Nutrition 0.000 claims description 3
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 3
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 3
229910000271 hectorite Inorganic materials 0.000 claims description 3
REYJJPSVUYRZGE-UHFFFAOYSA-O hydron;octadecan-1-amine Chemical compound CCCCCCCCCCCCCCCCCC[NH3+] REYJJPSVUYRZGE-UHFFFAOYSA-O 0.000 claims description 3
229910052749 magnesium Inorganic materials 0.000 claims description 3
239000011777 magnesium Substances 0.000 claims description 3
229910052901 montmorillonite Inorganic materials 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
239000002600 sunflower oil Substances 0.000 claims description 3
235000003911 Arachis Nutrition 0.000 claims description 2
244000105624 Arachis hypogaea Species 0.000 claims description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
235000019484 Rapeseed oil Nutrition 0.000 claims description 2
229910000323 aluminium silicate Inorganic materials 0.000 claims description 2
235000012211 aluminium silicate Nutrition 0.000 claims description 2
229960003022 amoxicillin Drugs 0.000 claims description 2
229960000723 ampicillin Drugs 0.000 claims description 2
229910052791 calcium Inorganic materials 0.000 claims description 2
239000011575 calcium Substances 0.000 claims description 2
FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 claims description 2
229960003669 carbenicillin Drugs 0.000 claims description 2
229960003326 cloxacillin Drugs 0.000 claims description 2
LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 claims description 2
235000005687 corn oil Nutrition 0.000 claims description 2
229910052742 iron Inorganic materials 0.000 claims description 2
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims 2
239000005995 Aluminium silicate Substances 0.000 claims 1
PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 claims 1
239000013020 final formulation Substances 0.000 claims 1
239000002562 thickening agent Substances 0.000 abstract description 2
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 6
239000000725 suspension Substances 0.000 description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
229960003311 ampicillin trihydrate Drugs 0.000 description 4
229960000892 attapulgite Drugs 0.000 description 3
229910052625 palygorskite Inorganic materials 0.000 description 3
229930182555 Penicillin Natural products 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical class O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
HKUFIYBZNQSHQS-UHFFFAOYSA-N n-octadecyloctadecan-1-amine Chemical compound CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC HKUFIYBZNQSHQS-UHFFFAOYSA-N 0.000 description 2
239000002904 solvent Substances 0.000 description 2
206010012735 Diarrhoea Diseases 0.000 description 1
101001073409 Homo sapiens Retrotransposon-derived protein PEG10 Proteins 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
102100035844 Retrotransposon-derived protein PEG10 Human genes 0.000 description 1
239000002253 acid Substances 0.000 description 1
229940010698 activated attapulgite Drugs 0.000 description 1
239000000654 additive Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
FWLORMQUOWCQPO-UHFFFAOYSA-N benzyl-dimethyl-octadecylazanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 FWLORMQUOWCQPO-UHFFFAOYSA-N 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000003801 milling Methods 0.000 description 1
NHLUVTZJQOJKCC-UHFFFAOYSA-N n,n-dimethylhexadecan-1-amine Chemical compound CCCCCCCCCCCCCCCCN(C)C NHLUVTZJQOJKCC-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000004533 oil dispersion Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Inorganic Chemistry (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Fodder In General (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA235,109A 1974-09-21 1975-09-09 Oleophilic clay pharmaceutical formulations Expired CA1062614A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB41231/74A GB1512378A (en)	1974-09-21	1974-09-21	Pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
CA1062614A true CA1062614A (en)	1979-09-18

Family

ID=10418733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA235,109A Expired CA1062614A (en)	1974-09-21	1975-09-09	Oleophilic clay pharmaceutical formulations

Country Status (12)

Country	Link
JP (1)	JPS5161619A (ja)
BE (1)	BE833432A (ja)
CA (1)	CA1062614A (ja)
DE (1)	DE2541881C2 (ja)
DK (1)	DK143887C (ja)
FR (1)	FR2285146A1 (ja)
GB (1)	GB1512378A (ja)
IE (1)	IE41461B1 (ja)
NL (1)	NL185060C (ja)
NZ (1)	NZ178490A (ja)
SE (1)	SE426909B (ja)
ZA (1)	ZA755515B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1105881B (it) *	1978-01-24	1985-11-04	Schiapparelli Spa	Preparazione farmaceutica per uso orale contenente gentamicina
GB2119649B (en) *	1982-05-12	1986-02-12	Beecham Group Plc	Ophthalmic cloxacillin compositions

1974
- 1974-09-21 GB GB41231/74A patent/GB1512378A/en not_active Expired
1975
- 1975-08-26 IE IE1865/75A patent/IE41461B1/en unknown
- 1975-08-26 NZ NZ178490A patent/NZ178490A/xx unknown
- 1975-08-28 ZA ZA00755515A patent/ZA755515B/xx unknown
- 1975-09-09 CA CA235,109A patent/CA1062614A/en not_active Expired
- 1975-09-12 FR FR7528027A patent/FR2285146A1/fr active Granted
- 1975-09-15 BE BE160057A patent/BE833432A/xx not_active IP Right Cessation
- 1975-09-16 SE SE7510365A patent/SE426909B/xx not_active IP Right Cessation
- 1975-09-19 NL NLAANVRAGE7511059,A patent/NL185060C/xx not_active IP Right Cessation
- 1975-09-19 DK DK421075A patent/DK143887C/da active
- 1975-09-19 DE DE2541881A patent/DE2541881C2/de not_active Expired
- 1975-09-22 JP JP50114633A patent/JPS5161619A/ja active Granted

Also Published As

Publication number	Publication date
DK143887C (da)	1982-04-13
NL185060B (nl)	1989-08-16
AU8506875A (en)	1977-03-31
GB1512378A (en)	1978-06-01
NZ178490A (en)	1978-06-02
FR2285146B1 (ja)	1978-07-28
NL7511059A (nl)	1976-03-23
DE2541881C2 (de)	1986-09-11
JPS5745413B2 (ja)	1982-09-28
ZA755515B (en)	1976-08-25
DK421075A (da)	1976-03-22
DE2541881A1 (de)	1976-04-08
IE41461B1 (en)	1980-01-02
FR2285146A1 (fr)	1976-04-16
NL185060C (nl)	1990-01-16
JPS5161619A (en)	1976-05-28
SE7510365L (sv)	1976-03-22
IE41461L (en)	1976-03-21
SE426909B (sv)	1983-02-21
BE833432A (fr)	1976-03-15
DK143887B (da)	1981-10-26

Publication	Publication Date	Title
DE69728783T2 (de)	2005-03-31	Verbesserte arzneimittel
US4282202A (en)	1981-08-04	Intramammary compositions
EP0210513B1 (de)	1990-05-23	Zubereitungen zur Behandlung von Mycoplasmosen und bakteriellen Erkrankungen bei Geflügel
DE2635476C2 (de)	1992-08-27	Tierarzneimittel
EP0010903B2 (en)	1986-01-22	Intramammary compositions and process for their preparation
US4145429A (en)	1979-03-20	Oral veterinary preparations
CA1062614A (en)	1979-09-18	Oleophilic clay pharmaceutical formulations
DE2611183A1 (de)	1976-10-14	Stabile dosierungsform von prostaglandinartigen verbindungen
WO1987003876A1 (en)	1987-07-02	Benzathine cephalothin, a process for its preparation and compositions containing it
DE2442314A1 (de)	1975-03-13	Aerosol-koerperdesodorans
EP0241804B1 (de)	1992-01-15	Konservierte Antacida-Zubereitungen
US3049473A (en)	1962-08-14	Udder-dispersible antibiotic mastitis creams
US4029782A (en)	1977-06-14	Cefazolin suspension for parenteral administration
DE60114384T2 (de)	2006-07-06	Anaesthetische zusammensetzungen enthaltend alfaxalon
KR0169711B1 (ko)	1999-01-15	수의학적 조성물
DE3044753C2 (ja)	1990-05-10
US3035971A (en)	1962-05-22	Ophthalmic composition
AT394946B (de)	1992-07-27	Verfahren zur behandlung von an primaer durch treponema hyodysenteriae verursachter schweinedysenterie leidenden schweinen
DE69132663T2 (de)	2001-10-31	Tierärztliche behandlung
US3055804A (en)	1962-09-25	Mange powders
DE2445400C3 (de)	1982-01-07	Injizierbare einphasige Zubereitung und Verfahren zu ihrer Herstellung
JPS60169431A (ja)	1985-09-02	β−ラクタム環を有する化合物を含有する安定な抗菌剤及びその製造法
US4093733A (en)	1978-06-06	Parenteral suspensions
DE961350C (de)	1957-04-04	Verfahren zur Herstellung eines leicht loeslichen Salzes des 1-(3', 4'-Diaethoxy-benzyl)-6, 7-diaethoxy-isochinolins
IE64620B1 (en)	1995-08-23	A veterinary preparation