CA1075605A - Solutions a base de sels de glycerophosphates pour infusions - Google Patents

Solutions a base de sels de glycerophosphates pour infusions

Info

Publication number: CA1075605A
Authority: CA; Canada
Prior art keywords: solution; glycerophosphate; phosphorus; sodium; phosphate
Prior art date: 1975-01-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA238,444A

Other languages

English (en)

Other versions

CA238444S (en

Inventor

Werner Fekl

Helmut Mader

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Health AB

Original Assignee

Kabi Pharmacia AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-01-23

Filing date

1975-10-22

Publication date

1980-04-15

1975-10-22 Application filed by Kabi Pharmacia AB filed Critical Kabi Pharmacia AB

1980-04-15 Application granted granted Critical

1980-04-15 Publication of CA1075605A publication Critical patent/CA1075605A/fr

Status Expired legal-status Critical Current

Links

239000003978 infusion fluid Substances 0.000 title abstract 3
150000002315 glycerophosphates Chemical class 0.000 title description 3
150000003839 salts Chemical class 0.000 title description 3
239000011574 phosphorus Substances 0.000 claims abstract description 20
229910052698 phosphorus Inorganic materials 0.000 claims abstract description 20
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 19
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims abstract description 16
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims abstract description 16
208000029663 Hypophosphatemia Diseases 0.000 claims abstract description 7
208000037147 Hypercalcaemia Diseases 0.000 claims abstract description 6
230000000148 hypercalcaemia Effects 0.000 claims abstract description 6
230000010412 perfusion Effects 0.000 claims description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 7
235000001014 amino acid Nutrition 0.000 claims description 7
150000001413 amino acids Chemical class 0.000 claims description 7
229910052749 magnesium Inorganic materials 0.000 claims description 7
238000011282 treatment Methods 0.000 claims description 7
150000001720 carbohydrates Chemical class 0.000 claims description 6
235000014633 carbohydrates Nutrition 0.000 claims description 6
239000011777 magnesium Substances 0.000 claims description 6
238000011321 prophylaxis Methods 0.000 claims description 6
235000021321 essential mineral Nutrition 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
235000011187 glycerol Nutrition 0.000 claims description 4
231100000252 nontoxic Toxicity 0.000 claims description 4
230000003000 nontoxic effect Effects 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
229910052708 sodium Inorganic materials 0.000 claims description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
239000011575 calcium Substances 0.000 claims description 3
229910052791 calcium Inorganic materials 0.000 claims description 3
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
235000000491 potassium glycerophosphate Nutrition 0.000 claims description 3
239000000600 sorbitol Substances 0.000 claims description 3
235000010356 sorbitol Nutrition 0.000 claims description 3
239000000811 xylitol Substances 0.000 claims description 3
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
235000010447 xylitol Nutrition 0.000 claims description 3
229960002675 xylitol Drugs 0.000 claims description 3
235000001130 magnesium glycerophosphate Nutrition 0.000 claims description 2
235000011008 sodium phosphates Nutrition 0.000 claims description 2
229920005862 polyol Polymers 0.000 claims 2
150000003077 polyols Chemical class 0.000 claims 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
159000000007 calcium salts Chemical class 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
239000000243 solution Substances 0.000 description 17
229910019142 PO4 Inorganic materials 0.000 description 9
239000010452 phosphate Substances 0.000 description 9
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 9
229910052816 inorganic phosphate Inorganic materials 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
229940024606 amino acid Drugs 0.000 description 5
229960002901 sodium glycerophosphate Drugs 0.000 description 5
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 description 4
239000001736 Calcium glycerylphosphate Substances 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 3
229940095618 calcium glycerophosphate Drugs 0.000 description 3
235000019299 calcium glycerylphosphate Nutrition 0.000 description 3
229940077731 carbohydrate nutrients Drugs 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
235000016236 parenteral nutrition Nutrition 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
239000004471 Glycine Substances 0.000 description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
229930064664 L-arginine Natural products 0.000 description 2
235000014852 L-arginine Nutrition 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
229930182821 L-proline Natural products 0.000 description 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
239000004228 Riboflavin-5'-Phosphate Substances 0.000 description 2
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 2
239000011768 flavin mononucleotide Substances 0.000 description 2
229960002989 glutamic acid Drugs 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
229960000310 isoleucine Drugs 0.000 description 2
229960003136 leucine Drugs 0.000 description 2
UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 2
239000011654 magnesium acetate Substances 0.000 description 2
235000011285 magnesium acetate Nutrition 0.000 description 2
229940069446 magnesium acetate Drugs 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
229960005190 phenylalanine Drugs 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
239000011591 potassium Substances 0.000 description 2
SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
229960002429 proline Drugs 0.000 description 2
ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
229960004172 pyridoxine hydrochloride Drugs 0.000 description 2
235000019171 pyridoxine hydrochloride Nutrition 0.000 description 2
239000011764 pyridoxine hydrochloride Substances 0.000 description 2
239000002994 raw material Substances 0.000 description 2
235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 2
239000001632 sodium acetate Substances 0.000 description 2
235000017281 sodium acetate Nutrition 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
229960002898 threonine Drugs 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
SPFMQWBKVUQXJV-QGROCUHESA-N (2s,3r,4s,5s)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)C=O SPFMQWBKVUQXJV-QGROCUHESA-N 0.000 description 1
OSNSWKAZFASRNG-WNFIKIDCSA-N (2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;hydrate Chemical compound O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O OSNSWKAZFASRNG-WNFIKIDCSA-N 0.000 description 1
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
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235000019766 L-Lysine Nutrition 0.000 description 1
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239000004395 L-leucine Substances 0.000 description 1
235000019454 L-leucine Nutrition 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
229930195722 L-methionine Natural products 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
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102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
229960003767 alanine Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
150000002402 hexoses Chemical class 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
-1 iron ions Chemical class 0.000 description 1
229910000398 iron phosphate Inorganic materials 0.000 description 1
WBJZTOZJJYAKHQ-UHFFFAOYSA-K iron(3+) phosphate Chemical compound [Fe+3].[O-]P([O-])([O-])=O WBJZTOZJJYAKHQ-UHFFFAOYSA-K 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
239000011742 magnesium glycerophosphate Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960004452 methionine Drugs 0.000 description 1
238000000034 method Methods 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
235000005152 nicotinamide Nutrition 0.000 description 1
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238000010606 normalization Methods 0.000 description 1
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COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
150000003017 phosphorus Chemical class 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
239000011600 potassium glycerophosphate Substances 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
239000002510 pyrogen Substances 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000008279 sol Substances 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
231100000456 subacute toxicity Toxicity 0.000 description 1
239000000758 substrate Substances 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA238,444A 1975-01-23 1975-10-22 Solutions a base de sels de glycerophosphates pour infusions Expired CA1075605A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2502735A DE2502735B2 (de)	1975-01-23	1975-01-23	Verwendung von Glycerophosphaten

Publications (1)

Publication Number	Publication Date
CA1075605A true CA1075605A (fr)	1980-04-15

Family

ID=5937143

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA238,444A Expired CA1075605A (fr)	1975-01-23	1975-10-22	Solutions a base de sels de glycerophosphates pour infusions

Country Status (4)

Country	Link
CA (1)	CA1075605A (fr)
DE (1)	DE2502735B2 (fr)
GB (1)	GB1516738A (fr)
ZA (1)	ZA755795B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8431086B2 (en)	2006-07-20	2013-04-30	Baxter International Inc.	Medical fluid access device with antiseptic indicator
US8485727B2 (en)	2005-08-02	2013-07-16	Baxter International Inc.	Multiple chamber container

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5916818A (ja) *	1982-07-20	1984-01-28	Shimizu Seiyaku Kk	経静脈投与用輸液剤
SE8701662L (sv) *	1987-04-22	1988-10-23	Gelder Nico M Van	Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna
EP1032403B1 (fr) *	1997-10-24	2012-05-02	John P. Blass	Supplement nutritionnel pour personnes atteintes d'insuffisances du metabolisme cerebral
GB2544782B (en) *	2015-11-26	2020-07-15	Fontus Health Ltd	Solution

1975
- 1975-01-23 DE DE2502735A patent/DE2502735B2/de not_active Withdrawn
- 1975-09-11 ZA ZA00755795A patent/ZA755795B/xx unknown
- 1975-09-25 GB GB39423/75A patent/GB1516738A/en not_active Expired
- 1975-10-22 CA CA238,444A patent/CA1075605A/fr not_active Expired

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8485727B2 (en)	2005-08-02	2013-07-16	Baxter International Inc.	Multiple chamber container
US8431086B2 (en)	2006-07-20	2013-04-30	Baxter International Inc.	Medical fluid access device with antiseptic indicator

Also Published As

Publication number	Publication date
AU8450175A (en)	1977-03-10
DE2502735B2 (de)	1978-11-23
DE2502735A1 (de)	1976-08-05
ZA755795B (en)	1976-09-29
GB1516738A (en)	1978-07-05

Legal Events

Date	Code	Title	Description
1997-04-15	MKEX	Expiry

Publication	Publication Date	Title
US4320146A (en)	1982-03-16	Treatment of hepatic and renal disorders with ornithine and arginine salts of branched chain keto acids
CA1115729A (fr)	1982-01-05	Sels d'ornithine et d'arginine de ceto-acides a chaine ramifiee, et applications dans le traitement des troubles hepatiques et renaux
EP1062879B1 (fr)	2003-08-27	Solution aqueuse pour nutrition parentérale
US5719119A (en)	1998-02-17	Parenteral nutrition therapy with amino acids
US4604286A (en)	1986-08-05	Infusion solution for parenteral nutrition
US4814326A (en)	1989-03-21	Pharmaceutical compositions based on diphosphonates for the treatment of arthrosis and osteoarthritis
DE60305113T2 (de)	2006-12-07	Borsäuresalze und deren Verwendung in der Bereitstellung von Medikamente für die Thrombosebehandlung
DE2260189A1 (de)	1973-06-20	Injizierbare aminosaeurepraeparate
JPH05163139A (ja)	1993-06-29	抗動脈硬化剤
CA1075605A (fr)	1980-04-15	Solutions a base de sels de glycerophosphates pour infusions
JPS6372626A (ja)	1988-04-02	薬学的組成物
ES2056620T3 (es)	1994-10-01	Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma.
Kidder et al.	1951	Studies on the inorganic requirements of Tetrahymena
EP0136463B1 (fr)	1989-10-25	Compositions thérapeutiques injectables contenant des sels stables de 5-adenosyl-L-méthionine
JP3182564B2 (ja)	2001-07-03	栄養組成物
DE69937574D1 (de)	2007-12-27	Verwendung des pharmazeutischen präparates "histochrome" zur behandlung des akuten herzinfarkts und ischämischer herzerkrankungen
CA1103160A (fr)	1981-06-16	Solute de perfusion pour le traitement de l'encephalopathie hepatique
GB2094142A (en)	1982-09-15	Injectable solution containing theophylline and a basic amino acid
US5348749A (en)	1994-09-20	Method for treating panic disorder
Eaton et al.	1951	Inhibition of influenza and mumps viruses in tissue culture by basic amino acids.
IT8319024A1 (it)	1984-07-06	Composizione medicinale per il trattamento di certe neurovirosi
US2803657A (en)	1957-08-20	Acid stabilized tetracycline salts
Tzortzatou et al.	1974	The effect of folate antagonists on dihydrofolate reductase activity demonstrated cytochemically
JPH07267855A (ja)	1995-10-17	グルタミン産生剤
Frankl et al.	1959	Enzyme activity in the serum and common duct bile of dogs

CA1075605A - Solutions a base de sels de glycerophosphates pour infusions - Google Patents

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ID=5937143

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