CA1084043A - 16.alpha.,17-C 2H PYRROLES STEROIDES - Google Patents

16.alpha.,17-C 2H PYRROLES STEROIDES

Info

Publication number
CA1084043A
CA1084043A CA276,459A CA276459A CA1084043A CA 1084043 A CA1084043 A CA 1084043A CA 276459 A CA276459 A CA 276459A CA 1084043 A CA1084043 A CA 1084043A
Authority
CA
Canada
Prior art keywords
steroid
beta
fluorine
hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA276,459A
Other languages
English (en)
Inventor
Ravi K. Varma
Christopher M. Cimarusti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1084043A publication Critical patent/CA1084043A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0052—Nitrogen only at position 16(17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/0035—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA276,459A 1976-05-20 1977-04-19 16.alpha.,17-C 2H PYRROLES STEROIDES Expired CA1084043A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US688,207 1976-05-20
US05/688,207 US4018757A (en) 1976-05-20 1976-05-20 Steroidal[16α,17-c][2H]pyrroles

Publications (1)

Publication Number Publication Date
CA1084043A true CA1084043A (fr) 1980-08-19

Family

ID=24763546

Family Applications (1)

Application Number Title Priority Date Filing Date
CA276,459A Expired CA1084043A (fr) 1976-05-20 1977-04-19 16.alpha.,17-C 2H PYRROLES STEROIDES

Country Status (6)

Country Link
US (1) US4018757A (fr)
JP (1) JPS52142057A (fr)
CA (1) CA1084043A (fr)
DE (1) DE2722664A1 (fr)
FR (1) FR2351999A1 (fr)
GB (1) GB1582551A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201139369A (en) * 2010-02-05 2011-11-16 Chiesi Farma Spa Pyrrolidine derivatives
CN103814043A (zh) * 2011-08-01 2014-05-21 奇斯药制品公司 在16，17位与吡咯烷环稠合的抗炎类固醇
CN105254697A (zh) * 2015-11-17 2016-01-20 湖南成大生物科技有限公司 △16甾体类化合物的制备方法
CN109206466B (zh) * 2017-06-30 2022-08-09 天津药业研究院股份有限公司 一种甾体21位羟基氯代或溴代方法
CN109206468B (zh) * 2017-06-30 2023-06-27 天津药业研究院股份有限公司 一种糠酸莫米松的制备方法
CN110713511A (zh) * 2019-11-19 2020-01-21 湖南新合新生物医药有限公司 一种醋酸三烯物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359287A (en) * 1959-11-16 1967-12-19 Upjohn Co 16-methylene-17alpha-hydroxy progesterones and derivatives thereof
US3349084A (en) * 1965-05-17 1967-10-24 Upjohn Co Steroidal [16, 17-d]-2'-isoxazolines of the pregnane series

Also Published As

Publication number Publication date
DE2722664A1 (de) 1977-12-01
FR2351999B1 (fr) 1980-03-28
US4018757A (en) 1977-04-19
JPS52142057A (en) 1977-11-26
FR2351999A1 (fr) 1977-12-16
GB1582551A (en) 1981-01-14

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19970819