CA1097643A - Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate compounds - Google Patents

Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate compounds

Info

Publication number: CA1097643A
Authority: CA; Canada
Prior art keywords: piperazine; methyl; carboxylate; hydroxypropyl; compound
Prior art date: 1978-05-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA327,766A

Other languages

English (en)

French (fr)

Inventor

Irving M. Goldman

Donald E. Kuhla

Constantine Sklavounos

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd Great Britain

Original Assignee

Pfizer Ltd Great Britain

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-18

Filing date

1979-05-16

Publication date

1981-03-17

1979-05-16 Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain

1981-03-17 Application granted granted Critical

1981-03-17 Publication of CA1097643A publication Critical patent/CA1097643A/en

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)

CA327,766A 1978-05-18 1979-05-16 Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate compounds Expired CA1097643A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US90708278A	1978-05-18	1978-05-18
US907,082		1978-05-18

Publications (1)

Publication Number	Publication Date
CA1097643A true CA1097643A (en)	1981-03-17

Family

ID=25423490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA327,766A Expired CA1097643A (en)	1978-05-18	1979-05-16	Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate compounds

Country Status (42)

Country	Link
US (1)	US4550164A (2)
JP (1)	JPS5946512B2 (2)
AR (1)	AR220195A1 (2)
AT (1)	AT375357B (2)
AU (1)	AU510441B2 (2)
BE (1)	BE876311A (2)
BG (1)	BG31228A3 (2)
CA (1)	CA1097643A (2)
CH (1)	CH638796A5 (2)
CS (1)	CS236762B2 (2)
DD (1)	DD143428A5 (2)
DE (1)	DE2919799C2 (2)
DK (6)	DK153878C (2)
EG (1)	EG13904A (2)
ES (1)	ES480669A1 (2)
FI (1)	FI64588C (2)
FR (2)	FR2432022A1 (2)
GB (1)	GB2021107B (2)
GR (1)	GR72720B (2)
GT (1)	GT197957903A (2)
HK (1)	HK13484A (2)
HU (1)	HU180282B (2)
IE (1)	IE48048B1 (2)
IL (1)	IL57295A (2)
IN (1)	IN151190B (2)
IT (1)	IT1114238B (2)
KE (1)	KE3353A (2)
LU (1)	LU81271A1 (2)
MX (1)	MX6289E (2)
MY (1)	MY8500095A (2)
NL (1)	NL183190C (2)
NO (1)	NO151156C (2)
NZ (1)	NZ190473A (2)
PH (2)	PH15546A (2)
PL (1)	PL118664B1 (2)
PT (1)	PT69623A (2)
RO (1)	RO76812A (2)
SE (1)	SE446183B (2)
SG (1)	SG65783G (2)
SU (1)	SU1007557A3 (2)
YU (1)	YU41633B (2)
ZA (1)	ZA792391B (2)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1096204A (fr) *	1949-06-30	1955-06-16	Saint Gobain	Procédé de fabrication d'uréthanes dérivées des glycols
FR62617E (fr) *	1951-06-29	1955-06-15	Saint Gobain	Procédé de fabrication d'uréthanes dérivées des glycols
DE1249852B (de) *	1964-10-07	1967-09-14	Dr Christian Brunnengraber Che mische Fabrik &. Co mbH Lübeck	Verfahren zur Herstellung von Carbamm saureestern von a Glycermathern
US3703538A (en) *	1969-02-03	1972-11-21	Jefferson Chem Co Inc	Production of anhydrous beta-hydroxy-alkyl carbamates
US3935213A (en) *	1973-12-05	1976-01-27	Pfizer Inc.	Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

1979
- 1979-03-08 IN IN166/DEL/79A patent/IN151190B/en unknown
- 1979-03-08 DK DK095979A patent/DK153878C/da active
- 1979-04-17 CH CH360979A patent/CH638796A5/fr not_active IP Right Cessation
- 1979-05-03 BG BG043441A patent/BG31228A3/xx unknown
- 1979-05-04 HU HU79PI675A patent/HU180282B/hu unknown
- 1979-05-04 SU SU792763448A patent/SU1007557A3/ru active
- 1979-05-05 PL PL1979215383A patent/PL118664B1/pl unknown
- 1979-05-06 CS CS793161A patent/CS236762B2/cs unknown
- 1979-05-07 RO RO7997441A patent/RO76812A/ro unknown
- 1979-05-07 DD DD79212699A patent/DD143428A5/de unknown
- 1979-05-15 YU YU1139/79A patent/YU41633B/xx unknown
- 1979-05-15 EG EG288/79A patent/EG13904A/xx active
- 1979-05-16 GB GB7916996A patent/GB2021107B/en not_active Expired
- 1979-05-16 LU LU81271A patent/LU81271A1/xx unknown
- 1979-05-16 PH PH22498A patent/PH15546A/en unknown
- 1979-05-16 SE SE7904313A patent/SE446183B/sv not_active IP Right Cessation
- 1979-05-16 GR GR59103A patent/GR72720B/el unknown
- 1979-05-16 CA CA327,766A patent/CA1097643A/en not_active Expired
- 1979-05-16 NO NO791641A patent/NO151156C/no unknown
- 1979-05-16 DE DE2919799A patent/DE2919799C2/de not_active Expired
- 1979-05-16 IL IL57295A patent/IL57295A/xx unknown
- 1979-05-16 AU AU47102/79A patent/AU510441B2/en not_active Expired
- 1979-05-17 JP JP54060999A patent/JPS5946512B2/ja not_active Expired
- 1979-05-17 IT IT22759/79A patent/IT1114238B/it active
- 1979-05-17 PT PT69623A patent/PT69623A/pt unknown
- 1979-05-17 NZ NZ190473A patent/NZ190473A/xx unknown
- 1979-05-17 NL NLAANVRAGE7903892,A patent/NL183190C/xx not_active IP Right Cessation
- 1979-05-17 ES ES480669A patent/ES480669A1/es not_active Expired
- 1979-05-17 FI FI791579A patent/FI64588C/fi not_active IP Right Cessation
- 1979-05-17 AT AT0366579A patent/AT375357B/de not_active IP Right Cessation
- 1979-05-17 BE BE0/195204A patent/BE876311A/xx not_active IP Right Cessation
- 1979-05-17 GT GT197957903A patent/GT197957903A/es unknown
- 1979-05-17 FR FR7912569A patent/FR2432022A1/fr active Granted
- 1979-05-17 ZA ZA792391A patent/ZA792391B/xx unknown
- 1979-05-17 MX MX797985U patent/MX6289E/es unknown
- 1979-05-18 AR AR276570A patent/AR220195A1/es active
- 1979-08-08 IE IE962/79A patent/IE48048B1/en not_active IP Right Cessation
- 1979-09-17 FR FR7923128A patent/FR2429788A1/fr active Granted
1980
- 1980-02-07 PH PH23617A patent/PH16236A/en unknown
1981
- 1981-04-24 US US06/257,365 patent/US4550164A/en not_active Expired - Lifetime
1983
- 1983-11-02 SG SG65783A patent/SG65783G/en unknown
- 1983-11-22 KE KE3353A patent/KE3353A/xx unknown
1984
- 1984-02-16 HK HK134/84A patent/HK13484A/xx not_active IP Right Cessation
1985
- 1985-12-30 MY MY95/85A patent/MY8500095A/xx unknown
1987
- 1987-01-15 DK DK019687A patent/DK153881C/da active
- 1987-01-15 DK DK019387A patent/DK153879C/da active
- 1987-01-15 DK DK019487A patent/DK153840C/da not_active IP Right Cessation
- 1987-01-15 DK DK019287A patent/DK19287A/da not_active Application Discontinuation
- 1987-01-15 DK DK019587A patent/DK153880C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK19487A (da)	1987-01-15
SU1007557A3 (ru)	1983-03-23
LU81271A1 (fr)	1979-12-07
DK153878B (da)	1988-09-19
FI791579A7 (fi)	1979-11-19
DK153879B (da)	1988-09-19
BE876311A (fr)	1979-11-19
IL57295A (en)	1982-01-31
CH638796A5 (fr)	1983-10-14
GT197957903A (es)	1980-11-07
DK19487D0 (da)	1987-01-15
DK19287D0 (da)	1987-01-15
FR2432022A1 (fr)	1980-02-22
DK153881C (da)	1989-02-06
PH15546A (en)	1983-02-09
IE790962L (en)	1979-11-18
IT1114238B (it)	1986-01-27
IT7922759A0 (it)	1979-05-17
DK19387A (da)	1987-01-15
HU180282B (en)	1983-02-28
DE2919799C2 (de)	1985-12-05
DK153879C (da)	1989-02-06
AU510441B2 (en)	1980-06-26
BG31228A3 (bg)	1981-11-16
CS236762B2 (en)	1985-05-15
KE3353A (en)	1983-12-16
DK153840C (da)	1989-01-30
DK19387D0 (da)	1987-01-15
DK19587A (da)	1987-01-15
NO151156B (no)	1984-11-12
HK13484A (en)	1984-02-24
FI64588C (fi)	1983-12-12
DK153881B (da)	1988-09-19
AT375357B (de)	1984-07-25
NO791641L (no)	1979-11-20
NL7903892A (nl)	1979-11-20
PH16236A (en)	1983-08-11
ATA366579A (de)	1983-12-15
DK153840B (da)	1988-09-12
NL183190B (nl)	1988-03-16
DD143428A5 (de)	1980-08-20
DK19587D0 (da)	1987-01-15
GR72720B (2)	1983-12-01
NL183190C (nl)	1988-08-16
PL215383A1 (2)	1980-08-11
DK153880C (da)	1989-02-06
ZA792391B (en)	1980-05-28
DE2919799A1 (de)	1979-11-22
IE48048B1 (en)	1984-09-05
DK95979A (da)	1979-11-19
US4550164A (en)	1985-10-29
IL57295A0 (en)	1979-09-30
IN151190B (2)	1983-03-05
AU4710279A (en)	1979-11-22
SE7904313L (sv)	1979-11-19
PT69623A (en)	1979-06-01
DK19687D0 (da)	1987-01-15
YU41633B (en)	1987-12-31
GB2021107A (en)	1979-11-28
FI64588B (fi)	1983-08-31
SG65783G (en)	1984-07-27
FR2432022B1 (2)	1983-07-08
AR220195A1 (es)	1980-10-15
JPS5946512B2 (ja)	1984-11-13
DK153880B (da)	1988-09-19
FR2429788A1 (fr)	1980-01-25
ES480669A1 (es)	1980-05-16
GB2021107B (en)	1982-07-28
JPS54151991A (en)	1979-11-29
NO151156C (no)	1985-02-20
RO76812A (ro)	1981-05-30
FR2429788B1 (2)	1982-04-16
PL118664B1 (en)	1981-10-31
EG13904A (en)	1983-12-31
MY8500095A (en)	1985-12-31
MX6289E (es)	1985-03-18
NZ190473A (en)	1981-01-23
DK153878C (da)	1989-02-06
SE446183B (sv)	1986-08-18
DK19287A (da)	1987-01-15
DK19687A (da)	1987-01-15
YU113979A (en)	1983-02-28

Legal Events

Date	Code	Title	Description
1998-03-17	MKEX	Expiry

Publication	Publication Date	Title
US5866562A (en)	1999-02-02	Ring-bridged bis-quinolines
US4987232A (en)	1991-01-22	Preparation of 2-chloropyridine 3-carboxylic acid esters
CA1097643A (en)	1981-03-17	Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate compounds
NO161620B (no)	1989-05-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido (5,4-d) pyrimidin-derivater.
US4507478A (en)	1985-03-26	2-Mercaptopyrimidohexahydroquinolines and related compounds
NO166712B (no)	1991-05-21	Fremgangsmaate ved fremstilling av pyrrolidonderivater.
Merino et al.	2010	Versatile synthesis of quaternary 1, 3-oxazolidine-2, 4-diones and their use in the preparation of α-hydroxyamides
CA1095914A (en)	1981-02-17	4-hydroxy-2-quinolinone-3-carboxylic acid compounds
US4468518A (en)	1984-08-28	Imidazole guanidine compounds and method of making same
US4443621A (en)	1984-04-17	p-Nitrophenyl 3-bromo-2,2-diethoxy-propionate and synthetic utility therefor
FI70895C (fi)	1986-10-27	Foerfarande foer framstaellning av vinkaminsyraestrar
Perron et al.	1962	Derivatives of 6-Aminopenicillanic Acid. III. Reactions with N-Substituted Phthalamic Acids
HISANO et al.	1976	Reaction of Aromatic N-Oxides with Dipolarophiles. II. Reaction of β-Alkylpyridine N-Oxides with Phenyl Isocyanate
KR820000868B1 (ko)	1982-05-17	2-메틸-2-하이드록시 프로필 피페라진-1카복실 레이트 화합물의 제조 방법
SU1482525A3 (ru)	1989-05-23	Способ получени 4-окси-2-оксопирролидин-1-ил-ацетамида
Li	1975	Synthesis of 1-substituted and 1, 3-disubstituted 5-hydantoincarboxylates
Sulay et al.	1987	Reaction of Ethyl 3, 3‐Diaminopropenoate with Isocyanates and Isothiocyanates
US5021587A (en)	1991-06-04	Synthesis of N,3,4-trisubstituted-3-azoline-2-ones
DE2510831A1 (de)	1975-09-25	Isonipecotinsaeurederivate enthaltende herbizidzubereitungen
AT358595B (de)	1980-09-25	Verfahren zur herstellung von neuen 4- (n-acetyl)-amino-tetrahydro-1,3,5-triazin-2,6- dion-derivaten
US4273930A (en)	1981-06-16	4-Hydroxy-2-quinolinone-3-carboxylic acid esters
SU645586A3 (ru)	1979-01-30	Способ получени замещенных в 14-положении производных винкана
SU757534A1 (ru)	1980-08-23	ПРОИЗВОДНЫЕ БЕНЗО-(а)-ХИНОЛИЗИНА КАК ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ В СИНТЕЗЕ БИОЛОГИЧЕСКИ АКТИВНЫХ . СОЕДИНЕНИИ
PL106031B1 (pl)	1979-11-30	Sposob wytwarzania 6,7-dwumetoksy-4-amino-2-/4-/2-furoilo/-1-piperazynylo/chinazoliny o dzialaniu przeciwnadcisnieniowym
DE2755638A1 (de)	1978-06-22	Zwischenprodukt zur herstellung von blutdrucksenkendem 6,7-dimethoxy- 4-amino-2-eckige klammer auf 4-(2-furoyl)- 1-piperazinyl eckige klammer zu chinazolin