CA1126138A - Microporous pellets for microorganism testing - Google Patents

Microporous pellets for microorganism testing

Info

Publication number: CA1126138A
Authority: CA; Canada
Prior art keywords: pellet; pellet according; reagent; test reagent; carrier
Prior art date: 1977-03-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA298,936A

Other languages

English (en)

French (fr)

Inventor

Michael J. Greenway

Charles B. Taskis

Pamela A. Hunter

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee

Beecham Group PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-16

Filing date

1978-03-15

Publication date

1982-06-22

1978-03-15 Application filed by Beecham Group PLC filed Critical Beecham Group PLC

1982-06-22 Application granted granted Critical

1982-06-22 Publication of CA1126138A publication Critical patent/CA1126138A/en

Status Expired legal-status Critical Current

Links

239000008188 pellet Substances 0.000 title claims abstract description 54
238000012360 testing method Methods 0.000 title claims abstract description 29
244000005700 microbiome Species 0.000 title claims abstract description 14
239000003153 chemical reaction reagent Substances 0.000 claims abstract description 38
239000006104 solid solution Substances 0.000 claims abstract description 3
239000000243 solution Substances 0.000 claims description 22
230000003115 biocidal effect Effects 0.000 claims description 16
150000003839 salts Chemical group 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims description 12
238000000034 method Methods 0.000 claims description 12
HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims description 8
229960003324 clavulanic acid Drugs 0.000 claims description 8
238000004108 freeze drying Methods 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 7
230000035945 sensitivity Effects 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
229930182555 Penicillin Natural products 0.000 claims description 6
239000000463 material Substances 0.000 claims description 6
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 5
239000003242 anti bacterial agent Substances 0.000 claims description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 5
229930186147 Cephalosporin Natural products 0.000 claims description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
229940124587 cephalosporin Drugs 0.000 claims description 4
150000001780 cephalosporins Chemical class 0.000 claims description 4
239000011159 matrix material Substances 0.000 claims description 4
-1 p-hydroxyphenyl Chemical group 0.000 claims description 3
229940049954 penicillin Drugs 0.000 claims description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims description 2
229920002689 polyvinyl acetate Polymers 0.000 claims description 2
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238000010998 test method Methods 0.000 claims 1
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LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 6
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 6
229920001817 Agar Polymers 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
239000008272 agar Substances 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
239000011734 sodium Substances 0.000 description 5
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239000002253 acid Substances 0.000 description 4
238000001035 drying Methods 0.000 description 4
150000002170 ethers Chemical class 0.000 description 4
JMRXTGCDVQLAFM-JSYANWSFSA-M lithium;(2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate Chemical compound [Li+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 JMRXTGCDVQLAFM-JSYANWSFSA-M 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
229920003083 Kollidon® VA64 Polymers 0.000 description 3
229920003080 Povidone K 25 Polymers 0.000 description 3
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
229960000723 ampicillin Drugs 0.000 description 3
239000003782 beta lactam antibiotic agent Substances 0.000 description 3
239000000969 carrier Substances 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
150000002960 penicillins Chemical class 0.000 description 3
229960004659 ticarcillin Drugs 0.000 description 3
OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 3
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
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FUBBGQLTSCSAON-PBFPGSCMSA-N cefaloglycin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)C)C(O)=O)=CC=CC=C1 FUBBGQLTSCSAON-PBFPGSCMSA-N 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
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159000000001 potassium salts Chemical class 0.000 description 2
238000013207 serial dilution Methods 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
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239000010935 stainless steel Substances 0.000 description 2
MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 1
JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
UQLLWWBDSUHNEB-CZUORRHYSA-N Cefaprin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CSC1=CC=NC=C1 UQLLWWBDSUHNEB-CZUORRHYSA-N 0.000 description 1
GNWUOVJNSFPWDD-XMZRARIVSA-M Cefoxitin sodium Chemical compound [Na+].N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)CC1=CC=CS1 GNWUOVJNSFPWDD-XMZRARIVSA-M 0.000 description 1
241001517488 Clavus Species 0.000 description 1
102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
229930195708 Penicillin V Natural products 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
239000002647 aminoglycoside antibiotic agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229960003669 carbenicillin Drugs 0.000 description 1
FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
229960003972 cefacetrile Drugs 0.000 description 1
RRYMAQUWDLIUPV-BXKDBHETSA-N cefacetrile Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CC#N)[C@@H]12 RRYMAQUWDLIUPV-BXKDBHETSA-N 0.000 description 1
229960003866 cefaloridine Drugs 0.000 description 1
CZTQZXZIADLWOZ-CRAIPNDOSA-N cefaloridine Chemical compound O=C([C@@H](NC(=O)CC=1SC=CC=1)[C@H]1SC2)N1C(C(=O)[O-])=C2C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-CRAIPNDOSA-N 0.000 description 1
229960000603 cefalotin Drugs 0.000 description 1
229960003012 cefamandole Drugs 0.000 description 1
OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 description 1
229960004350 cefapirin Drugs 0.000 description 1
UOCJDOLVGGIYIQ-PBFPGSCMSA-N cefatrizine Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)[C@H](N)C=2C=CC(O)=CC=2)CC=1CSC=1C=NNN=1 UOCJDOLVGGIYIQ-PBFPGSCMSA-N 0.000 description 1
229960001139 cefazolin Drugs 0.000 description 1
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
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239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940106164 cephalexin Drugs 0.000 description 1
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
VUFGUVLLDPOSBC-XRZFDKQNSA-M cephalothin sodium Chemical compound [Na+].N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C([O-])=O)C(=O)CC1=CC=CS1 VUFGUVLLDPOSBC-XRZFDKQNSA-M 0.000 description 1
RDLPVSKMFDYCOR-UEKVPHQBSA-N cephradine Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CCC=CC1 RDLPVSKMFDYCOR-UEKVPHQBSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000007705 chemical test Methods 0.000 description 1
229960004244 cyclacillin Drugs 0.000 description 1
HGBLNBBNRORJKI-WCABBAIRSA-N cyclacillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C1(N)CCCCC1 HGBLNBBNRORJKI-WCABBAIRSA-N 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
229960001760 dimethyl sulfoxide Drugs 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
229960002457 epicillin Drugs 0.000 description 1
RPBAFSBGYDKNRG-NJBDSQKTSA-N epicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CCC=CC1 RPBAFSBGYDKNRG-NJBDSQKTSA-N 0.000 description 1
235000010944 ethyl methyl cellulose Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
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229960003085 meticillin Drugs 0.000 description 1
239000012046 mixed solvent Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229960003128 mupirocin Drugs 0.000 description 1
MINDHVHHQZYEEK-HBBNESRFSA-N mupirocin Chemical compound C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-HBBNESRFSA-N 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
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229940056367 penicillin v Drugs 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
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239000000651 prodrug Substances 0.000 description 1
HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
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ZBBCUBMBMZNEME-QBGWIPKPSA-L ticarcillin disodium Chemical compound [Na+].[Na+].C=1([C@@H](C([O-])=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)C=CSC=1 ZBBCUBMBMZNEME-QBGWIPKPSA-L 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA298,936A 1977-03-16 1978-03-15 Microporous pellets for microorganism testing Expired CA1126138A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB11060/77A GB1594001A (en)	1977-03-16	1977-03-16	Pellets suitable for use in the testing of microorganisms
GB11060/77		1977-03-16

Publications (1)

Publication Number	Publication Date
CA1126138A true CA1126138A (en)	1982-06-22

Family

ID=9979270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA298,936A Expired CA1126138A (en)	1977-03-16	1978-03-15	Microporous pellets for microorganism testing

Country Status (14)

Country	Link
JP (1)	JPS5435279A (da)
AU (1)	AU523959B2 (da)
BE (1)	BE864841A (da)
CA (1)	CA1126138A (da)
CH (1)	CH636643A5 (da)
DE (1)	DE2810056A1 (da)
DK (1)	DK152296C (da)
FR (1)	FR2384022A1 (da)
GB (1)	GB1594001A (da)
IE (1)	IE46580B1 (da)
NL (1)	NL7802799A (da)
NZ (1)	NZ186646A (da)
SE (1)	SE7802928L (da)
ZA (1)	ZA781368B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2964817D1 (en) *	1978-09-06	1983-03-24	Beecham Group Plc	Pharmaceutical compositions containing two beta-lactam derivatives
EP0012495B1 (en) *	1978-12-08	1983-06-22	Beecham Group Plc	Pharmaceutical composition comprising a water soluble salt of amoxycillin and polyvinylpyrrolidone, and a vial containing a unit dose of said composition
US5350680A (en) *	1990-12-21	1994-09-27	Showa Yakuhin Kako Co., Ltd.	Cephalosporinase testing agent
DE69219989T2 (de) *	1991-05-06	1997-11-27	Dade Microscan Inc	Schneller auswahltest für induzierbare beta-laktamase
US5350679A (en) *	1993-06-14	1994-09-27	Dow Corning Corporation	Repeat insult microbial test method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3138544A (en) *	1961-05-03	1964-06-23	British Drug Houses Canada Ltd	Microbial sensitivity testing device
GB1057000A (en) *	1964-12-10	1967-02-01	Deputy Minister Of The Ministe	Method of making tablets for testing the sensitivity of bacteria to an antibiotic
GB1275706A (en) *	1970-07-07	1972-05-24	Inst Pentru Controlul De Stat	Microtablets for determining the sensitivity of microorganisms to antibiotics and chemotherapeutics
US3932943A (en) *	1970-08-14	1976-01-20	E. I. Du Pont De Nemours And Company	Method of preparation of lyophilized biological products
US3928566A (en) *	1970-08-14	1975-12-23	Du Pont	Lyophilized biological products
NZ177159A (en) *	1974-04-20	1978-03-06	Beecham Group Ltd	Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
AU1087176A (en) *	1975-03-03	1977-08-11	Miles Lab	Water soluble microbial composition
US4153512A (en) *	1976-04-07	1979-05-08	Fisher Scientific Company	Storage stable antibiotic susceptibility test kit and method of testing

1977
- 1977-03-16 GB GB11060/77A patent/GB1594001A/en not_active Expired
1978
- 1978-03-08 DE DE19782810056 patent/DE2810056A1/de active Granted
- 1978-03-08 NZ NZ186646A patent/NZ186646A/xx unknown
- 1978-03-08 ZA ZA00781368A patent/ZA781368B/xx unknown
- 1978-03-13 BE BE185895A patent/BE864841A/xx not_active IP Right Cessation
- 1978-03-14 SE SE7802928A patent/SE7802928L/xx unknown
- 1978-03-14 FR FR7807268A patent/FR2384022A1/fr active Granted
- 1978-03-15 CA CA298,936A patent/CA1126138A/en not_active Expired
- 1978-03-15 IE IE529/78A patent/IE46580B1/en unknown
- 1978-03-15 NL NL7802799A patent/NL7802799A/xx not_active Application Discontinuation
- 1978-03-15 DK DK117678A patent/DK152296C/da not_active IP Right Cessation
- 1978-03-16 AU AU34215/78A patent/AU523959B2/en not_active Expired
- 1978-03-16 JP JP3048378A patent/JPS5435279A/ja active Pending
- 1978-03-16 CH CH287678A patent/CH636643A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK152296B (da)	1988-02-15
FR2384022A1 (fr)	1978-10-13
DE2810056A1 (de)	1978-09-28
GB1594001A (en)	1981-07-30
DK117678A (da)	1978-09-17
SE7802928L (sv)	1978-09-17
AU3421578A (en)	1979-09-20
IE780529L (en)	1978-09-16
ZA781368B (en)	1979-02-28
IE46580B1 (en)	1983-07-27
DK152296C (da)	1988-07-11
FR2384022B1 (da)	1980-08-29
NL7802799A (nl)	1978-09-19
BE864841A (fr)	1978-09-13
CH636643A5 (en)	1983-06-15
NZ186646A (en)	1981-03-16
AU523959B2 (en)	1982-08-26
DE2810056C2 (da)	1987-09-03
JPS5435279A (en)	1979-03-15

Legal Events

Date	Code	Title	Description
1999-06-22	MKEX	Expiry

Publication	Publication Date	Title
SE453600B (sv)	1988-02-15	Forfarande for framstellning av ett salt av klavulansyra
JPS59500548A (ja)	1984-04-05	微生物学的試験方法
JPH07505788A (ja)	1995-06-29	液体中の抗菌性化合物の残留物検出用ユニット
EP0611001B1 (en)	2002-05-22	Unit for the detection of residues of antibacterial compounds in liquids
CA1126138A (en)	1982-06-22	Microporous pellets for microorganism testing
CA2186728A1 (en)	1996-08-08	A rapid microbiological test for the detection of antibacterial compounds
US3919415A (en)	1975-11-11	Substance MM 4550 and process for producing same
US4189473A (en)	1980-02-19	Antibiotic MM 13902
TAKAHASHI et al.	1980	Cefoxitin resistance by a chromosomal cephalosporinase in Escherichia coli
GB2128737A (en)	1984-05-02	Antiobiotic susceptibility test material
US4250264A (en)	1981-02-10	Growth limiting media
YAMAGUCHI et al.	1982	PHOSPHOLIPID BILAYER PERMEABILITY OF beta;-LACTAM ANTIBIOTICS
Greenwood	1977	Response profiles: A method of evaluating the activity of β-lactam antibiotics against enterobacteria
Smith et al.	1970	Hetacillin: a chemical and biological comparison with ampicillin
US4714675A (en)	1987-12-22	Stabilized sensitivity test disk
JP3964178B2 (ja)	2007-08-22	メタロ−β−ラクタマーゼ産生菌の薬剤感受性試験方法
US4113856A (en)	1978-09-12	Antibiotic mm 13902
JPS582675B2 (ja)	1983-01-18	シンキコウセイブツシツノセイホウ
US5350680A (en)	1994-09-27	Cephalosporinase testing agent
CA1210308A (en)	1986-08-26	Test materials
NOGUCHI et al.	1980	Isolation of two types of Pseudomonas aeruginosa mutants highly sensitive to a specific group of beta-lactam antibiotics and with defect in penicillin-binding proteins
JP2966523B2 (ja)	1999-10-25	セファロスポリナーゼ検査剤
JP2001321156A (ja)	2001-11-20	薬剤感受性試験用プレート
SU1400075A1 (ru)	1990-08-30	Штамм бактерий VIвRIо сноLеRае сноLеRае OGaWa, используемый дл получени холерного токсина
Liljequist et al.	1986	In vitro activity of amoxicillin plus clavulanic acid against Haemophilus influenzae and Branhamella catarrhalis