CA1131131A - Preparation pour le traitement de l'hypersecretion nasale - Google Patents

Preparation pour le traitement de l'hypersecretion nasale

Info

Publication number: CA1131131A
Authority: CA; Canada
Prior art keywords: composition; pharmaceutically acceptable; carrier; acceptable diluent; methobromide
Prior art date: 1979-02-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA321,974A

Other languages

English (en)

Inventor

Niels C. Mygind

Peter B. Bojsen

Christiane Grieben

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim International GmbH

Original Assignee

Boehringer Ingelheim International GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-21

Filing date

1979-02-21

Publication date

1982-09-07

1979-02-21 Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH

1979-02-21 Priority to CA321,974A priority Critical patent/CA1131131A/fr

1982-09-07 Application granted granted Critical

1982-09-07 Publication of CA1131131A publication Critical patent/CA1131131A/fr

Status Expired legal-status Critical Current

Links

STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical class C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 claims abstract description 8
230000000694 effects Effects 0.000 claims abstract description 8
239000003085 diluting agent Substances 0.000 claims abstract description 6
-1 -isopropyl nortro-pine tropic acid ester Chemical class 0.000 claims abstract description 5
JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 claims abstract description 5
230000000699 topical effect Effects 0.000 claims abstract description 5
YYMCYJLIYNNOMK-UHFFFAOYSA-N N-normethyltropine Natural products C1C(O)CC2CCC1N2 YYMCYJLIYNNOMK-UHFFFAOYSA-N 0.000 claims abstract description 3
239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
239000000203 mixture Substances 0.000 claims description 26
239000013543 active substance Substances 0.000 claims description 10
239000000443 aerosol Substances 0.000 claims description 10
LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims description 6
229960001022 fenoterol Drugs 0.000 claims description 6
239000003380 propellant Substances 0.000 claims description 6
229960001361 ipratropium bromide Drugs 0.000 claims description 5
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
239000004480 active ingredient Substances 0.000 claims description 3
229930004668 tropane alkaloid Natural products 0.000 claims description 3
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
239000004147 Sorbitan trioleate Substances 0.000 claims description 2
239000007864 aqueous solution Substances 0.000 claims description 2
229960000686 benzalkonium chloride Drugs 0.000 claims description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
LCELQERNWLBPSY-YAYGZGPXSA-M oxivent Chemical compound [Br-].C1([C@@H](CO)C(=O)OC2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 LCELQERNWLBPSY-YAYGZGPXSA-M 0.000 claims description 2
229960000391 sorbitan trioleate Drugs 0.000 claims description 2
235000019337 sorbitan trioleate Nutrition 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
CXYRUNPLKGGUJF-RAFJPFSSSA-M scopolamine methobromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)C)=CC=CC=C1 CXYRUNPLKGGUJF-RAFJPFSSSA-M 0.000 claims 1
239000004094 surface-active agent Substances 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
230000000903 blocking effect Effects 0.000 abstract description 2
241000033257 Epizoanthus vagus Species 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
210000004400 mucous membrane Anatomy 0.000 description 6
239000000126 substance Substances 0.000 description 5
239000007789 gas Substances 0.000 description 4
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
230000002009 allergenic effect Effects 0.000 description 3
206010039094 Rhinitis perennial Diseases 0.000 description 2
229940000425 combination drug Drugs 0.000 description 2
239000003246 corticosteroid Substances 0.000 description 2
229960001334 corticosteroids Drugs 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000011200 topical administration Methods 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
206010003694 Atrophy Diseases 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
208000036071 Rhinorrhea Diseases 0.000 description 1
206010039101 Rhinorrhoea Diseases 0.000 description 1
230000037444 atrophy Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
229960000265 cromoglicic acid Drugs 0.000 description 1
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
125000002636 imidazolinyl group Chemical group 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
230000001624 sedative effect Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
150000003813 tropane derivatives Chemical class 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA321,974A 1979-02-21 1979-02-21 Preparation pour le traitement de l'hypersecretion nasale Expired CA1131131A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA321,974A CA1131131A (fr)	1979-02-21	1979-02-21	Preparation pour le traitement de l'hypersecretion nasale

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA321,974A CA1131131A (fr)	1979-02-21	1979-02-21	Preparation pour le traitement de l'hypersecretion nasale

Publications (1)

Publication Number	Publication Date
CA1131131A true CA1131131A (fr)	1982-09-07

Family

ID=4113592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA321,974A Expired CA1131131A (fr)	1979-02-21	1979-02-21	Preparation pour le traitement de l'hypersecretion nasale

Country Status (1)

Country	Link
CA (1)	CA1131131A (fr)

1979
- 1979-02-21 CA CA321,974A patent/CA1131131A/fr not_active Expired

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Legal Events

Date	Code	Title	Description
1999-09-07	MKEX	Expiry