CA1136547A - Compose anesthesique en aerosol - Google Patents

Compose anesthesique en aerosol

Info

Publication number: CA1136547A
Authority: CA; Canada
Prior art keywords: composition; propellant; benzocaine; solvent; polyethylene glycol
Prior art date: 1979-03-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000345059A

Other languages

English (en)

Inventor

Song-Ling Lin

Moo-Kwang Park

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

American Home Products Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-08

Filing date

1980-02-05

Publication date

1982-11-30

1980-02-05 Application filed by American Home Products Corp filed Critical American Home Products Corp

1982-11-30 Application granted granted Critical

1982-11-30 Publication of CA1136547A publication Critical patent/CA1136547A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 62
230000003444 anaesthetic effect Effects 0.000 title claims abstract description 18
239000000443 aerosol Substances 0.000 title claims abstract description 13
BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims abstract description 86
229960005274 benzocaine Drugs 0.000 claims abstract description 43
239000003380 propellant Substances 0.000 claims abstract description 32
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
239000007788 liquid Substances 0.000 claims abstract description 8
239000002904 solvent Substances 0.000 claims description 31
229920001223 polyethylene glycol Polymers 0.000 claims description 19
239000002202 Polyethylene glycol Substances 0.000 claims description 18
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 13
239000004147 Sorbitan trioleate Substances 0.000 claims description 13
-1 polyoxyethylene chain Polymers 0.000 claims description 13
229960000391 sorbitan trioleate Drugs 0.000 claims description 13
235000019337 sorbitan trioleate Nutrition 0.000 claims description 13
NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical group CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 claims description 11
229920001214 Polysorbate 60 Polymers 0.000 claims description 11
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 9
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 6
NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 6
239000004215 Carbon black (E152) Substances 0.000 claims description 5
229930195733 hydrocarbon Natural products 0.000 claims description 5
150000002430 hydrocarbons Chemical class 0.000 claims description 5
ZVUNTIMPQCQCAQ-UHFFFAOYSA-N 2-dodecanoyloxyethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCC ZVUNTIMPQCQCAQ-UHFFFAOYSA-N 0.000 claims description 4
239000001282 iso-butane Substances 0.000 claims description 3
235000019441 ethanol Nutrition 0.000 description 7
150000001298 alcohols Chemical class 0.000 description 5
239000012141 concentrate Substances 0.000 description 5
238000009472 formulation Methods 0.000 description 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
CTXGTHVAWRBISV-UHFFFAOYSA-N 2-hydroxyethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCO CTXGTHVAWRBISV-UHFFFAOYSA-N 0.000 description 2
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
150000001733 carboxylic acid esters Chemical class 0.000 description 2
150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 2
239000003193 general anesthetic agent Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
235000013847 iso-butane Nutrition 0.000 description 2
229940041616 menthol Drugs 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000007921 spray Substances 0.000 description 2
208000002193 Pain Diseases 0.000 description 1
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
229960004050 aminobenzoic acid Drugs 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000002924 anti-infective effect Effects 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
229960005475 antiinfective agent Drugs 0.000 description 1
239000003908 antipruritic agent Substances 0.000 description 1
150000008378 aryl ethers Chemical class 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
229960003750 ethyl chloride Drugs 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Dispersion Chemistry (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000345059A 1979-03-08 1980-02-05 Compose anesthesique en aerosol Expired CA1136547A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1853579A	1979-03-08	1979-03-08
US18,535		1979-03-08

Publications (1)

Publication Number	Publication Date
CA1136547A true CA1136547A (fr)	1982-11-30

Family

ID=21788426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000345059A Expired CA1136547A (fr)	1979-03-08	1980-02-05	Compose anesthesique en aerosol

Country Status (8)

Country	Link
KR (1)	KR830001642A (fr)
CA (1)	CA1136547A (fr)
CY (1)	CY1310A (fr)
GB (1)	GB2046093B (fr)
HK (1)	HK85085A (fr)
KE (1)	KE3558A (fr)
MY (1)	MY8600371A (fr)
SG (1)	SG66285G (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5776434A (en)	1988-12-06	1998-07-07	Riker Laboratories, Inc.	Medicinal aerosol formulations
US5225183A (en) *	1988-12-06	1993-07-06	Riker Laboratories, Inc.	Medicinal aerosol formulations
GB8828477D0 (en) *	1988-12-06	1989-01-05	Riker Laboratories Inc	Medical aerosol formulations
US5439670A (en) *	1989-11-28	1995-08-08	Riker Laboratories, Inc.	Medicinal aerosol formulations
DE4003270A1 (de)	1990-02-03	1991-08-08	Boehringer Ingelheim Kg	Neue treibgase und ihre verwendung in arzneimittelzubereitungen
CA2085884C (fr) *	1990-06-29	2001-12-04	Asit Somani	Compositions d'aerosol sous pression
GB9103302D0 (en) *	1991-02-16	1991-04-03	Smithkline Beecham Plc	Pharmaceutical formulations
IL103238A (en) *	1991-09-25	1995-07-31	Fisons Plc	Pressurised aerosol compositions
US5891419A (en) *	1997-04-21	1999-04-06	Aeropharm Technology Limited	Environmentally safe flunisolide aerosol formulations for oral inhalation
US6129905A (en) *	1997-04-21	2000-10-10	Aeropharm Technology, Inc.	Aerosol formulations containing a sugar as a dispersant
US5891420A (en) *	1997-04-21	1999-04-06	Aeropharm Technology Limited	Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation
US6458338B1 (en)	1998-09-22	2002-10-01	Aeropharm Technology Incorporated	Amino acid stabilized medicinal aerosol formulations

1980
- 1980-02-05 CA CA000345059A patent/CA1136547A/fr not_active Expired
- 1980-03-07 CY CY1310A patent/CY1310A/en unknown
- 1980-03-07 GB GB8007867A patent/GB2046093B/en not_active Expired
- 1980-03-07 KR KR1019800000950A patent/KR830001642A/ko not_active Ceased
1985
- 1985-09-09 SG SG66285A patent/SG66285G/en unknown
- 1985-09-12 KE KE3558A patent/KE3558A/xx unknown
- 1985-10-31 HK HK850/85A patent/HK85085A/xx not_active IP Right Cessation
1986
- 1986-12-30 MY MY371/86A patent/MY8600371A/xx unknown

Also Published As

Publication number	Publication date
SG66285G (en)	1986-06-13
CY1310A (en)	1986-03-28
MY8600371A (en)	1986-12-31
GB2046093B (en)	1983-04-20
KR830001642A (ko)	1983-05-18
KE3558A (en)	1985-10-04
HK85085A (en)	1985-11-08
GB2046093A (en)	1980-11-12

Legal Events

Date	Code	Title	Description
1999-11-30	MKEX	Expiry

Publication	Publication Date	Title
CA1136547A (fr)	1982-11-30	Compose anesthesique en aerosol
EP0673240B1 (fr)	1999-03-24	Formulations de solutions medicinales aerosol stabilisees
US5798333A (en)	1998-08-25	Water-soluble concentrates containing cyclosporins
IE45321B1 (en)	1982-07-28	Sprayable germicidal foam compositions
AU701554B2 (en)	1999-01-28	Antifungal compositions
CA1288048C (fr)	1991-08-27	Steroide en solution aqueuse pour administration nasale
US5492688A (en)	1996-02-20	Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
AU655935B2 (en)	1995-01-19	Pharmaceutical composition of florfenicol
US4829083A (en)	1989-05-09	Stabilization of mercury-containing preservatives in ophthalmic medicaments
US20070292359A1 (en)	2007-12-20	Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
AU601423B2 (en)	1990-09-13	Dual phase solvent carrier system
KR102635195B1 (ko)	2024-02-13	살리실산 가용화 수용액, 그 제조방법, 및 이를 포함하는 화장료 조성물
EP0331489A2 (fr)	1989-09-06	Traitement de l'acné
WO2008038140A2 (fr)	2008-04-03	Vecteur expansible à base de polypropylène glycol et compositions pharmaceutiques associées
DE60009529T2 (de)	2005-04-14	Pharmazeutische zusammensetzung aus fibrinolytischem mittel
US7153888B2 (en)	2006-12-26	Stabilization of benzoyl peroxide in solution
US4600575A (en)	1986-07-15	Aerosol anesthetic compositions
AU634271B2 (en)	1993-02-18	Stable solutions of mitomycin c
ES2200467T5 (es)	2010-08-19	Concentrado desinfectante y esterilizante que contiene un dialdehido aromatico y un sistema de tamponamiento de ph neutro.
KR100591024B1 (ko)	2007-04-12	요오도프로피닐 부틸 카바메이트와 페녹시에탄올을 포함하는 방부제 조성물, 이의 제조방법, 및 이를 사용하는 와이프 및 신체 보호 제품
EP0037043A1 (fr)	1981-10-07	Formulation ophtalmique stabilisée
EP0603303B1 (fr)	1997-12-29	Compositions anti-microbiennes contenant du carbonate de propylene et/ou d'ethylene en tant que solvant excipient
EP1026945B1 (fr)	2008-04-16	Compositions antimicrobiennes ameliorees contenant de l'iode ainsi que des tensioactifs non ioniques et des anions d'halogene
WO1996018378A2 (fr)	1996-06-20	Compositions d'aerosol anti-transpiration a une phase
CA1146863A (fr)	1983-05-24	Onguent a usage local