CA1139221A - Anti-acide - Google Patents

Anti-acide

Info

Publication number: CA1139221A
Authority: CA; Canada
Prior art keywords: organopolysiloxane; composition; antacid; powder; silica
Prior art date: 1978-10-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000337031A

Other languages

English (en)

Inventor

Vijay B. Surpuriya

Colleen A. Gonyo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

American Home Products Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-10

Filing date

1979-10-04

Publication date

1983-01-11

1979-10-04 Application filed by American Home Products Corp filed Critical American Home Products Corp

1983-01-11 Application granted granted Critical

1983-01-11 Publication of CA1139221A publication Critical patent/CA1139221A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 46
229940069428 antacid Drugs 0.000 title claims abstract description 24
239000003159 antacid agent Substances 0.000 title claims abstract description 24
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 22
230000001458 anti-acid effect Effects 0.000 title claims abstract description 20
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 53
229920001296 polysiloxane Polymers 0.000 claims abstract description 35
239000000843 powder Substances 0.000 claims abstract description 30
239000000377 silicon dioxide Substances 0.000 claims abstract description 23
239000003795 chemical substances by application Substances 0.000 claims abstract description 9
239000003826 tablet Substances 0.000 claims abstract 2
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical group O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 21
229940083037 simethicone Drugs 0.000 claims description 21
238000000034 method Methods 0.000 claims description 10
229930006000 Sucrose Natural products 0.000 claims description 9
239000005720 sucrose Substances 0.000 claims description 9
JIFPTBLGXRKRAO-UHFFFAOYSA-K aluminum;magnesium;hydroxide;sulfate Chemical compound [OH-].[Mg+2].[Al+3].[O-]S([O-])(=O)=O JIFPTBLGXRKRAO-UHFFFAOYSA-K 0.000 claims description 7
229960004018 magaldrate Drugs 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 3
239000002904 solvent Substances 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims 2
125000000185 sucrose group Chemical group 0.000 claims 2
239000007891 compressed tablet Substances 0.000 claims 1
238000009472 formulation Methods 0.000 abstract description 13
239000007910 chewable tablet Substances 0.000 abstract 1
229940068682 chewable tablet Drugs 0.000 abstract 1
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 22
235000019359 magnesium stearate Nutrition 0.000 description 11
244000024873 Mentha crispa Species 0.000 description 7
235000014749 Mentha crispa Nutrition 0.000 description 7
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
239000004615 ingredient Substances 0.000 description 7
239000000463 material Substances 0.000 description 6
239000008119 colloidal silica Substances 0.000 description 5
229940096516 dextrates Drugs 0.000 description 5
239000008187 granular material Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
238000005469 granulation Methods 0.000 description 4
230000003179 granulation Effects 0.000 description 4
229940060367 inert ingredients Drugs 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
-1 polysiloxane Polymers 0.000 description 4
239000011230 binding agent Substances 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000002245 particle Substances 0.000 description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000008213 purified water Substances 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
239000004606 Fillers/Extenders Substances 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
239000008118 PEG 6000 Substances 0.000 description 2
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000000470 constituent Substances 0.000 description 2
239000004205 dimethyl polysiloxane Substances 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
235000012239 silicon dioxide Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
235000010356 sorbitol Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
OTHYPAMNTUGKDK-UHFFFAOYSA-N (3-acetylphenyl) acetate Chemical compound CC(=O)OC1=CC=CC(C(C)=O)=C1 OTHYPAMNTUGKDK-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
101100483630 Arabidopsis thaliana UCH3 gene Proteins 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
102000004882 Lipase Human genes 0.000 description 1
108090001060 Lipase Proteins 0.000 description 1
239000004367 Lipase Substances 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
108010019160 Pancreatin Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
239000004965 Silica aerogel Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
229920002494 Zein Polymers 0.000 description 1
HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
229940024545 aluminum hydroxide Drugs 0.000 description 1
229940009859 aluminum phosphate Drugs 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960002028 atropine sulfate Drugs 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 1
229940036358 bismuth subcarbonate Drugs 0.000 description 1
229940068366 butabarbital sodium Drugs 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
229960003563 calcium carbonate Drugs 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000003866 digestant Substances 0.000 description 1
102000038379 digestive enzymes Human genes 0.000 description 1
108091007734 digestive enzymes Proteins 0.000 description 1
229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
101150112906 fitm-2 gene Proteins 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
229910021485 fumed silica Inorganic materials 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229960001550 hyoscyamine sulfate Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
229960001708 magnesium carbonate Drugs 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
235000014380 magnesium carbonate Nutrition 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
229960000869 magnesium oxide Drugs 0.000 description 1
235000012245 magnesium oxide Nutrition 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229940099273 magnesium trisilicate Drugs 0.000 description 1
229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
235000019793 magnesium trisilicate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229940055695 pancreatin Drugs 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
229960002511 phenobarbital sodium Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960004499 scopolamine hydrobromide Drugs 0.000 description 1
WTGQALLALWYDJH-MOUKNHLCSA-N scopolamine hydrobromide (anhydrous) Chemical compound Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-MOUKNHLCSA-N 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
QORQZMBCPRBCAB-UHFFFAOYSA-N sodium;5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCC(C)C1(CC)C(=O)NC(=O)NC1=O QORQZMBCPRBCAB-UHFFFAOYSA-N 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
- C08K3/36—Silica

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA000337031A 1978-10-10 1979-10-04 Anti-acide Expired CA1139221A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95033278A	1978-10-10	1978-10-10
US950,332		1978-10-10

Publications (1)

Publication Number	Publication Date
CA1139221A true CA1139221A (fr)	1983-01-11

Family

ID=25490285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000337031A Expired CA1139221A (fr)	1978-10-10	1979-10-04	Anti-acide

Country Status (7)

Country	Link
CA (1)	CA1139221A (fr)
CY (1)	CY1314A (fr)
DE (1)	DE2940905A1 (fr)
GB (1)	GB2033915B (fr)
HK (1)	HK102585A (fr)
KE (1)	KE3574A (fr)
MY (1)	MY8600315A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5599577A (en) *	1992-05-21	1997-02-04	Mcneil-Ppc, Inc.	Simethicone containing pharmaceutical compositions
US6038608A (en) *	1996-11-25	2000-03-14	Nec Corporation	Virtual LAN system
US7341742B2 (en)	2002-09-30	2008-03-11	L. Perrigo Company	Simethicone containing tablet composition and method

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3261285D1 (en) *	1981-06-30	1985-01-03	Sipar Pharma Sa	Edible pharmaceutical form of a composition of matter containing a fluid dimethyl polysiloxane
US4396604A (en) *	1982-05-17	1983-08-02	Norcliff Thayer, Inc.	Simethicone antacid lozenge
FR2559063B1 (fr) *	1984-02-08	1987-03-06	Leribault Loic	Compositions a usage therapeutique comprenant des composes organo-silicies
US5173305A (en) *	1985-03-06	1992-12-22	Grimberg Georges Serge	Composition for protection of oesogastroduodenal mucous membrane
FR2578423B1 (fr) *	1985-03-06	1988-12-30	Grimberg Georges	Composition pharmaceutique a base de gomme de guar pour la protection de la muqueuse oeso-gastro-duodenale
HU206624B (en) *	1989-01-19	1992-12-28	Steigerwald Arzneimittelwerk	Process for producing pharmaceutical composition for treating illnesses of oesophagus and the gastro-intestinal system
KR920002149A (ko) *	1990-07-03	1992-02-28	안드레아 엘. 콜비	비스테로이드계 소염제에 의해 유발된 위장 장애 증상을 완화시키기 위한 약제 조성물 및 이를 완화시키는 방법
DE4140116A1 (de) *	1991-12-05	1993-06-09	Bolder Arzneimittel Gmbh	Dimeticon-pastillen
GB9310412D0 (en) *	1993-05-20	1993-07-07	Danbiosyst Uk	Nasal nicotine system
FR2705966B1 (fr) *	1993-06-04	1995-08-25	Dow Corning Sa	Compositions antimousse utiles notamment pour le traitement de troubles gastriques.
DE4415999A1 (de) *	1994-05-06	1995-11-09	Bolder Arzneimittel Gmbh	Magensäurebindende Kaupastillen
WO1998004156A1 (fr) *	1996-07-26	1998-02-05	Bateman Kristine A	Composition de succedane de sucre univoque a consommer telle quelle ou a utiliser dans la patisserie ou la cuisine

1979
- 1979-10-04 CA CA000337031A patent/CA1139221A/fr not_active Expired
- 1979-10-09 CY CY131479A patent/CY1314A/en unknown
- 1979-10-09 GB GB7934912A patent/GB2033915B/en not_active Expired
- 1979-10-09 DE DE19792940905 patent/DE2940905A1/de not_active Withdrawn
1985
- 1985-10-30 KE KE357485A patent/KE3574A/xx unknown
- 1985-12-24 HK HK102585A patent/HK102585A/xx not_active IP Right Cessation
1986
- 1986-12-30 MY MY8600315A patent/MY8600315A/xx unknown

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5599577A (en) *	1992-05-21	1997-02-04	Mcneil-Ppc, Inc.	Simethicone containing pharmaceutical compositions
US5679376A (en) *	1992-05-21	1997-10-21	Mcneil-Ppc, Inc.	Simethicone containing pharmaceutical compositions
US5716641A (en) *	1992-05-21	1998-02-10	Mcneil-Ppc, Inc.	Simethicone containing pharmaceutical compositions
US5980944A (en) *	1992-05-21	1999-11-09	Mcneil-Ppc, Inc.	Simethicone containing pharmaceutical compositions
US6038608A (en) *	1996-11-25	2000-03-14	Nec Corporation	Virtual LAN system
US7341742B2 (en)	2002-09-30	2008-03-11	L. Perrigo Company	Simethicone containing tablet composition and method

Also Published As

Publication number	Publication date
CY1314A (en)	1986-03-28
HK102585A (en)	1986-01-03
DE2940905A1 (de)	1980-04-30
MY8600315A (en)	1986-12-31
GB2033915B (en)	1983-02-09
KE3574A (en)	1985-11-22
GB2033915A (en)	1980-05-29

Legal Events

Date	Code	Title	Description
2000-01-11	MKEX	Expiry

Publication	Publication Date	Title
CA1139221A (fr)	1983-01-11	Anti-acide
EP0373499B1 (fr)	1994-03-02	Antitranspirant et déodorant
US4906478A (en)	1990-03-06	Simethicone/calcium silicate composition
PL189988B1 (pl)	2005-10-31	Doustny przeciwpieniący preparat na bazie symetykonu, swobodnie płynąca kompozycja ziarnista oraz sposób jej wytwarzania
US3789119A (en)	1974-01-29	Stabilized molded sublingual nitroglycerin tablets
US5851555A (en)	1998-12-22	Controlled release dosage forms containing water soluble drugs
EP0273209A2 (fr)	1988-07-06	Composition contenant un polycarbophile
KR101813222B1 (ko)	2017-12-28	워터드롭 고형 자외선 차단용 화장료 조성물
US5922351A (en)	1999-07-13	Lubricants for use in tabletting
DE4419607A1 (de)	1994-12-08	Schaumhemmende Zusammensetzungen
EP1220658A1 (fr)	2002-07-10	Composition granulee par fusion et forme posologique a liberation modifiee, preparee a partir de ladite composition
KR100481107B1 (ko)	2005-05-16	산화규소분체및그제조방법,그를이용한화장료,미셀유지분체,향료유지분체
EP0272832A2 (fr)	1988-06-29	Produit cosmétique sous forme de poudre
JPS647046B2 (fr)	1989-02-07
EP0324725B1 (fr)	1993-03-31	Préparation pharmaceutique
IL32020A (en)	1972-11-28	Antacid compositions
US5446063A (en)	1995-08-29	Anesthetic compositions
IE41922B1 (en)	1980-04-23	Pharmaceutical compositions containing bis-chromones
HU203477B (en)	1991-08-28	Process for producing antiflatulant pharmaceutical compositions containing activated poly-dimethyl-siloxane in form of solide dispersion
JPH0647538B2 (ja)	1994-06-22	ｄｌ―６―フェニル―２，３，５，６―テトラヒドロイミダゾ〔２，１―ｂ〕チアゾールのレジネートを含むペースト状駆虫組成物
JPS58105914A (ja)	1983-06-24	持続性活性制酸剤
KR0144721B1 (ko)	1998-07-15	트로치 조성물
KR102926803B1 (ko)	2026-02-13	모공 케어와 피부 탄력 개선용 화장료 조성물 및 그 제조방법
KR101434298B1 (ko)	2014-08-27	전분 및 무기계 겔화제를 포함하는 돔형 파우더 화장료 조성물 및 이의 제조방법
JP3671319B2 (ja)	2005-07-13	粉末状マッサージ料