CY1314A - Organopolysiloxane/silica pharmaceutical compositions - Google Patents

Organopolysiloxane/silica pharmaceutical compositions Download PDF

Info

Publication number: CY1314A
Authority: CY; Cyprus
Prior art keywords: powder; organopolysiloxane; composition; silica; simethicone
Prior art date: 1978-10-10

Application number

CY131479A

Other languages

English (en)

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-10

Filing date

1979-10-09

Publication date

1986-03-28

1979-10-09 Application filed by American Home Prod filed Critical American Home Prod

1986-03-28 Publication of CY1314A publication Critical patent/CY1314A/en

Links

VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims description 47
229920001296 polysiloxane Polymers 0.000 title claims description 33
239000000377 silicon dioxide Substances 0.000 title claims description 20
239000008194 pharmaceutical composition Substances 0.000 title claims 3
239000000203 mixture Substances 0.000 claims description 42
239000000843 powder Substances 0.000 claims description 38
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical group O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 20
229940083037 simethicone Drugs 0.000 claims description 20
229940069428 antacid Drugs 0.000 claims description 18
239000003159 antacid agent Substances 0.000 claims description 18
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
238000000034 method Methods 0.000 claims description 15
230000001458 anti-acid effect Effects 0.000 claims description 14
229930006000 Sucrose Natural products 0.000 claims description 9
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 9
239000005720 sucrose Substances 0.000 claims description 9
JIFPTBLGXRKRAO-UHFFFAOYSA-K aluminum;magnesium;hydroxide;sulfate Chemical compound [OH-].[Mg+2].[Al+3].[O-]S([O-])(=O)=O JIFPTBLGXRKRAO-UHFFFAOYSA-K 0.000 claims description 8
229960004018 magaldrate Drugs 0.000 claims description 8
238000005469 granulation Methods 0.000 claims description 7
230000003179 granulation Effects 0.000 claims description 7
239000003795 chemical substances by application Substances 0.000 claims description 6
239000000546 pharmaceutical excipient Substances 0.000 claims description 5
238000002156 mixing Methods 0.000 claims description 4
239000012798 spherical particle Substances 0.000 claims description 3
239000002904 solvent Substances 0.000 claims description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 22
238000009472 formulation Methods 0.000 description 12
235000019359 magnesium stearate Nutrition 0.000 description 11
239000004615 ingredient Substances 0.000 description 9
244000024873 Mentha crispa Species 0.000 description 7
235000014749 Mentha crispa Nutrition 0.000 description 7
239000000463 material Substances 0.000 description 6
239000008119 colloidal silica Substances 0.000 description 5
229940096516 dextrates Drugs 0.000 description 5
239000008187 granular material Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
229940060367 inert ingredients Drugs 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
239000011230 binding agent Substances 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000002245 particle Substances 0.000 description 3
229940093429 polyethylene glycol 6000 Drugs 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000008213 purified water Substances 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
239000004606 Fillers/Extenders Substances 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
239000008118 PEG 6000 Substances 0.000 description 2
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000000470 constituent Substances 0.000 description 2
239000004205 dimethyl polysiloxane Substances 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229960001855 mannitol Drugs 0.000 description 2
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
235000012239 silicon dioxide Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
229960002920 sorbitol Drugs 0.000 description 2
235000010356 sorbitol Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229940032147 starch Drugs 0.000 description 2
OTHYPAMNTUGKDK-UHFFFAOYSA-N (3-acetylphenyl) acetate Chemical compound CC(=O)OC1=CC=CC(C(C)=O)=C1 OTHYPAMNTUGKDK-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
102000004882 Lipase Human genes 0.000 description 1
108090001060 Lipase Proteins 0.000 description 1
239000004367 Lipase Substances 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
239000004965 Silica aerogel Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
229920002494 Zein Polymers 0.000 description 1
HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
229960002028 atropine sulfate Drugs 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
RUJUQAPQALJUPC-UHFFFAOYSA-K bis[(2-aminoacetyl)oxy]alumanyl 2-aminoacetate Chemical compound [Al+3].NCC([O-])=O.NCC([O-])=O.NCC([O-])=O RUJUQAPQALJUPC-UHFFFAOYSA-K 0.000 description 1
MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 1
229940036358 bismuth subcarbonate Drugs 0.000 description 1
229940068366 butabarbital sodium Drugs 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 1
239000003866 digestant Substances 0.000 description 1
102000038379 digestive enzymes Human genes 0.000 description 1
108091007734 digestive enzymes Proteins 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
229910021485 fumed silica Inorganic materials 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229960001550 hyoscyamine sulfate Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000347 magnesium hydroxide Substances 0.000 description 1
229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229940099273 magnesium trisilicate Drugs 0.000 description 1
229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
235000019793 magnesium trisilicate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960004499 scopolamine hydrobromide Drugs 0.000 description 1
WTGQALLALWYDJH-MOUKNHLCSA-N scopolamine hydrobromide (anhydrous) Chemical compound Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-MOUKNHLCSA-N 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
QORQZMBCPRBCAB-UHFFFAOYSA-N sodium;5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCC(C)C1(CC)C(=O)NC(=O)NC1=O QORQZMBCPRBCAB-UHFFFAOYSA-N 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
-1 trimethylsiloxy Chemical group 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
- C08K3/36—Silica

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CY131479A 1978-10-10 1979-10-09 Organopolysiloxane/silica pharmaceutical compositions CY1314A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US95033278A	1978-10-10	1978-10-10

Publications (1)

Publication Number	Publication Date
CY1314A true CY1314A (en)	1986-03-28

Family

ID=25490285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY131479A CY1314A (en)	1978-10-10	1979-10-09	Organopolysiloxane/silica pharmaceutical compositions

Country Status (7)

Country	Link
CA (1)	CA1139221A (fr)
CY (1)	CY1314A (fr)
DE (1)	DE2940905A1 (fr)
GB (1)	GB2033915B (fr)
HK (1)	HK102585A (fr)
KE (1)	KE3574A (fr)
MY (1)	MY8600315A (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3261285D1 (en) *	1981-06-30	1985-01-03	Sipar Pharma Sa	Edible pharmaceutical form of a composition of matter containing a fluid dimethyl polysiloxane
US4396604A (en) *	1982-05-17	1983-08-02	Norcliff Thayer, Inc.	Simethicone antacid lozenge
FR2559063B1 (fr) *	1984-02-08	1987-03-06	Leribault Loic	Compositions a usage therapeutique comprenant des composes organo-silicies
US5173305A (en) *	1985-03-06	1992-12-22	Grimberg Georges Serge	Composition for protection of oesogastroduodenal mucous membrane
FR2578423B1 (fr) *	1985-03-06	1988-12-30	Grimberg Georges	Composition pharmaceutique a base de gomme de guar pour la protection de la muqueuse oeso-gastro-duodenale
HU206624B (en) *	1989-01-19	1992-12-28	Steigerwald Arzneimittelwerk	Process for producing pharmaceutical composition for treating illnesses of oesophagus and the gastro-intestinal system
KR920002149A (ko) *	1990-07-03	1992-02-28	안드레아 엘. 콜비	비스테로이드계 소염제에 의해 유발된 위장 장애 증상을 완화시키기 위한 약제 조성물 및 이를 완화시키는 방법
DE4140116A1 (de) *	1991-12-05	1993-06-09	Bolder Arzneimittel Gmbh	Dimeticon-pastillen
GR1002332B (el) *	1992-05-21	1996-05-16	Mcneil-Ppc Inc.	Νεες φαρμακευτικες συνθεσεις που περιεχουν σιμεθεικονη.
GB9310412D0 (en) *	1993-05-20	1993-07-07	Danbiosyst Uk	Nasal nicotine system
FR2705966B1 (fr) *	1993-06-04	1995-08-25	Dow Corning Sa	Compositions antimousse utiles notamment pour le traitement de troubles gastriques.
DE4415999A1 (de) *	1994-05-06	1995-11-09	Bolder Arzneimittel Gmbh	Magensäurebindende Kaupastillen
WO1998004156A1 (fr) *	1996-07-26	1998-02-05	Bateman Kristine A	Composition de succedane de sucre univoque a consommer telle quelle ou a utiliser dans la patisserie ou la cuisine
JP3001440B2 (ja) *	1996-11-25	2000-01-24	日本電気通信システム株式会社	仮想ｌａｎ方式
US7341742B2 (en)	2002-09-30	2008-03-11	L. Perrigo Company	Simethicone containing tablet composition and method

1979
- 1979-10-04 CA CA000337031A patent/CA1139221A/fr not_active Expired
- 1979-10-09 CY CY131479A patent/CY1314A/en unknown
- 1979-10-09 GB GB7934912A patent/GB2033915B/en not_active Expired
- 1979-10-09 DE DE19792940905 patent/DE2940905A1/de not_active Withdrawn
1985
- 1985-10-30 KE KE357485A patent/KE3574A/xx unknown
- 1985-12-24 HK HK102585A patent/HK102585A/xx not_active IP Right Cessation
1986
- 1986-12-30 MY MY8600315A patent/MY8600315A/xx unknown

Also Published As

Publication number	Publication date
HK102585A (en)	1986-01-03
DE2940905A1 (de)	1980-04-30
MY8600315A (en)	1986-12-31
GB2033915B (en)	1983-02-09
KE3574A (en)	1985-11-22
GB2033915A (en)	1980-05-29
CA1139221A (fr)	1983-01-11

Publication	Publication Date	Title
CA1139221A (fr)	1983-01-11	Anti-acide
US4906478A (en)	1990-03-06	Simethicone/calcium silicate composition
CA1285483C (fr)	1991-07-02	Composes a liberation continue
US3843778A (en)	1974-10-22	Antacids
PL189988B1 (pl)	2005-10-31	Doustny przeciwpieniący preparat na bazie symetykonu, swobodnie płynąca kompozycja ziarnista oraz sposób jej wytwarzania
EP0403974B1 (fr)	1994-05-11	Utilisation de copolymères séquences d'oxyde d'éthylène et d'oxyde de propylène dans des masses à prise hydraulique et les masses ainsi obtenues
JPH0815521B2 (ja)	1996-02-21	マルトデキストリン／脱泡用組成物混合物
EP0273209A2 (fr)	1988-07-06	Composition contenant un polycarbophile
JPH05339518A (ja)	1993-12-21	有機ケイ素化合物処理顔料、その製法および化粧料
US5508029A (en)	1996-04-16	Isopropyl alcohol gel composition and process for preparing same
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