CA1145671A - Composition a base de glycol et d'iode, et methode de preparation - Google Patents

Composition a base de glycol et d'iode, et methode de preparation

Info

Publication number: CA1145671A
Authority: CA; Canada
Prior art keywords: composition; iodine; glycol; present; ethylene glycol
Prior art date: 1980-03-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000348227A

Other languages

English (en)

Inventor

Samuel Ruben

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

EMDEE CORP

Original Assignee

EMDEE CORP

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-20

Filing date

1980-03-20

Publication date

1983-05-03

1980-03-20 Application filed by EMDEE CORP filed Critical EMDEE CORP

1980-03-20 Priority to CA000348227A priority Critical patent/CA1145671A/fr

1983-05-03 Application granted granted Critical

1983-05-03 Publication of CA1145671A publication Critical patent/CA1145671A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 150
239000011630 iodine Substances 0.000 title claims abstract description 99
229910052740 iodine Inorganic materials 0.000 title claims abstract description 99
238000000034 method Methods 0.000 title claims abstract description 28
238000002360 preparation method Methods 0.000 title abstract description 12
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 134
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 32
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims abstract description 18
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 9
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 9
238000010438 heat treatment Methods 0.000 claims abstract description 6
238000001816 cooling Methods 0.000 claims abstract description 5
229920000642 polymer Polymers 0.000 claims abstract description 5
ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims abstract description 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract 18
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 16
239000000654 additive Substances 0.000 claims description 7
230000000996 additive effect Effects 0.000 claims description 5
239000002270 dispersing agent Substances 0.000 claims description 4
239000000969 carrier Substances 0.000 claims description 3
239000007795 chemical reaction product Substances 0.000 claims description 3
239000003974 emollient agent Substances 0.000 claims description 3
239000000047 product Substances 0.000 claims description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
229930195725 Mannitol Natural products 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims description 2
239000000594 mannitol Substances 0.000 claims description 2
235000010355 mannitol Nutrition 0.000 claims description 2
DFYQRCOZAAHDOU-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethanol;2-[2-(2-hydroxyethoxy)ethoxy]ethanol Chemical compound OCCOCCO.OCCOCCOCCO DFYQRCOZAAHDOU-UHFFFAOYSA-N 0.000 claims 1
239000002304 perfume Substances 0.000 claims 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract description 96
239000000243 solution Substances 0.000 abstract description 25
238000013019 agitation Methods 0.000 abstract description 14
230000008569 process Effects 0.000 abstract description 3
238000004140 cleaning Methods 0.000 abstract description 2
230000007613 environmental effect Effects 0.000 abstract description 2
230000001225 therapeutic effect Effects 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 1
239000011369 resultant mixture Substances 0.000 abstract 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
238000012360 testing method Methods 0.000 description 18
LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 9
150000001875 compounds Chemical class 0.000 description 8
235000011187 glycerol Nutrition 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
241000283973 Oryctolagus cuniculus Species 0.000 description 7
238000010521 absorption reaction Methods 0.000 description 7
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
230000002147 killing effect Effects 0.000 description 5
239000000523 sample Substances 0.000 description 5
238000012546 transfer Methods 0.000 description 5
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 4
239000001263 FEMA 3042 Substances 0.000 description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
JFSAQUVFHCKYKF-UHFFFAOYSA-N [I].C(CO)O Chemical compound [I].C(CO)O JFSAQUVFHCKYKF-UHFFFAOYSA-N 0.000 description 4
230000033228 biological regulation Effects 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
238000001228 spectrum Methods 0.000 description 4
235000015523 tannic acid Nutrition 0.000 description 4
229940033123 tannic acid Drugs 0.000 description 4
229920002258 tannic acid Polymers 0.000 description 4
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
239000001974 tryptic soy broth Substances 0.000 description 4
108010050327 trypticase-soy broth Proteins 0.000 description 4
125000003158 alcohol group Chemical group 0.000 description 3
GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
230000000845 anti-microbial effect Effects 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
150000002334 glycols Chemical class 0.000 description 3
238000011835 investigation Methods 0.000 description 3
230000014759 maintenance of location Effects 0.000 description 3
235000013772 propylene glycol Nutrition 0.000 description 3
238000012552 review Methods 0.000 description 3
239000011550 stock solution Substances 0.000 description 3
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
239000005977 Ethylene Substances 0.000 description 2
101100022451 Mus musculus Mbnl3 gene Proteins 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000005844 Thymol Substances 0.000 description 2
230000002421 anti-septic effect Effects 0.000 description 2
229940000425 combination drug Drugs 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000000645 desinfectant Substances 0.000 description 2
229940093470 ethylene Drugs 0.000 description 2
239000000383 hazardous chemical Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
230000003993 interaction Effects 0.000 description 2
230000007794 irritation Effects 0.000 description 2
238000002372 labelling Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
235000019341 magnesium sulphate Nutrition 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000002674 ointment Substances 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000012086 standard solution Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229960000790 thymol Drugs 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
238000002834 transmittance Methods 0.000 description 2
WRTMQOHKMFDUKX-UHFFFAOYSA-N triiodide Chemical compound I[I-]I WRTMQOHKMFDUKX-UHFFFAOYSA-N 0.000 description 2
238000002211 ultraviolet spectrum Methods 0.000 description 2
UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
GBBZLMLLFVFKJM-UHFFFAOYSA-N 1,2-diiodoethane Chemical compound ICCI GBBZLMLLFVFKJM-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
241000370685 Arge Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
238000009631 Broth culture Methods 0.000 description 1
241000589513 Burkholderia cepacia Species 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
241000588697 Enterobacter cloacae Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
206010015946 Eye irritation Diseases 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
206010018498 Goitre Diseases 0.000 description 1
241000191938 Micrococcus luteus Species 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
235000011613 Pinus brutia Nutrition 0.000 description 1
241000018646 Pinus brutia Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
241000191963 Staphylococcus epidermidis Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
230000007682 dermal toxicity Effects 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
231100000013 eye irritation Toxicity 0.000 description 1
201000003872 goiter Diseases 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
230000003641 microbiacidal effect Effects 0.000 description 1
231100000344 non-irritating Toxicity 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000013074 reference sample Substances 0.000 description 1
231100000438 skin toxicity Toxicity 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229920001864 tannin Polymers 0.000 description 1
235000018553 tannin Nutrition 0.000 description 1
239000001648 tannin Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
229940006158 triiodide ion Drugs 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000348227A 1980-03-20 1980-03-20 Composition a base de glycol et d'iode, et methode de preparation Expired CA1145671A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000348227A CA1145671A (fr)	1980-03-20	1980-03-20	Composition a base de glycol et d'iode, et methode de preparation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000348227A CA1145671A (fr)	1980-03-20	1980-03-20	Composition a base de glycol et d'iode, et methode de preparation

Publications (1)

Publication Number	Publication Date
CA1145671A true CA1145671A (fr)	1983-05-03

Family

ID=4116540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000348227A Expired CA1145671A (fr)	1980-03-20	1980-03-20	Composition a base de glycol et d'iode, et methode de preparation

Country Status (1)

Country	Link
CA (1)	CA1145671A (fr)

1980
- 1980-03-20 CA CA000348227A patent/CA1145671A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2000-05-03	MKEX	Expiry

Publication	Publication Date	Title
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EP2063851A1 (fr)	2009-06-03	Formulations antimicrobiennes
WO1991013617A1 (fr)	1991-09-19	Systeme de conservation antimicrobienne comprenant une hydantoïne substituee par du formaldehyde
US4145436A (en)	1979-03-20	Antimicrobial compositions and method for using same
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