CA1171788A - Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine - Google Patents

Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine

Info

Publication number: CA1171788A
Authority: CA; Canada
Prior art keywords: choline; cdp; weight; phospholipids; salt
Prior art date: 1981-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000375947A

Other languages

English (en)

Inventor

Eraldo Borgo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Made Italiana SRL

Original Assignee

Made Italiana SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-22

Filing date

1981-04-22

Publication date

1984-07-31

1981-04-22 Application filed by Made Italiana SRL filed Critical Made Italiana SRL

1981-04-22 Priority to CA000375947A priority Critical patent/CA1171788A/fr

1984-07-31 Application granted granted Critical

1984-07-31 Publication of CA1171788A publication Critical patent/CA1171788A/fr

Status Expired legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 20
UHDGCWIWMRVCDJ-XVFCMESISA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 title abstract description 4
150000003904 phospholipids Chemical group 0.000 claims abstract description 26
150000003839 salts Chemical class 0.000 claims abstract description 12
229960001231 choline Drugs 0.000 claims abstract description 3
238000000034 method Methods 0.000 claims description 12
241001465754 Metazoa Species 0.000 claims description 10
239000007864 aqueous solution Substances 0.000 claims description 10
239000008187 granular material Substances 0.000 claims description 10
239000000243 solution Substances 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 7
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
239000003431 cross linking reagent Substances 0.000 claims description 5
239000000463 material Substances 0.000 claims description 4
108090000623 proteins and genes Proteins 0.000 claims description 4
102000004169 proteins and genes Human genes 0.000 claims description 4
201000001320 Atherosclerosis Diseases 0.000 claims description 3
206010008132 Cerebral thrombosis Diseases 0.000 claims description 3
201000001429 Intracranial Thrombosis Diseases 0.000 claims description 3
230000006735 deficit Effects 0.000 claims description 3
239000000839 emulsion Substances 0.000 claims description 3
238000002156 mixing Methods 0.000 claims description 3
239000007787 solid Substances 0.000 claims description 3
230000037396 body weight Effects 0.000 claims description 2
239000002552 dosage form Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
102000009027 Albumins Human genes 0.000 claims 1
108010088751 Albumins Proteins 0.000 claims 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 4
229940067631 phospholipid Drugs 0.000 description 19
210000002966 serum Anatomy 0.000 description 7
230000009102 absorption Effects 0.000 description 6
238000010521 absorption reaction Methods 0.000 description 6
238000002360 preparation method Methods 0.000 description 5
241000282567 Macaca fascicularis Species 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000282693 Cercopithecidae Species 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
230000000875 corresponding effect Effects 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
238000009472 formulation Methods 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
238000003756 stirring Methods 0.000 description 3
241000700159 Rattus Species 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000001186 cumulative effect Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
230000002485 urinary effect Effects 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
108010058846 Ovalbumin Proteins 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
241000826860 Trapezium Species 0.000 description 1
229940046545 animal allergen extract Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical group C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
239000007931 coated granule Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000009826 distribution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000003304 gavage Methods 0.000 description 1
JCYWCSGERIELPG-UHFFFAOYSA-N imes Chemical class CC1=CC(C)=CC(C)=C1N1C=CN(C=2C(=CC(C)=CC=2C)C)[C]1 JCYWCSGERIELPG-UHFFFAOYSA-N 0.000 description 1
208000014674 injury Diseases 0.000 description 1
238000011835 investigation Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
-1 lecitines Chemical class 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
229940070376 protein Drugs 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000375947A 1981-04-22 1981-04-22 Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine Expired CA1171788A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000375947A CA1171788A (fr)	1981-04-22	1981-04-22	Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000375947A CA1171788A (fr)	1981-04-22	1981-04-22	Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine

Publications (1)

Publication Number	Publication Date
CA1171788A true CA1171788A (fr)	1984-07-31

Family

ID=4119791

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000375947A Expired CA1171788A (fr)	1981-04-22	1981-04-22	Compose pharmaceutique administre par voie orale et contenant de la cytidin-diphosphocholine

Country Status (1)

Country	Link
CA (1)	CA1171788A (fr)

1981
- 1981-04-22 CA CA000375947A patent/CA1171788A/fr not_active Expired

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Legal Events

Date	Code	Title	Description
2001-07-31	MKEX	Expiry