CA1205013A - Methode de production d'un adhesif tissulaire - Google Patents

Methode de production d'un adhesif tissulaire

Info

Publication number: CA1205013A
Authority: CA; Canada
Prior art keywords: flat material; collagen; fibrinogen; tissue; factor xiii
Prior art date: 1984-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000449868A

Other languages

English (en)

Inventor

Adolf Lindner

Yendra Linnau

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Oesterreichisches Institut fuer Haemoderivate

Original Assignee

Immuno AG fuer Chemisch Medizinische Produkte

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-19

Filing date

1984-03-19

Publication date

1986-05-27

1984-03-19 Application filed by Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG fuer Chemisch Medizinische Produkte

1984-03-19 Priority to CA000449868A priority Critical patent/CA1205013A/fr

1986-05-27 Application granted granted Critical

1986-05-27 Publication of CA1205013A publication Critical patent/CA1205013A/fr

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 19
239000003106 tissue adhesive Substances 0.000 title claims abstract description 9
239000000463 material Substances 0.000 claims abstract description 26
108010049003 Fibrinogen Proteins 0.000 claims abstract description 19
102000008946 Fibrinogen Human genes 0.000 claims abstract description 19
229940012952 fibrinogen Drugs 0.000 claims abstract description 19
108010071289 Factor XIII Proteins 0.000 claims abstract description 18
229940012444 factor xiii Drugs 0.000 claims abstract description 18
235000021120 animal protein Nutrition 0.000 claims abstract description 5
102000008186 Collagen Human genes 0.000 claims description 22
108010035532 Collagen Proteins 0.000 claims description 22
229920001436 collagen Polymers 0.000 claims description 22
239000004745 nonwoven fabric Substances 0.000 claims description 10
239000007864 aqueous solution Substances 0.000 claims description 8
239000000243 solution Substances 0.000 claims description 7
239000003242 anti bacterial agent Substances 0.000 claims description 4
230000003115 biocidal effect Effects 0.000 claims description 4
239000001828 Gelatine Substances 0.000 claims description 3
229940122791 Plasmin inhibitor Drugs 0.000 claims description 3
230000001427 coherent effect Effects 0.000 claims description 3
239000000824 cytostatic agent Substances 0.000 claims description 3
230000001085 cytostatic effect Effects 0.000 claims description 3
229920000159 gelatin Polymers 0.000 claims description 3
235000019322 gelatine Nutrition 0.000 claims description 3
239000011159 matrix material Substances 0.000 claims description 3
239000002806 plasmin inhibitor Substances 0.000 claims description 3
150000004676 glycans Chemical class 0.000 claims description 2
239000005017 polysaccharide Substances 0.000 claims description 2
229960005188 collagen Drugs 0.000 claims 9
229920001282 polysaccharide Polymers 0.000 claims 1
206010052428 Wound Diseases 0.000 description 12
208000027418 Wounds and injury Diseases 0.000 description 12
239000000203 mixture Substances 0.000 description 10
235000018102 proteins Nutrition 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
239000000872 buffer Substances 0.000 description 4
YBHYYFYQHRADCQ-UHFFFAOYSA-N 2-aminoacetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound NCC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O YBHYYFYQHRADCQ-UHFFFAOYSA-N 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
239000000706 filtrate Substances 0.000 description 3
229960002897 heparin Drugs 0.000 description 3
229920000669 heparin Polymers 0.000 description 3
229960004072 thrombin Drugs 0.000 description 3
YWMSSKBMOFPBDM-UHFFFAOYSA-N 4-carbamoylbenzenesulfonyl chloride Chemical compound NC(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 YWMSSKBMOFPBDM-UHFFFAOYSA-N 0.000 description 2
102000009123 Fibrin Human genes 0.000 description 2
108010073385 Fibrin Proteins 0.000 description 2
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
ZDXPYRJPNDTMRX-UHFFFAOYSA-N Glutamine Chemical compound OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
208000032843 Hemorrhage Diseases 0.000 description 2
229960001656 amikacin sulfate Drugs 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
208000034158 bleeding Diseases 0.000 description 2
231100000319 bleeding Toxicity 0.000 description 2
230000000740 bleeding effect Effects 0.000 description 2
229950003499 fibrin Drugs 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
238000007493 shaping process Methods 0.000 description 2
229940075469 tissue adhesives Drugs 0.000 description 2
108010039627 Aprotinin Proteins 0.000 description 1
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
108010014173 Factor X Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
229960004405 aprotinin Drugs 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000035876 healing Effects 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
230000035515 penetration Effects 0.000 description 1
150000004804 polysaccharides Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000002759 woven fabric Substances 0.000 description 1

Landscapes

Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)

CA000449868A 1984-03-19 1984-03-19 Methode de production d'un adhesif tissulaire Expired CA1205013A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000449868A CA1205013A (fr)	1984-03-19	1984-03-19	Methode de production d'un adhesif tissulaire

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000449868A CA1205013A (fr)	1984-03-19	1984-03-19	Methode de production d'un adhesif tissulaire

Publications (1)

Publication Number	Publication Date
CA1205013A true CA1205013A (fr)	1986-05-27

Family

ID=4127429

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000449868A Expired CA1205013A (fr)	1984-03-19	1984-03-19	Methode de production d'un adhesif tissulaire

Country Status (1)

Country	Link
CA (1)	CA1205013A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999065536A1 (fr) *	1998-06-18	1999-12-23	The Microsearch Foundation Of Australia	Reparation de tissus (ii)

1984
- 1984-03-19 CA CA000449868A patent/CA1205013A/fr not_active Expired

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999065536A1 (fr) *	1998-06-18	1999-12-23	The Microsearch Foundation Of Australia	Reparation de tissus (ii)

Legal Events

Date	Code	Title	Description
2004-03-19	MKEX	Expiry

Publication	Publication Date	Title
US4600574A (en)	1986-07-15	Method of producing a tissue adhesive
US4606337A (en)	1986-08-19	Resorptive sheet material for closing and healing wounds and method of making the same
JP5175412B2 (ja)	2013-04-03	二重複合コラーゲン性材料、その取得方法及び療法的適用
CA2258990C (fr)	2007-06-05	Emploi de cellulose oxydee et de complexes de ladite cellulose pour la guerison de plaies chroniques
US6022557A (en)	2000-02-08	Material on the basis of collagen fibers for covering wounds
US5837278A (en)	1998-11-17	Resorbable collagen membrane for use in guided tissue regeneration
CA1217135A (fr)	1987-01-27	Compose de collagene et de thrombine
EP1259269B1 (fr)	2008-06-18	Agent de traitement de plaies
CA1168982A (fr)	1984-06-12	Adhesif tissulaire
US20030133967A1 (en)	2003-07-17	Multilayer collagen matrix for tissue reconstruction
US20030007957A1 (en)	2003-01-09	Novel wound healing composition not containing bovine-derived activating reagents
US20030152639A1 (en)	2003-08-14	Novel wound healing composition not containing bovine-derived activating reagents
JPH09500897A (ja)	1997-01-28	銅と細胞接着タンパク質との錯体
JPS60204725A (ja)	1985-10-16	組織接着材の製法
CA1205013A (fr)	1986-05-27	Methode de production d'un adhesif tissulaire
Thornton et al.	1977	Graft adherence to wound surfaces: collagen fibrin interactions
AU1166692A (en)	1992-08-27	Depot formulations
JPS63115564A (ja)	1988-05-20	創傷被覆材
CN100381110C (zh)	2008-04-16	可展开的止血剂
AT374367B (de)	1984-04-10	Verfahren zur herstellung eines gewebeklebstoffes
JPH0481466B2 (fr)	1992-12-24
JPS63115562A (ja)	1988-05-20	創傷被覆材

CA1205013A - Methode de production d'un adhesif tissulaire - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (1)

Family

ID=4127429

Family Applications (1)

Country Status (1)

Cited By (1)

Cited By (1)

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