CA1168982A - Adhesif tissulaire - Google Patents

Adhesif tissulaire

Info

Publication number: CA1168982A
Authority: CA; Canada
Prior art keywords: factor xiii; fibrinogen; antibiotic; tissue adhesive; units
Prior art date: 1981-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000407154A

Other languages

English (en)

Inventor

Heinz Redl

Thomas Seelich

Yendra Linnau

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Oesterreichisches Institut fuer Haemoderivate

Original Assignee

Immuno AG fuer Chemisch Medizinische Produkte

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-07-28

Filing date

1982-07-13

Publication date

1984-06-12

1982-07-13 Application filed by Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG fuer Chemisch Medizinische Produkte

1984-06-12 Application granted granted Critical

1984-06-12 Publication of CA1168982A publication Critical patent/CA1168982A/fr

Status Expired legal-status Critical Current

Links

239000003106 tissue adhesive Substances 0.000 title claims abstract description 36
229940012444 factor xiii Drugs 0.000 claims abstract description 54
108010071289 Factor XIII Proteins 0.000 claims abstract description 52
108010049003 Fibrinogen Proteins 0.000 claims abstract description 50
102000008946 Fibrinogen Human genes 0.000 claims abstract description 50
229940012952 fibrinogen Drugs 0.000 claims abstract description 50
230000003115 biocidal effect Effects 0.000 claims abstract description 28
238000002360 preparation method Methods 0.000 claims abstract description 16
239000003242 anti bacterial agent Substances 0.000 claims abstract description 15
238000000034 method Methods 0.000 claims abstract description 14
210000002381 plasma Anatomy 0.000 claims abstract description 7
239000004098 Tetracycline Substances 0.000 claims abstract description 5
235000021120 animal protein Nutrition 0.000 claims abstract description 5
229920001184 polypeptide Polymers 0.000 claims abstract description 5
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 5
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 5
235000019364 tetracycline Nutrition 0.000 claims abstract description 5
150000003522 tetracyclines Chemical class 0.000 claims abstract description 5
229940040944 tetracyclines Drugs 0.000 claims abstract description 5
150000003952 β-lactams Chemical class 0.000 claims abstract description 5
238000010257 thawing Methods 0.000 claims abstract description 4
239000000243 solution Substances 0.000 claims description 15
108090000190 Thrombin Proteins 0.000 claims description 8
229960004072 thrombin Drugs 0.000 claims description 8
229940122791 Plasmin inhibitor Drugs 0.000 claims description 7
239000002806 plasmin inhibitor Substances 0.000 claims description 7
102000010752 Plasminogen Inactivators Human genes 0.000 claims description 6
108010077971 Plasminogen Inactivators Proteins 0.000 claims description 6
239000002797 plasminogen activator inhibitor Substances 0.000 claims description 6
239000007853 buffer solution Substances 0.000 claims description 5
238000005406 washing Methods 0.000 claims description 5
108010039627 Aprotinin Proteins 0.000 claims description 4
229960004405 aprotinin Drugs 0.000 claims description 4
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
229960002684 aminocaproic acid Drugs 0.000 claims description 3
229910052791 calcium Inorganic materials 0.000 claims description 3
239000011575 calcium Substances 0.000 claims description 3
GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 3
229960000401 tranexamic acid Drugs 0.000 claims description 3
239000002753 trypsin inhibitor Substances 0.000 claims description 3
239000012141 concentrate Substances 0.000 claims description 2
210000003918 fraction a Anatomy 0.000 claims 2
108010001014 Plasminogen Activators Proteins 0.000 claims 1
102000001938 Plasminogen Activators Human genes 0.000 claims 1
210000004369 blood Anatomy 0.000 claims 1
239000008280 blood Substances 0.000 claims 1
229940127126 plasminogen activator Drugs 0.000 claims 1
230000000845 anti-microbial effect Effects 0.000 abstract description 4
238000004108 freeze drying Methods 0.000 abstract 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 8
229930182566 Gentamicin Natural products 0.000 description 8
229960002518 gentamicin Drugs 0.000 description 8
239000000306 component Substances 0.000 description 6
238000004132 cross linking Methods 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
229940088710 antibiotic agent Drugs 0.000 description 5
239000000203 mixture Substances 0.000 description 5
229940075469 tissue adhesives Drugs 0.000 description 5
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
108010073385 Fibrin Proteins 0.000 description 3
102000009123 Fibrin Human genes 0.000 description 3
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
206010052428 Wound Diseases 0.000 description 3
208000027418 Wounds and injury Diseases 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
210000000988 bone and bone Anatomy 0.000 description 3
239000001110 calcium chloride Substances 0.000 description 3
229910001628 calcium chloride Inorganic materials 0.000 description 3
235000011148 calcium chloride Nutrition 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
229950003499 fibrin Drugs 0.000 description 3
239000004471 Glycine Substances 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
229930193140 Neomycin Natural products 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
239000004599 antimicrobial Substances 0.000 description 2
229960002449 glycine Drugs 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
229960004927 neomycin Drugs 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
206010000369 Accident Diseases 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
JTWOMNBEOCYFNV-NFFDBFGFSA-N azlocillin Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC=CC=1)C(=O)N1CCNC1=O JTWOMNBEOCYFNV-NFFDBFGFSA-N 0.000 description 1
229960003623 azlocillin Drugs 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
208000034158 bleeding Diseases 0.000 description 1
231100000319 bleeding Toxicity 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
WZOZEZRFJCJXNZ-ZBFHGGJFSA-N cefoxitin Chemical compound N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)CC1=CC=CS1 WZOZEZRFJCJXNZ-ZBFHGGJFSA-N 0.000 description 1
229960002682 cefoxitin Drugs 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
229940000425 combination drug Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
229960000308 fosfomycin Drugs 0.000 description 1
YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
229960001031 glucose Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229940070376 protein Drugs 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000006894 reductive elimination reaction Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Surgery (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

CA000407154A 1981-07-28 1982-07-13 Adhesif tissulaire Expired CA1168982A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ATA3337/81		1981-07-28
AT0333781A AT369990B (de)	1981-07-28	1981-07-28	Verfahren zur herstellung eines gewebeklebstoffes

Publications (1)

Publication Number	Publication Date
CA1168982A true CA1168982A (fr)	1984-06-12

Family

ID=3548998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000407154A Expired CA1168982A (fr)	1981-07-28	1982-07-13	Adhesif tissulaire

Country Status (14)

Country	Link
JP (1)	JPH0696039B2 (fr)
AR (1)	AR227252A1 (fr)
AT (1)	AT369990B (fr)
BE (1)	BE893851A (fr)
CA (1)	CA1168982A (fr)
CH (1)	CH659187B (fr)
DE (1)	DE3225102A1 (fr)
DK (1)	DK157977C (fr)
ES (1)	ES8306023A1 (fr)
FR (1)	FR2510408B1 (fr)
GB (1)	GB2102811B (fr)
IT (1)	IT1157313B (fr)
NL (1)	NL192665C (fr)
SE (1)	SE459848B (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4909251A (en) *	1988-05-31	1990-03-20	Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte	Tissue adhesive
US6054122A (en) *	1990-11-27	2000-04-25	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) *	1990-11-27	2000-09-12	The American National Red Cross	Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en)	1990-11-27	2001-03-06	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6506365B1 (en)	2000-09-25	2003-01-14	Baxter Aktiengesellschaft	Fibrin/fibrinogen binding conjugate
US6559119B1 (en)	1990-11-27	2003-05-06	Loyola University Of Chicago	Method of preparing a tissue sealant-treated biomedical material
US6762336B1 (en)	1998-01-19	2004-07-13	The American National Red Cross	Hemostatic sandwich bandage
US7189410B1 (en)	1990-11-27	2007-03-13	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US8445009B2 (en)	2006-08-04	2013-05-21	Stb, Ltd	Processes for the production of solid dressings for treating wounded tissue
US8679528B2 (en)	2002-09-10	2014-03-25	American National Red Cross	Hemostatic dressing
US9131929B2 (en)	2007-08-06	2015-09-15	Stb, Ltd.	Methods and dressings for sealing internal injuries

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06102628B2 (ja) *	1984-03-27	1994-12-14	イムノ・アクチエンゲゼルシャフト	組織接着材の製法
JPS6185304A (ja) *	1984-10-01	1986-04-30	Green Cross Corp:The	歯槽骨用材料
DE3622642A1 (de) *	1986-07-05	1988-01-14	Behringwerke Ag	Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
US4837379A (en) *	1988-06-02	1989-06-06	Organogenesis Inc.	Fibrin-collagen tissue equivalents and methods for preparation thereof
NZ229385A (en) *	1989-06-01	1992-02-25	Life Technologies Inc	Treatment of processed fish product (surimi) with alpha-2-macroglobulin to neutralise alkaline proteases in the fish
IT1243180B (it) *	1990-07-31	1994-05-24	Nunzio Rapisarda	Uso della fosfomicina e dei suoi sali come agente cicatrizzante topico
KR950702434A (ko) *	1992-07-18	1995-07-29	로버트 타웁	시험관내 수정을 향상시켜주는 2성분 피브린-글루 조성물(a two component fibrin-glue composition for improving in vitro fertilization)
US5330974A (en) *	1993-03-01	1994-07-19	Fibratek, Inc.	Therapeutic fibrinogen compositions
DE69433920T2 (de) *	1993-03-12	2005-06-02	American National Red Cross	Supplementierte verdichtungsmittel für gewebe, methoden für ihre herstellung und ihre verwendung
DE69422165T2 (de) *	1993-03-30	2001-10-04	Omrix Biopharmaceuticals S.A., Bruessel/Bruxelles	Zweikomponenten-fibrinkleber
DE19521324C1 (de) *	1995-06-12	1996-10-31	Immuno Ag	Gewebeklebstoff und Verwendung desselben als Hämostyptikum
DE19617369A1 (de) *	1996-04-30	1997-11-06	Immuno Ag	Lagerstabile Fibrinogen-Präparate
AT406120B (de) *	1997-08-28	2000-02-25	Immuno Ag	Gewebekleber
AT407484B (de)	1997-11-12	2001-03-26	Bio Prod & Bio Eng Ag	Arzneimittel zur förderung der wundheilung
ES2327208T3 (es)	1999-12-23	2009-10-27	Csl Limited	Separacion de fibrinogeno de proteasas de plasma.
IL144446A0 (en) *	2001-07-19	2002-05-23	Prochon Biotech Ltd	Plasma protein matrices and methods for their preparation
CN101010333B (zh)	2004-08-27	2013-08-14	诺和诺德医疗保健公司	从生物材料中纯化凝血因子xⅲ多肽
ATE540974T1 (de)	2004-11-23	2012-01-15	Zymogenetics Inc	Reinigung des rekombinanten menschlichen faktors xiii
CA2623106C (fr)	2005-09-19	2013-12-24	Histogenics Corporation	Matrice support de cellules dont la densite des pores et la porosite sont definies specifiquement de maniere uniforme verticalement et organisees de maniere non aleatoire, et procede de preparation de celle-ci
US10077420B2 (en)	2014-12-02	2018-09-18	Histogenics Corporation	Cell and tissue culture container
KR20240125667A (ko)	2021-12-30	2024-08-19	백스터 인터내셔널 인코포레이티드	피브린 실란트용 피브리노겐 및 트롬빈 용액 및 피브린 실란트 키트

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT359653B (de) *	1979-02-15	1980-11-25	Immuno Ag	Verfahren zur herstellung eines gewebekleb- stoffes
AT359652B (de) *	1979-02-15	1980-11-25	Immuno Ag	Verfahren zur herstellung eines gewebekleb- stoffes
JPS56501129A (fr) *	1979-08-31	1981-08-13

1981
- 1981-07-28 AT AT0333781A patent/AT369990B/de not_active IP Right Cessation
1982
- 1982-07-01 SE SE8204064A patent/SE459848B/sv not_active IP Right Cessation
- 1982-07-05 DE DE19823225102 patent/DE3225102A1/de active Granted
- 1982-07-05 DK DK300682A patent/DK157977C/da active
- 1982-07-05 CH CH409482A patent/CH659187B/de unknown
- 1982-07-06 GB GB08219500A patent/GB2102811B/en not_active Expired
- 1982-07-13 CA CA000407154A patent/CA1168982A/fr not_active Expired
- 1982-07-16 BE BE0/208601A patent/BE893851A/fr not_active IP Right Cessation
- 1982-07-21 AR AR290039A patent/AR227252A1/es active
- 1982-07-22 JP JP57126829A patent/JPH0696039B2/ja not_active Expired - Lifetime
- 1982-07-23 NL NL8202982A patent/NL192665C/nl not_active IP Right Cessation
- 1982-07-23 FR FR8212918A patent/FR2510408B1/fr not_active Expired
- 1982-07-27 IT IT22595/82A patent/IT1157313B/it active
- 1982-07-27 ES ES514441A patent/ES8306023A1/es not_active Expired

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4909251A (en) *	1988-05-31	1990-03-20	Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte	Tissue adhesive
US7189410B1 (en)	1990-11-27	2007-03-13	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
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US6506365B1 (en)	2000-09-25	2003-01-14	Baxter Aktiengesellschaft	Fibrin/fibrinogen binding conjugate
US8679528B2 (en)	2002-09-10	2014-03-25	American National Red Cross	Hemostatic dressing
US8445009B2 (en)	2006-08-04	2013-05-21	Stb, Ltd	Processes for the production of solid dressings for treating wounded tissue
US9131929B2 (en)	2007-08-06	2015-09-15	Stb, Ltd.	Methods and dressings for sealing internal injuries

Also Published As

Publication number	Publication date
GB2102811A (en)	1983-02-09
FR2510408A1 (fr)	1983-02-04
JPH0696039B2 (ja)	1994-11-30
ES514441A0 (es)	1983-05-01
IT8222595A0 (it)	1982-07-27
ES8306023A1 (es)	1983-05-01
DE3225102A1 (de)	1983-02-17
AT369990B (de)	1983-02-25
DK157977B (da)	1990-03-12
AR227252A1 (es)	1982-09-30
NL192665B (nl)	1997-08-01
FR2510408B1 (fr)	1987-02-27
SE8204064L (sv)	1983-01-29
NL8202982A (nl)	1983-02-16
SE459848B (sv)	1989-08-14
ATA333781A (de)	1982-07-15
DK300682A (da)	1983-01-29
GB2102811B (en)	1985-01-30
CH659187B (fr)	1987-01-15
DE3225102C2 (fr)	1990-05-31
BE893851A (fr)	1982-11-16
NL192665C (nl)	1997-12-02
IT1157313B (it)	1987-02-11
JPS5826821A (ja)	1983-02-17
DK157977C (da)	1990-08-13
SE8204064D0 (sv)	1982-07-01

Legal Events

Date	Code	Title	Description
2001-06-12	MKEX	Expiry

Publication	Publication Date	Title
GB2102811A (en)	1983-02-09	A tissue adhesive and a method of producing the same
KR100276372B1 (ko)	2001-11-22	안정한피브리노겐용액
US4407787A (en)	1983-10-04	Collagenous dressing
US4650678A (en)	1987-03-17	Readily dissolvable lyophilized fibrinogen formulation
US4414976A (en)	1983-11-15	Tissue adhesive
US6500427B1 (en)	2002-12-31	One-component tissue adhesive and a process for the production thereof
DE69333080T2 (de)	2004-04-15	Fibrindichtungsmittelzusammensetzungen und Verfahren zu deren Verwendung
AU2004201982B2 (en)	2007-12-06	A Method for Producing a Preparation Based on Fibrinogen and Fibronectin as Well as Protein Compositions Obtainable According to This Method
ES2206529T3 (es)	2004-05-16	Pegamento para tejidos a base de fibronogeno y su utilizacion para la preparacion de un hemostatico.
US4683142A (en)	1987-07-28	Resorptive sheet material for closing and healing wounds and method of making the same
KR100858830B1 (ko)	2008-09-17	조직 접합제용의 안정화된 단백질 제제
US4427650A (en)	1984-01-24	Enriched plasma derivative for advancement of wound closure and healing
EP1568709B1 (fr)	2011-05-11	Purification du fibrinogène
JPS5838216A (ja)	1983-03-05	濃縮血漿誘導体製剤
US8124075B2 (en)	2012-02-28	Enhanced biological autologous tissue adhesive composition and methods of preparation and use
US6916911B1 (en)	2005-07-12	Use of fibrinogen multimers
BUGARSKI et al.	2002	The use of single-donor brin glue prepared by recycled cryoprecipitation in experimental liver surgery
JP2002539087A (ja)	2002-11-19	フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物