CA1217768A - Process for the preparation of pyrimidinones and their acid addition salts - Google Patents

Process for the preparation of pyrimidinones and their acid addition salts

Info

Publication number
CA1217768A
CA1217768A CA000429507A CA429507A CA1217768A CA 1217768 A CA1217768 A CA 1217768A CA 000429507 A CA000429507 A CA 000429507A CA 429507 A CA429507 A CA 429507A CA 1217768 A CA1217768 A CA 1217768A
Authority
CA
Canada
Prior art keywords
group
hydroxy
carbon atoms
methoxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000429507A
Other languages
English (en)
French (fr)
Inventor
Joachim Heider
Volkhard Austel
Wolfgang Eberlein
Rudolf Kadatz
Christian Lillie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of CA1217768A publication Critical patent/CA1217768A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000429507A 1982-06-03 1983-06-02 Process for the preparation of pyrimidinones and their acid addition salts Expired CA1217768A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823220898 DE3220898A1 (de) 1982-06-03 1982-06-03 Verfahren zur herstellung von pyrimidinonen und ihren saeureadditionssalzen
DEP3220898.7 1982-06-03

Publications (1)

Publication Number Publication Date
CA1217768A true CA1217768A (en) 1987-02-10

Family

ID=6165198

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000429507A Expired CA1217768A (en) 1982-06-03 1983-06-02 Process for the preparation of pyrimidinones and their acid addition salts

Country Status (10)

Country Link
KR (1) KR840005107A (da)
CA (1) CA1217768A (da)
DD (1) DD210904A5 (da)
DE (1) DE3220898A1 (da)
DK (1) DK250883A (da)
ES (2) ES8403115A1 (da)
FI (1) FI831914A7 (da)
HU (1) HU190846B (da)
NO (1) NO831994L (da)
PT (1) PT76806B (da)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111943A1 (zh) * 2008-03-13 2009-09-17 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
CN1960977B (zh) * 2004-05-31 2010-07-21 万有制药株式会社 喹唑啉衍生物
US8853221B2 (en) 2008-07-18 2014-10-07 Guangzhou Institute Of Biomedicine & Health, Chinese Academy Of Sciences Compounds of estrogen-related receptor modulators and the uses thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
CN1518447A (zh) * 2001-04-23 2004-08-04 �������Ǵ�ѧר������� 作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估
MXPA05004328A (es) * 2002-11-04 2005-08-02 Nps Pharma Inc Compuestos de quinazolinona como calciliticos.

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960977B (zh) * 2004-05-31 2010-07-21 万有制药株式会社 喹唑啉衍生物
AU2005247808B2 (en) * 2004-05-31 2011-02-10 Msd K.K. Quinazoline derivative
WO2009111943A1 (zh) * 2008-03-13 2009-09-17 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
AU2009225171B2 (en) * 2008-03-13 2014-05-01 Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences The compounds as the estrogen related receptors modulators and the uses thereof
AU2009225171C1 (en) * 2008-03-13 2014-11-27 Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences The compounds as the estrogen related receptors modulators and the uses thereof
US8853221B2 (en) 2008-07-18 2014-10-07 Guangzhou Institute Of Biomedicine & Health, Chinese Academy Of Sciences Compounds of estrogen-related receptor modulators and the uses thereof

Also Published As

Publication number Publication date
PT76806B (de) 1986-04-09
ES522898A0 (es) 1984-03-01
KR840005107A (ko) 1984-11-03
ES527906A0 (es) 1984-08-01
PT76806A (de) 1983-07-01
HU190846B (en) 1986-11-28
NO831994L (no) 1983-12-05
DD210904A5 (de) 1984-06-27
DK250883D0 (da) 1983-06-02
FI831914A0 (fi) 1983-05-30
FI831914L (fi) 1983-12-04
ES8403115A1 (es) 1984-03-01
FI831914A7 (fi) 1983-12-04
DE3220898A1 (de) 1983-12-08
ES8406450A1 (es) 1984-08-01
DK250883A (da) 1983-12-04

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Legal Events

Date Code Title Description
MKEX Expiry