CA1242147A - Methode de traitement des infections a virus - Google Patents
Methode de traitement des infections a virusInfo
- Publication number
- CA1242147A CA1242147A CA000473084A CA473084A CA1242147A CA 1242147 A CA1242147 A CA 1242147A CA 000473084 A CA000473084 A CA 000473084A CA 473084 A CA473084 A CA 473084A CA 1242147 A CA1242147 A CA 1242147A
- Authority
- CA
- Canada
- Prior art keywords
- docusate sodium
- sodium
- composition
- cells
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000036142 Viral infection Diseases 0.000 title claims abstract description 16
- 230000009385 viral infection Effects 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title abstract description 23
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical group [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims description 58
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 8
- 230000009885 systemic effect Effects 0.000 claims description 7
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 abstract description 56
- 208000015181 infectious disease Diseases 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 7
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 abstract description 3
- 229960000878 docusate sodium Drugs 0.000 description 53
- 210000004027 cell Anatomy 0.000 description 40
- 239000000243 solution Substances 0.000 description 27
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 15
- 241000700605 Viruses Species 0.000 description 12
- 208000009889 Herpes Simplex Diseases 0.000 description 9
- 230000003902 lesion Effects 0.000 description 8
- 231100000433 cytotoxic Toxicity 0.000 description 6
- 230000001472 cytotoxic effect Effects 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 5
- 230000002779 inactivation Effects 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 231100000135 cytotoxicity Toxicity 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000012894 fetal calf serum Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000702670 Rotavirus Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 229940018602 docusate Drugs 0.000 description 3
- 210000003953 foreskin Anatomy 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 206010067152 Oral herpes Diseases 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 244000309711 non-enveloped viruses Species 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 1
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000490229 Eucephalus Species 0.000 description 1
- 208000001688 Herpes Genitalis Diseases 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037898 Rash vesicular Diseases 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229960000503 bisacodyl Drugs 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 244000240602 cacao Species 0.000 description 1
- DWKPZOZZBLWFJX-UHFFFAOYSA-L calcium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate Chemical compound [Ca+2].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC DWKPZOZZBLWFJX-UHFFFAOYSA-L 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 235000020187 evaporated milk Nutrition 0.000 description 1
- 210000001752 female genitalia Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 201000004946 genital herpes Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 208000037798 influenza B Diseases 0.000 description 1
- 208000037799 influenza C Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000000260 male genitalia Anatomy 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- -1 phenol, 4,4'-(2-pyridinyl methylene) bis, diacetate ester Chemical class 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- CACRHRQTJDKAPJ-UHFFFAOYSA-M potassium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate Chemical compound [K+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CACRHRQTJDKAPJ-UHFFFAOYSA-M 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000026775 severe diarrhea Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 208000012991 uterine carcinoma Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66139684A | 1984-10-16 | 1984-10-16 | |
| US661,396 | 1984-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1242147A true CA1242147A (fr) | 1988-09-20 |
Family
ID=24653418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000473084A Expired CA1242147A (fr) | 1984-10-16 | 1985-01-29 | Methode de traitement des infections a virus |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS62500524A (fr) |
| CA (1) | CA1242147A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425711A (zh) * | 2020-03-23 | 2021-09-24 | 萧湘 | 磺基琥珀酸酯盐在制备广谱抗病毒药物中的应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7534729B2 (ja) * | 2022-01-28 | 2024-08-15 | 花王株式会社 | Ｓａｒｓコロナウイルス２不活性化剤 |
| WO2024154192A1 (fr) * | 2023-01-16 | 2024-07-25 | 花王株式会社 | Agent de stérilisation |
-
1985
- 1985-01-29 CA CA000473084A patent/CA1242147A/fr not_active Expired
- 1985-10-15 JP JP60504805A patent/JPS62500524A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425711A (zh) * | 2020-03-23 | 2021-09-24 | 萧湘 | 磺基琥珀酸酯盐在制备广谱抗病毒药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62500524A (ja) | 1987-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Arvin et al. | Effect of leukocyte interferon on urinary excretion of cytomegalovirus by infants | |
| Kern et al. | Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate | |
| Ch'ien et al. | Effect of adenine arabinoside on severe Herpesvirus hominis infections in man | |
| US6197834B1 (en) | Method of inhibiting formation of infectious herpes virus particles | |
| CA1256032A (fr) | Methodes et composes pour le traitement des infections virales | |
| EP0270317A3 (fr) | Médicament pour le traitement des maladies virales | |
| JPH11503457A (ja) | 哺乳類における癌およびウィルスの成長を阻止するｎ−クロロフェニルカルバメート、ｎ−クロロフェニルチオカルバメートおよびｎ−ホスホノグリシン誘導体を含有する医薬組成物 | |
| US5716959A (en) | Method of treating disease with piperazine zwitterion compounds | |
| Klein et al. | Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice | |
| Al-Nakib et al. | Intranasal chalcone, Ro 09–0410, as prophylaxis against rhinovirus infection in human volunteers | |
| CA1242147A (fr) | Methode de traitement des infections a virus | |
| Hyndiuk et al. | Newer compounds in therapy of herpes simplex keratitis | |
| EP0188499A1 (fr) | Preparation antivirale et son procede de production | |
| US4795636A (en) | Method for treating genital and oral herpes | |
| US4520132A (en) | Use of undecylenic acid to treat herpes labialis | |
| Yamamoto et al. | Further studies on the absorption of vitamin B12 following oral and parenteral administration | |
| US5869446A (en) | Preparation of lactoferrin (or serotransferrin or ovotransferrin) and desferrioxamine methanesulfonate (or other low molecular weight metal ion chelators) for the therapy of viral infections | |
| US5534523A (en) | Anti-aids virus composition | |
| JPH03500656A (ja) | ウイルス感染の治療および予防薬剤アシル・カルニチン | |
| Togo et al. | Clinical evaluation of prophylactic intranasal 1-phenyl-3-(4-phenyl-2-thiazolyl) guanidine (CL 88,277) medication against rhinovirus 44 challenge | |
| EP0082667A1 (fr) | Compositions pharmaceutiques | |
| Vilde et al. | Comparative use of adenine arabinoside and adenine arabinoside monophosphate in varicella and disseminated zoster in immunosuppressed patients | |
| EP0753309A2 (fr) | Composition de lactoferrine (ou de protéines analogues) et de méthanesulfonate de désferrioxamine (ou d'autres chélateurs d'ions métalliques) pour la thérapie de maladies infectieuses virales | |
| CA1307740C (fr) | Preparation pharmaceutique et methode permettant d'inhiber la replication du htlv-iii (sida) | |
| US4177281A (en) | Therapeutic treatment for measles viral infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |