CA1255604A - Compose cosmetique pour blanchir la peau - Google Patents

Compose cosmetique pour blanchir la peau

Info

Publication number: CA1255604A
Authority: CA; Canada
Prior art keywords: kojic acid; fraction; placenta extract; placenta; cosmetic composition
Prior art date: 1985-07-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000486357A

Other languages

English (en)

Inventor

Yoshitaka Higa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sansho Pharmaceutical Co Ltd

Original Assignee

Sansho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-05

Filing date

1985-07-05

Publication date

1989-06-13

1985-07-05 Application filed by Sansho Pharmaceutical Co Ltd filed Critical Sansho Pharmaceutical Co Ltd

1985-07-05 Priority to CA000486357A priority Critical patent/CA1255604A/fr

1989-06-13 Application granted granted Critical

1989-06-13 Publication of CA1255604A publication Critical patent/CA1255604A/fr

Status Expired legal-status Critical Current

Links

239000002537 cosmetic Substances 0.000 title claims abstract description 29
239000000203 mixture Substances 0.000 title claims abstract description 19
230000002087 whitening effect Effects 0.000 title claims abstract description 15
BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 57
239000000284 extract Substances 0.000 claims abstract description 40
229960004705 kojic acid Drugs 0.000 claims abstract description 39
WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 39
210000002826 placenta Anatomy 0.000 claims abstract description 38
230000000694 effects Effects 0.000 abstract description 10
239000000243 solution Substances 0.000 description 14
230000015572 biosynthetic process Effects 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
239000008346 aqueous phase Substances 0.000 description 8
210000004027 cell Anatomy 0.000 description 8
239000008213 purified water Substances 0.000 description 8
239000002253 acid Substances 0.000 description 7
239000000839 emulsion Substances 0.000 description 7
239000003921 oil Substances 0.000 description 7
239000003795 chemical substances by application Substances 0.000 description 6
-1 for example Chemical compound 0.000 description 6
239000006071 cream Substances 0.000 description 5
239000006210 lotion Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
230000001815 facial effect Effects 0.000 description 4
235000011187 glycerol Nutrition 0.000 description 4
230000002401 inhibitory effect Effects 0.000 description 4
238000000034 method Methods 0.000 description 4
230000003020 moisturizing effect Effects 0.000 description 4
239000012071 phase Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
241000283690 Bos taurus Species 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
102000003425 Tyrosinase Human genes 0.000 description 3
108060008724 Tyrosinase Proteins 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
229940057995 liquid paraffin Drugs 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
238000002156 mixing Methods 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
235000013871 bee wax Nutrition 0.000 description 2
239000012166 beeswax Substances 0.000 description 2
229940092738 beeswax Drugs 0.000 description 2
229960000541 cetyl alcohol Drugs 0.000 description 2
229910001431 copper ion Inorganic materials 0.000 description 2
239000010696 ester oil Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
238000011534 incubation Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
229940056211 paraffin Drugs 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
150000002978 peroxides Chemical class 0.000 description 2
229940032094 squalane Drugs 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
229940099259 vaseline Drugs 0.000 description 2
URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 description 1
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
241001340526 Chrysoclista linneella Species 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
206010014970 Ephelides Diseases 0.000 description 1
241000257303 Hymenoptera Species 0.000 description 1
SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
208000003351 Melanosis Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
239000013522 chelant Substances 0.000 description 1
230000009920 chelation Effects 0.000 description 1
150000004777 chromones Chemical class 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 1
229960005215 dichloroacetic acid Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
150000007946 flavonol Chemical class 0.000 description 1
HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Chemical class O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
235000011957 flavonols Nutrition 0.000 description 1
210000002196 fr. b Anatomy 0.000 description 1
210000003918 fraction a Anatomy 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
238000007710 freezing Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
229960002163 hydrogen peroxide Drugs 0.000 description 1
DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
229960004995 magnesium peroxide Drugs 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
229940114937 microcrystalline wax Drugs 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000009877 rendering Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
229940105296 zinc peroxide Drugs 0.000 description 1
PLVWNARVBMHCST-UHFFFAOYSA-L zinc;oxidooxy(oxo)borane Chemical compound [Zn+2].[O-]OB=O.[O-]OB=O PLVWNARVBMHCST-UHFFFAOYSA-L 0.000 description 1

Landscapes

Cosmetics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CA000486357A 1985-07-05 1985-07-05 Compose cosmetique pour blanchir la peau Expired CA1255604A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000486357A CA1255604A (fr)	1985-07-05	1985-07-05	Compose cosmetique pour blanchir la peau

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000486357A CA1255604A (fr)	1985-07-05	1985-07-05	Compose cosmetique pour blanchir la peau

Publications (1)

Publication Number	Publication Date
CA1255604A true CA1255604A (fr)	1989-06-13

Family

ID=4130932

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000486357A Expired CA1255604A (fr)	1985-07-05	1985-07-05	Compose cosmetique pour blanchir la peau

Country Status (1)

Country	Link
CA (1)	CA1255604A (fr)

1985
- 1985-07-05 CA CA000486357A patent/CA1255604A/fr not_active Expired

Legal Events

Date	Code	Title	Description
2006-06-13	MKEX	Expiry

Publication	Publication Date	Title
EP0208799B1 (fr)	1990-09-26	Composition cosmétique blanchissante
KR100345096B1 (ko)	2002-07-24	하나 이상의 뽕나무 추출물, 하나 이상의 골무꽃 추출물 및 하나 이상의 살리실산 유도체를 함유하는 화장용 및/또는 피부용 조성물
US4847074A (en)	1989-07-11	Whitening cosmetic
JPH0725742A (ja)	1995-01-27	美白化粧料
JP3480953B2 (ja)	2003-12-22	皮膚外用剤
JP2903240B2 (ja)	1999-06-07	皮膚外用剤
JP3513872B2 (ja)	2004-03-31	皮膚外用剤
JPH0314508A (ja)	1991-01-23	メラニン生成抑制外用剤
JPH11501663A (ja)	1999-02-09	皮膚剥離の促進または表皮再生の刺激のための硫黄官能基を有するカルボン酸の使用
JP2004099503A (ja)	2004-04-02	Ｈｇｆ産生促進剤およびこれを含有する化粧料
CA1255604A (fr)	1989-06-13	Compose cosmetique pour blanchir la peau
JPH06128142A (ja)	1994-05-10	皮膚外用剤
JP3000224B2 (ja)	2000-01-17	皮膚化粧料
JPH0532556A (ja)	1993-02-09	皮膚外用剤
JP2004107269A (ja)	2004-04-08	蛋白質のカルボニル化抑制剤、皮膚外用剤及び方法
KR20220020110A (ko)	2022-02-18	피부톤, 피부결, 기미, 잡티, 윤기 및 탄력 개선 효과가 우수한 화장료 조성물
JP3013130B2 (ja)	2000-02-28	美白化粧料
KR870001430B1 (ko)	1987-08-06	색백(色白)화장료
EP0445735A1 (fr)	1991-09-11	Préparation endermique inhibitrice de la mélanogénèse
EP0503763A1 (fr)	1992-09-16	Matériel cosmétique
JPH0665043A (ja)	1994-03-08	皮膚外用剤
JPH049325A (ja)	1992-01-14	美白化粧料
JP2004107268A (ja)	2004-04-08	蛋白質のカルボニル化抑制剤、皮膚外用剤及び方法
JP2610310B2 (ja)	1997-05-14	外用剤
JPS61152614A (ja)	1986-07-11	色白化粧料