CA1257203A - Dialyse avec du monophosphoryl lipide a - Google Patents

Dialyse avec du monophosphoryl lipide a

Info

Publication number: CA1257203A
Authority: CA; Canada
Prior art keywords: peritoneal dialysis; dialysis solution; peritoneal; monophosphoryl lipid; solution
Prior art date: 1984-05-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000482739A

Other languages

English (en)

Inventor

Frederick C. Pearson

Mary H. Dulek

Marc G. Salit

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Baxter International Inc

Original Assignee

Baxter Travenol Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1985-05-29

Publication date

1989-07-11

1985-05-29 Application filed by Baxter Travenol Laboratories Inc filed Critical Baxter Travenol Laboratories Inc

1989-07-11 Application granted granted Critical

1989-07-11 Publication of CA1257203A publication Critical patent/CA1257203A/fr

Status Expired legal-status Critical Current

Links

229940035032 monophosphoryl lipid a Drugs 0.000 title claims abstract description 19
238000000502 dialysis Methods 0.000 title claims description 19
239000000385 dialysis solution Substances 0.000 claims abstract description 38
210000003200 peritoneal cavity Anatomy 0.000 claims abstract description 15
206010034674 peritonitis Diseases 0.000 claims abstract description 14
208000024891 symptom Diseases 0.000 claims abstract description 5
238000000034 method Methods 0.000 claims description 7
239000000243 solution Substances 0.000 claims description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
230000000694 effects Effects 0.000 claims description 5
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
239000001110 calcium chloride Substances 0.000 claims description 3
229910001628 calcium chloride Inorganic materials 0.000 claims description 3
239000008121 dextrose Substances 0.000 claims description 3
239000011780 sodium chloride Substances 0.000 claims description 3
239000001540 sodium lactate Substances 0.000 claims description 3
229940005581 sodium lactate Drugs 0.000 claims description 3
235000011088 sodium lactate Nutrition 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
229910001629 magnesium chloride Inorganic materials 0.000 claims description 2
239000002357 osmotic agent Substances 0.000 claims description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
241000699670 Mus sp. Species 0.000 description 8
239000002158 endotoxin Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
108700022034 Opsonin Proteins Proteins 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
229960001031 glucose Drugs 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000003204 osmotic effect Effects 0.000 description 2
230000001629 suppression Effects 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
206010070863 Toxicity to various agents Diseases 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
210000003837 chick embryo Anatomy 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
208000020832 chronic kidney disease Diseases 0.000 description 1
230000001351 cycling effect Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
230000034994 death Effects 0.000 description 1
229960001795 dextrose hydrous Drugs 0.000 description 1
MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000028208 end stage renal disease Diseases 0.000 description 1
201000000523 end stage renal failure Diseases 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
229960002442 glucosamine Drugs 0.000 description 1
229940027941 immunoglobulin g Drugs 0.000 description 1
239000000367 immunologic factor Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
231100000225 lethality Toxicity 0.000 description 1
150000004668 long chain fatty acids Chemical class 0.000 description 1
210000004379 membrane Anatomy 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Engineering & Computer Science (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000482739A 1984-05-30 1985-05-29 Dialyse avec du monophosphoryl lipide a Expired CA1257203A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61541284A	1984-05-30	1984-05-30
US615,412		1984-05-31

Publications (1)

Publication Number	Publication Date
CA1257203A true CA1257203A (fr)	1989-07-11

Family

ID=24465263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000482739A Expired CA1257203A (fr)	1984-05-30	1985-05-29	Dialyse avec du monophosphoryl lipide a

Country Status (4)

Country	Link
EP (1)	EP0183773A4 (fr)
JP (1)	JPS61502234A (fr)
CA (1)	CA1257203A (fr)
WO (1)	WO1985005555A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4976683A (en) *	1986-06-20	1990-12-11	Abbott Laboratories	Peritoneal dialysis method
WO2000042994A2 (fr) *	1999-01-21	2000-07-27	North Shore-Long Island Jewish Research Institute	Inhibition de la dissemination de bacteries

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4148877A (en) *	1975-12-29	1979-04-10	Choay S. A.	Fraction capable of inducing in vivo a resistance to bacterial infections, process for obtaining said fraction from bacteria and drugs containing said fraction
US4335716A (en) *	1979-02-12	1982-06-22	University Of Utah Research Foundation	Composition and method for prevention and treatment of dialysis induced peritonitis

1985
- 1985-05-09 WO PCT/US1985/000842 patent/WO1985005555A1/fr not_active Ceased
- 1985-05-09 EP EP19850902767 patent/EP0183773A4/fr not_active Withdrawn
- 1985-05-09 JP JP60502363A patent/JPS61502234A/ja active Pending
- 1985-05-29 CA CA000482739A patent/CA1257203A/fr not_active Expired

Also Published As

Publication number	Publication date
EP0183773A1 (fr)	1986-06-11
WO1985005555A1 (fr)	1985-12-19
EP0183773A4 (fr)	1988-06-20
JPS61502234A (ja)	1986-10-09

Legal Events

Date	Code	Title	Description
2006-07-11	MKEX	Expiry

Publication	Publication Date	Title
EP2322236B1 (fr)	2012-09-12	Solutions à base de bicarbonate pour thérapies de dialyse
EP0456806B1 (fr)	1996-12-11	Solution de dialyse peritoneale tamponnee a l'histidine
US5906978A (en)	1999-05-25	Method for iron delivery to a patient by transfer from dialysate
Yolken et al.	1976	Acute fluoride poisoning
US4906616A (en)	1990-03-06	Hydrolyzed sodium casein compositions for dialysis procedures
EP0078832A1 (fr)	1983-05-18	Solution de dialyse contenant du glycerol.
JP3676362B2 (ja)	2005-07-27	ポリペプチドを含んだ改良された腹膜透析液
Murphy et al.	1979	A case of poisoning with mercuric chloride
Satta et al.	1988	Evaluation of ceftriaxone and other antibiotics against Escherichia coli, Pseudomonas aeruginosa, and Streptococcus pneumoniae under in vitro conditions simulating those of serious infections
KR101338766B1 (ko)	2013-12-06	복막 투석액
WO1985005555A1 (fr)	1985-12-19	Dialyse avec lipide monophosphoryle a
Finnegan et al.	1981	Overwhelming post-splenectomy infection with group B Streptococcus
SE448882B (sv)	1987-03-23	Forfarande for utvinning av myeloperoxidas och farmaceutisk komposition innehallande enzymet
Davies	1987	Paraquat poisoning: the rationale for current treatment regimes
CA1219212A (fr)	1987-03-17	Opsonines utilisees en dialyse peritoneale
US4335716A (en)	1982-06-22	Composition and method for prevention and treatment of dialysis induced peritonitis
Ing et al.	1992	Peritoneal dialysis using conventional, lactate-containing solution sterilized by ultrafiltration
KR20020031404A (ko)	2002-05-01	혈장 대체 조성물
Golper et al.	1984	Incomplete activation of intraperitoneal clindamycin phosphate during peritoneal dialysis
Page, PF, Kallmeyer, JC & Malherbe	1968	Modification of Britton's technique for the treatment of intractable cirrhotic ascites
Pleshakov	1999	Peritoneal sorption and lymphotropic therapy of postoperative diffuse purulent peritonitis
JPS59501983A (ja)	1984-11-29	腹膜透析におけるオプソニン