CA1268183A - Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques - Google Patents

Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques

Info

Publication number: CA1268183A
Authority: CA; Canada
Prior art keywords: compounds; intermediates; phosphorane; penem antibiotics; easily removable
Prior art date: 1978-12-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000423146A

Other languages

English (en)

Inventor

Marcel Menard

Alain Martel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-12-18

Filing date

1983-03-08

Publication date

1990-04-24

1983-03-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1983-03-08 Priority to CA000423146A priority Critical patent/CA1268183A/fr

1990-04-24 Application granted granted Critical

1990-04-24 Publication of CA1268183A publication Critical patent/CA1268183A/fr

2007-04-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Saccharide Compounds (AREA)

CA000423146A 1978-12-18 1983-03-08 Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques Expired - Fee Related CA1268183A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000423146A CA1268183A (fr)	1978-12-18	1983-03-08	Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US96866378A	1978-12-18	1978-12-18
CA000342069A CA1286661C (fr)	1978-12-18	1979-12-17	Composes de type penem disubstitues en 2,6
CA000423146A CA1268183A (fr)	1978-12-18	1983-03-08	Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000342069A Division CA1286661C (fr)	1978-12-18	1979-12-17	Composes de type penem disubstitues en 2,6

Publications (1)

Publication Number	Publication Date
CA1268183A true CA1268183A (fr)	1990-04-24

Family

ID=25514601

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CA000342069A Expired - Fee Related CA1286661C (fr)	1978-12-18	1979-12-17	Composes de type penem disubstitues en 2,6
CA000423146A Expired - Fee Related CA1268183A (fr)	1978-12-18	1983-03-08	Intermediaires du phosphorane utilises dans la preparation de penems antibiotiques

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CA000342069A Expired - Fee Related CA1286661C (fr)	1978-12-18	1979-12-17	Composes de type penem disubstitues en 2,6

Country Status (13)

Country	Link
JP (1)	JPS60222486A (fr)
AU (4)	AU541717B2 (fr)
CA (2)	CA1286661C (fr)
CH (2)	CH643265A5 (fr)
DK (5)	DK161520C (fr)
ES (1)	ES487034A0 (fr)
FI (2)	FI69845C (fr)
GR (2)	GR81420B (fr)
IE (3)	IE49876B1 (fr)
IL (2)	IL58576A (fr)
SE (5)	SE448995B (fr)
YU (4)	YU43628B (fr)
ZA (2)	ZA796813B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8509180D0 (en) *	1985-04-10	1985-05-15	Erba Farmitalia	Penem derivatives
US4826832A (en) *	1986-05-06	1989-05-02	Ciba-Geigy Corporation	Penen compounds
HUP9602872A3 (en) *	1995-02-17	1999-03-01	Daiichi Asubio Pharma Co Ltd	Penem derivatives and antimicrobial agent containing the same
KR20000076105A (ko)	1998-01-13	2000-12-26	도리이 신이찌로	항생제를 함유한 국소 투여용 항균 조성물
JP2005239696A (ja)	2004-01-30	2005-09-08	Daiichi Suntory Pharma Co Ltd	無機物質を配合した医薬硬質カプセル剤
CN112746066B (zh) *	2021-01-25	2023-10-31	洛阳华荣生物技术有限公司	一种l-赖氨酸脱羧酶突变体及其应用

1979
- 1979-10-29 IL IL58576A patent/IL58576A/xx unknown
- 1979-11-07 GR GR60450A patent/GR81420B/el unknown
- 1979-11-12 YU YU2760/79A patent/YU43628B/xx unknown
- 1979-11-26 IL IL58804A patent/IL58804A/xx unknown
- 1979-11-29 GR GR60633A patent/GR74491B/el unknown
- 1979-12-10 JP JP79159315D patent/JPS60222486A/ja active Pending
- 1979-12-11 AU AU53710/79A patent/AU541717B2/en not_active Ceased
- 1979-12-13 FI FI793903A patent/FI69845C/fi not_active IP Right Cessation
- 1979-12-13 AU AU53787/79A patent/AU539983B2/en not_active Ceased
- 1979-12-13 FI FI793905A patent/FI67853C/fi not_active IP Right Cessation
- 1979-12-14 DK DK533779A patent/DK161520C/da not_active IP Right Cessation
- 1979-12-14 ZA ZA00796813A patent/ZA796813B/xx unknown
- 1979-12-14 DK DK533879A patent/DK533879A/da not_active Application Discontinuation
- 1979-12-14 ZA ZA00796812A patent/ZA796812B/xx unknown
- 1979-12-17 YU YU3076/79A patent/YU43464B/xx unknown
- 1979-12-17 CA CA000342069A patent/CA1286661C/fr not_active Expired - Fee Related
- 1979-12-17 SE SE7910391A patent/SE448995B/sv not_active IP Right Cessation
- 1979-12-17 SE SE7910390A patent/SE454779B/sv not_active IP Right Cessation
- 1979-12-18 IE IE2462/79A patent/IE49876B1/en unknown
- 1979-12-18 IE IE2246/85A patent/IE49877B1/en unknown
- 1979-12-18 IE IE1853/85A patent/IE50597B1/en unknown
- 1979-12-18 CH CH1121979A patent/CH643265A5/de not_active IP Right Cessation
- 1979-12-18 ES ES487034A patent/ES487034A0/es active Granted
- 1979-12-18 CH CH1121879A patent/CH643846A5/de not_active IP Right Cessation
1982
- 1982-09-27 YU YU2153/82A patent/YU43280B/xx unknown
- 1982-09-27 YU YU2157/82A patent/YU42125B/xx unknown
1983
- 1983-03-08 CA CA000423146A patent/CA1268183A/fr not_active Expired - Fee Related
1984
- 1984-08-24 AU AU32408/84A patent/AU557545B2/en not_active Ceased
- 1984-09-10 AU AU32884/84A patent/AU563015B2/en not_active Ceased
- 1984-11-14 SE SE8405719A patent/SE461395B/sv not_active IP Right Cessation
- 1984-11-19 SE SE8405813A patent/SE464027B/sv not_active IP Right Cessation
- 1984-11-19 SE SE8405812A patent/SE8405812L/xx not_active Application Discontinuation
1990
- 1990-10-01 DK DK237690A patent/DK237690A/da not_active Application Discontinuation
- 1990-10-01 DK DK236590A patent/DK161970C/da not_active IP Right Cessation
1991
- 1991-07-15 DK DK911352A patent/DK135291D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
SE448995B (sv)	1987-03-30
AU5371079A (en)	1980-06-26
DK161970B (da)	1991-09-02
IL58576A (en)	1985-12-31
IE792462L (en)	1980-06-18
FI793905A7 (fi)	1980-06-19
SE8405813L (sv)	1984-11-19
AU563015B2 (en)	1987-06-25
SE8405719L (sv)	1984-11-14
AU5378779A (en)	1980-08-28
AU3240884A (en)	1984-12-13
ES8101594A1 (es)	1980-12-16
SE8405719D0 (sv)	1984-11-14
DK236590D0 (da)	1990-10-01
GR81420B (fr)	1984-12-11
DK161970C (da)	1992-02-03
ZA796812B (en)	1981-05-27
DK161520C (da)	1991-12-23
IL58804A0 (en)	1980-02-29
YU307679A (en)	1983-02-28
IE50597B1 (en)	1986-05-28
YU276079A (en)	1983-02-28
FI793903A7 (fi)	1980-06-19
DK237690D0 (da)	1990-10-01
ES487034A0 (es)	1980-12-16
DK236590A (da)	1990-10-01
IE49876B1 (en)	1986-01-08
DK161520B (da)	1991-07-15
IL58804A (en)	1986-03-31
GR74491B (fr)	1984-06-28
FI69845B (fi)	1985-12-31
YU43280B (en)	1989-06-30
SE8405813D0 (sv)	1984-11-19
SE461395B (sv)	1990-02-12
SE464027B (sv)	1991-02-25
YU43628B (en)	1989-10-31
IE851853L (en)	1980-06-18
YU43464B (en)	1989-08-31
IE49877B1 (en)	1986-01-08
YU42125B (en)	1988-04-30
YU215782A (en)	1983-06-30
AU557545B2 (en)	1986-12-24
IL58576A0 (en)	1980-01-31
SE8405812D0 (sv)	1984-11-19
FI67853C (fi)	1985-06-10
DK135291A (da)	1991-07-15
AU541717B2 (en)	1985-01-17
AU3288484A (en)	1985-03-07
SE7910391L (sv)	1981-06-18
SE454779B (sv)	1988-05-30
DK135291D0 (da)	1991-07-15
IE852246L (en)	1980-06-18
DK533879A (da)	1980-06-19
CH643265A5 (en)	1984-05-30
AU539983B2 (en)	1984-10-25
SE8405812L (sv)	1984-11-19
DK533779A (da)	1980-06-19
DK237690A (da)	1990-10-01
CA1286661C (fr)	1991-07-23
FI67853B (fi)	1985-02-28
JPS60222486A (ja)	1985-11-07
SE7910390L (sv)	1981-06-18
CH643846A5 (en)	1984-06-29
YU215382A (en)	1983-06-30
ZA796813B (en)	1981-05-27
FI69845C (fi)	1986-05-26

Legal Events

Date	Code	Title	Description
1992-10-26	MKLA	Lapsed

Publication	Publication Date	Title
YU47099B (sh)	1994-12-28	Postupak za dobijanje makrolidnih jedinjenja
SE7907811L (sv)	1979-09-20	Azetidinylforening for framstellning av cefemforeningar och forfarande for dess framstellning
IE820753L (en)	1982-09-30	Acyl dipeptides
ES474289A1 (es)	1979-11-01	Un procedimiento para la preparacion de derivados del acido 6-(1'-hidroxietil)-7-oxi-1-aza-biciclo(3,2,0)hept-2-en -2- carboxilico-3-sustutuidos
ES455089A1 (es)	1978-04-16	Procedimiento de preparacion de nuevas oximas derivadas del acido 7-aminotioazolil-acetamido-cefalosporanico.
IE41528L (en)	1975-04-27	Furfuryl-benzomorphane derivatives.
GB2006195A (en)	1979-05-02	2-Azetidinone Derivatives
ES2012507A6 (es)	1990-04-01	Un procedimiento para la preparacion de derivados de b-lactama.
ES482504A1 (es)	1980-04-01	Un procedimiento para la preparacion de derivados peptidicos
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
SE7906011L (sv)	1980-02-03	Nya imidazokinoxaliner och salter derav, sett for framstellning och anvendning derav sasom lekemedel samt farmaceutiska kompositioner innehallande dessa foreningar
GB1427139A (en)	1976-03-10	Penicillins
SE7910391L (sv)	1981-06-18	Antibakteriella medel
ES8106903A1 (es)	1981-10-01	Procedimiento de preparar compuestos de acido benzo(ij)qui- nolicin-2-carboxilico
GB1169945A (en)	1969-11-05	Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
ES8303397A1 (es)	1983-02-01	Un procedimiento para la preparacion de nuevos derivados de quinoleinetanol o quinoleinpropanol utiles como medicamentos
ES442217A1 (es)	1977-07-01	Procedimiento para la obtencion de derivados cefem.
ES431673A1 (es)	1976-11-16	Un procedimiento para la preparacion de compuestos de 7- acilamido-7-metoxi-cefalosporina.
ES8305730A1 (es)	1983-04-16	Un procedimiento para la preparacion de un derivado del imidazol.
SE7902354L (sv)	1979-09-17	Nya fungicida kompositioner for bekempning av svampsjukdomar hos vexter och innehaller sasom verksam bestandsdel isotiouroniumfosfiter
ES8305742A1 (es)	1983-04-16	Un procedimiento para la preparacion de un derivado de tetrazol.
ES8105330A1 (es)	1981-06-01	Un procedimiento para la preparacion de derivados de tiazolo(2,3-b)benzo(y azobenzo)tiazol
HUT38907A (en)	1986-07-28	Process for preparing 2-pyridine-thiol-derivatives
ES8301479A1 (es)	1982-05-01	Un procedimiento para la preparacion de antibioticos de b-lactama.
IE820238L (en)	1982-08-04	Carbapenem derivatives