CA1273399A - Dispositif pour mesurer les liquides biologiques - Google Patents

Dispositif pour mesurer les liquides biologiques

Info

Publication number: CA1273399A
Authority: CA; Canada
Prior art keywords: membrane; biological fluid; measuring device; fluid measuring; electrodes
Prior art date: 1986-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000534440A

Other languages

English (en)

Inventor

Mark C. Shults

Stuart J. Updike

Christopher C. Capelli

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Markwell Medical Institute Inc

Original Assignee

Markwell Medical Institute Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-15

Filing date

1987-04-10

Publication date

1990-08-28

1987-04-10 Application filed by Markwell Medical Institute Inc filed Critical Markwell Medical Institute Inc

1990-08-28 Application granted granted Critical

1990-08-28 Publication of CA1273399A publication Critical patent/CA1273399A/fr

2007-08-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000013060 biological fluid Substances 0.000 title claims abstract description 41
239000012528 membrane Substances 0.000 claims abstract description 127
239000000126 substance Substances 0.000 claims abstract description 58
229920001400 block copolymer Polymers 0.000 claims description 22
102000004190 Enzymes Human genes 0.000 claims description 21
108090000790 Enzymes Proteins 0.000 claims description 21
239000000463 material Substances 0.000 claims description 17
230000002209 hydrophobic effect Effects 0.000 claims description 6
238000007789 sealing Methods 0.000 claims description 2
239000012080 ambient air Substances 0.000 claims 2
239000012530 fluid Substances 0.000 abstract description 8
238000010790 dilution Methods 0.000 abstract description 2
239000012895 dilution Substances 0.000 abstract description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 32
239000008103 glucose Substances 0.000 description 32
239000000523 sample Substances 0.000 description 25
229940088598 enzyme Drugs 0.000 description 22
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 18
-1 polyethylene Polymers 0.000 description 18
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
239000011148 porous material Substances 0.000 description 14
229920000642 polymer Polymers 0.000 description 12
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 11
238000009792 diffusion process Methods 0.000 description 11
239000008280 blood Substances 0.000 description 9
210000004369 blood Anatomy 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 9
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238000004458 analytical method Methods 0.000 description 8
238000005259 measurement Methods 0.000 description 8
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BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 7
238000000034 method Methods 0.000 description 7
239000001301 oxygen Substances 0.000 description 7
229910052760 oxygen Inorganic materials 0.000 description 7
229910052709 silver Inorganic materials 0.000 description 6
239000004332 silver Substances 0.000 description 6
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 5
229910021607 Silver chloride Inorganic materials 0.000 description 5
150000002334 glycols Chemical class 0.000 description 5
230000035699 permeability Effects 0.000 description 5
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
230000004888 barrier function Effects 0.000 description 4
238000006911 enzymatic reaction Methods 0.000 description 4
239000011521 glass Substances 0.000 description 4
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238000000926 separation method Methods 0.000 description 4
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238000012546 transfer Methods 0.000 description 4
UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 3
229920000298 Cellophane Polymers 0.000 description 3
102000008186 Collagen Human genes 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 3
108010015776 Glucose oxidase Proteins 0.000 description 3
239000004698 Polyethylene Substances 0.000 description 3
239000004743 Polypropylene Substances 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000005540 biological transmission Effects 0.000 description 3
239000007795 chemical reaction product Substances 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
238000013461 design Methods 0.000 description 3
206010012601 diabetes mellitus Diseases 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
235000012208 gluconic acid Nutrition 0.000 description 3
239000000174 gluconic acid Substances 0.000 description 3
150000002500 ions Chemical class 0.000 description 3
229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
229920002401 polyacrylamide Polymers 0.000 description 3
239000004417 polycarbonate Substances 0.000 description 3
229920000515 polycarbonate Polymers 0.000 description 3
229920000573 polyethylene Polymers 0.000 description 3
239000004926 polymethyl methacrylate Substances 0.000 description 3
229920001155 polypropylene Polymers 0.000 description 3
229920000915 polyvinyl chloride Polymers 0.000 description 3
239000004800 polyvinyl chloride Substances 0.000 description 3
230000008569 process Effects 0.000 description 3
229920005573 silicon-containing polymer Polymers 0.000 description 3
BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 3
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
108010015133 Galactose oxidase Proteins 0.000 description 2
239000004366 Glucose oxidase Substances 0.000 description 2
108090000854 Oxidoreductases Proteins 0.000 description 2
102000004316 Oxidoreductases Human genes 0.000 description 2
ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 description 2
108010092464 Urate Oxidase Proteins 0.000 description 2
238000013459 approach Methods 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
239000012472 biological sample Substances 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
239000010839 body fluid Substances 0.000 description 2
238000006555 catalytic reaction Methods 0.000 description 2
229920002301 cellulose acetate Polymers 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
125000005442 diisocyanate group Chemical group 0.000 description 2
150000002009 diols Chemical class 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000010528 free radical solution polymerization reaction Methods 0.000 description 2
230000006870 function Effects 0.000 description 2
229940116332 glucose oxidase Drugs 0.000 description 2
235000019420 glucose oxidase Nutrition 0.000 description 2
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
230000006872 improvement Effects 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
208000030159 metabolic disease Diseases 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920003226 polyurethane urea Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000000638 solvent extraction Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
LJCNDNBULVLKSG-UHFFFAOYSA-N 2-aminoacetic acid;butane Chemical compound CCCC.CCCC.NCC(O)=O LJCNDNBULVLKSG-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
108010025188 Alcohol oxidase Proteins 0.000 description 1
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
108010089254 Cholesterol oxidase Proteins 0.000 description 1
102000004674 D-amino-acid oxidase Human genes 0.000 description 1
108010003989 D-amino-acid oxidase Proteins 0.000 description 1
101100130497 Drosophila melanogaster Mical gene Proteins 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
108010008292 L-Amino Acid Oxidase Proteins 0.000 description 1
102000007070 L-amino-acid oxidase Human genes 0.000 description 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
108010093894 Xanthine oxidase Proteins 0.000 description 1
102100033220 Xanthine oxidase Human genes 0.000 description 1
BWVAOONFBYYRHY-UHFFFAOYSA-N [4-(hydroxymethyl)phenyl]methanol Chemical group OCC1=CC=C(CO)C=C1 BWVAOONFBYYRHY-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
PMMYEEVYMWASQN-IMJSIDKUSA-N cis-4-Hydroxy-L-proline Chemical compound O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 description 1
238000010276 construction Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
FOTKYAAJKYLFFN-UHFFFAOYSA-N decane-1,10-diol Chemical compound OCCCCCCCCCCO FOTKYAAJKYLFFN-UHFFFAOYSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
238000003487 electrochemical reaction Methods 0.000 description 1
230000002996 emotional effect Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940012017 ethylenediamine Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
108010004902 lactose oxidase Proteins 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
239000000178 monomer Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000012811 non-conductive material Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
125000006353 oxyethylene group Chemical group 0.000 description 1
238000003909 pattern recognition Methods 0.000 description 1
239000012466 permeate Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000007747 plating Methods 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
235000015277 pork Nutrition 0.000 description 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
GGHDAUPFEBTORZ-UHFFFAOYSA-N propane-1,1-diamine Chemical compound CCC(N)N GGHDAUPFEBTORZ-UHFFFAOYSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000007873 sieving Methods 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
238000005245 sintering Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000002352 surface water Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
101150019895 thiE gene Proteins 0.000 description 1
DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
238000012549 training Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
150000003673 urethanes Chemical class 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Electrochemistry (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Optics & Photonics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Medical Informatics (AREA)
Surgery (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Investigating Or Analysing Biological Materials (AREA)

CA000534440A 1986-04-15 1987-04-10 Dispositif pour mesurer les liquides biologiques Expired - Fee Related CA1273399A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US852,343		1977-11-17
US85234686A	1986-04-15	1986-04-15
US85234386A	1986-04-15	1986-04-15
US852,346		1986-04-15

Publications (1)

Publication Number	Publication Date
CA1273399A true CA1273399A (fr)	1990-08-28

Family

ID=27127062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000534440A Expired - Fee Related CA1273399A (fr)	1986-04-15	1987-04-10	Dispositif pour mesurer les liquides biologiques

Country Status (4)

Country	Link
EP (1)	EP0267236A4 (fr)
AU (1)	AU7354987A (fr)
CA (1)	CA1273399A (fr)
WO (1)	WO1987006342A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1307825C (fr) *	1987-12-09	1992-09-22	Michael H. Burnam	Methode et appareil pour l'analyse du sang par dosage unique
CA1299653C (fr) *	1988-07-07	1992-04-28	Markwell Medical Institute, Inc.	Appareil de mesure des liquides biologiques
DE4139121C1 (fr) *	1991-11-28	1993-06-03	Petermann, Geb. Hirsch, Heike, 8520 Erlangen, De
FR2691248A1 (fr) *	1992-05-12	1993-11-19	Bayer Diagnostics	Procédé de surveillance d'une grandeur physique, système convenant à la mise en Óoeuvre de ce procédé, et boîtier compact faisant partie de ce système.
FR2691249A1 (fr) *	1992-05-12	1993-11-19	Bayer Diagnostics	Procédé de surveillance d'une grandeur physique, système convenant à la mise en Óoeuvre de ce procédé, et boîtier compact faisant partie de ce système.
US20190357827A1 (en)	2003-08-01	2019-11-28	Dexcom, Inc.	Analyte sensor
US7920906B2 (en)	2005-03-10	2011-04-05	Dexcom, Inc.	System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en)	2004-07-13	2016-02-02	Dexcom, Inc.	Analyte sensor
ATE480761T1 (de)	2003-12-05	2010-09-15	Dexcom Inc	Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor
US8532730B2 (en)	2006-10-04	2013-09-10	Dexcom, Inc.	Analyte sensor
US8364231B2 (en)	2006-10-04	2013-01-29	Dexcom, Inc.	Analyte sensor
US11633133B2 (en)	2003-12-05	2023-04-25	Dexcom, Inc.	Dual electrode system for a continuous analyte sensor
US8423114B2 (en)	2006-10-04	2013-04-16	Dexcom, Inc.	Dual electrode system for a continuous analyte sensor
US8989833B2 (en)	2004-07-13	2015-03-24	Dexcom, Inc.	Transcutaneous analyte sensor
US9149220B2 (en)	2011-04-15	2015-10-06	Dexcom, Inc.	Advanced analyte sensor calibration and error detection
JP5705075B2 (ja) *	2011-09-20	2015-04-22	日立マクセル株式会社	電極保護体

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Publication number	Priority date	Publication date	Assignee	Title
GB1442303A (en) *	1972-09-08	1976-07-14	Radiometer As	Cell for electro-chemical analysis
US3979274A (en) *	1975-09-24	1976-09-07	The Yellow Springs Instrument Company, Inc.	Membrane for enzyme electrodes
JPS5921500B2 (ja) *	1978-01-28	1984-05-21	東洋紡績株式会社	酸素電極用酵素膜
US4225410A (en) *	1978-12-04	1980-09-30	Technicon Instruments Corporation	Integrated array of electrochemical sensors
JPS5627643A (en) *	1979-08-14	1981-03-18	Toshiba Corp	Electrochemical measuring device
US4404066A (en) *	1980-08-25	1983-09-13	The Yellow Springs Instrument Company	Method for quantitatively determining a particular substrate catalyzed by a multisubstrate enzyme
IE51643B1 (en) *	1980-10-15	1987-01-21	Smith & Nephew Ass	Coated articles and materials suitable for coating
US4418148A (en) *	1981-11-05	1983-11-29	Miles Laboratories, Inc.	Multilayer enzyme electrode membrane

1987
- 1987-04-10 WO PCT/US1987/000822 patent/WO1987006342A1/fr not_active Ceased
- 1987-04-10 CA CA000534440A patent/CA1273399A/fr not_active Expired - Fee Related
- 1987-04-10 EP EP19870903096 patent/EP0267236A4/en not_active Withdrawn
- 1987-04-10 AU AU73549/87A patent/AU7354987A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0267236A4 (en)	1990-10-10
EP0267236A1 (fr)	1988-05-18
WO1987006342A1 (fr)	1987-10-22
AU7354987A (en)	1987-11-09

Legal Events

Date	Code	Title	Description
1994-02-28	MKLA	Lapsed

Publication	Publication Date	Title
US4994167A (en)	1991-02-19	Biological fluid measuring device
CA1299653C (fr)	1992-04-28	Appareil de mesure des liquides biologiques
US4757022A (en)	1988-07-12	Biological fluid measuring device
CA1273399A (fr)	1990-08-28	Dispositif pour mesurer les liquides biologiques
WO1992013271A1 (fr)	1992-08-06	Dispositif implantable de mesure de liquides biologiques
CA2079748C (fr)	2003-09-30	Membranes hydrophiles de polyurethane pour detecteurs electrochimiques du glucose.
US5284140A (en)	1994-02-08	Acrylic copolymer membranes for biosensors
AU734003B2 (en)	2001-05-31	Implantable sensor employing an auxiliary electrode
US4415666A (en)	1983-11-15	Enzyme electrode membrane
CA2567899C (fr)	2014-07-15	Detecteurs d'analyte et procedes de fabrication et d'utilisation de ces detecteurs
US6214185B1 (en)	2001-04-10	Sensor with PVC cover membrane
US5773270A (en)	1998-06-30	Three-layered membrane for use in an electrochemical sensor system
EP0948743B1 (fr)	2009-03-25	Detecteur de glucose
EP1411823B1 (fr)	2006-07-12	Tete d'analyse pour dispositifs implantables
JPH11503772A (ja)	1999-03-30	バイオセンサー膜のためのシリコーンを含むポリウレタン／ポリ尿素組成物
CA1067457A (fr)	1979-12-04	Membrane pour electrodes a enzyme
US5567290A (en)	1996-10-22	Sensor devices
CN113083647A (zh)	2021-07-09	聚合物扩散限制膜层及其制备方法和葡萄糖传感器
CA1215660A (fr)	1986-12-23	Membrane pour electrode renfermant une enzyme protegee par encapsulage
US12376772B2 (en)	2025-08-05	Diabetes biosensor
Chan et al.	1988	An electropolymerized membrane for a glucose sensor