CA1299653C - Appareil de mesure des liquides biologiques - Google Patents

Appareil de mesure des liquides biologiques

Info

Publication number: CA1299653C
Authority: CA; Canada
Prior art keywords: membrane; biological fluid; measuring device; electrode; electrodes
Prior art date: 1988-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000604867A

Other languages

English (en)

Inventor

Mark C. Shults

Stuart J. Updike

Christopher C. Capelli

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Markwell Medical Institute Inc

Original Assignee

Markwell Medical Institute Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-07

Filing date

1989-07-05

Publication date

1992-04-28

1988-07-07 Priority claimed from US07/216,683 external-priority patent/US4994167A/en

1989-07-05 Application filed by Markwell Medical Institute Inc filed Critical Markwell Medical Institute Inc

1992-04-28 Application granted granted Critical

1992-04-28 Publication of CA1299653C publication Critical patent/CA1299653C/fr

2009-07-05 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000013060 biological fluid Substances 0.000 title claims abstract description 88
239000012528 membrane Substances 0.000 claims abstract description 254
239000000126 substance Substances 0.000 claims abstract description 68
238000000576 coating method Methods 0.000 claims abstract description 33
230000003204 osmotic effect Effects 0.000 claims abstract description 33
239000011248 coating agent Substances 0.000 claims abstract description 29
102000004190 Enzymes Human genes 0.000 claims abstract description 22
108090000790 Enzymes Proteins 0.000 claims abstract description 22
239000012530 fluid Substances 0.000 claims abstract description 13
238000010790 dilution Methods 0.000 claims abstract description 7
239000012895 dilution Substances 0.000 claims abstract description 7
229920001400 block copolymer Polymers 0.000 claims description 21
239000000463 material Substances 0.000 claims description 21
239000002357 osmotic agent Substances 0.000 claims description 16
239000007788 liquid Substances 0.000 claims description 13
238000012545 processing Methods 0.000 claims description 13
239000000047 product Substances 0.000 claims description 11
239000003792 electrolyte Substances 0.000 claims description 10
238000003860 storage Methods 0.000 claims description 10
230000002209 hydrophobic effect Effects 0.000 claims description 8
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 8
229910052753 mercury Inorganic materials 0.000 claims description 8
239000012466 permeate Substances 0.000 claims description 7
210000001124 body fluid Anatomy 0.000 claims description 4
239000010839 body fluid Substances 0.000 claims description 4
238000007789 sealing Methods 0.000 claims description 3
229920003169 water-soluble polymer Polymers 0.000 claims description 3
239000012080 ambient air Substances 0.000 claims 4
239000012088 reference solution Substances 0.000 claims 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 33
239000008103 glucose Substances 0.000 description 33
239000000523 sample Substances 0.000 description 30
229920000642 polymer Polymers 0.000 description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
229940088598 enzyme Drugs 0.000 description 23
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 21
-1 polyethylene Polymers 0.000 description 21
229920002635 polyurethane Polymers 0.000 description 21
239000004814 polyurethane Substances 0.000 description 21
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 20
229920000036 polyvinylpyrrolidone Polymers 0.000 description 15
239000001267 polyvinylpyrrolidone Substances 0.000 description 15
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 15
238000009792 diffusion process Methods 0.000 description 14
239000011148 porous material Substances 0.000 description 14
239000007787 solid Substances 0.000 description 14
239000000243 solution Substances 0.000 description 13
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 11
238000005259 measurement Methods 0.000 description 11
238000000034 method Methods 0.000 description 11
230000035945 sensitivity Effects 0.000 description 11
239000008280 blood Substances 0.000 description 10
210000004369 blood Anatomy 0.000 description 10
229920001577 copolymer Polymers 0.000 description 9
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 9
229920001223 polyethylene glycol Polymers 0.000 description 9
238000004458 analytical method Methods 0.000 description 8
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
238000006243 chemical reaction Methods 0.000 description 7
239000007795 chemical reaction product Substances 0.000 description 7
239000001301 oxygen Substances 0.000 description 7
229910052760 oxygen Inorganic materials 0.000 description 7
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
239000008199 coating composition Substances 0.000 description 6
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239000004332 silver Substances 0.000 description 6
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 5
239000004698 Polyethylene Substances 0.000 description 5
229910021607 Silver chloride Inorganic materials 0.000 description 5
150000001718 carbodiimides Chemical class 0.000 description 5
150000007942 carboxylates Chemical group 0.000 description 5
239000006185 dispersion Substances 0.000 description 5
238000006911 enzymatic reaction Methods 0.000 description 5
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238000000926 separation method Methods 0.000 description 5
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
239000002904 solvent Substances 0.000 description 5
UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
108010015776 Glucose oxidase Proteins 0.000 description 4
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 4
230000004888 barrier function Effects 0.000 description 4
239000011521 glass Substances 0.000 description 4
229920001519 homopolymer Polymers 0.000 description 4
229920005573 silicon-containing polymer Polymers 0.000 description 4
230000008961 swelling Effects 0.000 description 4
238000012546 transfer Methods 0.000 description 4
229920000298 Cellophane Polymers 0.000 description 3
239000004971 Cross linker Substances 0.000 description 3
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 3
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
239000004366 Glucose oxidase Substances 0.000 description 3
239000004721 Polyphenylene oxide Substances 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
125000000129 anionic group Chemical group 0.000 description 3
230000005540 biological transmission Effects 0.000 description 3
238000013461 design Methods 0.000 description 3
206010012601 diabetes mellitus Diseases 0.000 description 3
125000005442 diisocyanate group Chemical group 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
230000006870 function Effects 0.000 description 3
235000012208 gluconic acid Nutrition 0.000 description 3
239000000174 gluconic acid Substances 0.000 description 3
229940116332 glucose oxidase Drugs 0.000 description 3
235000019420 glucose oxidase Nutrition 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
229920002401 polyacrylamide Polymers 0.000 description 3
229920000570 polyether Polymers 0.000 description 3
229920000573 polyethylene Polymers 0.000 description 3
239000004926 polymethyl methacrylate Substances 0.000 description 3
229920000915 polyvinyl chloride Polymers 0.000 description 3
239000004800 polyvinyl chloride Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 3
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
108010015133 Galactose oxidase Proteins 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
108010092464 Urate Oxidase Proteins 0.000 description 2
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
238000013459 approach Methods 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
238000004140 cleaning Methods 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
239000006184 cosolvent Substances 0.000 description 2
150000004985 diamines Chemical class 0.000 description 2
150000002009 diols Chemical class 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000003487 electrochemical reaction Methods 0.000 description 2
238000010528 free radical solution polymerization reaction Methods 0.000 description 2
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
208000030159 metabolic disease Diseases 0.000 description 2
239000000178 monomer Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920000647 polyepoxide Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920003009 polyurethane dispersion Polymers 0.000 description 2
229920003226 polyurethane urea Polymers 0.000 description 2
230000008569 process Effects 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
239000000758 substrate Substances 0.000 description 2
DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
LJCNDNBULVLKSG-UHFFFAOYSA-N 2-aminoacetic acid;butane Chemical compound CCCC.CCCC.NCC(O)=O LJCNDNBULVLKSG-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
108010025188 Alcohol oxidase Proteins 0.000 description 1
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
241000905957 Channa melasoma Species 0.000 description 1
108010089254 Cholesterol oxidase Proteins 0.000 description 1
241001550206 Colla Species 0.000 description 1
102000004674 D-amino-acid oxidase Human genes 0.000 description 1
108010003989 D-amino-acid oxidase Proteins 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
108010008292 L-Amino Acid Oxidase Proteins 0.000 description 1
102000007070 L-amino-acid oxidase Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
229920003082 Povidone K 90 Polymers 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
108010093894 Xanthine oxidase Proteins 0.000 description 1
102100033220 Xanthine oxidase Human genes 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
235000011114 ammonium hydroxide Nutrition 0.000 description 1
238000004164 analytical calibration Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000012472 biological sample Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
238000001246 colloidal dispersion Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000008151 electrolyte solution Substances 0.000 description 1
230000002996 emotional effect Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
229940012017 ethylenediamine Drugs 0.000 description 1
IVJISJACKSSFGE-UHFFFAOYSA-N formaldehyde;1,3,5-triazine-2,4,6-triamine Chemical compound O=C.NC1=NC(N)=NC(N)=N1 IVJISJACKSSFGE-UHFFFAOYSA-N 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000003949 imides Chemical class 0.000 description 1
239000003317 industrial substance Substances 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
108010004902 lactose oxidase Proteins 0.000 description 1
239000004973 liquid crystal related substance Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
231100000647 material safety data sheet Toxicity 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000012811 non-conductive material Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
150000002924 oxiranes Chemical class 0.000 description 1
125000005702 oxyalkylene group Chemical group 0.000 description 1
239000005022 packaging material Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
238000003909 pattern recognition Methods 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000007747 plating Methods 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001692 polycarbonate urethane Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
GGHDAUPFEBTORZ-UHFFFAOYSA-N propane-1,1-diamine Chemical compound CCC(N)N GGHDAUPFEBTORZ-UHFFFAOYSA-N 0.000 description 1
LLHKCFNBLRBOGN-UHFFFAOYSA-N propylene glycol methyl ether acetate Chemical compound COCC(C)OC(C)=O LLHKCFNBLRBOGN-UHFFFAOYSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000001953 sensory effect Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
238000005245 sintering Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000002352 surface water Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
238000012549 training Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
150000003673 urethanes Chemical class 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Electrochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

CA000604867A 1988-07-07 1989-07-05 Appareil de mesure des liquides biologiques Expired - Fee Related CA1299653C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US21656388A	1988-07-07	1988-07-07
US07/216,683 US4994167A (en)	1986-04-15	1988-07-07	Biological fluid measuring device
US216,683		1988-07-07
US216,563		1988-07-07

Publications (1)

Publication Number	Publication Date
CA1299653C true CA1299653C (fr)	1992-04-28

Family

ID=26911115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000604867A Expired - Fee Related CA1299653C (fr)	1988-07-07	1989-07-05	Appareil de mesure des liquides biologiques

Country Status (5)

Country	Link
EP (1)	EP0423225A4 (fr)
JP (1)	JPH03505783A (fr)
AU (1)	AU3970089A (fr)
CA (1)	CA1299653C (fr)
WO (1)	WO1990000738A1 (fr)

Families Citing this family (64)

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1989
- 1989-07-05 CA CA000604867A patent/CA1299653C/fr not_active Expired - Fee Related
- 1989-07-06 EP EP19890908576 patent/EP0423225A4/en not_active Withdrawn
- 1989-07-06 AU AU39700/89A patent/AU3970089A/en not_active Abandoned
- 1989-07-06 WO PCT/US1989/002978 patent/WO1990000738A1/fr not_active Ceased
- 1989-07-06 JP JP1508060A patent/JPH03505783A/ja active Pending

Also Published As

Publication number	Publication date
AU3970089A (en)	1990-02-05
EP0423225A4 (en)	1993-08-04
WO1990000738A1 (fr)	1990-01-25
EP0423225A1 (fr)	1991-04-24
JPH03505783A (ja)	1991-12-12

Legal Events

Date	Code	Title	Description
1994-10-28	MKLA	Lapsed

Publication	Publication Date	Title
CA1299653C (fr)	1992-04-28	Appareil de mesure des liquides biologiques
US4994167A (en)	1991-02-19	Biological fluid measuring device
US4757022A (en)	1988-07-12	Biological fluid measuring device
WO1992013271A1 (fr)	1992-08-06	Dispositif implantable de mesure de liquides biologiques
CA1273399A (fr)	1990-08-28	Dispositif pour mesurer les liquides biologiques
CA2079748C (fr)	2003-09-30	Membranes hydrophiles de polyurethane pour detecteurs electrochimiques du glucose.
US10154807B2 (en)	2018-12-18	Techniques to improve polyurethane membranes for implantable glucose sensors
US4886740A (en)	1989-12-12	Enzyme-electrode sensor with organosilane treated membrane
EP0625883B1 (fr)	1999-09-22	Biodetecteurs comprenant des membranes a copolymeres acryliques
AU734003B2 (en)	2001-05-31	Implantable sensor employing an auxiliary electrode
US6214185B1 (en)	2001-04-10	Sensor with PVC cover membrane
JP4295615B2 (ja)	2009-07-15	埋設可能なデバイスと一緒に使用するためのセンサヘッド
JP4763777B2 (ja)	2011-08-31	親水性ポリマーで被覆されたカバー膜層を含む酵素センサー
Yu et al.	2005	Coil-type implantable glucose biosensor with excess enzyme loading
Chan et al.	1988	An electropolymerized membrane for a glucose sensor