CA1277594C - Composes ayant une activite semblable a celle de la somatostatine utiles comme agents anti-inflammatoires locaux - Google Patents

Composes ayant une activite semblable a celle de la somatostatine utiles comme agents anti-inflammatoires locaux

Info

Publication number
CA1277594C
CA1277594C CA000507714A CA507714A CA1277594C CA 1277594 C CA1277594 C CA 1277594C CA 000507714 A CA000507714 A CA 000507714A CA 507714 A CA507714 A CA 507714A CA 1277594 C CA1277594 C CA 1277594C
Authority
CA
Canada
Prior art keywords
phe
loweralkyl
compound
formula
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000507714A
Other languages
English (en)
Inventor
Evan R. Morgan
Sanford L. Steelman
Daniel F. Veber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1277594C publication Critical patent/CA1277594C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000507714A 1985-04-29 1986-04-28 Composes ayant une activite semblable a celle de la somatostatine utiles comme agents anti-inflammatoires locaux Expired - Lifetime CA1277594C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/728,019 US4585755A (en) 1985-04-29 1985-04-29 Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
US728,019 1985-04-29

Publications (1)

Publication Number Publication Date
CA1277594C true CA1277594C (fr) 1990-12-11

Family

ID=24925097

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000507714A Expired - Lifetime CA1277594C (fr) 1985-04-29 1986-04-28 Composes ayant une activite semblable a celle de la somatostatine utiles comme agents anti-inflammatoires locaux

Country Status (4)

Country Link
US (1) US4585755A (fr)
EP (1) EP0200188A3 (fr)
JP (1) JPS625921A (fr)
CA (1) CA1277594C (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748153A (en) * 1985-04-29 1988-05-31 Merck & Co., Inc. Compounds having somatostatin-like activity useful as local anti-inflammatory agents
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
EP0222578A3 (fr) * 1985-11-06 1990-04-04 Merck & Co. Inc. Utilisation d'analogues cycliques de la somatostatine pour le traitement des maladies d'hypersensitivité immédiate
IT1208760B (it) * 1986-11-04 1989-07-10 Ind Farmaceutica Serono S P A Trattamento delle malattie infiammatorie articolari
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
WO1995000553A1 (fr) * 1993-06-23 1995-01-05 Diatech, Inc. Peptides radiomarques derives de la somatostatine et utilises dans des procedes d'imagerie et therapeutiques
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5700905A (en) * 1992-09-01 1997-12-23 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US5965694A (en) * 1992-09-01 1999-10-12 The Trustees Of The University Of Pennsylvania Somatostatin mimics and synthetic methods therefor
US6001960A (en) * 1992-09-01 1999-12-14 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
SE9403526D0 (sv) 1994-10-14 1994-10-14 Astra Ab New Peptides
SE9501067D0 (sv) 1995-03-24 1995-03-24 Astra Ab New peptides
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
CA2289499C (fr) * 1997-05-13 2010-02-23 Michael Anthony Cawthorne Somatostatine et agonistes de somatostatine pour traiter l'insensibilite a l'insuline et le syndrome x
CA2290592A1 (fr) * 1997-05-13 1998-11-19 Michael Anthony Cawthorne Somatostatine et agonistes de somatostatine servant a la reduction du poids corporel
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0981364B1 (fr) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Procede et compositions pour traiter l'hyperlipidemie
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
NZ530007A (en) 2001-06-08 2006-02-24 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2523197C (fr) 2003-04-22 2016-05-24 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Vectors de peptide
AU2004238713A1 (en) 2003-05-16 2004-11-25 Sumitomo Electric Industries, Ltd. Oligopeptide
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
WO2009150470A2 (fr) 2008-06-12 2009-12-17 Syntaxin Limited Suppression de cancers
EP2310028B1 (fr) 2008-06-12 2016-11-16 Ipsen Bioinnovation Limited Protéines de fusion pour leur utilisation dans le traitement de l'acromégalie
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
EP2398500B1 (fr) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Sustème d'administration de médicament à base de glutathionne
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012073004A2 (fr) 2010-11-29 2012-06-07 Ian Darby Récipient, découpe de récipient et procédé de fabrication associé
EP3007704B1 (fr) 2013-06-13 2021-01-06 Antisense Therapeutics Ltd Polythérapie pour l'acromégalie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
DE3114824A1 (de) * 1980-05-07 1982-04-08 Gerhard Prof.Dr.med. 8500 Nürnberg Weber "verwendung eines mittels zur behandlung der psoriasis (schuppenflechte)"
US4505897A (en) * 1983-04-18 1985-03-19 The Administrators Of The Tulane Educational Fund Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
JPS625921A (ja) 1987-01-12
US4585755A (en) 1986-04-29
EP0200188A2 (fr) 1986-11-05
EP0200188A3 (fr) 1990-04-04

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