CA1285842C - Systeme de distribution pour l'adminstration d'agents benefiques aux ruminants - Google Patents

Systeme de distribution pour l'adminstration d'agents benefiques aux ruminants

Info

Publication number: CA1285842C
Authority: CA; Canada
Prior art keywords: beneficial agent; formulation; environment; dispensing device; compartment
Prior art date: 1985-08-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000515470A

Other languages

English (en)

Inventor

James B. Eckenhoff

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alza Corp

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-16

Filing date

1986-08-07

Publication date

1991-07-09

1986-08-07 Application filed by Alza Corp filed Critical Alza Corp

1991-07-09 Application granted granted Critical

1991-07-09 Publication of CA1285842C publication Critical patent/CA1285842C/fr

2008-07-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 148
230000009286 beneficial effect Effects 0.000 title claims abstract description 123
238000009472 formulation Methods 0.000 title claims abstract description 96
241000282849 Ruminantia Species 0.000 title description 15
239000003795 chemical substances by application Substances 0.000 claims description 147
239000012530 fluid Substances 0.000 claims description 62
-1 tichlorfan Chemical compound 0.000 claims description 38
229920000642 polymer Polymers 0.000 claims description 35
229920002678 cellulose Polymers 0.000 claims description 34
239000001913 cellulose Substances 0.000 claims description 33
239000000017 hydrogel Substances 0.000 claims description 21
239000000463 material Substances 0.000 claims description 17
229920002301 cellulose acetate Polymers 0.000 claims description 14
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims description 9
229960001614 levamisole Drugs 0.000 claims description 9
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 7
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 7
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RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 6
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VRYKTHBAWRESFI-VOTSOKGWSA-N oxantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CC(O)=C1 VRYKTHBAWRESFI-VOTSOKGWSA-N 0.000 claims description 5
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FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims description 4
YRWLZFXJFBZBEY-UHFFFAOYSA-N N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCCC1=CC=C2N=C(NC(=O)OC)NC2=C1 YRWLZFXJFBZBEY-UHFFFAOYSA-N 0.000 claims description 4
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HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 claims description 4
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IRHZVMHXVHSMKB-UHFFFAOYSA-N fenbendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1SC1=CC=CC=C1 IRHZVMHXVHSMKB-UHFFFAOYSA-N 0.000 claims description 4
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
RCKMWOKWVGPNJF-UHFFFAOYSA-N diethylcarbamazine Chemical compound CCN(CC)C(=O)N1CCN(C)CC1 RCKMWOKWVGPNJF-UHFFFAOYSA-N 0.000 claims 3
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239000008107 starch Substances 0.000 description 1
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239000010959 steel Substances 0.000 description 1
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150000003522 tetracyclines Chemical class 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
229960000344 thiamine hydrochloride Drugs 0.000 description 1
235000019190 thiamine hydrochloride Nutrition 0.000 description 1
239000011747 thiamine hydrochloride Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
FRDNONBEXWDRDM-UHFFFAOYSA-N tris(2-ethylhexyl) 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)(OC(C)=O)CC(=O)OCC(CC)CCCC FRDNONBEXWDRDM-UHFFFAOYSA-N 0.000 description 1
YPDXSCXISVYHOB-UHFFFAOYSA-N tris(7-methyloctyl) benzene-1,2,4-tricarboxylate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCC(C)C)C(C(=O)OCCCCCCC(C)C)=C1 YPDXSCXISVYHOB-UHFFFAOYSA-N 0.000 description 1
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239000011701 zinc Substances 0.000 description 1
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239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Preparation (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Fodder In General (AREA)
Feed For Specific Animals (AREA)
Packages (AREA)
Closures For Containers (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA000515470A 1985-08-16 1986-08-07 Systeme de distribution pour l'adminstration d'agents benefiques aux ruminants Expired - Lifetime CA1285842C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76623585A	1985-08-16	1985-08-16
US766,235		1985-08-16

Publications (1)

Publication Number	Publication Date
CA1285842C true CA1285842C (fr)	1991-07-09

Family

ID=25075818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000515470A Expired - Lifetime CA1285842C (fr)	1985-08-16	1986-08-07	Systeme de distribution pour l'adminstration d'agents benefiques aux ruminants

Country Status (14)

Country	Link
JP (1)	JPH0657222B2 (fr)
AR (1)	AR246177A1 (fr)
AU (1)	AU578374B2 (fr)
BE (1)	BE905283A (fr)
BR (1)	BR8603897A (fr)
CA (1)	CA1285842C (fr)
DE (1)	DE3626559C2 (fr)
ES (1)	ES8800043A1 (fr)
FR (1)	FR2586189B1 (fr)
GB (1)	GB2179252B (fr)
IT (1)	IT1195825B (fr)
NL (1)	NL194715C (fr)
NZ (1)	NZ217122A (fr)
ZA (1)	ZA866176B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960416A (en) *	1986-04-30	1990-10-02	Alza Corporation	Dosage form with improved delivery capability
GB2189702B (en) *	1986-04-30	1989-10-18	Alza Corp	Dosage form with improved delivery capability
US4716496A (en) *	1986-05-09	1987-12-29	Eaton Corporation	Panel-mounted control station housing
GB8630876D0 (en) *	1986-12-24	1987-02-04	Graham N B	Hydrogel-containing envelopes
US4892778A (en) *	1987-05-27	1990-01-09	Alza Corporation	Juxtaposed laminated arrangement
US4874388A (en) *	1987-06-25	1989-10-17	Alza Corporation	Multi-layer delivery system
GB2206046B (en) *	1987-06-25	1991-04-03	Alza Corp	Multi-unit delivery system
US4855141A (en) *	1988-03-25	1989-08-08	Alza Corporation	Device comprising means for protecting and dispensing fluid sensitive medicament
US5034229A (en) *	1988-12-13	1991-07-23	Alza Corporation	Dispenser for increasing feed conversion of hog
ATE129405T1 (de) *	1989-07-18	1995-11-15	Alza Corp	Ionophore enthaltende abgabevorrichtung.
US5156623A (en) *	1990-04-16	1992-10-20	Olympus Optical Co., Ltd.	Sustained release material and method of manufacturing the same
DE4330991A1 (de) *	1993-09-13	1995-03-16	Peter Pelz	Verfahren und Vorrichtung bzw. Mittel zur Applikation von medizinischen bzw. gesundheitsfördernden Mitteln an Tieren
DE10000823A1 (de) *	2000-01-12	2001-07-19	Hartwin Hobler	Einbringen von Gasen in eine Körperflüssigkeit
JP7709914B2 (ja) *	2018-09-10	2025-07-17	アージェンタ・イノベイション・リミテッド	送達装置における放出制御製剤
HUE067496T2 (hu)	2020-12-08	2024-10-28	Ruminant Biotech Corp Ltd	Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1540258A (fr) *	1964-11-30	1968-09-27	Magnesium Elektron Ltd	Pastilles pour ruminants comportant un corps creux en magnésium ou alliage de magnésium
DE2729068A1 (de) *	1977-06-28	1979-01-11	Rainer Dr Med Liedtke	Verfahren zur freisetzungssteuerung von arzneimitteln aus kapseln
US4235236A (en) *	1979-02-12	1980-11-25	Alza Corporation	Device for dispensing drug by combined diffusional and osmotic operations
US4320759A (en) *	1980-04-28	1982-03-23	Alza Corporation	Dispenser with diffuser
US4309996A (en) *	1980-04-28	1982-01-12	Alza Corporation	System with microporous releasing diffusor
IE54171B1 (en) *	1982-06-22	1989-07-05	Univ Glasgow	Device for introducing nutrients and/or therapeutic materials into ruminant animals
NZ206600A (en) *	1983-05-11	1987-01-23	Alza Corp	Osmotic drug delivery device
US4595583A (en) *	1984-03-19	1986-06-17	Alza Corporation	Delivery system controlled administration of beneficial agent to ruminants
JP2648909B2 (ja) *	1985-02-07	1997-09-03	三菱電機株式会社	書込みタイミング補償装置
US4704118A (en) *	1985-08-16	1987-11-03	Alza Corporation	Ruminant dispensing device with thermo-activated memory
US4643731A (en) *	1985-08-16	1987-02-17	Alza Corporation	Means for providing instant agent from agent dispensing system
US4675174A (en) *	1985-08-16	1987-06-23	Alza Corporation	Veterinary dispenser delivering beneficial agent by gas power generated in situ

1986
- 1986-06-24 ES ES556572A patent/ES8800043A1/es not_active Expired
- 1986-08-05 JP JP61184111A patent/JPH0657222B2/ja not_active Expired - Fee Related
- 1986-08-06 DE DE3626559A patent/DE3626559C2/de not_active Expired - Lifetime
- 1986-08-06 FR FR868611373A patent/FR2586189B1/fr not_active Expired - Lifetime
- 1986-08-06 NL NL8602015A patent/NL194715C/nl not_active IP Right Cessation
- 1986-08-06 GB GB8619184A patent/GB2179252B/en not_active Expired
- 1986-08-07 CA CA000515470A patent/CA1285842C/fr not_active Expired - Lifetime
- 1986-08-07 NZ NZ217122A patent/NZ217122A/xx unknown
- 1986-08-08 AU AU61020/86A patent/AU578374B2/en not_active Expired
- 1986-08-14 BE BE0/217051A patent/BE905283A/fr not_active IP Right Cessation
- 1986-08-14 IT IT67663/86A patent/IT1195825B/it active
- 1986-08-15 ZA ZA866176A patent/ZA866176B/xx unknown
- 1986-08-15 BR BR8603897A patent/BR8603897A/pt not_active IP Right Cessation
- 1986-08-15 AR AR86304936A patent/AR246177A1/es active

Also Published As

Publication number	Publication date
BE905283A (fr)	1986-12-01
NZ217122A (en)	1989-06-28
ZA866176B (en)	1987-03-25
AR246177A1 (es)	1994-07-29
ES556572A0 (es)	1987-10-16
IT1195825B (it)	1988-10-27
NL194715C (nl)	2003-01-07
FR2586189B1 (fr)	1990-08-10
FR2586189A1 (fr)	1987-02-20
JPS6244249A (ja)	1987-02-26
IT8667663A0 (it)	1986-08-14
ES8800043A1 (es)	1987-10-16
BR8603897A (pt)	1987-11-17
AU578374B2 (en)	1988-10-20
DE3626559A1 (de)	1987-04-09
DE3626559C2 (de)	1997-05-07
GB2179252A (en)	1987-03-04
GB8619184D0 (en)	1986-09-17
GB2179252B (en)	1989-08-02
AU6102086A (en)	1987-02-19
NL194715B (nl)	2002-09-02
JPH0657222B2 (ja)	1994-08-03
NL8602015A (nl)	1987-03-16

Legal Events

Date	Code	Title	Description
2008-07-09	MKEX	Expiry

Publication	Publication Date	Title
US4717566A (en)	1988-01-05	Dosage system and method of using same
US4675174A (en)	1987-06-23	Veterinary dispenser delivering beneficial agent by gas power generated in situ
US4963141A (en)	1990-10-16	Dispensing system for administering beneficial agent formulation to ruminants
US4612186A (en)	1986-09-16	Method for establishing blood levels of biocide in animals
US4704118A (en)	1987-11-03	Ruminant dispensing device with thermo-activated memory
US4595583A (en)	1986-06-17	Delivery system controlled administration of beneficial agent to ruminants
US5474785A (en)	1995-12-12	Delivery system comprising means for controlling internal pressure
CA1319071C (fr)	1993-06-15	Distributeur a magasin mobile pour particules de tres petites dimensions
CA1244738A (fr)	1988-11-15	Dispositif a ouverture controlee pour l'administration d'un agent therapeutique
US6419952B2 (en)	2002-07-16	Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings
US4955881A (en)	1990-09-11	Ruminant dispensing device
US4865598A (en)	1989-09-12	Dispensing system for administering beneficial agent
US5213809A (en)	1993-05-25	Delivery system comprising means for controlling internal pressure
CA1285842C (fr)	1991-07-09	Systeme de distribution pour l'adminstration d'agents benefiques aux ruminants
US4624945A (en)	1986-11-25	Dispensing system with means for increasing delivery of beneficial agent from the system
US4844984A (en)	1989-07-04	Dispensing system with means for increasing delivery of beneficial agent from the system
US4883667A (en)	1989-11-28	Process for forming dispensing device
US5229133A (en)	1993-07-20	Delivery system comprising means for controlling internal pressure
US4871544A (en)	1989-10-03	Ruminant dispensing device
US5098425A (en)	1992-03-24	Method of administering a ruminant dispensing device comprising density member dispersed in hydrogel member
US4966767A (en)	1990-10-30	Ruminant dispensing device comprising agent displacement member
CA2563972C (fr)	2009-03-17	Systeme distributeur dote de moyens de regulation de la pression interne
HK1040632B (en)	2004-12-31	Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings