JPH0657222B2 - 有効剤組成物を反芻動物に投与するための投与デイバイス - Google Patents

有効剤組成物を反芻動物に投与するための投与デイバイス

Info

Publication number: JPH0657222B2
Authority: JP; Japan
Prior art keywords: active agent; agent composition; compartment; cellulose; dosing device
Prior art date: 1985-08-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP61184111A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6244249A (ja

Inventor

ジェームス・ビー・エッケンホフ

Original Assignee

アルザ・コ−ポレ−シヨン

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-16

Filing date

1986-08-05

Publication date

1994-08-03

1986-08-05 Application filed by アルザ・コ−ポレ−シヨン filed Critical アルザ・コ−ポレ−シヨン

1987-02-26 Publication of JPS6244249A publication Critical patent/JPS6244249A/ja

1994-08-03 Publication of JPH0657222B2 publication Critical patent/JPH0657222B2/ja

2009-08-03 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 135
239000013543 active substance Substances 0.000 title claims description 103
241000282849 Ruminantia Species 0.000 title description 14
239000007788 liquid Substances 0.000 claims description 55
229920000642 polymer Polymers 0.000 claims description 48
229920002678 cellulose Polymers 0.000 claims description 32
239000001913 cellulose Substances 0.000 claims description 31
239000000017 hydrogel Substances 0.000 claims description 20
-1 fuembendazole Chemical compound 0.000 claims description 19
238000000034 method Methods 0.000 claims description 19
229920002301 cellulose acetate Polymers 0.000 claims description 15
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 5
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 5
229960002418 ivermectin Drugs 0.000 claims description 5
239000005660 Abamectin Substances 0.000 claims description 4
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims description 4
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 4
229960001614 levamisole Drugs 0.000 claims description 4
229920001747 Cellulose diacetate Polymers 0.000 claims description 3
229920002284 Cellulose triacetate Polymers 0.000 claims description 3
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 3
VRYKTHBAWRESFI-VOTSOKGWSA-N oxantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CC(O)=C1 VRYKTHBAWRESFI-VOTSOKGWSA-N 0.000 claims description 3
229960000535 oxantel Drugs 0.000 claims description 3
YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 claims description 3
ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 claims description 2
YRWLZFXJFBZBEY-UHFFFAOYSA-N N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCCC1=CC=C2N=C(NC(=O)OC)NC2=C1 YRWLZFXJFBZBEY-UHFFFAOYSA-N 0.000 claims description 2
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
229960003475 cambendazole Drugs 0.000 claims description 2
229960003439 mebendazole Drugs 0.000 claims description 2
BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 claims description 2
229950007337 parbendazole Drugs 0.000 claims description 2
QZWHWHNCPFEXLL-UHFFFAOYSA-N propan-2-yl n-[2-(1,3-thiazol-4-yl)-3h-benzimidazol-5-yl]carbamate Chemical compound N1C2=CC(NC(=O)OC(C)C)=CC=C2N=C1C1=CSC=N1 QZWHWHNCPFEXLL-UHFFFAOYSA-N 0.000 claims description 2
229960005134 pyrantel Drugs 0.000 claims description 2
229910052711 selenium Inorganic materials 0.000 claims description 2
239000011669 selenium Substances 0.000 claims description 2
239000004308 thiabendazole Substances 0.000 claims description 2
229960004546 thiabendazole Drugs 0.000 claims description 2
235000010296 thiabendazole Nutrition 0.000 claims description 2
WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 claims description 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 claims 1
HLFSDGLLUJUHTE-UHFFFAOYSA-N 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole Chemical compound N1=C2SCCN2CC1C1=CC=CC=C1 HLFSDGLLUJUHTE-UHFFFAOYSA-N 0.000 claims 1
229960002669 albendazole Drugs 0.000 claims 1
HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 claims 1
RCKMWOKWVGPNJF-UHFFFAOYSA-N diethylcarbamazine Chemical compound CCN(CC)C(=O)N1CCN(C)CC1 RCKMWOKWVGPNJF-UHFFFAOYSA-N 0.000 claims 1
229960003974 diethylcarbamazine Drugs 0.000 claims 1
229960005121 morantel Drugs 0.000 claims 1
239000002775 capsule Substances 0.000 description 38
210000004767 rumen Anatomy 0.000 description 21
241001465754 Metazoa Species 0.000 description 18
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
239000000463 material Substances 0.000 description 15
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 14
239000003795 chemical substances by application Substances 0.000 description 12
230000003204 osmotic effect Effects 0.000 description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 11
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 11
229920006217 cellulose acetate butyrate Polymers 0.000 description 11
230000004907 flux Effects 0.000 description 11
239000002904 solvent Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
108010010803 Gelatin Proteins 0.000 description 9
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 9
239000003814 drug Substances 0.000 description 9
239000008273 gelatin Substances 0.000 description 9
229920000159 gelatin Polymers 0.000 description 9
235000019322 gelatine Nutrition 0.000 description 9
235000011852 gelatine desserts Nutrition 0.000 description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
229940079593 drug Drugs 0.000 description 8
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
239000011780 sodium chloride Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
241000283690 Bos taurus Species 0.000 description 7
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 7
239000000126 substance Substances 0.000 description 7
229910052742 iron Inorganic materials 0.000 description 6
230000035699 permeability Effects 0.000 description 6
239000000047 product Substances 0.000 description 6
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239000000921 anthelmintic agent Substances 0.000 description 5
238000000576 coating method Methods 0.000 description 5
235000019441 ethanol Nutrition 0.000 description 5
230000005484 gravity Effects 0.000 description 5
238000002156 mixing Methods 0.000 description 5
239000004014 plasticizer Substances 0.000 description 5
229920002492 poly(sulfone) Polymers 0.000 description 5
239000007787 solid Substances 0.000 description 5
210000002784 stomach Anatomy 0.000 description 5
230000001225 therapeutic effect Effects 0.000 description 5
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 4
125000000217 alkyl group Chemical group 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
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230000002708 enhancing effect Effects 0.000 description 4
235000011187 glycerol Nutrition 0.000 description 4
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239000003607 modifier Substances 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
239000000725 suspension Substances 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 3
QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical class [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 3
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KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
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YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
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TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 3
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XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 3
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239000000843 powder Substances 0.000 description 3
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 3
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QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
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IRIAEXORFWYRCZ-UHFFFAOYSA-N Butylbenzyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCC1=CC=CC=C1 IRIAEXORFWYRCZ-UHFFFAOYSA-N 0.000 description 2
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229920002379 silicone rubber Polymers 0.000 description 1
GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
229940006186 sodium polystyrene sulfonate Drugs 0.000 description 1
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239000011781 sodium selenite Substances 0.000 description 1
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235000015921 sodium selenite Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
KEAYESYHFKHZAL-OUBTZVSYSA-N sodium-24 Chemical compound [24Na] KEAYESYHFKHZAL-OUBTZVSYSA-N 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000001797 sucrose acetate isobutyrate Substances 0.000 description 1
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UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
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ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
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150000003522 tetracyclines Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
229960000344 thiamine hydrochloride Drugs 0.000 description 1
235000019190 thiamine hydrochloride Nutrition 0.000 description 1
239000011747 thiamine hydrochloride Substances 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
150000005691 triesters Chemical class 0.000 description 1
PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
WDRCVXGINNJWPH-UHFFFAOYSA-N tris(6-methylheptyl) benzene-1,2,4-tricarboxylate Chemical compound CC(C)CCCCCOC(=O)C1=CC=C(C(=O)OCCCCCC(C)C)C(C(=O)OCCCCCC(C)C)=C1 WDRCVXGINNJWPH-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Preparation (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Fodder In General (AREA)
Feed For Specific Animals (AREA)
Packages (AREA)
Closures For Containers (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

JP61184111A 1985-08-16 1986-08-05 有効剤組成物を反芻動物に投与するための投与デイバイス Expired - Fee Related JPH0657222B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76623585A	1985-08-16	1985-08-16
US766235		1985-08-16

Publications (2)

Publication Number	Publication Date
JPS6244249A JPS6244249A (ja)	1987-02-26
JPH0657222B2 true JPH0657222B2 (ja)	1994-08-03

Family

ID=25075818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61184111A Expired - Fee Related JPH0657222B2 (ja)	1985-08-16	1986-08-05	有効剤組成物を反芻動物に投与するための投与デイバイス

Country Status (14)

Country	Link
JP (1)	JPH0657222B2 (fr)
AR (1)	AR246177A1 (fr)
AU (1)	AU578374B2 (fr)
BE (1)	BE905283A (fr)
BR (1)	BR8603897A (fr)
CA (1)	CA1285842C (fr)
DE (1)	DE3626559C2 (fr)
ES (1)	ES8800043A1 (fr)
FR (1)	FR2586189B1 (fr)
GB (1)	GB2179252B (fr)
IT (1)	IT1195825B (fr)
NL (1)	NL194715C (fr)
NZ (1)	NZ217122A (fr)
ZA (1)	ZA866176B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960416A (en) *	1986-04-30	1990-10-02	Alza Corporation	Dosage form with improved delivery capability
GB2189702B (en) *	1986-04-30	1989-10-18	Alza Corp	Dosage form with improved delivery capability
US4716496A (en) *	1986-05-09	1987-12-29	Eaton Corporation	Panel-mounted control station housing
GB8630876D0 (en) *	1986-12-24	1987-02-04	Graham N B	Hydrogel-containing envelopes
US4892778A (en) *	1987-05-27	1990-01-09	Alza Corporation	Juxtaposed laminated arrangement
US4874388A (en) *	1987-06-25	1989-10-17	Alza Corporation	Multi-layer delivery system
GB2206046B (en) *	1987-06-25	1991-04-03	Alza Corp	Multi-unit delivery system
US4855141A (en) *	1988-03-25	1989-08-08	Alza Corporation	Device comprising means for protecting and dispensing fluid sensitive medicament
US5034229A (en) *	1988-12-13	1991-07-23	Alza Corporation	Dispenser for increasing feed conversion of hog
ATE129405T1 (de) *	1989-07-18	1995-11-15	Alza Corp	Ionophore enthaltende abgabevorrichtung.
US5156623A (en) *	1990-04-16	1992-10-20	Olympus Optical Co., Ltd.	Sustained release material and method of manufacturing the same
DE4330991A1 (de) *	1993-09-13	1995-03-16	Peter Pelz	Verfahren und Vorrichtung bzw. Mittel zur Applikation von medizinischen bzw. gesundheitsfördernden Mitteln an Tieren
DE10000823A1 (de) *	2000-01-12	2001-07-19	Hartwin Hobler	Einbringen von Gasen in eine Körperflüssigkeit
JP7709914B2 (ja) *	2018-09-10	2025-07-17	アージェンタ・イノベイション・リミテッド	送達装置における放出制御製剤
HUE067496T2 (hu)	2020-12-08	2024-10-28	Ruminant Biotech Corp Ltd	Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése

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US4704118A (en) *	1985-08-16	1987-11-03	Alza Corporation	Ruminant dispensing device with thermo-activated memory
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1986
- 1986-06-24 ES ES556572A patent/ES8800043A1/es not_active Expired
- 1986-08-05 JP JP61184111A patent/JPH0657222B2/ja not_active Expired - Fee Related
- 1986-08-06 DE DE3626559A patent/DE3626559C2/de not_active Expired - Lifetime
- 1986-08-06 FR FR868611373A patent/FR2586189B1/fr not_active Expired - Lifetime
- 1986-08-06 NL NL8602015A patent/NL194715C/nl not_active IP Right Cessation
- 1986-08-06 GB GB8619184A patent/GB2179252B/en not_active Expired
- 1986-08-07 CA CA000515470A patent/CA1285842C/fr not_active Expired - Lifetime
- 1986-08-07 NZ NZ217122A patent/NZ217122A/xx unknown
- 1986-08-08 AU AU61020/86A patent/AU578374B2/en not_active Expired
- 1986-08-14 BE BE0/217051A patent/BE905283A/fr not_active IP Right Cessation
- 1986-08-14 IT IT67663/86A patent/IT1195825B/it active
- 1986-08-15 ZA ZA866176A patent/ZA866176B/xx unknown
- 1986-08-15 BR BR8603897A patent/BR8603897A/pt not_active IP Right Cessation
- 1986-08-15 AR AR86304936A patent/AR246177A1/es active

Also Published As

Publication number	Publication date
BE905283A (fr)	1986-12-01
NZ217122A (en)	1989-06-28
ZA866176B (en)	1987-03-25
AR246177A1 (es)	1994-07-29
ES556572A0 (es)	1987-10-16
IT1195825B (it)	1988-10-27
NL194715C (nl)	2003-01-07
FR2586189B1 (fr)	1990-08-10
FR2586189A1 (fr)	1987-02-20
JPS6244249A (ja)	1987-02-26
IT8667663A0 (it)	1986-08-14
ES8800043A1 (es)	1987-10-16
BR8603897A (pt)	1987-11-17
AU578374B2 (en)	1988-10-20
DE3626559A1 (de)	1987-04-09
DE3626559C2 (de)	1997-05-07
GB2179252A (en)	1987-03-04
GB8619184D0 (en)	1986-09-17
CA1285842C (fr)	1991-07-09
GB2179252B (en)	1989-08-02
AU6102086A (en)	1987-02-19
NL194715B (nl)	2002-09-02
NL8602015A (nl)	1987-03-16

Legal Events

Date	Code	Title	Description
2003-08-03	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
US4675174A (en)	1987-06-23	Veterinary dispenser delivering beneficial agent by gas power generated in situ
US4717566A (en)	1988-01-05	Dosage system and method of using same
US4612186A (en)	1986-09-16	Method for establishing blood levels of biocide in animals
CA1319071C (fr)	1993-06-15	Distributeur a magasin mobile pour particules de tres petites dimensions
US4595583A (en)	1986-06-17	Delivery system controlled administration of beneficial agent to ruminants
US4704118A (en)	1987-11-03	Ruminant dispensing device with thermo-activated memory
US4963141A (en)	1990-10-16	Dispensing system for administering beneficial agent formulation to ruminants
US5474785A (en)	1995-12-12	Delivery system comprising means for controlling internal pressure
US4915949A (en)	1990-04-10	Dispenser with movable matrix comprising a plurality of tiny pills
US5126142A (en)	1992-06-30	Dispenser comprising ionophore
US4772474A (en)	1988-09-20	Dispenser with internal arrangement of lamina means for dispensing beneficial agent
JP2529941B2 (ja)	1996-09-04	薬物結腸放出用浸透構成体
US4955881A (en)	1990-09-11	Ruminant dispensing device
US5213809A (en)	1993-05-25	Delivery system comprising means for controlling internal pressure
US4844984A (en)	1989-07-04	Dispensing system with means for increasing delivery of beneficial agent from the system
US4865598A (en)	1989-09-12	Dispensing system for administering beneficial agent
JPS63297319A (ja)	1988-12-05	固体の性質を有する移動可能マトリツクスを含有する投与用製剤
US4883667A (en)	1989-11-28	Process for forming dispensing device
KR20010087422A (ko)	2001-09-15	다중 코팅에 의한, 액체 충진 젤라틴 캡슐로부터 제어방출 시스템으로의 전환
JPH0818972B2 (ja)	1996-02-28	有効剤放出促進部材を含む投与装置
JPH0657222B2 (ja)	1994-08-03	有効剤組成物を反芻動物に投与するための投与デイバイス
US4871544A (en)	1989-10-03	Ruminant dispensing device
US5098425A (en)	1992-03-24	Method of administering a ruminant dispensing device comprising density member dispersed in hydrogel member
US4966767A (en)	1990-10-30	Ruminant dispensing device comprising agent displacement member
CA2563972C (fr)	2009-03-17	Systeme distributeur dote de moyens de regulation de la pression interne