CA1294960C - 7-deazaguanines en tant qu'immunomodulateurs - Google Patents

7-deazaguanines en tant qu'immunomodulateurs

Info

Publication number
CA1294960C
CA1294960C CA000549128A CA549128A CA1294960C CA 1294960 C CA1294960 C CA 1294960C CA 000549128 A CA000549128 A CA 000549128A CA 549128 A CA549128 A CA 549128A CA 1294960 C CA1294960 C CA 1294960C
Authority
CA
Canada
Prior art keywords
compound
formula
hydrogen
compounds
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000549128A
Other languages
English (en)
Inventor
Thomas C. Malone
Jagadish C. Sircar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of CA1294960C publication Critical patent/CA1294960C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
CA000549128A 1986-10-24 1987-10-13 7-deazaguanines en tant qu'immunomodulateurs Expired - Fee Related CA1294960C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92352186A 1986-10-24 1986-10-24
US923,521 1986-10-24
US8623187A 1987-08-20 1987-08-20
US086,231 1987-08-20

Publications (1)

Publication Number Publication Date
CA1294960C true CA1294960C (fr) 1992-01-28

Family

ID=26774505

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000549128A Expired - Fee Related CA1294960C (fr) 1986-10-24 1987-10-13 7-deazaguanines en tant qu'immunomodulateurs

Country Status (9)

Country Link
EP (1) EP0327590A1 (fr)
JP (1) JPH02501306A (fr)
KR (1) KR880701721A (fr)
AU (1) AU614947B2 (fr)
CA (1) CA1294960C (fr)
ES (1) ES2008756A6 (fr)
FI (1) FI891870L (fr)
GR (1) GR871606B (fr)
WO (1) WO1988003142A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
RU2093513C1 (ru) * 1989-02-27 1997-10-20 Биокрайст Фармасьютикалз Инк. Производные 9-деазагуанины или их таутомеры и фармацевтическая композиция, обладающая способностью ингибировать активность пуриннуклеозид фосфорилазы у млекопитающих
CA2072123C (fr) * 1989-10-31 2001-06-12 John A. Secrist, Iii Inhibiteurs de la phosphorylase du nucleoside de la purine
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
US5834469A (en) * 1994-06-09 1998-11-10 Smithkline Beecham Corporation Endothelin receptor antagonists
GB201417165D0 (en) * 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748177A (en) * 1984-03-26 1988-05-31 Warner-Lambert Company Guanine derivatives
FR2574407B1 (fr) * 1984-12-12 1987-06-05 Rhone Poulenc Sante Nouveaux derives de la pyrrolo(2,3-d) pyrimidine, leur preparation et les compositions pharmaceutiques qui les contiennent
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Also Published As

Publication number Publication date
GR871606B (en) 1988-02-23
KR880701721A (ko) 1988-11-04
FI891870A7 (fi) 1989-04-19
WO1988003142A2 (fr) 1988-05-25
WO1988003142A3 (fr) 1988-05-19
AU614947B2 (en) 1991-09-19
AU8328187A (en) 1988-05-25
FI891870A0 (fi) 1989-04-19
FI891870L (fi) 1989-04-19
EP0327590A1 (fr) 1989-08-16
ES2008756A6 (es) 1989-08-01
JPH02501306A (ja) 1990-05-10

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