JPH02501306A - 免疫調整剤としての７‐デアザグアニン類 - Google Patents

免疫調整剤としての７‐デアザグアニン類

Info

Publication number
JPH02501306A
JPH02501306A JP63500138A JP50013888A JPH02501306A JP H02501306 A JPH02501306 A JP H02501306A JP 63500138 A JP63500138 A JP 63500138A JP 50013888 A JP50013888 A JP 50013888A JP H02501306 A JPH02501306 A JP H02501306A
Authority
JP
Japan
Prior art keywords
formula
compound
compound according
hydrogen
tables
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63500138A
Other languages
English (en)
Japanese (ja)
Inventor
マローン，トマス・シー
サーカー，ジヤガデイツシユ・シー
Original Assignee
ワーナー‐ランバート・コンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ワーナー‐ランバート・コンパニー filed Critical ワーナー‐ランバート・コンパニー
Publication of JPH02501306A publication Critical patent/JPH02501306A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
JP63500138A 1986-10-24 1987-10-19 免疫調整剤としての７‐デアザグアニン類 Pending JPH02501306A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92352186A 1986-10-24 1986-10-24
US923,521 1986-10-24
US8623187A 1987-08-20 1987-08-20
US086,231 1987-08-20

Publications (1)

Publication Number Publication Date
JPH02501306A true JPH02501306A (ja) 1990-05-10

Family

ID=26774505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63500138A Pending JPH02501306A (ja) 1986-10-24 1987-10-19 免疫調整剤としての７‐デアザグアニン類

Country Status (9)

Country Link
EP (1) EP0327590A1 (fr)
JP (1) JPH02501306A (fr)
KR (1) KR880701721A (fr)
AU (1) AU614947B2 (fr)
CA (1) CA1294960C (fr)
ES (1) ES2008756A6 (fr)
FI (1) FI891870L (fr)
GR (1) GR871606B (fr)
WO (1) WO1988003142A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529402A (ja) * 2014-09-29 2017-10-05 ザ プロボースト，フェローズ，ファンデーション スカラーズ，アンド ジ アザー メンバーズ オブ ボード，オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッド トリニティ オブ クイーン エリザベス ニア ダブリン 自己免疫疾患の処置

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
RU2093513C1 (ru) * 1989-02-27 1997-10-20 Биокрайст Фармасьютикалз Инк. Производные 9-деазагуанины или их таутомеры и фармацевтическая композиция, обладающая способностью ингибировать активность пуриннуклеозид фосфорилазы у млекопитающих
CA2072123C (fr) * 1989-10-31 2001-06-12 John A. Secrist, Iii Inhibiteurs de la phosphorylase du nucleoside de la purine
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
US5834469A (en) * 1994-06-09 1998-11-10 Smithkline Beecham Corporation Endothelin receptor antagonists
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748177A (en) * 1984-03-26 1988-05-31 Warner-Lambert Company Guanine derivatives
FR2574407B1 (fr) * 1984-12-12 1987-06-05 Rhone Poulenc Sante Nouveaux derives de la pyrrolo(2,3-d) pyrimidine, leur preparation et les compositions pharmaceutiques qui les contiennent
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529402A (ja) * 2014-09-29 2017-10-05 ザ プロボースト，フェローズ，ファンデーション スカラーズ，アンド ジ アザー メンバーズ オブ ボード，オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッド トリニティ オブ クイーン エリザベス ニア ダブリン 自己免疫疾患の処置
JP2020090515A (ja) * 2014-09-29 2020-06-11 ザ プロボースト，フェローズ，ファンデーション スカラーズ，アンド ジ アザー メンバーズ オブ ボード，オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッド トリニティ オブ クイーン エリザベス ニア ダブリン 自己免疫疾患の処置

Also Published As

Publication number Publication date
GR871606B (en) 1988-02-23
KR880701721A (ko) 1988-11-04
FI891870A7 (fi) 1989-04-19
WO1988003142A2 (fr) 1988-05-25
WO1988003142A3 (fr) 1988-05-19
AU614947B2 (en) 1991-09-19
AU8328187A (en) 1988-05-25
CA1294960C (fr) 1992-01-28
FI891870A0 (fi) 1989-04-19
FI891870L (fi) 1989-04-19
EP0327590A1 (fr) 1989-08-16
ES2008756A6 (es) 1989-08-01

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