CA1297792C - Composition fibrinolytique - Google Patents
Composition fibrinolytiqueInfo
- Publication number
- CA1297792C CA1297792C CA000537052A CA537052A CA1297792C CA 1297792 C CA1297792 C CA 1297792C CA 000537052 A CA000537052 A CA 000537052A CA 537052 A CA537052 A CA 537052A CA 1297792 C CA1297792 C CA 1297792C
- Authority
- CA
- Canada
- Prior art keywords
- c2h4o
- approximately
- c3h6o
- integer
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 111
- 239000003527 fibrinolytic agent Substances 0.000 title claims abstract description 61
- 230000003480 fibrinolytic effect Effects 0.000 title claims abstract description 60
- 229920001577 copolymer Polymers 0.000 claims abstract description 219
- 150000001875 compounds Chemical class 0.000 claims abstract description 61
- 125000000963 oxybis(methylene) group Chemical group [H]C([H])(*)OC([H])([H])* 0.000 claims abstract description 57
- 208000007536 Thrombosis Diseases 0.000 claims abstract description 37
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 25
- 101710196208 Fibrinolytic enzyme Proteins 0.000 claims abstract description 23
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims abstract description 23
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims abstract description 23
- 230000017531 blood circulation Effects 0.000 claims abstract description 21
- 108010023197 Streptokinase Proteins 0.000 claims abstract description 20
- 229960005202 streptokinase Drugs 0.000 claims abstract description 19
- 229960005356 urokinase Drugs 0.000 claims abstract description 19
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims abstract description 16
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims abstract description 16
- 229960000187 tissue plasminogen activator Drugs 0.000 claims abstract description 16
- 230000001976 improved effect Effects 0.000 claims abstract description 15
- 239000000243 solution Substances 0.000 claims description 158
- 238000000034 method Methods 0.000 claims description 76
- 210000004369 blood Anatomy 0.000 claims description 64
- 239000008280 blood Substances 0.000 claims description 64
- 238000002399 angioplasty Methods 0.000 claims description 43
- 241001465754 Metazoa Species 0.000 claims description 36
- 206010028980 Neoplasm Diseases 0.000 claims description 36
- 102000009123 Fibrin Human genes 0.000 claims description 31
- 108010073385 Fibrin Proteins 0.000 claims description 31
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 31
- 229950003499 fibrin Drugs 0.000 claims description 31
- 239000002516 radical scavenger Substances 0.000 claims description 23
- 239000001301 oxygen Substances 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
- 239000003146 anticoagulant agent Substances 0.000 claims description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 21
- 230000010412 perfusion Effects 0.000 claims description 21
- 210000002216 heart Anatomy 0.000 claims description 20
- 229940127219 anticoagulant drug Drugs 0.000 claims description 18
- 210000000056 organ Anatomy 0.000 claims description 18
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 17
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 17
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 17
- 229960002897 heparin Drugs 0.000 claims description 17
- 229920000669 heparin Polymers 0.000 claims description 17
- 239000000082 organ preservation Substances 0.000 claims description 17
- 230000006378 damage Effects 0.000 claims description 16
- 208000028867 ischemia Diseases 0.000 claims description 15
- 230000002934 lysing effect Effects 0.000 claims description 14
- 230000000302 ischemic effect Effects 0.000 claims description 13
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 12
- 229930195725 Mannitol Natural products 0.000 claims description 12
- 235000010355 mannitol Nutrition 0.000 claims description 12
- 239000000594 mannitol Substances 0.000 claims description 12
- 208000007056 sickle cell anemia Diseases 0.000 claims description 10
- 208000010125 myocardial infarction Diseases 0.000 claims description 9
- 238000002560 therapeutic procedure Methods 0.000 claims description 9
- 108010073863 saruplase Proteins 0.000 claims description 7
- 230000000451 tissue damage Effects 0.000 claims description 6
- 231100000827 tissue damage Toxicity 0.000 claims description 6
- 239000012266 salt solution Substances 0.000 claims description 5
- 238000002054 transplantation Methods 0.000 claims description 5
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 4
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 4
- 238000006213 oxygenation reaction Methods 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 230000003680 myocardial damage Effects 0.000 claims 10
- 210000003734 kidney Anatomy 0.000 claims 4
- 239000003055 low molecular weight heparin Substances 0.000 claims 3
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 3
- 238000013171 endarterectomy Methods 0.000 claims 2
- 229940127090 anticoagulant agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 abstract description 35
- 108090000790 Enzymes Proteins 0.000 abstract description 35
- 229940088598 enzyme Drugs 0.000 abstract description 35
- 239000007859 condensation product Substances 0.000 abstract description 5
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
- 230000000694 effects Effects 0.000 description 15
- 210000001367 artery Anatomy 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 208000032843 Hemorrhage Diseases 0.000 description 9
- 210000004351 coronary vessel Anatomy 0.000 description 9
- 230000009089 cytolysis Effects 0.000 description 9
- 239000011324 bead Substances 0.000 description 8
- 238000001802 infusion Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 210000004165 myocardium Anatomy 0.000 description 7
- 229920005862 polyol Polymers 0.000 description 7
- 150000003077 polyols Chemical class 0.000 description 7
- 102000008946 Fibrinogen Human genes 0.000 description 6
- 108010049003 Fibrinogen Proteins 0.000 description 6
- 229940012952 fibrinogen Drugs 0.000 description 6
- 210000000440 neutrophil Anatomy 0.000 description 6
- 108091006146 Channels Proteins 0.000 description 5
- 230000000747 cardiac effect Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 230000010410 reperfusion Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229940123457 Free radical scavenger Drugs 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 206010061216 Infarction Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 230000001010 compromised effect Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000020764 fibrinolysis Effects 0.000 description 4
- 230000007574 infarction Effects 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 4
- 238000002407 reforming Methods 0.000 description 4
- -1 superoxide ions Chemical class 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- 230000002885 thrombogenetic effect Effects 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 3
- 206010028851 Necrosis Diseases 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 208000010378 Pulmonary Embolism Diseases 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000005003 heart tissue Anatomy 0.000 description 3
- 239000012456 homogeneous solution Substances 0.000 description 3
- 230000004941 influx Effects 0.000 description 3
- 230000002427 irreversible effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000008223 sterile water Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010011091 Coronary artery thrombosis Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 206010054094 Tumour necrosis Diseases 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000004931 aggregating effect Effects 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 230000010100 anticoagulation Effects 0.000 description 2
- 230000003143 atherosclerotic effect Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 208000002528 coronary thrombosis Diseases 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000002695 general anesthesia Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- YTSACTNRGUJEGO-UHFFFAOYSA-N oxirane prop-1-ene Chemical group CC=C.C1CO1 YTSACTNRGUJEGO-UHFFFAOYSA-N 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 230000002537 thrombolytic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 206010069729 Collateral circulation Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 101150090997 DLAT gene Proteins 0.000 description 1
- 206010051055 Deep vein thrombosis Diseases 0.000 description 1
- 239000004243 E-number Substances 0.000 description 1
- 235000019227 E-number Nutrition 0.000 description 1
- 241000490229 Eucephalus Species 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 229940030602 cardiac therapy drug Drugs 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 229940106780 human fibrinogen Drugs 0.000 description 1
- 230000000544 hyperemic effect Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940043200 pentothal Drugs 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004895 regional blood flow Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- AWLILQARPMWUHA-UHFFFAOYSA-M thiopental sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC([S-])=NC1=O AWLILQARPMWUHA-UHFFFAOYSA-M 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86358286A | 1986-05-15 | 1986-05-15 | |
| US863,582 | 1986-05-15 | ||
| US07/045,459 US4801452A (en) | 1986-05-15 | 1987-05-07 | Fibrinolytic composition |
| US045,459 | 1993-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1297792C true CA1297792C (fr) | 1992-03-24 |
Family
ID=26722792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000537052A Expired - Lifetime CA1297792C (fr) | 1986-05-15 | 1987-05-13 | Composition fibrinolytique |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA1297792C (fr) |
| GR (1) | GR870758B (fr) |
| IE (4) | IE922400L (fr) |
| NZ (1) | NZ220288A (fr) |
| PH (1) | PH25909A (fr) |
| PT (1) | PT84880B (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9603966B2 (en) | 2007-02-19 | 2017-03-28 | Plurogen Therapeutics, Inc. | Compositions for treating biofilms and methods for using same |
| US10456416B2 (en) | 2015-01-20 | 2019-10-29 | Plurogen Therapeutics, Llc | Compositions and methods of treating microbes |
-
1987
- 1987-05-13 NZ NZ220288A patent/NZ220288A/xx unknown
- 1987-05-13 CA CA000537052A patent/CA1297792C/fr not_active Expired - Lifetime
- 1987-05-14 IE IE922400A patent/IE922400L/xx not_active Application Discontinuation
- 1987-05-14 IE IE922401A patent/IE922401L/xx not_active Application Discontinuation
- 1987-05-14 IE IE922399A patent/IE922399L/xx not_active Application Discontinuation
- 1987-05-14 IE IE126187A patent/IE62088B1/en not_active IP Right Cessation
- 1987-05-15 GR GR870758A patent/GR870758B/el unknown
- 1987-05-15 PH PH35259A patent/PH25909A/en unknown
- 1987-05-15 PT PT84880A patent/PT84880B/pt not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9603966B2 (en) | 2007-02-19 | 2017-03-28 | Plurogen Therapeutics, Inc. | Compositions for treating biofilms and methods for using same |
| US9884136B2 (en) | 2007-02-19 | 2018-02-06 | Plurogen Therapeutics, Inc. | Compositions for treating biofilms and methods for using same |
| US10456416B2 (en) | 2015-01-20 | 2019-10-29 | Plurogen Therapeutics, Llc | Compositions and methods of treating microbes |
Also Published As
| Publication number | Publication date |
|---|---|
| IE922399L (en) | 1987-11-15 |
| PT84880B (pt) | 1990-02-08 |
| IE871261L (en) | 1987-11-15 |
| IE62088B1 (en) | 1994-12-14 |
| IE922400L (en) | 1987-11-15 |
| NZ220288A (en) | 1989-08-29 |
| IE922401L (en) | 1987-11-15 |
| PT84880A (en) | 1987-06-01 |
| PH25909A (en) | 1991-12-19 |
| GR870758B (en) | 1988-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5089260A (en) | Method of treating ischemic tissue | |
| US4801452A (en) | Fibrinolytic composition | |
| US5017370A (en) | Improved method of performing angioplasty procedures | |
| EP0266419B1 (fr) | Composition fibrinolytique | |
| US5047236A (en) | Method of treating stroke | |
| US5028599A (en) | Method of treating mycardial damage | |
| US5080894A (en) | Method and composition for reducing tissue damage | |
| US5078995A (en) | Fibrionolytic composition | |
| US5064643A (en) | Method for treating sickle cell disease | |
| US4837014A (en) | An improved method of treating sickle cell anemia | |
| US4873083A (en) | Fibrinolytic composition | |
| US4879109A (en) | Method for treating burns | |
| US5030448A (en) | Method of delivering drugs to damaged or diseased tissue | |
| US5071649A (en) | Method of preventing blockage in catheters | |
| US5039520A (en) | Plasma extender | |
| US5041288A (en) | Method of treating tissue damaged by reperfusion injury | |
| US4897263A (en) | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids | |
| US4937070A (en) | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids | |
| US5032394A (en) | Method of treating burns | |
| US5182106A (en) | Method for treating hypothermia | |
| US5250294A (en) | Improved perfusion medium for transplantation of organs | |
| US5648071A (en) | Method of treating tumors | |
| US5198211A (en) | Method of treating myocardial damage | |
| US5240702A (en) | Method of treating stroke | |
| US5240701A (en) | Method of performing angioplasty procedures |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |