CA1310159C - Membrane de fibres creuses de polypropylene poreux, methode pour sa production et son utilisation dans des poumons artificiels - Google Patents

Membrane de fibres creuses de polypropylene poreux, methode pour sa production et son utilisation dans des poumons artificiels

Info

Publication number: CA1310159C
Authority: CA; Canada
Prior art keywords: hollow fiber; fiber membrane; polypropylene; range; artificial lung
Prior art date: 1987-01-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000556829A

Other languages

English (en)

Inventor

Yukio Seita

Shoichi Nagaki

Ken Tatebe

Kousuke Kido

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Terumo Corp

Original Assignee

Terumo Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-20

Filing date

1988-01-19

Publication date

1992-11-17

1988-01-19 Application filed by Terumo Corp filed Critical Terumo Corp

1992-11-17 Application granted granted Critical

1992-11-17 Publication of CA1310159C publication Critical patent/CA1310159C/fr

2009-11-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000012528 membrane Substances 0.000 title claims abstract description 229
239000012510 hollow fiber Substances 0.000 title claims abstract description 224
-1 polypropylene Polymers 0.000 title claims abstract description 174
229920001155 polypropylene Polymers 0.000 title claims abstract description 171
239000004743 Polypropylene Substances 0.000 title claims abstract description 170
210000004072 lung Anatomy 0.000 title claims abstract description 80
238000004519 manufacturing process Methods 0.000 title claims description 25
210000004369 blood Anatomy 0.000 claims abstract description 65
239000008280 blood Substances 0.000 claims abstract description 65
239000002245 particle Substances 0.000 claims abstract description 38
239000011148 porous material Substances 0.000 claims abstract description 37
239000000835 fiber Substances 0.000 claims abstract description 36
210000002381 plasma Anatomy 0.000 claims abstract description 28
239000007790 solid phase Substances 0.000 claims abstract description 28
208000027418 Wounds and injury Diseases 0.000 claims abstract description 12
210000000601 blood cell Anatomy 0.000 claims abstract description 12
230000006378 damage Effects 0.000 claims abstract description 11
239000012071 phase Substances 0.000 claims abstract description 11
208000014674 injury Diseases 0.000 claims abstract description 10
238000001816 cooling Methods 0.000 claims description 69
239000007788 liquid Substances 0.000 claims description 51
239000012766 organic filler Substances 0.000 claims description 50
239000007789 gas Substances 0.000 claims description 45
238000000034 method Methods 0.000 claims description 42
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
239000001301 oxygen Substances 0.000 claims description 23
229910052760 oxygen Inorganic materials 0.000 claims description 23
239000003795 chemical substances by application Substances 0.000 claims description 20
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 17
229940057995 liquid paraffin Drugs 0.000 claims description 17
229910001882 dioxygen Inorganic materials 0.000 claims description 16
230000004087 circulation Effects 0.000 claims description 14
230000004907 flux Effects 0.000 claims description 14
239000000126 substance Substances 0.000 claims description 13
238000009987 spinning Methods 0.000 claims description 11
238000000605 extraction Methods 0.000 claims description 9
238000002156 mixing Methods 0.000 claims description 8
229920002545 silicone oil Polymers 0.000 claims description 8
238000002844 melting Methods 0.000 claims description 6
230000008018 melting Effects 0.000 claims description 6
230000015556 catabolic process Effects 0.000 claims description 5
238000002425 crystallisation Methods 0.000 claims description 5
230000008025 crystallization Effects 0.000 claims description 5
238000006731 degradation reaction Methods 0.000 claims description 5
238000007599 discharging Methods 0.000 claims description 5
229920001223 polyethylene glycol Polymers 0.000 claims description 5
239000011369 resultant mixture Substances 0.000 claims description 5
239000002202 Polyethylene glycol Substances 0.000 claims description 4
239000004698 Polyethylene Substances 0.000 claims 1
229920000573 polyethylene Polymers 0.000 claims 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 24
239000000203 mixture Substances 0.000 description 18
239000001569 carbon dioxide Substances 0.000 description 12
229910002092 carbon dioxide Inorganic materials 0.000 description 12
239000012530 fluid Substances 0.000 description 10
230000000694 effects Effects 0.000 description 9
238000012546 transfer Methods 0.000 description 9
238000010438 heat treatment Methods 0.000 description 8
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 8
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 8
230000001747 exhibiting effect Effects 0.000 description 7
230000035699 permeability Effects 0.000 description 7
239000002994 raw material Substances 0.000 description 7
241000283690 Bos taurus Species 0.000 description 6
239000000945 filler Substances 0.000 description 6
238000012856 packing Methods 0.000 description 6
235000010356 sorbitol Nutrition 0.000 description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
206010018910 Haemolysis Diseases 0.000 description 5
239000003570 air Substances 0.000 description 5
239000000306 component Substances 0.000 description 5
230000008588 hemolysis Effects 0.000 description 5
229920000098 polyolefin Polymers 0.000 description 5
238000004382 potting Methods 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
AJDIZQLSFPQPEY-UHFFFAOYSA-N 1,1,2-Trichlorotrifluoroethane Chemical compound FC(F)(Cl)C(F)(Cl)Cl AJDIZQLSFPQPEY-UHFFFAOYSA-N 0.000 description 4
102000001554 Hemoglobins Human genes 0.000 description 4
108010054147 Hemoglobins Proteins 0.000 description 4
238000009826 distribution Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
229920002379 silicone rubber Polymers 0.000 description 4
239000004945 silicone rubber Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000013078 crystal Substances 0.000 description 3
150000008282 halocarbons Chemical class 0.000 description 3
229920001519 homopolymer Polymers 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
229920005989 resin Polymers 0.000 description 3
239000011347 resin Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
241000894007 species Species 0.000 description 3
CBQYNPHHHJTCJS-UHFFFAOYSA-N Alline Chemical compound C1=CC=C2C3(O)CCN(C)C3NC2=C1 CBQYNPHHHJTCJS-UHFFFAOYSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
239000005977 Ethylene Substances 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000002950 deficient Effects 0.000 description 2
239000011521 glass Substances 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
239000000155 melt Substances 0.000 description 2
239000005026 oriented polypropylene Substances 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
238000005191 phase separation Methods 0.000 description 2
238000007639 printing Methods 0.000 description 2
230000008569 process Effects 0.000 description 2
FMZUHGYZWYNSOA-VVBFYGJXSA-N (1r)-1-[(4r,4ar,8as)-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol Chemical compound C([C@@H]1OC(O[C@@H]([C@@H]1O1)[C@H](O)CO)C=2C=CC=CC=2)OC1C1=CC=CC=C1 FMZUHGYZWYNSOA-VVBFYGJXSA-N 0.000 description 1
UGCSPKPEHQEOSR-UHFFFAOYSA-N 1,1,2,2-tetrachloro-1,2-difluoroethane Chemical compound FC(Cl)(Cl)C(F)(Cl)Cl UGCSPKPEHQEOSR-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical class CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
239000012503 blood component Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
229940087101 dibenzylidene sorbitol Drugs 0.000 description 1
UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
229940099364 dichlorofluoromethane Drugs 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000000635 electron micrograph Methods 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000001307 helium Substances 0.000 description 1
229910052734 helium Inorganic materials 0.000 description 1
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical class CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002074 melt spinning Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
239000000178 monomer Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000008188 pellet Substances 0.000 description 1
238000005453 pelletization Methods 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920003216 poly(methylphenylsiloxane) Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical class CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
229920001384 propylene homopolymer Polymers 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000009877 rendering Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
239000008279 sol Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000004804 winding Methods 0.000 description 1

Landscapes

External Artificial Organs (AREA)
Separation Using Semi-Permeable Membranes (AREA)

CA000556829A 1987-01-20 1988-01-19 Membrane de fibres creuses de polypropylene poreux, methode pour sa production et son utilisation dans des poumons artificiels Expired - Lifetime CA1310159C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8,982/1987		1987-01-20
JP898287		1987-01-20

Publications (1)

Publication Number	Publication Date
CA1310159C true CA1310159C (fr)	1992-11-17

Family

ID=11707895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000556829A Expired - Lifetime CA1310159C (fr)	1987-01-20	1988-01-19	Membrane de fibres creuses de polypropylene poreux, methode pour sa production et son utilisation dans des poumons artificiels

Country Status (1)

Country	Link
CA (1)	CA1310159C (fr)

1988
- 1988-01-19 CA CA000556829A patent/CA1310159C/fr not_active Expired - Lifetime

Legal Events

Date	Code	Title	Description
2009-11-17	MKEX	Expiry

Publication	Publication Date	Title
EP0341309B1 (fr)	1996-12-27	Membrane de polypropylene poreux et procede de production
CA1271907A (fr)	1990-07-24	Membrane de fibres creuses derivees de la filature d'une composition de polyolefine et de produit de charge en fusion
EP0209465B1 (fr)	1992-03-18	Membrane sous forme de fibre creuse pour poumon artificiel, son procédé de fabrication, et poumon artificiel utilisant cette fibre creuse
US6375876B1 (en)	2002-04-23	Method for producing an integrally asymmetrical polyolefin membrane
JP4996011B2 (ja)	2012-08-08	一体型非対称ポリオレフィン膜
KR100991596B1 (ko)	2010-11-04	할라 막
US5489382A (en)	1996-02-06	Oxygenator using porous hollow fiber membrane
EP0217698A2 (fr)	1987-04-08	Procédé de fabrication d'une membrane poreuse pour séparer des éléments du sang
JPH0235918A (ja)	1990-02-06	ポリプロピレン多孔質中空糸膜およびその製造方法
CA1310159C (fr)	1992-11-17	Membrane de fibres creuses de polypropylene poreux, methode pour sa production et son utilisation dans des poumons artificiels
CA1324470C (fr)	1993-11-23	Membrane poreuse en fibres creuses, methode de production et oxygenateur forme de ce type de membrane
JPS6297603A (ja)	1987-05-07	ポリプロピレン多孔質膜およびその製造方法
JPH01168303A (ja)	1989-07-03	多孔質中空糸膜およびその製造方法ならびに人工肺
JPH01228505A (ja)	1989-09-12	多孔質中空糸膜、その製造方法およびその中空糸膜を用いた人工肺
JPH0474046B2 (fr)	1992-11-25
JP2932189B2 (ja)	1999-08-09	多孔質中空糸膜および中空糸膜型人工肺
JPH0563212B2 (fr)	1993-09-10
JPH01228503A (ja)	1989-09-12	多孔質中空糸膜、その製造方法およびその中空糸膜を用いた人工肺
JPH0542207A (ja)	1993-02-23	多孔質中空糸膜、人工肺および体外循環回路
JPS6190707A (ja)	1986-05-08	中空糸膜の製造方法
JPS63224702A (ja)	1988-09-19	ポリプロピレン多孔質膜およびその製造方法
JPH0564663A (ja)	1993-03-19	多孔質中空糸膜および人工肺
JPH01228506A (ja)	1989-09-12	多孔質中空糸膜、その製造方法およびその中空糸膜を用いた人工肺