CA1317206C - Methode pour la detection d'un composant d'un systeme biologique, et dispositif et trousse de detection utilises a cette fin - Google Patents
Methode pour la detection d'un composant d'un systeme biologique, et dispositif et trousse de detection utilises a cette finInfo
- Publication number
- CA1317206C CA1317206C CA000547339A CA547339A CA1317206C CA 1317206 C CA1317206 C CA 1317206C CA 000547339 A CA000547339 A CA 000547339A CA 547339 A CA547339 A CA 547339A CA 1317206 C CA1317206 C CA 1317206C
- Authority
- CA
- Canada
- Prior art keywords
- layer
- detecting
- light
- biological component
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 229910001512 metal fluoride Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002052 molecular layer Substances 0.000 description 1
- 229910000476 molybdenum oxide Inorganic materials 0.000 description 1
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- QGLKJKCYBOYXKC-UHFFFAOYSA-N nonaoxidotritungsten Chemical compound O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 QGLKJKCYBOYXKC-UHFFFAOYSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- CCCMONHAUSKTEQ-UHFFFAOYSA-N octadecene Natural products CCCCCCCCCCCCCCCCC=C CCCMONHAUSKTEQ-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- YEXPOXQUZXUXJW-UHFFFAOYSA-N oxolead Chemical compound [Pb]=O YEXPOXQUZXUXJW-UHFFFAOYSA-N 0.000 description 1
- PQQKPALAQIIWST-UHFFFAOYSA-N oxomolybdenum Chemical compound [Mo]=O PQQKPALAQIIWST-UHFFFAOYSA-N 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- AHTFMWCHTGEJHA-UHFFFAOYSA-N s-(2,5-dioxooxolan-3-yl) ethanethioate Chemical compound CC(=O)SC1CC(=O)OC1=O AHTFMWCHTGEJHA-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229910001930 tungsten oxide Inorganic materials 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/29—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22205886A JPS6378052A (ja) | 1986-09-22 | 1986-09-22 | 安定化された免疫検出用簡易デバイス及び免疫検出方法 |
| JP222,058/86 | 1986-09-22 | ||
| JP62095367A JP2545387B2 (ja) | 1987-04-20 | 1987-04-20 | 生体成分検出法 |
| JP95,367/87 | 1987-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1317206C true CA1317206C (fr) | 1993-05-04 |
Family
ID=26436615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000547339A Expired - Fee Related CA1317206C (fr) | 1986-09-22 | 1987-09-21 | Methode pour la detection d'un composant d'un systeme biologique, et dispositif et trousse de detection utilises a cette fin |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US4820649A (fr) |
| EP (1) | EP0261642A3 (fr) |
| CA (1) | CA1317206C (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060237A (en) * | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
| US5468606A (en) * | 1989-09-18 | 1995-11-21 | Biostar, Inc. | Devices for detection of an analyte based upon light interference |
| US5482830A (en) * | 1986-02-25 | 1996-01-09 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US5102798A (en) * | 1988-09-08 | 1992-04-07 | Allage Associates | Surface functionalized Langmuir-Blodgett films for immobilization of active moieties |
| US5017986A (en) * | 1989-08-28 | 1991-05-21 | At&T Bell Laboratories | Optical device mounting apparatus |
| US5541057A (en) * | 1989-09-18 | 1996-07-30 | Biostar, Inc. | Methods for detection of an analyte |
| WO1991004483A1 (fr) * | 1989-09-18 | 1991-04-04 | Biostar Medical Products, Inc. | Appareil de detection d'un analyte immobilise |
| US5639671A (en) * | 1989-09-18 | 1997-06-17 | Biostar, Inc. | Methods for optimizing of an optical assay device |
| DK0429907T3 (da) * | 1989-11-21 | 1994-10-03 | Bayer Ag | Optisk biosensor |
| US5169599A (en) * | 1990-08-30 | 1992-12-08 | Teknekron Sensor Development Corporation | Method and apparatus for optically detecting presence of immunological components |
| US5550063A (en) * | 1991-02-11 | 1996-08-27 | Biostar, Inc. | Methods for production of an optical assay device |
| US5955377A (en) * | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| US5418136A (en) * | 1991-10-01 | 1995-05-23 | Biostar, Inc. | Devices for detection of an analyte based upon light interference |
| DE4200088C2 (de) * | 1992-01-04 | 1997-06-19 | Nahm Werner | Verfahren und Vorrichtung zum optischen Nachweis einer An- oder Einlagerung mindestens einer stofflichen Spezies in oder an mindestens einer dünnen Schicht |
| US6015683A (en) * | 1992-07-15 | 2000-01-18 | Clinical Diagnostic Systems, Inc. | Dry analytical element for acetaminophen assay |
| US5494829A (en) * | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| EP1126278B1 (fr) * | 1992-07-31 | 2007-05-23 | Inverness Medical - BioStar Inc. | Dispositifs et méthodes de détection d'un analyte basés sur l'interférence de lumière |
| US5919712A (en) | 1993-05-18 | 1999-07-06 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5512492A (en) | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| US5677196A (en) * | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| EP0701698B1 (fr) * | 1993-06-01 | 1997-11-19 | E.I. Du Pont De Nemours And Company | Composition de ktp sensible a un analyte et procede |
| US5552272A (en) * | 1993-06-10 | 1996-09-03 | Biostar, Inc. | Detection of an analyte by fluorescence using a thin film optical device |
| US5413939A (en) * | 1993-06-29 | 1995-05-09 | First Medical, Inc. | Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor |
| CA2133946C (fr) * | 1993-11-12 | 2006-04-18 | Richard Barner | Silanes servant a recouvrir la surface de materiaux dielectriques |
| JPH092926A (ja) * | 1995-04-12 | 1997-01-07 | Quest Internatl Bv | 口内組成物 |
| JPH095326A (ja) * | 1995-06-22 | 1997-01-10 | Ss Pharmaceut Co Ltd | 金コロイド免疫測定法 |
| EP0787298A1 (fr) | 1995-08-22 | 1997-08-06 | Koninklijke Philips Electronics N.V. | Procede et dispositif de recherche d'un comportement optique non lineaire d'une couche formee d'un premier et d'un deuxieme reactif, par exemple anticorps et antigene |
| DE19601488C1 (de) | 1996-01-17 | 1997-05-28 | Itt Ind Gmbh Deutsche | Verfahren zum Herstellen einer Meßeinrichtung sowie danach hergestellte Meßeinrichtung |
| US5679579A (en) * | 1996-01-29 | 1997-10-21 | First Medical, Inc. | Immunofluorescence measurement of analytes bound to a substrate and apparatus therefor |
| US5958704A (en) | 1997-03-12 | 1999-09-28 | Ddx, Inc. | Sensing system for specific substance and molecule detection |
| US6333093B1 (en) | 1997-03-17 | 2001-12-25 | Westaim Biomedical Corp. | Anti-microbial coatings having indicator properties and wound dressings |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| US6492133B1 (en) * | 2000-05-01 | 2002-12-10 | 3M Innovative Properties Company | Reflective disc assay devices, systems and methods |
| RU2181487C2 (ru) | 2000-05-11 | 2002-04-20 | Никитин Петр Иванович | Способ оптического детектирования присоединения вещественного компонента к сенсорному материалу на основе биологического, химического или физического взаимодействия и устройство для его осуществления (варианты) |
| US6706479B2 (en) | 2000-10-05 | 2004-03-16 | Virginia Tech Intellectual Properties, Inc. | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
| FR2818378B1 (fr) * | 2000-12-14 | 2003-06-13 | Commissariat Energie Atomique | Dispositif de renforcement de fluorescence large bande a faibles pertes et capteur optique biologique ou chimique l'utilisant |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US20020168667A1 (en) * | 2001-03-23 | 2002-11-14 | Fuji Photo Film Co., Ltd. | Antigen detecting agent and antigen detecting kit, antigen detecting apparatus and antigen detecting method using the same |
| JP3907508B2 (ja) * | 2001-07-30 | 2007-04-18 | 松下エコシステムズ株式会社 | 微生物採取チップ、微生物採取キット、微生物計量方法及び微生物計量装置 |
| DE10148778C2 (de) * | 2001-10-02 | 2003-10-09 | Univ Braunschweig Tech | Verfahren zur Bestimmung der Beschaffenheit einer Probe |
| US7449146B2 (en) * | 2002-09-30 | 2008-11-11 | 3M Innovative Properties Company | Colorimetric sensor |
| US20040062682A1 (en) * | 2002-09-30 | 2004-04-01 | Rakow Neal Anthony | Colorimetric sensor |
| US7402279B2 (en) * | 2002-10-31 | 2008-07-22 | Agilent Technologies, Inc. | Device with integrated microfluidic and electronic components |
| US7285789B2 (en) * | 2003-06-06 | 2007-10-23 | Oc Oerlikon Balzers Ag | Optical device for surface-generated fluorescence |
| JP4360265B2 (ja) * | 2004-05-06 | 2009-11-11 | 株式会社日立製作所 | 生化学測定チップおよび測定装置 |
| US7656525B2 (en) | 2004-10-21 | 2010-02-02 | University Of Georgia Research Foundation, Inc. | Fiber optic SERS sensor systems and SERS probes |
| US7880876B2 (en) | 2004-10-21 | 2011-02-01 | University Of Georgia Research Foundation, Inc. | Methods of use for surface enhanced raman spectroscopy (SERS) systems for the detection of bacteria |
| US7658991B2 (en) | 2004-10-21 | 2010-02-09 | University Of Georgia Research Foundation, Inc. | Structures having aligned nanorods and methods of making |
| US7738096B2 (en) | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
| US7583379B2 (en) | 2005-07-28 | 2009-09-01 | University Of Georgia Research Foundation | Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof |
| EP1828750A1 (fr) * | 2004-12-22 | 2007-09-05 | Süd-Chemie Ag | Dispositif pour detecter au moins un constituant chimique |
| US7940387B2 (en) | 2005-03-15 | 2011-05-10 | Univeristy Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof |
| US7889334B2 (en) | 2005-03-15 | 2011-02-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof |
| US7767143B2 (en) | 2006-06-27 | 2010-08-03 | 3M Innovative Properties Company | Colorimetric sensors |
| WO2009092498A2 (fr) * | 2007-12-13 | 2009-07-30 | Universität Wien | Dispositif comprenant deux couches réfléchissantes et une couche polymère pour analyser l'âge et/ou la qualité d'un produit naturel |
| KR20120016286A (ko) * | 2009-05-22 | 2012-02-23 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 다층 비색 센서 어레이 |
| BRPI1009623A2 (pt) * | 2009-05-22 | 2016-06-28 | 3M Innovative Properties Co | elemento de detecção opticamente interrogável e método para fabricação de elemento de detecção |
| IT1396382B1 (it) * | 2009-10-30 | 2012-11-19 | Bellini | Metodo per la misurazione di interazioni molecolari mediante rilevazione di luce riflessa da multistrati dielettrici funzionalzzati. |
| US8810789B2 (en) | 2011-11-07 | 2014-08-19 | University Of Georgia Research Foundation, Inc. | Thin layer chromatography-surfaced enhanced Raman spectroscopy chips and methods of use |
| EP2848251B1 (fr) * | 2013-09-12 | 2017-04-19 | King Saud University | Extraits et composés isolés à partir de Cakile arabica pour le traitements des ulcers |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054646A (en) * | 1973-07-30 | 1977-10-18 | General Electric | Method and apparatus for detection of antibodies and antigens |
| CA1039649A (fr) * | 1973-08-30 | 1978-10-03 | General Electric Company | Methode pour former des films d'un complexe immunologique en plusieurs couches |
| US3926564A (en) * | 1974-02-25 | 1975-12-16 | Gen Electric | Substrate for immunological tests and method of fabrication thereof |
| US3960488A (en) * | 1974-04-01 | 1976-06-01 | General Electric Company | Method and apparatus for quantitative surface inhibition test |
| US3979184A (en) * | 1975-05-27 | 1976-09-07 | General Electric Company | Diagnostic device for visually detecting presence of biological particles |
| US4090849A (en) * | 1976-12-20 | 1978-05-23 | General Electric Company | Diagnostic device and manufacture thereof |
| NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
| GB2095258B (en) * | 1981-03-19 | 1984-09-05 | Janssen Pharmaceutica Nv | A bright field light microscopic method of localizing tissue antigens |
| ATE30780T1 (de) * | 1981-06-22 | 1987-11-15 | Battelle Memorial Institute | Verfahren zum bestimmen bioaktiver substanzen. |
| DE3215484A1 (de) * | 1982-04-26 | 1983-11-03 | Sagax Instrument AB, 18302 Täby | Aus mehreren schichten bestehender schichtkoerper und verfahren zum nachweis und/oder messen der konzentration einer chemischen substanz, insbesondere biologischer herkunft |
-
1987
- 1987-09-21 CA CA000547339A patent/CA1317206C/fr not_active Expired - Fee Related
- 1987-09-22 US US07/099,906 patent/US4820649A/en not_active Expired - Fee Related
- 1987-09-22 EP EP87113842A patent/EP0261642A3/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0261642A2 (fr) | 1988-03-30 |
| US4820649A (en) | 1989-04-11 |
| EP0261642A3 (fr) | 1989-11-29 |
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