CA1317226C - Liquide visco-elastique pour chirurgie ophtalmique et methode d'utilisation - Google Patents

Liquide visco-elastique pour chirurgie ophtalmique et methode d'utilisation

Info

Publication number: CA1317226C
Authority: CA; Canada
Prior art keywords: ophthalmic surgery; surgery; same; corneal; solution
Prior art date: 1987-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000562926A

Other languages

English (en)

Inventor

Phillip E. Pennell

John M. Blackmore

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MDR Group Inc

Original Assignee

MDR Group Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-04

Filing date

1988-03-30

Publication date

1993-05-04

1988-03-30 Application filed by MDR Group Inc filed Critical MDR Group Inc

1993-05-04 Application granted granted Critical

1993-05-04 Publication of CA1317226C publication Critical patent/CA1317226C/fr

2010-05-04 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000001356 surgical procedure Methods 0.000 title claims abstract description 19
239000012530 fluid Substances 0.000 title abstract description 7
238000000034 method Methods 0.000 title abstract description 6
239000000243 solution Substances 0.000 claims abstract description 11
229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 6
239000003855 balanced salt solution Substances 0.000 claims abstract description 5
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 5
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 5
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 5
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 5
238000002360 preparation method Methods 0.000 claims description 2
239000000203 mixture Substances 0.000 abstract description 7
210000004087 cornea Anatomy 0.000 abstract description 4
230000001050 lubricating effect Effects 0.000 abstract 1
239000000463 material Substances 0.000 description 8
230000000699 topical effect Effects 0.000 description 7
239000003795 chemical substances by application Substances 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
-1 polyethylene Polymers 0.000 description 5
239000004698 Polyethylene Substances 0.000 description 4
229920002385 Sodium hyaluronate Polymers 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
229920000573 polyethylene Polymers 0.000 description 4
239000000047 product Substances 0.000 description 4
229940010747 sodium hyaluronate Drugs 0.000 description 4
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 3
239000001856 Ethyl cellulose Substances 0.000 description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
238000000576 coating method Methods 0.000 description 3
229920001249 ethyl cellulose Polymers 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
238000009472 formulation Methods 0.000 description 3
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 3
229940014041 hyaluronate Drugs 0.000 description 3
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000011734 sodium Substances 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
210000002159 anterior chamber Anatomy 0.000 description 2
238000001035 drying Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
210000002889 endothelial cell Anatomy 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
239000012266 salt solution Substances 0.000 description 2
230000002226 simultaneous effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000009736 wetting Methods 0.000 description 2
NSMXQKNUPPXBRG-SECBINFHSA-N (R)-lisofylline Chemical compound O=C1N(CCCC[C@H](O)C)C(=O)N(C)C2=C1N(C)C=N2 NSMXQKNUPPXBRG-SECBINFHSA-N 0.000 description 1
JVLFMTZUPSBCNJ-UHFFFAOYSA-N 3,5-difluoropyridin-2-amine Chemical compound NC1=NC=C(F)C=C1F JVLFMTZUPSBCNJ-UHFFFAOYSA-N 0.000 description 1
244000058084 Aegle marmelos Species 0.000 description 1
235000003930 Aegle marmelos Nutrition 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
208000003556 Dry Eye Syndromes Diseases 0.000 description 1
206010013774 Dry eye Diseases 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000084978 Rena Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
239000000607 artificial tear Substances 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000002844 continuous effect Effects 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
230000003511 endothelial effect Effects 0.000 description 1
210000000871 endothelium corneal Anatomy 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000004410 intraocular pressure Effects 0.000 description 1
230000003020 moisturizing effect Effects 0.000 description 1
208000001491 myopia Diseases 0.000 description 1
230000004379 myopia Effects 0.000 description 1
229940023490 ophthalmic product Drugs 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Ophthalmology & Optometry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Surgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)
Medicinal Preparation (AREA)

CA000562926A 1987-05-04 1988-03-30 Liquide visco-elastique pour chirurgie ophtalmique et methode d'utilisation Expired - Fee Related CA1317226C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4532687A	1987-05-04	1987-05-04
US045,326		1987-05-04

Publications (1)

Publication Number	Publication Date
CA1317226C true CA1317226C (fr)	1993-05-04

Family

ID=21937238

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000562926A Expired - Fee Related CA1317226C (fr)	1987-05-04	1988-03-30	Liquide visco-elastique pour chirurgie ophtalmique et methode d'utilisation

Country Status (6)

Country	Link
EP (1)	EP0359766A4 (fr)
JP (1)	JPS6464653A (fr)
AU (1)	AU1726088A (fr)
CA (1)	CA1317226C (fr)
GB (1)	GB2204238A (fr)
WO (1)	WO1988008709A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4020623C2 (de) *	1990-06-29	1996-06-05	Mezotraslevoj Nt Kompleks Mikr	Hornhaut-Protektor und Verfahren zu dessen Herstellung
KR100246016B1 (ko)	1993-04-30	2000-04-01	피르 포겔	안과용 합성 점탄성 물질
RU2115413C1 (ru) *	1997-03-03	1998-07-20	Малое государственное предприятие "Научно-экспериментальное производство"	Ирригационный раствор "интрасол"
EP1132065A1 (fr) *	2000-03-07	2001-09-12	Gerrit Reinold Jacob Melles	Composition visco-élastique colorée
JP2005502581A (ja) *	2000-12-20	2005-01-27	アルコン、インコーポレイテッド	改良された流動特性を有する眼内潅流溶液
US7169755B2 (en)	2000-12-20	2007-01-30	Alcon, Inc.	Solution for removing cataracts via liquefracture
US7084130B2 (en)	2001-12-11	2006-08-01	Alcon, Inc.	Intraocular irrigating solution having improved flow characteristics
TWI544922B (zh)	2011-05-19	2016-08-11	愛爾康研究有限公司	高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
CN105749360B (zh) *	2016-03-28	2019-06-18	赛克赛斯生物科技股份有限公司	一种保护角膜的组合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3856919A (en) *	1970-06-08	1974-12-24	Burton Parsons Chemicals Inc	Ophthalmic solution
US3947573A (en) *	1969-12-01	1976-03-30	Burton, Parsons And Company, Inc.	Opthalmic solution
GB1340517A (en) *	1969-12-01	1973-12-12	Burton Parsons Chemicals Inc	Ophthalmic solution
NL188266C (nl) *	1975-07-29	1992-05-18	Merck & Co Inc	Werkwijze ter bereiding van een oogheelkundig inplantaat.
US4287175A (en) *	1978-06-22	1981-09-01	Merck & Co., Inc.	Contact lens wetting agents
US4629623A (en) *	1984-06-11	1986-12-16	Biomatrix, Inc.	Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
GB2167300B (en) *	1984-11-23	1988-11-23	Fisons Plc	Formulations

1988
- 1988-03-30 CA CA000562926A patent/CA1317226C/fr not_active Expired - Fee Related
- 1988-04-15 GB GB08808983A patent/GB2204238A/en not_active Withdrawn
- 1988-04-27 AU AU17260/88A patent/AU1726088A/en not_active Abandoned
- 1988-04-27 EP EP19880904341 patent/EP0359766A4/en not_active Withdrawn
- 1988-04-27 WO PCT/US1988/001389 patent/WO1988008709A1/fr not_active Ceased
- 1988-05-02 JP JP63107739A patent/JPS6464653A/ja active Pending

Also Published As

Publication number	Publication date
AU1726088A (en)	1988-12-06
WO1988008709A1 (fr)	1988-11-17
EP0359766A1 (fr)	1990-03-28
EP0359766A4 (en)	1990-12-19
JPS6464653A (en)	1989-03-10
GB8808983D0 (en)	1988-05-18
GB2204238A (en)	1988-11-09

Legal Events

Date	Code	Title	Description
1997-05-05	MKLA	Lapsed

Publication	Publication Date	Title
US5792103A (en)	1998-08-11	Viscosurgical method and apparatus
CA2589397C (fr)	2015-03-31	Solutions viscoelastiques contenant de l'hyaluronate de sodium et de l'hydroxypropyl methyl cellulose, preparation et utilisations
US5273056A (en)	1993-12-28	Use of combinations of viscoelastics during surgery
US4486416A (en)	1984-12-04	Protection of human and animal cells subject to exposure to trauma
US3920810A (en)	1975-11-18	Polyacrylamide containing ophthalmic solutions
KR100543055B1 (ko)	2006-01-20	콘택트렌즈 패킹 용액과 일회용 콘택트렌즈의 착용감을개선시키는 방법
CA1317226C (fr)	1993-05-04	Liquide visco-elastique pour chirurgie ophtalmique et methode d'utilisation
EP1263363B1 (fr)	2005-02-02	Composition viscoelastique coloree
WO2014032804A1 (fr)	2014-03-06	Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium
WO2003051332A1 (fr)	2003-06-26	Compositions ophtalmiques comprenant deux composants polyanioniques differents pour lubrifier les yeux et leurs procedes de fabrication et d'utilisation
Kabir et al.	2024	Development of an in-situ forming collagen-based hydrogel as a regenerative bioadhesive for corneal perforations
FR2968996A1 (fr)	2012-06-22	Formulation aqueuse injectable sterile utilisee en ophtalmologie
EP1455750B1 (fr)	2006-02-08	Combinaisons de produits viscoelastiques a l'usage de la chirurgie
Yang et al.	2025	Evaluating the feasibility and safety of a self-crosslinked hyaluronic acid hydrogel for experimental retinal detachment repair
ES2309735T3 (es)	2008-12-16	Composicion viscoelastica que comprende un nuevo fagocito de radical libre; metodos de utilizacion y empaquetado.
EP3294778B1 (fr)	2019-04-10	Micro-éponges de acide hyaluronique et procede de production
US20040118414A1 (en)	2004-06-24	Surface modified viscoelastics for ocular surgery
KR102610288B1 (ko)	2023-12-05	안과 점탄성 조성물
US20060003964A1 (en)	2006-01-05	Dilution resistant viscoelastic compositions
RU2086217C1 (ru)	1997-08-10	Протектор эндотелия роговицы для экстренной офтальмохирургии
US7101564B1 (en)	2006-09-05	Plastically deformable implant
WO2015102000A2 (fr)	2015-07-09	Dispositif viscochirurgical ophtalmique
JPS5857319A (ja)	1983-04-05	高粘性ヒアルロン酸製剤
US5110590A (en)	1992-05-05	Use of a solution of alpha-chymotrypsin
US5061696A (en)	1991-10-29	Hypotonic compositions for selectively killing undesirable lens cells in the human eye and methods for using such compositions