CA1318630C - Preparation de l'antibiotique chloropolysporin c - Google Patents

Preparation de l'antibiotique chloropolysporin c

Info

Publication number: CA1318630C
Authority: CA; Canada
Prior art keywords: chloropolysporin; hydrolysis; measured; water; residue
Prior art date: 1986-07-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000542099A

Other languages

English (en)

Inventor

Tatsuo Haneishi

Toshiaki Katayama

Seigo Iwado

Ryuzo Enokita

Akio Torikata

Mutsuo Nakajima

Takao Okazaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-11

Filing date

1987-07-13

Publication date

1993-06-01

1987-07-13 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

1993-06-01 Application granted granted Critical

1993-06-01 Publication of CA1318630C publication Critical patent/CA1318630C/fr

2010-06-01 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

108010067172 chloropolysporin C Proteins 0.000 title claims abstract description 24
238000002360 preparation method Methods 0.000 title claims description 12
230000003115 biocidal effect Effects 0.000 title claims description 11
108010067160 chloropolysporin B Proteins 0.000 claims abstract description 25
PCGBWZQZOMMXGB-UHFFFAOYSA-N chloropolysporin b Chemical compound C=1C=C(OC2C(C(O)C(O)C(C)O2)O)C=CC=1C(NC)C(=O)NC(C(NC(C(=O)NC1C(=O)NC2C(=O)NC(C(NC(C3=CC(O)=CC(O)=C3C=3C(O)=CC=C2C=3)C(O)=O)=O)C(OC2OC(C)C(O)C(N)C2)C2=CC=C(C(=C2)Cl)OC=2C=C1C=C(C=2OC1C(C(O)C(O)C(CO)O1)O)OC1=CC=C2C=C1Cl)C=1C=C(Cl)C(O)=CC=1)=O)C2OC1OC(CO)C(O)C(O)C1O PCGBWZQZOMMXGB-UHFFFAOYSA-N 0.000 claims abstract description 25
150000001875 compounds Chemical class 0.000 claims abstract description 4
230000007071 enzymatic hydrolysis Effects 0.000 claims abstract description 3
238000006047 enzymatic hydrolysis reaction Methods 0.000 claims abstract description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 37
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 23
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 12
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)

CA000542099A 1986-07-11 1987-07-13 Preparation de l'antibiotique chloropolysporin c Expired - Fee Related CA1318630C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16299086		1986-07-11
JP61-162990		1986-07-11

Publications (1)

Publication Number	Publication Date
CA1318630C true CA1318630C (fr)	1993-06-01

Family

ID=15765112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000542099A Expired - Fee Related CA1318630C (fr)	1986-07-11	1987-07-13	Preparation de l'antibiotique chloropolysporin c

Country Status (5)

Country	Link
JP (1)	JPS63146797A (fr)
KR (1)	KR950014463B1 (fr)
AR (1)	AR246095A1 (fr)
CA (1)	CA1318630C (fr)
ES (1)	ES2007074A6 (fr)

1987
- 1987-06-30 JP JP62161132A patent/JPS63146797A/ja active Pending
- 1987-07-10 ES ES8702041A patent/ES2007074A6/es not_active Expired
- 1987-07-10 AR AR87308121A patent/AR246095A1/es active
- 1987-07-11 KR KR1019870007475A patent/KR950014463B1/ko not_active Expired - Lifetime
- 1987-07-13 CA CA000542099A patent/CA1318630C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR950014463B1 (ko)	1995-11-28
JPS63146797A (ja)	1988-06-18
AR246095A1 (es)	1994-03-30
KR880001819A (ko)	1988-04-27
ES2007074A6 (es)	1989-06-01

Legal Events

Date	Code	Title	Description
1995-12-03	MKLA	Lapsed

Publication	Publication Date	Title
TANAKA et al.	1997	Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity
NL192989C (nl)	1998-07-03	Antibioticum, werkwijze voor de bereiding en farmaceutisch preparaat dat dit antibioticum bevat.
CA1297825C (fr)	1992-03-24	Antibiotiques appeles "chloropolysporines b et c", leur procede de preparation et leurs utilisations pharmaceutiques et veterinaires
AU614760B2 (en)	1991-09-12	A new antimicrobial agent, fr 109615 and production thereof
US4409210A (en)	1983-10-11	Antibiotic compound
CA1318630C (fr)	1993-06-01	Preparation de l'antibiotique chloropolysporin c
US4376778A (en)	1983-03-15	Antibiotic substances and processes for production thereof
CA1212060A (fr)	1986-09-30	Chloropolysporine antibiotique, procede de preparation et usages therapeutiques et veterinaires
GB2042532A (en)	1980-09-24	Antibiotics c-19393 s2 and 'i
US4341768A (en)	1982-07-27	Antibiotic compounds
US20090023665A1 (en)	2009-01-22	Antibiotics ge 81112 factors a, b, b1, pharmaceutically acceptable salts and compositions, and use thereof
US4533631A (en)	1985-08-06	Fermentation process for preparation of antibiotic Bu-2517
EP0253413B1 (fr)	1993-10-13	Antibiotiques appelés "Mureidomycines A,B,C et D", leur procédé de préparation et leur emploi thérapeutique
JPH07114704B2 (ja)	1995-12-13	抗生物質ａ４２８６７およびその付加塩
CA1046965A (fr)	1979-01-23	Naphthyridinomycines produite par un streptomyces
JP2594167B2 (ja)	1997-03-26	新規抗生物質ｓｆ２６９８物質およびその製造法
US4360593A (en)	1982-11-23	Process of producing a peptide antibiotic with Bacillus circulans
JPS6310797A (ja)	1988-01-18	抗生物質ｆ―０７６９
US4950605A (en)	1990-08-21	FR-900493 substance, a process for its production and a pharmaceutical composition containing the same
CA1228313A (fr)	1987-10-20	Antibiotique sb 22 484
JPH06234784A (ja)	1994-08-23	新規抗生物質ｓｆ２７６８物質及びその製造法
US4298599A (en)	1981-11-03	Novel antibiotic BN-235 substance, and process for the production thereof
US3995028A (en)	1976-11-30	Antibiotic OS-3256-B
JP2002226499A (ja)	2002-08-14	抗生物質ｇｅ２３０７７、その医薬上許容される塩および組成物ならびにそれらの用途
SU574162A3 (ru)	1977-09-25	"Способ получени гидроокиси ангидро-4-карбамоил-5-окси-1рибофуранозилимидазола (брединина)