CA1320162C - Methode de stabilisation de l'expression de la proteine heterologue, et vecteurs servant a cette fin - Google Patents

Methode de stabilisation de l'expression de la proteine heterologue, et vecteurs servant a cette fin

Info

Publication number: CA1320162C
Authority: CA; Canada
Prior art keywords: cat; protein; gene; expression; gene sequence
Prior art date: 1988-08-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000607908A

Other languages

English (en)

Inventor

Sandra Hilliker

R. Tyler White

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Scios LLC

Original Assignee

California Biotechnology Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-11

Filing date

1989-08-09

Publication date

1993-07-13

1989-08-09 Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc

1993-07-13 Application granted granted Critical

1993-07-13 Publication of CA1320162C publication Critical patent/CA1320162C/fr

2010-07-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Neurology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA000607908A 1988-08-11 1989-08-09 Methode de stabilisation de l'expression de la proteine heterologue, et vecteurs servant a cette fin Expired - Fee Related CA1320162C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23122488A	1988-08-11	1988-08-11
US231,224		1988-08-11

Publications (1)

Publication Number	Publication Date
CA1320162C true CA1320162C (fr)	1993-07-13

Family

ID=22868276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000607908A Expired - Fee Related CA1320162C (fr)	1988-08-11	1989-08-09	Methode de stabilisation de l'expression de la proteine heterologue, et vecteurs servant a cette fin

Country Status (6)

Country	Link
EP (1)	EP0428615A4 (fr)
JP (1)	JPH04501204A (fr)
AU (1)	AU4216689A (fr)
CA (1)	CA1320162C (fr)
IL (1)	IL91272A0 (fr)
WO (1)	WO1990001540A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
TW327194B (en) *	1992-05-01	1998-02-21	American Cyanamid Co	Novel amyloid precursor proteins and methods of using same
NL9201173A (nl) *	1992-07-01	1994-02-01	Leuven K U Res & Dev	Vector voor positieve selectie van recombinanten.
DK144093D0 (fr) *	1993-12-23	1993-12-23	Novo Nordisk As
US6031075A (en) *	1996-02-05	2000-02-29	Children's Hospital Medical Center	Mature alveolar SP-B and a process for producing the same
DE69930938T2 (de) *	1998-07-10	2007-01-11	Scios Inc., Fremont	Verfahren zur herstellung eines peptids mit einem pi grösser als 8 oder kleiner als 5
EP2213743A1 (fr)	2000-04-12	2010-08-04	Human Genome Sciences, Inc.	Protéines de fusion d'albumine
AT410444B (de) *	2001-03-02	2003-04-25	Oesterr Forsch Seibersdorf	Verfahren zur detektion von nukleinsäuremolekülen
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins
WO2005003296A2 (fr)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Proteines hybrides d'albumine
HUE027902T2 (en)	2004-02-09	2016-11-28	Human Genome Sciences Inc Corp Service Company	Albumin fusion proteins
WO2010068754A2 (fr)	2008-12-10	2010-06-17	Paka Pulmonary Pharmaceuticals, Inc.	Procédés et compositions pour la délivrance de médicaments aux poumons
CN117343200B (zh) *	2023-12-04	2024-01-30	北京质肽生物医药科技有限公司	一种包含淀粉样核心多肽的融合蛋白、制备方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8314362D0 (en) *	1983-05-24	1983-06-29	Celltech Ltd	Polypeptide and protein products
US4933280A (en) *	1984-12-11	1990-06-12	California Biotechnology Inc.	Recombinant DNA sequence encoding Alveolar Surfactant Protein
GR861037B (en) *	1985-04-22	1986-07-16	Genentech Inc	Novel human tissue plasminogen activator mutants
DE3523701A1 (de) *	1985-07-03	1987-01-08	Bayer Ag	Verfahren zur herstellung von proteinen und polypeptiden
GB8518753D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Microbiological products
WO1988003170A1 (fr) *	1986-10-24	1988-05-05	Whitsett Jeffrey A	Proteines associees a des agents tensioactifs hydrophobes pulmonaires
EP0332640A1 (fr) *	1986-11-17	1989-09-20	California Biotechnology, Inc.	Proteine amyloide recombinante relative a la maladie d'alzheimer
ATE163013T1 (de) *	1987-11-04	1998-02-15	Byk Gulden Lomberg Chem Fab	Alveolare oberflächenaktive proteine

1989
- 1989-08-09 AU AU42166/89A patent/AU4216689A/en not_active Abandoned
- 1989-08-09 WO PCT/US1989/003417 patent/WO1990001540A1/fr not_active Ceased
- 1989-08-09 JP JP1509538A patent/JPH04501204A/ja active Pending
- 1989-08-09 CA CA000607908A patent/CA1320162C/fr not_active Expired - Fee Related
- 1989-08-09 EP EP19890910335 patent/EP0428615A4/en not_active Withdrawn
- 1989-08-10 IL IL91272A patent/IL91272A0/xx unknown

Also Published As

Publication number	Publication date
IL91272A0 (en)	1990-03-19
EP0428615A4 (en)	1991-11-13
WO1990001540A1 (fr)	1990-02-22
AU4216689A (en)	1990-03-05
EP0428615A1 (fr)	1991-05-29
JPH04501204A (ja)	1992-03-05

Legal Events

Date	Code	Title	Description
2002-07-15	MKLA	Lapsed

Publication	Publication Date	Title
US6500645B1 (en)	2002-12-31	N-terminally extended proteins expressed in yeast
CA1320162C (fr)	1993-07-13	Methode de stabilisation de l'expression de la proteine heterologue, et vecteurs servant a cette fin
KR100227167B1 (ko)	1999-10-15	인체혈청알부민의 n-말단 단편을 함유하는 융합단백질
JP3369168B2 (ja)	2003-01-20	精製が向上される組換えポリペプチドの発現
Kaster et al.	1983	Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing
JP3730255B2 (ja)	2005-12-21	イーストにおいて発現されたｎ末端に伸長した蛋白質
JP2566933B2 (ja)	1996-12-25	真核細胞融合タンパク質、その生産及び用途、並びに方法
JPH05268962A (ja)	1993-10-19	任意の箇所で２本鎖ｄｎａを切断する方法
JP4624495B2 (ja)	2011-02-02	ヒト・インスリンの生成
JPH0759193B2 (ja)	1995-06-28	外来性蛋白質発現用クロ−ニングベクタ−
JP3305781B2 (ja)	2002-07-24	新規なるｄｎａ分子及び宿主
JP2970811B2 (ja)	1999-11-02	原核生物細胞中にポリペプチドを調製するための発現システム
US6962796B1 (en)	2005-11-08	Production of human parathyroid hormone from microorganisms
US5420242A (en)	1995-05-30	Production of human parathyroid hormone from microorganisms
EP0946735B1 (fr)	2006-02-08	Proteines a extension d'extremite n-terminal exprimees dans la levure
JPH10511845A (ja)	1998-11-17	細菌において細胞外タンパク質を製造するための方法
HU216335B (hu)	1999-06-28	Eljárás peptidek előállítására
PT87211B (pt)	1992-07-31	Processo para a preparacao de polipeptideos por manipulacao genetica
EP0225860B1 (fr)	1992-11-11	Méthode pour transmettre des produits de gènes à un milieu de croissance de bactéries gram-négatives
JP4180112B2 (ja)	2008-11-12	酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター
US5378613A (en)	1995-01-03	Method for increased expression of low molecular weight recombinant polypeptides
Ishizaki et al.	1992	Production of recombinant human glucagon in the form of a fusion protein in Escherichia coli; recovery of glucagon by sequence-specific digestion
JPH05500615A (ja)	1993-02-12	ヒルジン及び新規のヒルジンの組換え製造方法
KR900001014B1 (ko)	1990-02-24	소 성장 호르몬 유도체 발현 벡터의 제조방법
KR900001015B1 (ko)	1990-02-24	재조합체 dna 발현 벡터의 제조방법