CA1335187C - Dideoxyinosine by enzymatic deamination of dideoxyadenosine - Google Patents

Dideoxyinosine by enzymatic deamination of dideoxyadenosine

Info

Publication number
CA1335187C
CA1335187C CA000572184A CA572184A CA1335187C CA 1335187 C CA1335187 C CA 1335187C CA 000572184 A CA000572184 A CA 000572184A CA 572184 A CA572184 A CA 572184A CA 1335187 C CA1335187 C CA 1335187C
Authority
CA
Canada
Prior art keywords
formula
group
hydroxy
protecting group
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000572184A
Other languages
English (en)
French (fr)
Inventor
Vittorio Farina
Daniel A. Benigni
Paul R. Brodfuehrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of CA1335187C publication Critical patent/CA1335187C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000572184A 1987-07-17 1988-07-15 Dideoxyinosine by enzymatic deamination of dideoxyadenosine Expired - Lifetime CA1335187C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7484487A 1987-07-17 1987-07-17
US074,844 1987-07-17

Publications (1)

Publication Number Publication Date
CA1335187C true CA1335187C (en) 1995-04-11

Family

ID=22122017

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000572184A Expired - Lifetime CA1335187C (en) 1987-07-17 1988-07-15 Dideoxyinosine by enzymatic deamination of dideoxyadenosine

Country Status (8)

Country Link
KR (1) KR930005870B1 (de)
AT (1) AT395977B (de)
CA (1) CA1335187C (de)
ES (1) ES2007532A6 (de)
FI (1) FI92602C (de)
GR (1) GR1000483B (de)
LU (1) LU87280A1 (de)
PT (1) PT88017B (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
EP0285884A3 (de) * 1987-03-20 1990-07-04 Bristol-Myers Squibb Company Verfahren zur Herstellung von 2',3'-Dideoxynucleoside

Also Published As

Publication number Publication date
FI92602C (fi) 1994-12-12
FI883339A0 (fi) 1988-07-13
AT395977B (de) 1993-04-26
PT88017B (pt) 1995-03-01
ATA173088A (de) 1992-09-15
FI883339A7 (fi) 1989-01-18
KR900001858A (ko) 1990-02-27
GR880100455A (en) 1989-04-12
KR930005870B1 (ko) 1993-06-25
PT88017A (pt) 1989-06-30
ES2007532A6 (es) 1989-06-16
FI92602B (fi) 1994-08-31
GR1000483B (el) 1992-07-30
LU87280A1 (fr) 1989-03-08

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Legal Events

Date Code Title Description
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121205