CA1336088C - 1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile - Google Patents

1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile

Info

Publication number: CA1336088C
Authority: CA; Canada
Prior art keywords: compound; formula; anomer; compound according; virus
Prior art date: 1987-04-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000580141A

Other languages

English (en)

Inventor

Roelf Dateman

Zsuzsanna M.I. Kovacs

Bjorn Gunnar Lindborg

Goran Bertil Stening

Karl Nils Gunnar Johansson

Bo Fredrik Oberg

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Medivir AB

Original Assignee

Medivir AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-10-14

Publication date

1995-06-27

1987-04-16 Priority to SE8701605A priority Critical patent/SE8701605D0/xx

1988-04-06 Priority to AU16899/88A priority patent/AU614082B2/en

1988-04-06 Priority to PCT/SE1988/000169 priority patent/WO1988008001A1/fr

1988-04-06 Priority to EP88903972A priority patent/EP0309560B1/fr

1988-04-06 Priority to EP94108798A priority patent/EP0615975A1/fr

1988-04-06 Priority to JP63503532A priority patent/JPH01503069A/ja

1988-04-06 Priority to EP19920112530 priority patent/EP0516186A3/en

1988-04-06 Priority to AT88903972T priority patent/ATE115958T1/de

1988-04-06 Priority to DE3852531T priority patent/DE3852531T2/de

1988-10-14 Priority to CA000580141A priority patent/CA1336088C/fr

1988-10-14 Application filed by Medivir AB filed Critical Medivir AB

1988-12-15 Priority to DK696988A priority patent/DK168443B1/da

1991-06-07 Priority to DK108491A priority patent/DK108491A/da

1991-11-20 Priority to US07/794,704 priority patent/US5215970A/en

1993-04-01 Priority to US08/041,165 priority patent/US5409906A/en

1994-09-13 Priority to DK104994A priority patent/DK104994A/da

1995-05-12 Priority to HU95P/P00134P priority patent/HU211547A9/hu

1995-06-27 Application granted granted Critical

1995-06-27 Publication of CA1336088C publication Critical patent/CA1336088C/fr

2012-06-27 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title claims description 6
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 title description 8
229940113082 thymine Drugs 0.000 title description 4
229940035893 uracil Drugs 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 68
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150000003839 salts Chemical class 0.000 claims abstract description 14
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 11
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims abstract description 9
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125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 claims abstract description 3
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125000003729 nucleotide group Chemical group 0.000 description 1
125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
125000005440 p-toluyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C(*)=O)C([H])([H])[H] 0.000 description 1
239000008188 pellet Substances 0.000 description 1
ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
229960002385 streptomycin sulfate Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
235000011044 succinic acid Nutrition 0.000 description 1
150000003444 succinic acids Chemical class 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical class S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
SIOVKLKJSOKLIF-HJWRWDBZSA-N trimethylsilyl (1z)-n-trimethylsilylethanimidate Chemical compound C[Si](C)(C)OC(/C)=N\[Si](C)(C)C SIOVKLKJSOKLIF-HJWRWDBZSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
229960000523 zalcitabine Drugs 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Virology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000580141A 1987-04-16 1988-10-14 1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile Expired - Fee Related CA1336088C (fr)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
SE8701605A SE8701605D0 (sv)	1987-04-16	1987-04-16	Novel medicinal compounds
PCT/SE1988/000169 WO1988008001A1 (fr)	1987-04-16	1988-04-06	Nucleosides et analogues de nucleosides, compositions et procedes pharmaceutiques permettant la preparation des composes
EP88903972A EP0309560B1 (fr)	1987-04-16	1988-04-06	Nucleosides et analogues de nucleosides, compositions et procedes pharmaceutiques permettant la preparation des composes
EP94108798A EP0615975A1 (fr)	1987-04-16	1988-04-06	Nucléosides et leurs analogues, composition pharmaceutique et procédé pour leur préparation
JP63503532A JPH01503069A (ja)	1987-04-16	1988-04-06	新規な医薬化合物
EP19920112530 EP0516186A3 (en)	1987-04-16	1988-04-06	Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
AT88903972T ATE115958T1 (de)	1987-04-16	1988-04-06	Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.
DE3852531T DE3852531T2 (de)	1987-04-16	1988-04-06	Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.
AU16899/88A AU614082B2 (en)	1987-04-16	1988-04-06	Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
CA000580141A CA1336088C (fr)	1987-04-16	1988-10-14	1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile
DK696988A DK168443B1 (da)	1987-04-16	1988-12-15	Pyrimid-2-on-1-yl-forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåde til fremstilling af forbindelserne
DK108491A DK108491A (da)	1987-04-16	1991-06-07	Nucleosider og nucleosidanaloge samt farmaceutiske praeparater indeholdende disse forbindelser
US07/794,704 US5215970A (en)	1987-04-16	1991-11-20	Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US08/041,165 US5409906A (en)	1987-04-16	1993-04-01	α nucleoside compounds and a method for treating HBV using said compounds
DK104994A DK104994A (da)	1987-04-16	1994-09-13	Anvendelse af beta-anomere forbindelser til fremstilling af farmaceutiske præparater til behandling eller forebyggelse af HIV eller hepatitis B Virus
HU95P/P00134P HU211547A9 (en)	1987-04-16	1995-05-12	Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8701605A SE8701605D0 (sv)	1987-04-16	1987-04-16	Novel medicinal compounds
CA000580141A CA1336088C (fr)	1987-04-16	1988-10-14	1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile

Publications (1)

Publication Number	Publication Date
CA1336088C true CA1336088C (fr)	1995-06-27

Family

ID=25672174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000580141A Expired - Fee Related CA1336088C (fr)	1987-04-16	1988-10-14	1- (3'-substituant-2', 3'-didesoxy-d-ribofuranosyl) thymine et uracile

Country Status (9)

Country	Link
JP (1)	JPH01503069A (fr)
AT (1)	ATE115958T1 (fr)
AU (1)	AU614082B2 (fr)
CA (1)	CA1336088C (fr)
DE (1)	DE3852531T2 (fr)
DK (3)	DK168443B1 (fr)
HU (1)	HU211547A9 (fr)
SE (1)	SE8701605D0 (fr)
WO (1)	WO1988008001A1 (fr)

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US4950758A (en) *	1988-01-20	1990-08-21	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) *	1988-01-20	1992-12-29	Regents Of The University Of Minnesota	Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en)	1988-01-20	1997-05-20	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
ATE109789T1 (de) *	1988-02-24	1994-08-15	Inst Rech Chim Biolog	Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha- amino-gruppen, verfahren zur herstellung und arzneimittel daraus.
US7119202B1 (en)	1989-02-08	2006-10-10	Glaxo Wellcome Inc.	Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5157114A (en) *	1988-08-19	1992-10-20	Burroughs Wellcome Co.	2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US5198539A (en) *	1988-08-19	1993-03-30	Burroughs Wellcome Co.	5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
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FR2648045B1 (fr) *	1989-06-13	1991-09-27	Centre Nat Rech Scient	Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
IE902574A1 (en) *	1989-07-17	1991-02-27	Univ Birmingham	Antiviral pyrimidine nucleosides
ES2253732T3 (es) *	1989-09-15	2006-06-01	Southern Research Institute	2'-deoxi-4'-tioribonucleosidos como agentes antivirales y anticancerosos.
US5591722A (en) *	1989-09-15	1997-01-07	Southern Research Institute	2'-deoxy-4'-thioribonucleosides and their antiviral activity
US6069252A (en)	1990-02-01	2000-05-30	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) *	1990-04-18	1990-06-13	Wellcome Found	Anti-viral compounds
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
US6369066B1 (en)	1990-11-13	2002-04-09	Biochem Pharma, Inc.	Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) *	1990-11-13	1996-12-24	Biochem Pharma, Inc.	Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6228860B1 (en)	1990-11-13	2001-05-08	Biochem Pharma Inc.	Substituted 1,3-oxathiolanes with antiviral properties
JP2960164B2 (ja) *	1990-11-13	1999-10-06	バイオケムファーマインコーポレイテッド	抗ウイルス特性を有する置換１，３−オキサチオラン類および置換１，３−ジチオラン類
US6235887B1 (en)	1991-11-26	2001-05-22	Isis Pharmaceuticals, Inc.	Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
EP0637965B1 (fr) *	1991-11-26	2002-10-16	Isis Pharmaceuticals, Inc.	Formation amelioree de triple et double helices a l'aide d'oligomeres contenant des pyrimidines modifiees
TW393513B (en) *	1991-11-26	2000-06-11	Isis Pharmaceuticals Inc	Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US20020120130A1 (en)	1993-09-10	2002-08-29	Gilles Gosselin	2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) *	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
US5612319A (en) *	1994-05-31	1997-03-18	Medivir Ab	Postexposure prevention of HIV infection or seroconversion
JPH10501217A (ja) *	1994-05-31	1998-02-03	メディヴィル・アクチボラグ	Ｈｉｖの被爆後阻止
US5703058A (en) *	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) *	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ES2276404T3 (es)	1995-06-07	2007-06-16	Emory University	Nucleosidos con actividad antivirus de la hepatitis-b.
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
EA200700564A1 (ru)	1998-02-25	2007-08-31	Эмори Юниверсити	2`-фторнуклеозиды
KR20090089922A (ko)	2000-10-18	2009-08-24	파마셋 인코포레이티드	바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
HRP20110193T1 (hr)	2006-10-10	2011-05-31	Medivir Ab	Inhibitor hcv nukleozida
WO2014109384A1 (fr) *	2013-01-10	2014-07-17	塩野義製薬株式会社	Procédé de production de dérivé d'acide nucléique réticulé

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PT82580B (pt) *	1985-05-15	1989-01-17	Wellcome Found	Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
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1987
- 1987-04-16 SE SE8701605A patent/SE8701605D0/xx unknown
1988
- 1988-04-06 WO PCT/SE1988/000169 patent/WO1988008001A1/fr not_active Ceased
- 1988-04-06 AT AT88903972T patent/ATE115958T1/de not_active IP Right Cessation
- 1988-04-06 DE DE3852531T patent/DE3852531T2/de not_active Expired - Fee Related
- 1988-04-06 JP JP63503532A patent/JPH01503069A/ja active Pending
- 1988-04-06 AU AU16899/88A patent/AU614082B2/en not_active Ceased
- 1988-10-14 CA CA000580141A patent/CA1336088C/fr not_active Expired - Fee Related
- 1988-12-15 DK DK696988A patent/DK168443B1/da not_active IP Right Cessation
1991
- 1991-06-07 DK DK108491A patent/DK108491A/da not_active Application Discontinuation
1994
- 1994-09-13 DK DK104994A patent/DK104994A/da not_active Application Discontinuation
1995
- 1995-05-12 HU HU95P/P00134P patent/HU211547A9/hu unknown

Also Published As

Publication number	Publication date
HU211547A9 (en)	1995-12-28
AU614082B2 (en)	1991-08-22
DK696988A (da)	1989-01-31
SE8701605D0 (sv)	1987-04-16
ATE115958T1 (de)	1995-01-15
DK696988D0 (da)	1988-12-15
DE3852531T2 (de)	1995-08-10
DK104994A (da)	1994-09-13
DK168443B1 (da)	1994-03-28
AU1689988A (en)	1988-11-04
WO1988008001A1 (fr)	1988-10-20
DK108491D0 (da)	1991-06-07
JPH01503069A (ja)	1989-10-19
DK108491A (da)	1991-06-07
DE3852531D1 (de)	1995-02-02

Legal Events

Date	Code	Title	Description
2001-06-27	MKLA	Lapsed

Publication	Publication Date	Title
WO1988008001A1 (fr)	1988-10-20	Nucleosides et analogues de nucleosides, compositions et procedes pharmaceutiques permettant la preparation des composes
EP0322384B1 (fr)	1996-03-13	Nucléosides pour utilisation en thérapie
CA1336820C (fr)	1995-08-29	Nucleosides fluores et methode correspondante de traitement des infections par un retrovirus
EP0352248A1 (fr)	1990-01-24	Dérivés de nucléosides
US5952500A (en)	1999-09-14	Nucleoside derivatives
JP4980059B2 (ja)	2012-07-18	抗ウイルスヌクレオシド類似体およびウイルス感染特にｈｉｖ感染の処置方法
JP2851094B2 (ja)	1999-01-27	ピリミジン誘導体
US4788181A (en)	1988-11-29	5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
JPS63290895A (ja)	1988-11-28	抗ウイルスヌクレオシド
US5215971A (en)	1993-06-01	Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
US5215970A (en)	1993-06-01	Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US4710492A (en)	1987-12-01	3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
EP0294443B1 (fr)	1992-07-29	Utilisation de nucleosides pour la fabrication d'un medicament destine aux traitements de maladies causees par un retrovirus ou par le virus de l'hepatite b
JPH07145058A (ja)	1995-06-06	レトロウイルスに感染した患者を治療するための２’，３’−ジデオキシシチジン−２’−エン（２’，３’−ジデオキシ−２’，３’−ジデヒドロシチジン）の製造方法
US5153180A (en)	1992-10-06	Fluorinated nucleosides and process for treating retrovirus infections therewith
JPH02108695A (ja)	1990-04-20	治療用ヌクレオシド
WO1991019727A1 (fr)	1991-12-26	5-hydrogenophosphonates et 5'-methylphosphonates de nucleosides modifies du sucre, compositions et utilisations de ces produits pour traiter des infections virales
EP0516186A2 (fr)	1992-12-02	Nucléosides et analogues de nucléosides, compositions et procédés pharamaceutiques permettant la préparation des composés
EP0309560B1 (fr)	1994-12-21	Nucleosides et analogues de nucleosides, compositions et procedes pharmaceutiques permettant la preparation des composes
US5086044A (en)	1992-02-04	Treatment of human viral infections
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