CA2000596A1 - Substrats enzymatiques de merocyanine chromogene - Google Patents

Substrats enzymatiques de merocyanine chromogene

Info

Publication number
CA2000596A1
CA2000596A1 CA2000596A CA2000596A CA2000596A1 CA 2000596 A1 CA2000596 A1 CA 2000596A1 CA 2000596 A CA2000596 A CA 2000596A CA 2000596 A CA2000596 A CA 2000596A CA 2000596 A1 CA2000596 A1 CA 2000596A1
Authority
CA
Canada
Prior art keywords
chromogenic
acid
enzyme substrates
merocyanine enzyme
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2000596A
Other languages
English (en)
Other versions
CA2000596C (fr
Inventor
Paul F. Corey
M. Teresa Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Publication of CA2000596A1 publication Critical patent/CA2000596A1/fr
Application granted granted Critical
Publication of CA2000596C publication Critical patent/CA2000596C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0091—Methine or polymethine dyes, e.g. cyanine dyes having only one heterocyclic ring at one end of the methine chain, e.g. hemicyamines, hemioxonol
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
CA002000596A 1989-02-13 1989-10-12 Substrats enzymatiques de merocyanine chromogene Expired - Fee Related CA2000596C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US310,060 1989-02-13
US07/310,060 US5122602A (en) 1989-02-13 1989-02-13 Chromogenic merocyanine enzyme substrates

Publications (2)

Publication Number Publication Date
CA2000596A1 true CA2000596A1 (fr) 1990-08-13
CA2000596C CA2000596C (fr) 2000-12-05

Family

ID=23200833

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002000596A Expired - Fee Related CA2000596C (fr) 1989-02-13 1989-10-12 Substrats enzymatiques de merocyanine chromogene

Country Status (6)

Country Link
US (1) US5122602A (fr)
EP (1) EP0383092B1 (fr)
JP (1) JP2926100B2 (fr)
AU (2) AU617237B2 (fr)
CA (1) CA2000596C (fr)
DE (1) DE69024071T2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0517050T3 (fr) * 1991-06-06 1997-03-03 Bayer Ag
US5534416A (en) * 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5601986A (en) * 1994-07-14 1997-02-11 Amgen Inc. Assays and devices for the detection of extrahepatic biliary atresia
US5616502A (en) * 1995-05-19 1997-04-01 Molecular Probes, Inc. Non-specific protein staining using merocyanine dyes
GB9716476D0 (en) * 1997-08-04 1997-10-08 Amersham Int Plc Dye intermediate and method
FR2809820B1 (fr) * 2000-05-30 2002-10-25 Proteus Methode de detection d'une transformation d'un substrat et ses applications
FR2832729B1 (fr) * 2001-11-28 2004-01-16 Proteus Methode de detection d'une activite catalytique d'un echantillon mettant en oeuvre la detection de la transformation d'un substrat
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
US7563891B2 (en) * 2004-05-21 2009-07-21 Becton, Dickinson & Company Long wavelength thiol-reactive fluorophores
US7598390B2 (en) 2005-05-11 2009-10-06 Life Technologies Corporation Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
CA2664649A1 (fr) 2006-09-28 2008-05-08 Ensemble Discovery Corporation Compositions et procedes de biodetection par chimie a matrice d'acides nucleiques
WO2011050323A1 (fr) * 2009-10-22 2011-04-28 The Washington University Composés et méthodes pour le traitement d'infections bactériennes
WO2012109263A1 (fr) 2011-02-07 2012-08-16 The Washington University Composés mannosides et leurs procédés d'utilisation
EP3003322B1 (fr) 2013-05-30 2023-09-13 Washington University Dérivés du mannose et leur utilisation dans le traitement d'infections bactériennes
AU2017238392A1 (en) 2016-03-23 2018-09-27 Fimbrion Therapeutics, Inc. Mannose-derived antagonists of FimH useful for treating disease
CN106336442B (zh) * 2016-07-27 2018-11-27 昆药集团股份有限公司 天麻素衍生物、其制备方法、其应用与药物制剂
UY38293A (es) 2018-07-10 2020-05-29 Glaxosmithkline Ip Dev Ltd Nuevos compuestos y composiciones de c-manósido antagonistas de fimh
US12297223B2 (en) 2019-05-07 2025-05-13 Glaxosmithkline Intellectual Property Development Limited Compounds
WO2020254369A1 (fr) 2019-06-19 2020-12-24 Glaxosmithkline Intellectual Property Development Limited Biphényl- ou phénylhétéroaryl-mannosides substitués en tant qu'antagonistes de fimh
CN113234111A (zh) * 2021-02-22 2021-08-10 西北大学 同时检测β-半乳糖苷酶和溶酶体pH的荧光探针及其制备方法和应用
CN121045286A (zh) * 2025-08-26 2025-12-02 黑龙江中医药大学 青龙衣中一种萘酚苷类化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047470B1 (fr) * 1980-09-02 1985-04-24 Fuji Photo Film Co., Ltd. Méthode de mesure immunochimique
US4536572A (en) * 1982-11-17 1985-08-20 University Of Utah Amido-phenyl-α-D-glucopyranoside derivatives
DE3345748A1 (de) * 1983-12-17 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
NZ211872A (en) * 1984-04-27 1989-06-28 Ishihara Sangyo Kaisha Chartreusin derivatives and antitumorous compositions
US4760135A (en) * 1984-09-06 1988-07-26 University Of Kentucky Research Foundation Phloretin and phlorizin derivative containing compounds
JPS61112092A (ja) * 1984-11-07 1986-05-30 Meiji Seika Kaisha Ltd 新規グルコサミン誘導体及びこれを基質として用いるＮ−アセチル−β−Ｄ−グルコサミニダ−ゼの活性測定試薬
GB8721302D0 (en) * 1987-09-10 1987-10-14 London King S College Substrates for assay of enzymes

Also Published As

Publication number Publication date
EP0383092B1 (fr) 1995-12-13
DE69024071D1 (de) 1996-01-25
JPH02245200A (ja) 1990-09-28
JP2926100B2 (ja) 1999-07-28
AU8367091A (en) 1991-11-07
EP0383092A2 (fr) 1990-08-22
AU640517B2 (en) 1993-08-26
CA2000596C (fr) 2000-12-05
DE69024071T2 (de) 1996-05-15
AU617237B2 (en) 1991-11-21
AU4868290A (en) 1990-08-16
US5122602A (en) 1992-06-16
EP0383092A3 (fr) 1992-03-25

Similar Documents

Publication Publication Date Title
CA2000596A1 (fr) Substrats enzymatiques de merocyanine chromogene
Guilbault et al. Fluorometric Determination of Lipase, Acylase, Alpha-, and Gamma-Chymotrypsin and Inhibitors of These Enzymes.
AU551907B2 (en) Determining the presence of leukocytes, esterase and protease
AU540076B2 (en) Composition for testing for glucose comprising glucose oxitase perotidase and hydrogen peroxide
AU558425B2 (en) Novel compounds
AU4251297A (en) 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
AU563001B2 (en) Peptide derivatives as chromogenic compounds
ATE117311T1 (de) Substrate für hydrolasen, verfahren zu ihrer herstellung und ihre verwendung.
HK54785A (en) PROCESS AND REAGENT FOR THE DETERMINATION OF α-AMYLASE
EP0240914A3 (en) Peptide derivatives and activity measuring method of physiologically active substances using the same as substrates
DE3273160D1 (en) Reagent and method for detecting hydrogen peroxide or peroxidases
JPS5569549A (en) Novel substrate for determination of enzyme activity
Elmore et al. A new method for determining the absolute molarity of solutions of trypsin and chymotrypsin by using p-nitrophenyl N 2-acetyl-N 1-benzylcarbazate
DK161205C (da) Enzymatisk fremgangsmaade til bestemmelse af beta-lactamantibiotica indeholdende en beta-lactam-kerne og proeveudstyr til saadan bestemmelse
Kosman et al. ESR probing of macromolecules: Function and operation of structural units within the active site of α-chymotrypsin
US5155026A (en) Method for determination of nagase and reagent therefor
Subbarao et al. Correlation of carbonic anhydrase inhibitory activities of benzenesulfonamides with the data obtained by use of nitrogen-14 nuclear quadrupole resonance
CA2131474A1 (fr) Preparation d'hydroxyoxaalkylmelamines
US4983512A (en) Reagent for determination of acid phosphatase
Banerjee et al. Physicochemical property modification strategies based on enzyme substrate specificities II: α‐chymotrypsin hydrolysis of aspirin derivatives
EP0134078A3 (fr) Procédé pour la détermination des antibiotiques dans des liquides biologiques
JPS5775959A (en) Substrate for enzyme
KAMACHI et al. New Chromogenic Substrates for the Assy of Esterases-Acetates and Butyrates of Phenolic Naphthylazo Compounds with Sulfonic Acid Group
JPS5630956A (en) Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same
FUKUDA et al. powder have been rep0rted, 7'1) such as chitooligosaccharides of various sizes or a spin

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20041012