CA2000596A1 - Substrats enzymatiques de merocyanine chromogene - Google Patents

Substrats enzymatiques de merocyanine chromogene

Info

Publication number: CA2000596A1
Authority: CA; Canada
Prior art keywords: chromogenic; acid; enzyme substrates; merocyanine enzyme; compounds
Prior art date: 1989-02-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2000596A

Other languages

English (en)

Other versions

CA2000596C (fr

Inventor

Paul F. Corey

M. Teresa Yip

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Corp

Original Assignee

Miles Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-13

Filing date

1989-10-12

Publication date

1990-08-13

1989-10-12 Application filed by Miles Inc filed Critical Miles Inc

1990-08-13 Publication of CA2000596A1 publication Critical patent/CA2000596A1/fr

2000-12-05 Application granted granted Critical

2000-12-05 Publication of CA2000596C publication Critical patent/CA2000596C/fr

2009-10-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000004190 Enzymes Human genes 0.000 title abstract 3
108090000790 Enzymes Proteins 0.000 title abstract 3
DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 title abstract 2
239000000758 substrate Substances 0.000 title abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
238000004458 analytical method Methods 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0091—Methine or polymethine dyes, e.g. cyanine dyes having only one heterocyclic ring at one end of the methine chain, e.g. hemicyamines, hemioxonol
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

CA002000596A 1989-02-13 1989-10-12 Substrats enzymatiques de merocyanine chromogene Expired - Fee Related CA2000596C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/310,060 US5122602A (en)	1989-02-13	1989-02-13	Chromogenic merocyanine enzyme substrates
US310,060		1989-02-13

Publications (2)

Publication Number	Publication Date
CA2000596A1 true CA2000596A1 (fr)	1990-08-13
CA2000596C CA2000596C (fr)	2000-12-05

Family

ID=23200833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002000596A Expired - Fee Related CA2000596C (fr)	1989-02-13	1989-10-12	Substrats enzymatiques de merocyanine chromogene

Country Status (6)

Country	Link
US (1)	US5122602A (fr)
EP (1)	EP0383092B1 (fr)
JP (1)	JP2926100B2 (fr)
AU (2)	AU617237B2 (fr)
CA (1)	CA2000596C (fr)
DE (1)	DE69024071T2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2092595T3 (es) *	1991-06-06	1996-12-01	Bayer Ag	Tira de ensayo que contiene merocianina y fenolsulfonoftaleinas polihalogenadas nitro o nitroso sustituidas como indicadores de proteinas.
US5534416A (en) *	1993-04-13	1996-07-09	Molecular Probes, Inc.	Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5601986A (en) *	1994-07-14	1997-02-11	Amgen Inc.	Assays and devices for the detection of extrahepatic biliary atresia
US5616502A (en) *	1995-05-19	1997-04-01	Molecular Probes, Inc.	Non-specific protein staining using merocyanine dyes
GB9716476D0 (en) *	1997-08-04	1997-10-08	Amersham Int Plc	Dye intermediate and method
FR2809820B1 (fr) *	2000-05-30	2002-10-25	Proteus	Methode de detection d'une transformation d'un substrat et ses applications
FR2832729B1 (fr) *	2001-11-28	2004-01-16	Proteus	Methode de detection d'une activite catalytique d'un echantillon mettant en oeuvre la detection de la transformation d'un substrat
US7776529B2 (en)	2003-12-05	2010-08-17	Life Technologies Corporation	Methine-substituted cyanine dye compounds
US7563891B2 (en) *	2004-05-21	2009-07-21	Becton, Dickinson & Company	Long wavelength thiol-reactive fluorophores
JP5306811B2 (ja) *	2005-05-11	2013-10-02	ライフテクノロジーズコーポレーション	２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
US7781187B2 (en) *	2005-12-30	2010-08-24	Corning Incorporated	Fluorescent dyes
WO2008054600A2 (fr) *	2006-09-28	2008-05-08	Ensemble Discovery Corporation	Compositions et procédés de biodétection par chimie à matrice d'acides nucléiques
WO2011050323A1 (fr) *	2009-10-22	2011-04-28	The Washington University	Composés et méthodes pour le traitement d'infections bactériennes
EP2672820B1 (fr)	2011-02-07	2019-04-17	The Washington University	Composés mannosides et leurs procédés d'utilisation
CN105682665A (zh)	2013-05-30	2016-06-15	华盛顿大学	用于治疗细菌性感染的化合物和方法
AU2017238392A1 (en)	2016-03-23	2018-09-27	Fimbrion Therapeutics, Inc.	Mannose-derived antagonists of FimH useful for treating disease
CN106336442B (zh) *	2016-07-27	2018-11-27	昆药集团股份有限公司	天麻素衍生物、其制备方法、其应用与药物制剂
RS63712B1 (sr)	2018-07-10	2022-11-30	Glaxosmithkline Ip Dev Ltd	Jedinjenja c-manozida korisna za tretman infekcija urinarnog trakta
CA3138394A1 (fr)	2019-05-07	2020-11-12	Glaxosmithkline Intellectual Property Development Limited	Nouveaux composes
WO2020254369A1 (fr)	2019-06-19	2020-12-24	Glaxosmithkline Intellectual Property Development Limited	Biphényl- ou phénylhétéroaryl-mannosides substitués en tant qu'antagonistes de fimh
CN113234111A (zh) *	2021-02-22	2021-08-10	西北大学	同时检测β-半乳糖苷酶和溶酶体pH的荧光探针及其制备方法和应用
CN121045286B (zh) *	2025-08-26	2026-04-28	黑龙江中医药大学	青龙衣中一种萘酚苷类化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0047470B1 (fr) *	1980-09-02	1985-04-24	Fuji Photo Film Co., Ltd.	Méthode de mesure immunochimique
US4536572A (en) *	1982-11-17	1985-08-20	University Of Utah	Amido-phenyl-α-D-glucopyranoside derivatives
DE3345748A1 (de) *	1983-12-17	1985-08-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
NZ211872A (en) *	1984-04-27	1989-06-28	Ishihara Sangyo Kaisha	Chartreusin derivatives and antitumorous compositions
US4760135A (en) *	1984-09-06	1988-07-26	University Of Kentucky Research Foundation	Phloretin and phlorizin derivative containing compounds
JPS61112092A (ja) *	1984-11-07	1986-05-30	Meiji Seika Kaisha Ltd	新規グルコサミン誘導体及びこれを基質として用いるＮ−アセチル−β−Ｄ−グルコサミニダ−ゼの活性測定試薬
GB8721302D0 (en) *	1987-09-10	1987-10-14	London King S College	Substrates for assay of enzymes

1989
- 1989-02-13 US US07/310,060 patent/US5122602A/en not_active Expired - Lifetime
- 1989-10-12 CA CA002000596A patent/CA2000596C/fr not_active Expired - Fee Related
1990
- 1990-01-22 AU AU48682/90A patent/AU617237B2/en not_active Ceased
- 1990-01-31 EP EP90101862A patent/EP0383092B1/fr not_active Expired - Lifetime
- 1990-01-31 DE DE69024071T patent/DE69024071T2/de not_active Expired - Fee Related
- 1990-02-09 JP JP2028630A patent/JP2926100B2/ja not_active Expired - Fee Related
1991
- 1991-09-05 AU AU83670/91A patent/AU640517B2/en not_active Ceased

Also Published As

Publication number	Publication date
JP2926100B2 (ja)	1999-07-28
US5122602A (en)	1992-06-16
AU4868290A (en)	1990-08-16
CA2000596C (fr)	2000-12-05
EP0383092A2 (fr)	1990-08-22
AU617237B2 (en)	1991-11-21
DE69024071D1 (de)	1996-01-25
DE69024071T2 (de)	1996-05-15
AU8367091A (en)	1991-11-07
AU640517B2 (en)	1993-08-26
JPH02245200A (ja)	1990-09-28
EP0383092A3 (fr)	1992-03-25
EP0383092B1 (fr)	1995-12-13

Legal Events

Date	Code	Title	Description
1993-10-25	EEER	Examination request
2004-10-12	MKLA	Lapsed
2023-05-26	MKLA	Lapsed	Effective date: 20041012

Publication	Publication Date	Title
CA2000596A1 (fr)	1990-08-13	Substrats enzymatiques de merocyanine chromogene
Guilbault et al.	1964	Fluorometric Determination of Lipase, Acylase, Alpha-, and Gamma-Chymotrypsin and Inhibitors of These Enzymes.
AU551907B2 (en)	1986-05-15	Determining the presence of leukocytes, esterase and protease
AU558425B2 (en)	1987-01-29	Novel compounds
AU1403883A (en)	1984-02-09	Composition for testing for glucose comprising glucose oxitase perotidase and hydrogen peroxide
AU4251297A (en)	1998-04-17	4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
AU563001B2 (en)	1987-06-25	Peptide derivatives as chromogenic compounds
AU4089385A (en)	1985-10-10	Substrates for hydrolases, a method for their preparation and their use
JPS5569549A (en)	1980-05-26	Novel substrate for determination of enzyme activity
Elmore et al.	1968	A new method for determining the absolute molarity of solutions of trypsin and chymotrypsin by using p-nitrophenyl N 2-acetyl-N 1-benzylcarbazate
CA2088368A1 (fr)	1992-04-16	Technique d'immunodetection
ES2053547T3 (es)	1994-08-01	Reactivo para someter a ensayo enfermedades periodontales.
DK161205C (da)	1991-11-25	Enzymatisk fremgangsmaade til bestemmelse af beta-lactamantibiotica indeholdende en beta-lactam-kerne og proeveudstyr til saadan bestemmelse
Kosman et al.	1969	ESR probing of macromolecules: Function and operation of structural units within the active site of α-chymotrypsin
Subbarao et al.	1979	Correlation of carbonic anhydrase inhibitory activities of benzenesulfonamides with the data obtained by use of nitrogen-14 nuclear quadrupole resonance
AU618004B2 (en)	1991-12-12	Method for determination of nagase and reagent therefor
US4983512A (en)	1991-01-08	Reagent for determination of acid phosphatase
Banerjee et al.	1981	Physicochemical property modification strategies based on enzyme substrate specificities II: α‐chymotrypsin hydrolysis of aspirin derivatives
EP0134078A3 (fr)	1986-03-12	Procédé pour la détermination des antibiotiques dans des liquides biologiques
Morii et al.	1984	Quasi-elastic light-scattering studies of conformational states of the proton-potassium ATPase. Intervesicular aggregation of gastric vesicles by disulfide crosslinking
JPS6434298A (en)	1989-02-03	Method for fractionating and determining alpha-amylase isozyme
ES8401255A1 (es)	1983-12-01	Metodo para la determinacion colorimetrica de peroxidos.
FUKUDA et al.	1985	powder have been rep0rted, 7'1) such as chitooligosaccharides of various sizes or a spin